Category: imidazoles-derivatives

Malsawmdawngliana published the artcileAntioxidant efficacy and cytotoxicity of ethanol extract of Clerodendrum infortunatum against different cell lines, Synthetic Route of 30086-17-0, the main research area is Clerodendrum infortunatum cell line ethanol extract antioxidant efficacy cytotoxicity.

Clerodendrum infortunatum belongs to the Lamiaceae family and is a perennial shrub. It is widely known for their important medicinal values among the Mizo tribe. In the present study, the preliminary phytochem. screening, quantification of phenols, flavonoids and alkaloids, antioxidant activities by DPPH, O2- and ABTS assays and cytotoxicity by MTT assay against AGS (gastric cancer), HeLa (cervical) and HT-29 (colon) cell lines compared with normal cell line (Chang liver) were performed. Furthermore, the GC-MS profiling was also conducted. The results imply the presence of saponin, alkaloid, cardiac glycoside, phenol and flavonoid. The quantification shows that phenol content (64.35 mg/ g) was highest followed by flavonoid (61.93 mg/ g) and alkaloid (13.33 mg/ g). Its scavenging efficiency against DPPH with IC50 value was 47.99, against O2- with IC50 was 108 μg/mL and against ABTS cations with IC50 was 50.05 μg/mL, resp. The ethanol extract exhibited a maximum cytotoxicity against HeLa with IC50 value of 53.55 μg/mL, AGS with IC50 value 82.44 μg/mL and HT-29 with IC50 value of 142.2 μg/mL. However, the extract showed comparatively less toxicity against normal cell lines. Moreover, 14 active compounds were confirmed in the GC-MS anal. of the extract HPLC study also infers the occurrence of the flavonoids rutin and quercetin. Therefore, the results of C. infortunatum ethanolic extract clearly specified that it has a very high antioxidant activity as well as cytotoxic properties; which proved that this ethnomedicinal plant can be used as an alternative agent to treat a variety of illnesses.

Indian Journal of Biochemistry & Biophysics published new progress about Alkaloids Role: ANT (Analyte), ANST (Analytical Study). 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, Synthetic Route of 30086-17-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Morita, Kunihiko published the artcileOzagrel hydrochloride monohydrate, a thromboxane synthase inhibitor, and its metabolites as inhibitors of hepatic microsomal drug metabolism, Computed Properties of 94084-75-0, the main research area is ozagrel metabolite liver microsome drug metabolism.

The change in the hepatic oxidative drug-metabolizing capacity in humans treated with ozagrel hydrochloride (I; OZA), an imidazole derivative and a new thromboxane A2 synthase inhibitor, was studied and the inhibitory potencies of the metabolites of OZA (M-1 and M-2) on the mouse hepatic microsomal monooxygenase system in vitro were compared with that of OZA. In vitro, M-1 and M-2, which are the β-oxidized form and the reduced form of OZA, resp., inhibited aminopyrine N-demethylation, aniline hydroxylation and testosterone hydroxylations in mouse hepatic microsomes and produced type II difference spectra in the same manner as OZA. The kinetic data indicated that the inhibitory potencies and the affinities of these compounds for cytochrome P 450 were decreased in the order of M-2 > OZA > M-1. The ratio of 6β-hydroxycortisol to cortisol in urine, used as an indicator of oxidative drug-metabolizing capacity in humans, did not change significant during oral treatment with 400 mg/day of OZA, while the ratio decreased to 80-85% of the original level during treatment with 800 mg/d of OZA. Although the participation of the metabolites of OZA in the reduction of drug-metabolizing capacity in vivo is not yet clear, the results suggest that hepatic oxidative drug-metabolizing enzyme activities in humans are inhibited by treatment with a relatively high dose of OZA.

Chemical & Pharmaceutical Bulletin published new progress about Drug-metabolizing enzymes Role: PROC (Process). 94084-75-0 belongs to class imidazoles-derivatives, name is 4-((1H-Imidazol-1-yl)methyl)benzoic acid, and the molecular formula is C11H10N2O2, Computed Properties of 94084-75-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Evleth, Earl M. published the artcileSystematics of the electronic absorption spectra of fused 5-6 ring heterocyclics, HPLC of Formula: 274-78-2, the main research area is heterocyclics electronic spectra; electronic spectra heterocyclics; aza substitution spectral effect; indolizines spectra.

The electronic absorption spectra of indene, indole, benzofuran isoindole, indolizine, and 1- and 2-pyrindine are rationalized by using semiempirical SCF-configuration interaction calculations The absorption spectra of these materials are also rationalized by using indenyl anion as the common perturbational model. Perturbation theory is also applied to explaining the effect of aza-substitution on the spectra of indolizines.

Theoretica Chimica Acta published new progress about Heterocyclic compounds Role: PRP (Properties). 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, HPLC of Formula: 274-78-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Joshi-Pangu, Amruta published the artcileDearomatization of Electron-Deficient Nitrogen Heterocycles via Cobalt-Catalyzed Asymmetric Cyclopropanation, Application In Synthesis of 67625-38-1, the main research area is dearomatization electron deficient nitrogen heterocycle cobalt catalyst stereoselective cyclopropanation.

The dearomatization of a series of electron-deficient nitrogen heterocycles has been achieved through a cobalt-catalyzed asym. cyclopropanation reaction. This reaction proceeds with high levels of enantio- and diastereoselectivity to afford unique cyclopropanes that can be further functionalized to provide complex heterocyclic building blocks.

Journal of Organic Chemistry published new progress about Cyclopropanation catalysts, stereoselective. 67625-38-1 belongs to class imidazoles-derivatives, name is Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate, and the molecular formula is C10H9ClN2O2, Application In Synthesis of 67625-38-1.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kikalishvili, T. J. published the artcileTrimeric mechanism of proton transfer in imidazole, COA of Formula: C3H3FN2, the main research area is imidazole derivative proton transfer trimeric mechanism AM1 MO.

The energy, electronic, and structural characteristics of the tautomeric transformation of imidazole were calculated by the quantum-chem. semiempirical AM1 method. It was concluded on the basis of the calculated data that proton transfer in the tautomeric transformation 1H-imidazole ⇄ 3H-imidazole can take place by a trimeric mechanism.

Chemistry of Heterocyclic Compounds published new progress about Potential energy surface (proton transfer). 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, COA of Formula: C3H3FN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zink, Laura published the artcileLong distance-SRN1 in nitroimidazole series favored by temperature, Product Details of C4H4BrN3O2, the main research area is long distance unimol radical nucleophilic substitution reaction nitroimidazole; imidazole nitro long distance unimol radical nucleophilic substitution.

New reductive alkylating agents in 4- and 5-nitroimidazole series produce exclusively O-alkylation with nitronate anions under classical SRN1 conditions at room temperature Electron-transfer C-alkylation is observed under microwave irradiation or under conventional heating. Furthermore, X-ray spectroscopy shows that the dihedral angles between the Ph and imidazole rings for the two series are different, which could greatly influence reactivity in 4- and 5-nitroimidazole series.

Tetrahedron Letters published new progress about Radical nucleophilic substitution reaction. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Product Details of C4H4BrN3O2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hys, Vasyl Y. published the artcileSynthetic Approach to Fused Azasultams with 1,2,4-Thiadiazepine Framework, Formula: C9H8N2O2, the main research area is fused azasultam thiadiazepine preparation; azole pyrrole carboxylate sulfonamide heterocyclization.

Synthetic approach to fused azasultams with 1,2,4-thiadiazepine framework via base promoted protocols has been developed. 1H-Azole-2-carboxylates and N-(chloromethyl)-N-methylmethanesulfonamide were used as ambiphilic building blocks in the one-pot and two-step reaction sequences. Chem. behavior of the obtained azasultams in reactions with amines, hydrazine, DMFDMA, and NaBH4 was investigated. An enamino ketone derived from an azasultam was exploited in the synthesis of new pyrazole and pyrimidine heterocycles.

Synthesis published new progress about Condensation reaction (sulfa-Dieckmann). 5805-53-8 belongs to class imidazoles-derivatives, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, and the molecular formula is C9H8N2O2, Formula: C9H8N2O2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Alhede, Boerge published the artcileA simple and efficient synthesis of 9-substituted guanines. Cyclodesulfurization of 1-substituted 5-[(thiocarbamoyl)amino]imidazole-4-carboxamides under aqueous basic conditions, Related Products of imidazoles-derivatives, the main research area is guanine substituted; thiocarbamoylaminoimidazolecarboxamide cyclodesulfurization metal salt catalyzed; imidazolecarboxamide thiocarbamoyl cyclodesulfurization alk; nucleoside acyclo; desulfurization cyclo thiocarbamoylaminoimidazolecarboxmide; acyclonucleoside.

5-Aminoimidazole-4-carboxamide (I; R = R1 = H) is 1-alkylated by an improved method. The resulting alkylimidazolecarboxamides, e.g. I (R = Me, Et, Pr, PhCH2, HOCH2CH2O, R1 = H), are converted to the corresponding thiocarbamoylcarboxamides, e.g. I (R = same, R1 = CSNH2). These compounds are ring closed under alk. conditions to 9-substituted guanines II (R = same) in very high yields by treatment with heavy-metal salts in aqueous NaOH, or, in lower yields, by S-oxidation with H2O2 or NaBO3 in aqueous NaOH.

Journal of Organic Chemistry published new progress about Cyclocondensation reaction catalysts. 21343-04-4 belongs to class imidazoles-derivatives, name is 5-Amino-1-methyl-1H-imidazole-4-carboxamide, and the molecular formula is C5H8N4O, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ping, Kefeng published the artcileFused Hybrid Linkers for Metal-Organic Framework-Derived Bifunctional Oxygen Electrocatalysts, SDS of cas: 72721-02-9, the main research area is metal organic framework hybrid linker oxygen evolution reaction electrocatalyst.

Preparation of electrocatalysts often relies on the use of multiple starting materials, with examples arising from a single precursor being less common. A series of heterobivalent scaffolds are surveyed to identify an iron/benzimidazole-based metal-organic framework as a uniform starting material. By merging the catechol and imidazole units together, a direct entry is obtained into a highly efficient bifunctional oxygen electrocatalyst, which alleviates the need for dopants and modifying conditions. It is demonstrated that by fine-tuning the chem. nature of an organic linker, one is able to modulate the electrochem. properties of a single precursor-derived electrocatalyst material.

ACS Applied Energy Materials published new progress about Electrochemical reaction catalysts. 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, SDS of cas: 72721-02-9.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kulkarni, Surendra published the artcileNucleophilic displacements of imidazoles. II. Displacements of halogen by S-nucleophiles and displacements of mesyl groups activated by nitro; oxidation of imidazolethiols, Synthetic Route of 18874-52-7, the main research area is sulfonylimidazole; nitrothioimidazole; thionitroimidazole; substitution nucleophile halonitroimidazole thiophenol kinetics; mesylnitroimidazole nucleophile substitution; imidazolethiol preparation oxide.

RC6H4SH (R = H, p-Me) react with halonitroimidazoles I and II (R1, R2 = H, Me; R3 = Br, iodo) to give I and II (R3 = SC6H4R). The bromo compounds are slightly more reactive than the iodo analogs. Substituents at C-5 are more readily displaced than those at C-4. I and II (R3 = SO2Me) undergo nucleophilic substitution reactions with a variety of nucleophiles (e.g., PhSH, MeO-, piperidine). The imidazolethiol products are readily oxidized to the sulfones.

Australian Journal of Chemistry published new progress about Nucleophilic substitution reaction. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Synthetic Route of 18874-52-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem