Category: imidazoles-derivatives

On June 15, 2021, Welzen, Pascal L. W.; Martinez Ciriano, Sydney W.; Cao, Shoupeng; Mason, Alexander F.; Welzen-Pijpers, Imke A. B.; van Hest, Jan C. M. published an article.Category: imidazoles-derivatives The title of the article was Reversibly self-assembled pH-responsive PEG-p(CL-g-TMC) polymersomes. And the article contained the following:

Polymersomes have gained much interest within the biomedical field as drug delivery systems due to their ability to transport and protect cargo from the harsh environment inside the body. For an improved drug efficacy, control over cargo release is however also an important factor to take into account. An often employed method is to incorporate pH sensitive groups in the vesicle membrane, which induce disassembly and content release when the particles have reached a target site in the body with the appropriate pH, such as the acidic microenvironment of tumor tissue or the endosome. In this paper, biodegradable poly(ethylene glycol)-poly(caprolactone-gradient-trimethylene carbonate)-based polymeric vesicles have been developed with disassembly features at mild acidic conditions. Modifying the polymer backbone with imidazole moieties results in vesicle disassembly upon protonation due to the lowered pH. Furthermore, upon increasing the pH efficient re-assembly into vesicles is observed due to the switchable amphiphilic nature of the polymer. When this re-assembly process is conducted in presence of cargo, enhanced encapsulation is achieved. Furthermore, the potency of the polymeric system for future biomedical applications such as adjuvant delivery is demonstrated. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Category: imidazoles-derivatives

The Article related to polyethylene glycol polycaprolactone gradient trimethylene carbonate polymersome selfassembly, Placeholder for records without volume info and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 31, 2021, Ke, Mi; Yuan, Xiao; He, An; Yu, Peiyuan; Chen, Wendong; Shi, Yu; Hunter, Tony; Zou, Peng; Tian, Ruijun published an article.Safety of N-(4-Hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide The title of the article was Spatiotemporal profiling of cytosolic signalling complexes in living cells by selective proximity proteomics. And the article contained the following:

Signaling complexes are often organized in a spatiotemporal manner and on a minute timescale. Proximity labeling based on engineered ascorbate peroxidase APEX2 pioneered in situ capture of spatiotemporal membrane protein complexes in living cells, but its application to cytosolic proteins remains limited due to the high labeling background. Here, we develop proximity labeling probes with increased labeling selectivity. These probes, in combination with label-free quant. proteomics, allow exploring cytosolic protein assemblies such as phosphotyrosine-mediated protein complexes formed in response to minute-scale EGF stimulation. As proof-of-concept, we systematically profile the spatiotemporal interactome of the EGFR signaling component STS1. For STS1 core complexes, our proximity proteomics approach shows comparable performance to affinity purification-mass spectrometry-based temporal interactome profiling, while also capturing addnl.-especially endosomally-located-protein complexes. In summary, we provide a generic approach for exploring the interactome of mobile cytosolic proteins in living cells at a temporal resolution of minutes. The experimental process involved the reaction of N-(4-Hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide(cas: 901770-40-9).Safety of N-(4-Hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

The Article related to living cell cytosolic signalling complex selective proteomic spatiotemporal profiling, Placeholder for records without volume info and other aspects.Safety of N-(4-Hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yang, Chaokun; Chen, Yanglin; Qu, Ye; Zhang, Jiaxu; Sun, Jianmin published an article in 2021, the title of the article was Phase-controllable polymerized ionic liquids for CO2 fixation into cyclic carbonates.Electric Literature of 5036-48-6 And the article contains the following content:

A catalyst with activity comparable with homogeneous catalysts and easy separation like heterogeneous catalysts would be attractive for CO2 cycloaddition Here, a series of polymerized bis-imidazolium based ionic liquids (PBIL-m) were synthesized and could act as homogeneous catalysts during the CO2 cycloaddition to epoxide process. They could be separated as heterogeneous catalysts after the cycloaddition reaction. PBIL-m was highly active for the cycloaddition reaction due to functional groups such as the imidazole ring, amino group and Br-. Specifically, the solid-liquid transition behavior endowed the PBIL-m with comparable activity to its homogeneous monomer catalysts (BIL-m). Among these PBIL-m catalysts, poly(1-vinyl imidazole-3-hexyl-1-imidazole-3-aminopropyl)dibromide (PBIL-3) exhibited superior catalytic performance due to the appropriate bridge chain compared with other PBIL-m. Under the conditions of 80 掳C, 1.0 MPa and 24 h, 99% propylene carbonate yield and 99% selectivity were obtained. The PBIL-3 also showed excellent universality and recyclability. A reasonable reaction mechanism was deduced that the imidazole ring, amino group and Br- promoted the cycloaddition reaction under metal-, solvent-, and cocatalyst-free conditions. Therefore, the polymerized bis-imidazolium based ionic liquid with solid-liquid transition behavior is a promising candidate for smooth catalysis of CO2 conversion and utilization. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Electric Literature of 5036-48-6

The Article related to carbon dioxide phase controllable polymerized ionicliquid cyclic carbonate fixation, Placeholder for records without volume info and other aspects.Electric Literature of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 31, 2021, He, Shiqian; Kong, Liang; Chen, Jing published an article.Quality Control of N-Methyl-7H-purin-6-amine The title of the article was iDNA6mA-Rice-DL: A local web server for identifying DNA N6-methyladenine sites in rice genome by deep learning method. And the article contained the following:

Accurate detection of N6-methyladenine (6mA) sites by biochem. experiments will help to reveal their biol. functions, still, these wet experiments are laborious and expensive. Therefore, it is necessary to introduce a powerful computational model to identify the 6mA sites on a genomic scale, especially for plant genomes. In view of this, we proposed a model called iDNA6mA-Rice-DL for the effective identification of 6mA sites in rice genome, which is an intelligent computing model based on deep learning method. Traditional machine learning methods assume the preparation of the features for anal. However, our proposed model automatically encodes and extracts key DNA features through an embedded layer and several groups of dense layers. We use an independent dataset to evaluate the generalization ability of our model. An area under the receiver operating characteristic curve (auROC) of 0.98 with an accuracy of 95.96% was obtained. The experiment results demonstrate that our model had good performance in predicting 6mA sites in the rice genome. A user-friendly local web server has been established. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Quality Control of N-Methyl-7H-purin-6-amine

The Article related to rice genome web server deep learning, 6ma, dna, docker, deep learning, web server, Placeholder for records without volume info and other aspects.Quality Control of N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 22, 1999, Lutsenko, Eugene; Bhagwat, Ashok S. published an article.Quality Control of Imidazo[1,2-c]pyrimidin-5(6H)-one The title of the article was The role of the Escherichia coli Mug protein in the removal of uracil and 3,N4-ethenocytosine from DNA. And the article contained the following:

The human thymine-DNA glycosylase has a sequence homolog in Escherichia coli that is described to excise uracils from U路G mismatches (Gallinari, P., and Jiricny, J. (1996) Nature 383, 735-738) and is named mismatched uracil glycosylase (Mug). It has also been described to remove 3,N4-ethenocytosine (蔚C) from 蔚C路G mismatches (Saparbaev, M., and Laval, J. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 8508-8513). We used a mug mutant to clarify the role of this protein in DNA repair and mutation avoidance. We find that inactivation of mug has no effect on C to T or 5-methylcytosine to T mutations in E. coli and that this contrasts with the effect of ung defect on C to T mutations and of vsr defect on 5-methylcytosine to T mutations. Even under conditions where it is overproduced in cells, Mug has little effect on the frequency of C to T mutations. Because uracil-DNA glycosylase (Ung) and Vsr are known to repair U路G and T路G mismatches, resp., we conclude that Mug does not repair U路G or T路G mismatches in vivo. A defect in mug also has little effect on forward mutations, suggesting that Mug does not play a role in avoiding mutations due to endogenous damage to DNA in growing E. coli. Cell-free extracts from mug+ ung cells show very little ability to remove uracil from DNA, but can excise 蔚C. The latter activity is missing in extracts from mug cells, suggesting that Mug may be the only enzyme in E. coli that can remove this mutagenic adduct. Thus, the principal role of Mug in E. coli may be to help repair damage to DNA caused by exogenous chem. agents such as chloroacetaldehyde. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Quality Control of Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to escherichia dna repair mismatched uracil glycosylase mug protein ethenocytosine, General Biochemistry: Subcellular Processes and other aspects.Quality Control of Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 15, 2021, Guo, Huijuan; Sun, Weiming; Zhang, Quanli; Wu, Yang; Wu, Di; Liu, Yinghua; Yu, Bo; Yu, Qiangliang; Cai, Meirong published an article.Reference of N-(3-Aminopropyl)-imidazole The title of the article was Imidazolium ionic liquid bearing urea moiety as a new corrosion inhibitor of mild steel. And the article contained the following:

The ureido substituted imidazolium bromides (code M-n) were synthesized and their anti-corrosion performance on A3 steel in 5 M HCl solution was studied by weight loss test, electrochem. impedance spectroscopy (EIS), potentiodynamic polarization. The exptl. results reveal that the inhibitor are efficient mixed type corrosion inhibitors, and their inhibition efficiencies increase with increasing the concentration and alkyl chain. Thermodn. parameters were calculated and discussed, indicating the adsorption of M-n on steel surface obeys the Langmuir adsorption isotherm and spontaneous exothermic process. SEM (SEM), XPS and quantum chem. calculation further confirm the existence of an effective protective film of M-n on A3 steel surface. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Reference of N-(3-Aminopropyl)-imidazole

The Article related to imidazolium ionic liquid bearing corrosion inhibitor density functional theory, Placeholder for records without volume info and other aspects.Reference of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 31, 2021, Safiulina, A. M.; Lizunov, A. V.; Borisova, N. E.; Baulina, T. V.; Goryunov, E. I.; Goryunova, I. B.; Brel� V. K. published an article.Application of 5036-48-6 The title of the article was Extraction Properties of Diphenylposphorylureas with Aliphatic �Nitrogen-Containing Substituents. And the article contained the following:

Extraction of lanthanides and actinides from nitric acid solutions with N-(diphenylphosphoryl)-N�n-propylureas containing imidazolyl, diethylamino, pyrid-2-yl, 2-oxopyrrolidino fragments in the �position of the alkyl substituent has been studied. It has been shown that Ho(III) and Yb(III) related to the yttrium subgroup of lanthanides are extracted much better than La(III) and Nd(III) related to the cerium subgroup. N-(Diphenylphosphoryl)urea containing �(2-oxopyrrolidino)propyl fragment at the terminal nitrogen atom shows the best extraction properties. This dependence has been theor. explained by modeling complexation because the coordination of f-block element ion with amide oxygen atom is more preferable The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Application of 5036-48-6

The Article related to chlorodiphenylphosphine lanthanum uranium extraction distillation distribution, Placeholder for records without volume info and other aspects.Application of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 18, 2020, Rees, Kelly; Tran, Michael V.; Massey, Melissa; Kim, Hyungki; Krause, Katherine D.; Algar, W. Russ published an article.Name: N-(3-Aminopropyl)-imidazole The title of the article was Dextran-Functionalized Semiconductor Quantum Dot Bioconjugates for Bioanalysis and Imaging. And the article contained the following:

The prerequisites for maximizing the advantageous optical properties of colloidal semiconductor quantum dots (QDs) in biol. applications are effective surface functionalization and bioconjugation strategies. Functionalization with dextran has been highly successful with some nanoparticle materials, but has had very limited application with QDs. Here, we report the preparation, characterization, and proof-of-concept applications of dextran-functionalized QDs. Multiple approaches to dextran ligands were evaluated, including performance with respect to colloidal stability across a range of pH, nonspecific binding with proteins and cells, and microinjection into cells and viability assays. Multiple bioconjugation strategies were demonstrated and applied, including covalent coupling to develop a simple pH sensor, binding of polyhistidine-tagged peptides to the QD for energy transfer-based proteolytic activity assays, and binding with tetrameric antibody complexes (TACs) to enable a sandwich immunoassay and cell immunolabeling and imaging. Our results show that dextran ligands are highly promising for the functionalization of QDs, and that the design of the ligands is tailorable to help optimally meet the requirements of applications. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Name: N-(3-Aminopropyl)-imidazole

The Article related to sequence dextran semiconductor quantum dot bioconjugates bioanalysis imaging, Placeholder for records without volume info and other aspects.Name: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On June 22, 2022, Luo, Yi; Clabbers, Max T. B.; Qiao, Jian; Yuan, Zhiqing; Yang, Weimin; Zou, Xiaodong published an article.Product Details of 5036-48-6 The title of the article was Visualizing the Entire Range of Noncovalent Interactions in Nanocrystalline Hybrid Materials Using 3D Electron Diffraction. And the article contained the following:

Noncovalent interactions are essential in the formation and properties of a diverse range of hybrid materials. However, reliably identifying the noncovalent interactions in nanocrystalline materials remains challenging using conventional methods such as X-ray diffraction and spectroscopy. Here, we demonstrate that accurate at. positions including hydrogen atoms can be determined using three-dimensional electron diffraction (3D ED), from which the entire range of noncovalent interactions in a nanocrystalline aluminophosphate hybrid material SCM-34 are directly visualized. The protonation states of both the inorganic and organic components in SCM-34 are determined from the hydrogen positions. All noncovalent interactions, including hydrogen-bonding, electrostatic, ��stacking, and van der Waals interactions, are unambiguously identified, which provides detailed insights into the formation of the material. The 3D ED data also allow us to distinguish different types of covalent bonds based on their bond lengths and to identify an elongated terminal P = O �bond caused by noncovalent interactions. Our results show that 3D ED can be a powerful tool for resolving detailed noncovalent interactions in nanocrystalline materials. This can improve our understanding of hybrid systems and guide the development of novel functional materials. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6

The Article related to noncovalent interaction nanocrystalline hybrid material electron diffraction, Placeholder for records without volume info and other aspects.Product Details of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On November 30, 2021, Slassi, Siham; Aarjane, Mohammed; Amine, Amina published an article.Formula: C6H11N3 The title of the article was A novel imidazole-derived Schiff base as selective and sensitive colorimetric chemosensor for fluorescent detection of Cu2+ in methanol with mixed aqueous medium. And the article contained the following:

A highly efficient, selective, sensitive, and colorimetric chemosensor SB for Cu2+ detection with turn-on fluorescence behavior in CH3-water solution was synthesized. A good enhancement of the intensity of fluorescence was detected by the incremental addition of Cu2+ after excitation at 286 nm. The fluorescence quantum yield (æ¡? of SB-Cu2+ was calculated for 0.41. The responsive mechanism of SB to copper ion is involved for on the combined effects of C-N isomerization and intramol. charge transfer (ICT) process and chelation-enhanced fluorescence (CHEF). The detection limit for the fluorescent chemosensor SB toward Cu2+ was 0.6 x 10-6 M. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Formula: C6H11N3

The Article related to imidazole schiff base colorimetric chemosensor fluorescent detection copper, Placeholder for records without volume info and other aspects.Formula: C6H11N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem