Category: imidazoles-derivatives

Ranganathan, Darshan published the artcileRepetitive imidazole synthesis using an immobilized imidazole template, HPLC of Formula: 21343-04-4, the main research area is imidazole repetitive synthesis template; ATP imidazole cycle model.

A model is presented for the chem. simulation of the ATP-imidazole cycle programmed to continuous production of the daughter imidazoles from the immobilized parent imidazole template. 6-Chloropurine was treated with chloromethylated polystyrene and hydrolysis of the product followed by alkylation with PhCOCH2Br afforded polymer-bound hypoxanthine I (R = CH2COPh, R1 = chloromethylated polystyrene). Treating I (R = CH2COPh, R1 = chloromethylated polystyrene) with PhCH2NH2 and p-MeC6H4SO3H produced the expected daughter mol., 1-benzyl-5-phenylimidazole (II) in 30% yield and the polymer-bound 5-aminoimidazole-4-carboxamide III, which, in turn, was transformed to the template hypoxanthine I (R = H) by treatment with MeSO3H followed by HCONH2. To prove the concept of the continuous generation of the daughter mol., the regenerated parent template was processed through a second cycle using the same protocol when the expected daughter product II was obtained in 14% yield. Polymer-bound adenine when subjected to a similar protocol failed to yield any daughter mol. Endeavors to prepare polymer-linked 4-oxoquinazoline and anthranilic acid are also reported.

Journal of Organic Chemistry published new progress about imidazole repetitive synthesis template; ATP imidazole cycle model. 21343-04-4 belongs to class imidazoles-derivatives, name is 5-Amino-1-methyl-1H-imidazole-4-carboxamide, and the molecular formula is C5H8N4O, HPLC of Formula: 21343-04-4.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kochergin, P. M. published the artcileSynthesis of 7-methyl-6-(nitroimidazolyl)thiopurines, Recommanded Product: 5-Bromo-2-methyl-4-nitroimidazole, the main research area is methylnitroimidazolylthiopurine preparation; purine methylnitroimidazolylthio preparation; imidazolylthiopurine methylnitro preparation.

We have studied the reactions of 7-methyl-6-thiopurine with 5(4)-halo-4(5)-nitroimidazoles and 6-chloro-7-methylpurine with sodium and ammonium salts of 5-mercapto-4-nitroimidazoles. We have obtained a series of 7-methyl-6-(nitroimidazolyl)thiopurines not previously described in the literature.

Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about methylnitroimidazolylthiopurine preparation; purine methylnitroimidazolylthio preparation; imidazolylthiopurine methylnitro preparation. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Recommanded Product: 5-Bromo-2-methyl-4-nitroimidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kochergin, P. M. published the artcileInvestigations in the imidazole series 97. Synthesis and some transformations of 5-nitro-5-hydroxyalkylamino- and 4-hydroxyalkylamino-5-nitroimidazoles, Application In Synthesis of 18874-52-7, the main research area is nitrohydroxyalkylaminoimidazole preparation reaction; imidazole nitro hydroxyalkylamino preparation reaction; hydroxyalkylaminoimidazole nitro preparation reaction.

A series of 1-alkyl(1,2-dialkyl)-substituted 4-nitro-5-hydroxyalkylamino- and 4-hydroxyalkylamino-5-nitroimidazoles were obtained by the reaction of 1-alkyl(1,2-dialkyl)-substituted 4-nitro-5-chloro(bromo)imidazoles with amino alcs. Their reactions with thionyl chloride and carboxylic acid halides and their catalytic hydrogenation were studied.

Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about nitrohydroxyalkylaminoimidazole preparation reaction; imidazole nitro hydroxyalkylamino preparation reaction; hydroxyalkylaminoimidazole nitro preparation reaction. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Application In Synthesis of 18874-52-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Albright, J. Donald published the artcileSynthesis of 4-aroyl-5-nitro-1H-imidazoles and 4-aroyl-5-aminoimidazoles, Related Products of imidazoles-derivatives, the main research area is nitroimidazole; aroylaminoimidazole; aminoimidazole aroyl; imidazole aroyl amino nitro.

The reaction of α-(aryl)-4-morpholineacetonitriles (masked aroyl anion equivalent) with N-protected 4(5)-bromo-5(4)-nitro-1H-imidazoles gave 4-aroyl-5-nitroimidazoles, which were reduced to afford 4-aroyl-5-aminoimidazoles. Thus, imidazole I (R = Bz) was prepared from I (R = Br) and nitrile II.

Journal of Heterocyclic Chemistry published new progress about nitroimidazole; aroylaminoimidazole; aminoimidazole aroyl; imidazole aroyl amino nitro. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kirk, Kenneth L. published the artcilePhotochemistry of diazonium salts. I. Synthesis of 4-fluoroimidazoles, 4-fluorohistamine, and 4-fluorohistidine, Related Products of imidazoles-derivatives, the main research area is photochem diazonium salt; fluorinated imidazole.

Imidazolediazonium ions, prepared by diazotization of aminoimidazoles in HBF4 and irradiated in situ, decompose with formation of fluoroimidazoles in 30-40% yield. 2-Fluoroimidazole, 4-fluoroimidazole, and Et 4-fluoroimidazole-5-carboxylate (I) were prepared I was the starting point for various transformations, including the synthesis of 4-fluorohistamine and 4-fluorohistidine. The fluorinated amino acid parallels histidine as a substrate for several enzymes and, in the case of histidine-ammonia lyase, serves as a competitive inhibitor.

Journal of the American Chemical Society published new progress about photochem diazonium salt; fluorinated imidazole. 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cooper, G. published the artcile1-styrylimidazoles, Related Products of imidazoles-derivatives, the main research area is styrylimidazole; imidazole styryl; benzimidazole styryl; dehydration hydroxyphenylethylimidazole.

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. Styrene oxide reacted with imidazole, its 2-methyl, 2-phenyl, and 4,5-diphenyl derivatives and benzimidazole in DMF in the presence of catalytic quantities of K at room temperature to give 45-98% of the corresponding 1-(2-hydroxy-2-phenylethyl)imidazole, which on heating with SOCl2 and KOH were dehydrated to give 51-90% trans-1-styrylimidazoles.

Journal of the Chemical Society, Perkin Transactions 6: Organic and Bio-Organic Chemistry published new progress about styrylimidazole; imidazole styryl; benzimidazole styryl; dehydration hydroxyphenylethylimidazole. 5805-53-8 belongs to class imidazoles-derivatives, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, and the molecular formula is C9H8N2O2, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chermahini, Alireza Najafi published the artcileRelation between the substituent effect and aromaticity in imidazole derivatives: A comparative study, Application of 5-Fluoro-1H-imidazole, the main research area is aromaticity imidazole derivative.

The energies and aromaticity of R substituted imidazoles [R = NH2, OH, H, CH3, F, Cl, CN, NO, NO2], their anions and protonated forms in the gas phase were calculated with the DFT/B3LYP and MP2 methods at the 6-311++G(d,p) level. The authors analyzed the change of local aromaticity using several aromaticity indicators (Pozharsky Index, HOMA, NICS, ASE and pEDA) and found a considerable ring aromaticity for imidazoles, imidazolate anions and their protonated forms. In each class anion forms have the most aromaticity and in neutral forms, 1-H imidazoles have less aromaticity character. The HOMA and structural AI show good correlation with each other but NICS (0) values showed a poor correlation with other scales. The geometrical indexes seem to be better correlate with substituent effect.

Computational & Theoretical Chemistry published new progress about Aromaticity. 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, Application of 5-Fluoro-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rao, A. K. S. Bhujanga published the artcileA new high-yielding method for the preparation of 2-alkyl- and 1,2-dialkyl-4-nitro-5-bromoimidazoles, Synthetic Route of 18874-52-7, the main research area is alkylnitroimidazole bromination; bromoimidazole alkylnitro; alkylbromonitroimidazole; imidazole alkylnitro bromination.

A new brominating system Br2-DMF-KHCO3 is described for the preparation of the title compounds I (R = H, Et, CH2CH2CN, CH2CH2COMe, CH2CH2CO2Et, CH2CH2CO2H, CH2CO2Et, CH2Ph, CH2C6H4Cl-4, CH2CH2SO2Et, cyclopropylmethyl; R1 = Me, Et). The mild conditions of the reaction allow bromination to be carried out in the presence of acid and base sensitive functionalities in nearly quant. yields.

Journal of Organic Chemistry published new progress about Bromination. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Synthetic Route of 18874-52-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Clark, Jim published the artcileHeterocyclic studies. XVI. Imidazo and diimidazopyrimidines, Quality Control of 274-78-2, the main research area is imidazopyrimidines; diimidazopyrimidines; pyrimidines imidazo.

Condensation of 2,4-dichloro-6-methyl-5-nitropyrimidine (I, X = Cl) with Cl(CH2)2NH2 gave the tetrahydrodiimidazopyrimidine (II). A hydrated derivative (III) of II was prepared by POCl3 treatment of either the 2,4-bis[(2-hydroxyethyl)amino]pyrimidine (I, X = NH(CH2)2OH), the dihydroimidazo[1,2-a]pyrimidine [IV, R1 = Me, R2 = NH(CH2)2OH] or the dihydroimidazo[1,2-a]pyrimidine (V). 4,6-Dichloro-2-methyl-5-nitropyrimidine (VI, X = Cl) and Cl(CH2)2NH2 gave the bis[(2-chloroethyl)amino]-pyrimidine (VI, X = NH(CH2)2Cl), which cyclized in two steps to the dihydroimidazo[1,2-c]pyrimidine [IV, R1 = NH(CH2)2Cl, R2 = Me] and then the quaternary tricyclic compound (VII).

Journal of the Chemical Society [Section] C: Organic published new progress about Cyclization. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Quality Control of 274-78-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Armarego, W. L. F. published the artcileTriazaindenes (diazaindolizines). The site of protonation, Application of Imidazo[1,2-c]pyrimidine, the main research area is .

The syntheses of 1,3a,4-, 1,3a,5-, 1,3a,6-, and 1,3a,7-triazaindenes and their 2,3-dihydro derivatives are described. Ionization and uv spectra measurements indicate that in each case protonation occurs on N-1. Evidence is given that 1,2,3a- and 2-methyl-1,3,3a-triazaindene cations are also protonated on N-1, but 1,2,7a-triazaindene cation is protonated on N-2.

Journal of the Chemical Society published new progress about Protonation. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Application of Imidazo[1,2-c]pyrimidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem