Category: imidazoles-derivatives

Latifi, Reza; Minnick, Jennifer L.; Quesne, Matthew G.; de Visser, Sam P.; Tahsini, Laleh published an article in 2020, the title of the article was Computational studies of DNA base repair mechanisms by nonheme iron dioxygenases: selective epoxidation and hydroxylation pathways.HPLC of Formula: 55662-66-3 And the article contains the following content:

DNA base repair mechanisms of alkylated DNA bases is an important reaction in chem. biol. and particularly in the human body. It is typically catalyzed by an ä¼?ketoglutarate-dependent nonheme iron dioxygenase named the AlkB repair enzyme. In this work we report a detailed computational study into the structure and reactivity of AlkB repair enzymes with alkylated DNA bases. In particular, we investigate the aliphatic hydroxylation and C=C epoxidation mechanisms of alkylated DNA bases by a high-valent iron(IV)-oxo intermediate. Our computational studies use quantum mechanics/mol. mechanics methods on full enzymic structures as well as cluster models on active site systems. The work shows that the iron(IV)-oxo species is rapidly formed after dioxygen binding to an iron(IV) center and passes a bicyclic ring structure as intermediate. Subsequent cluster models explore the mechanism of substrate hydroxylation and epoxidation of alkylated DNA bases. The work shows low energy barriers for substrate activation and consequently energetically feasible pathways are predicted. Overall, the work shows that a high-valent iron(IV)-oxo species can efficiently dealkylate alkylated DNA bases and return them into their original form. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).HPLC of Formula: 55662-66-3

The Article related to human dioxygenase alkb dna base repair mechanism epoxidation hydroxylation, Enzymes: Structure-Conformation-Active Site and other aspects.HPLC of Formula: 55662-66-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 31, 2021, Leopoldino, Elder C.; Pinheiro, Gabriela; Alves, Ricardo J.; Gerola, Adriana; Souza, Bruno S. published an article.Electric Literature of 5036-48-6 The title of the article was Post-modified polymer with imidazole groups as an efficient and reusable heterogeneous catalyst for organophosphate degradation. And the article contained the following:

In this work, the com. polymer poly(ethylene-alt-maleic anhydride) was used as a platform for the preparation of an imidazole-rich polymeric catalyst (PEIIm) designed for organophosphate degradation The catalyst was prepared at gram-scale using simple and cost-effective steps and was characterized by 1H NMR, IR, CHN and TGA. PEIIm showed higher activity than the free imidazole towards the degradation of di-Et 2,4-dinitrophenylphosphate, an organophosphate model, and was recovered by centrifugation and reused without loss of activity. Importantly, experiments performed under excess of substrate demonstrate that true catalysis takes place. Solvent kinetic isotope effect indicates that the pendant imidazole groups attack the phosphorus atom to form a phosphorylated polymeric intermediate that is rapidly hydrolyzed, allowing for the catalyst regeneration. PEIIm was also employed in the degradation of toxic pesticide Et paraoxon, resulting in a reduction in its half-life from 780 days to 25 days at 25 掳C, pH 8.0. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Electric Literature of 5036-48-6

The Article related to imidazole group polymer heterogeneous catalyst organophosphate degradation, Placeholder for records without volume info and other aspects.Electric Literature of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Biswas, Sneha; Chowdhury, Tania; Ghosh, Avik; Das, Abhijit K.; Das, Debasis published an article in 2022, the title of the article was Effect of O-substitution in imidazole based Zn(II) dual fluorescent probes in the light of arsenate detection in potable water: a combined experimental and theoretical approach.Computed Properties of 5036-48-6 And the article contains the following content:

Efficient detection of arsenate (AsO43-) from contaminated drinking water extracted from underground has become a matter of utmost necessity and an exquisite challenge owing to the growing public health issue due to arsenicosis. In order to combat this we planned to detect arsenate with the naked eye under UV light using a novel chemosensor material whose structure and functioning as a sensor could be certified mechanistically. Hence we were encouraged to synthesize two differently O-substituted imidazole based homologous ligands: C1 (HL1 = 2-((E)-(3-(1H-imidazole-1-yl)propylimino)methyl)-6-ethoxyphenol) and C2 (HL2 = 2-((E)-(3-(1H-imidazole-1-yl)propylimino)methyl)-6-methoxyphenol). To accomplish the purposeful exploration of the luminescent sensor, we considered Chelation Enhanced Fluorescence (CHEF) and kept on searching for a metal cation that would be able to turn on the fluorescence of the ligands. Considering Zn(II) as the most suitable candidate, luminescent complexes D1 and D2 ({[Zn2(L1)2(I)2](DMF)} and [Zn2(L2)2(I)2](DMF), resp.) were synthesized and characterized by SXRD, UV-Vis, FT-IR, and photoluminescence spectroscopy. In spite of the resemblance in the solid state structures of D1 and D2, the selective response of D1 towards arsenate with high quenching constants (2.13 x 106), unlike D2, has been demonstrated mechanistically with steady state and time resolved fluorescence titration, solution phase ESI-MS spectral anal. and DFT studies. The selectivity and sensitivity of the sensor D1 explicitly make this material a potent candidate for arsenate detection due to its very low detection limit (8.2 ppb), low cost and user friendly characteristics. Real life implementation of this work in a test strip is expected to prove beneficial for public health to identify arsenate polluted water. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Computed Properties of 5036-48-6

The Article related to zinc dual fluorescent probe arsenate detection density functional theory, Placeholder for records without volume info and other aspects.Computed Properties of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 30, 2022, Pham, Julie; Forget, Amelie; Bridonneau, Nathalie; Mattana, Giorgio; Stavrinidou, Eleni; Zrig, Samia; Piro, Benoit; Noel, Vincent published an article.Recommanded Product: N-(3-Aminopropyl)-imidazole The title of the article was In vivo electrochemically-assisted polymerization of conjugated functionalized terthiophenes inside the vascular system of a plant. And the article contained the following:

We investigate the possibility of producing biofuel cell electrode materials in vivo by injecting the reagents directly into plant tissues. We first introduce model electroactive substances Fe(CN)64- and Ru(NH3)63+ into a Nicotiana tabacum leaf. In situ electrochem. measurements make it possible to trace the distribution of these substances. As well as mapping the vascular content, electrochem. can be used to trigger reactions directly inside the plant. The injection of thiophene (T) and ethylenedioxythiophene (E)-based trimers (ETE) anchoring an Os(2,2�bipyridine)2(1-(3-aminopropyl)-imidazole)Cl Os-complex followed by the application of anodic polarization triggers a polymerization reaction in the region of the plant vascular system containing the monomer, showing that it is possible to generate electroactive organic macromols. locally in vivo. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: N-(3-Aminopropyl)-imidazole

The Article related to terthiophene injection anodic polarization plant vascular polymerization, Placeholder for records without volume info and other aspects.Recommanded Product: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 19, 2013, Li, Deyu; Fedeles, Bogdan I.; Shrivastav, Nidhi; Delaney, James C.; Yang, Xuedong; Wong, Cintyu; Drennan, Catherine L.; Essigmann, John M. published an article.Safety of Imidazo[1,2-c]pyrimidin-5(6H)-one The title of the article was Removal of N-Alkyl Modifications from N2-Alkylguanine and N4-Alkylcytosine in DNA by the Adaptive Response Protein AlkB. And the article contained the following:

The AlkB enzyme is an Fe(II)- and ä¼?ketoglutarate-dependent dioxygenase that repairs DNA alkyl lesions by a direct reversal of damage mechanism as part of the adaptive response in E. coli. The reported substrate scope of AlkB includes simple DNA alkyl adducts, such as 1-methyladenine, 3-methylcytosine, 3-ethylcytosine, 1-methylguanine, 3-methylthymine, and N6-methyladenine, as well as more complex DNA adducts, such as 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 1,N6-ethanoadenine. Previous studies have revealed, in a piecemeal way, that AlkB has an impressive repertoire of substrates. The present study makes two additions to this list, showing that alkyl adducts on the N2 position of guanine and N4 position of cytosine are also substrates for AlkB. Using high resolution ESI-TOF mass spectrometry, we show that AlkB has the biochem. capability to repair in vitro N2-methylguanine, N2-ethylguanine, N2-furan-2-yl-methylguanine, N2-tetrahydrofuran-2-yl-methylguanine, and N4-methylcytosine in ssDNA but not in dsDNA. When viewed together with previous work, the exptl. data herein demonstrate that AlkB is able to repair all simple N-alkyl adducts occurring at the Watson-Crick base pairing interface of the four DNA bases, confirming AlkB as a versatile gatekeeper of genomic integrity under alkylation stress. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Safety of Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to alkyl alkylguanine alkylcytosine dna adaptation protein alkb dioxygenase, Enzymes: Analysis (Determination-Detection) and other aspects.Safety of Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 11, 2018, Gu, Zhen; Yu, Jicheng published a patent.Name: 2-Nitro-1H-benzo[d]imidazole The title of the patent was Patch loaded with dual-sensitive vesicles for enhanced glucose-responsive insulin delivery. And the patent contained the following:

A composition comprising an amphiphilic polymeric material that is both hydrogen peroxide- and hypoxia-sensitive is described. The composition can further include a glucose-oxidizing enzyme and insulin, a bioactive derivative thereof, and/or another therapeutic agent (e.g., another diabetes treatment agent). The polymeric material can form vesicles that comprise single or multiple layers of the polymeric material that enclose the glucose-oxidizing enzyme and the insulin, bioactive derivative and/or other therapeutic agent. The vesicles can be loaded into microneedles to, for example, prepare microneedle arrays for skin patches. Methods of delivering insulin to a subject using the compositions, vesicles, microneedles, and/or microneedle array skin patches are also described. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Name: 2-Nitro-1H-benzo[d]imidazole

The Article related to patch dual sensitive vesicle insulin delivery polymer preparation, Pharmaceuticals: Formulation and Compounding and other aspects.Name: 2-Nitro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pinyakit, Yuwaporn; Palaga, Tanapat; Kiatkamjornwong, Suda; Hoven, Voravee P. published an article in 2020, the title of the article was Sequential post-polymerization modification of a pentafluorophenyl ester-containing homopolymer: a convenient route to effective pH-responsive nanocarriers for anticancer drugs.Recommanded Product: N-(3-Aminopropyl)-imidazole And the article contains the following content:

Recently, pH-responsive polymeric micelles have gained significant attention as effective carriers for anti-cancer drug delivery. Herein, pH-responsive polymeric micelles were constructed by a simple post-polymerization modification of a single homopolymer, poly(pentafluorophenyl acrylate) (PPFPA). The PPFPA was first subjected to modification with 1-amino-2-propanol yielding the amphiphilic copolymer of poly(pentafluorophenyl acrylate)-ran-poly(N-(2-hydroxypropyl acrylamide)). A series of amphiphilic random copolymers of different compositions could self-assemble into spherical micelles with a unimodal size distribution in aqueous solution Then, 1-(3-aminopropyl)imidazole (API), a reagent to introduce charge conversional entities, was reacted with the remaining PPFPA segment in the micellar core resulting in API-modified micelles which can encapsulate doxorubicin (DOX), a hydrophobic anti-cancer drug. As monitored by dynamic light scattering, the API-modified micelles underwent disintegration upon pH switching from 7.4 to 5.0, presumably due to imidazolyl group protonation. This pH-responsiveness of the API-modified micelles was responsible for the faster and greater in vitro DOX release in an acidic environment than neutral pH. Cellular uptake studies revealed that the developed carriers were internalized into MDA-MB-231 cells within 30 min via endocytosis and exhibited cytotoxicity in a dose-dependent manner. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: N-(3-Aminopropyl)-imidazole

The Article related to pentafluorophenyl ester ph responsive nanocarrier anticancer drug, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 4, 2021, Tanaka, Yuta; Tanaka, Yuta; Kikuchi, Fumiaki; Yamamoto, Takeshi; Nakamura, Minoru; Takami, Kazuaki; Murakami, Masataka; Daini, Masaki; Wada, Yasufumi; Kakegawa, Keiko; Kasahara, Takahito; Ohashi, Tomohiro; Wang, Junsi; Ikeda, Zenichi; Puenner, Florian; Seto, Masaki; Mikami, Satoshi; Sasaki, Minoru published a patent.Related Products of 50743-01-6 The title of the patent was Heterocyclic compound for Gaucher disease. And the patent contained the following:

Provided is a compound which has a glucosylceramide synthase-inhibiting activity and is expected to be useful as a prophylactic or therapeutic agent for a lysosomal storage disease (e.g., Gaucher disease, Fabry disease, GM1-gangliosidosis, GM2 activation factor deficiency disease, Tay-Sachs disease, Sandhoff disease), a neurodegenerative disease (e.g., Parkinson’s disease, dementia with Lewy bodies, multiple system atrophy) and the like. The present invention relates to a compound represented by formula (I); or a salt thereof. The experimental process involved the reaction of 5-Bromo-1H-imidazole-4-carbaldehyde(cas: 50743-01-6).Related Products of 50743-01-6

The Article related to glucosylceramide synthase heterocyclic compound gaucher disease, Pharmaceuticals: Formulation and Compounding and other aspects.Related Products of 50743-01-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 1, 2012, Tudek, Barbara; Speina, Elzbieta published an article.Formula: C6H5N3O The title of the article was Oxidatively damaged DNA and its repair in colon carcinogenesis. And the article contained the following:

A review. Inflammation, high fat, high red meat and low fiber consumption have for long been known as the most important etiol. factors of sporadic colorectal cancers (CRC). Colon cancer originates from neoplastic transformation in a single layer of epithelial cells occupying colonic crypts, in which migration and apoptosis program becomes disrupted. This results in the formation of polyps and metastatic cancers. Mutational program in sporadic cancers involves APC gene, in which mutations occur most abundantly in the early phase of the process. This is followed by mutations in RAS, TP53, and other genes. Progression of carcinogenic process in the colon is accompanied by augmentation of the oxidative stress, which manifests in the increased level of oxidatively damaged DNA both in the colon epithelium, and in blood leukocytes and urine, already at the earliest stages of disease development. Defense mechanisms are deregulated in CRC patients: (i) antioxidative vitamins level in blood plasma declines with the development of disease; (ii) mRNA level of base excision repair enzymes in blood leukocytes of CRC patients is significantly increased; however, excision rate is regulated sep., being increased for 8-oxoGua, while decreased for lipid peroxidation derived ethenoadducts, 蔚Ade and 蔚Cyt; (iii) excision rate of 蔚Ade and 蔚Cyt in colon tumors is significantly increased in comparison to asymptomatic colon margin, and ethenoadducts level is decreased. This review highlights mechanisms underlying such deregulation, which is the driving force to colon carcinogenesis. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Formula: C6H5N3O

The Article related to review colon rectum cancer oxidative stress dna repair, Mammalian Pathological Biochemistry: Reviews and other aspects.Formula: C6H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tudek, Barbara; Winczura, Alicja; Janik, Justyna; Siomek, Agnieszka; Foksinski, Marek; Olinski, Ryszard published an article in 2010, the title of the article was Involvement of oxidatively damaged DNA and repair in cancer development and aging.Category: imidazoles-derivatives And the article contains the following content:

A review. DNA damage and DNA repair may mediate several cellular processes, like replication and transcription, mutagenesis and apoptosis and thus may be important factors in the development and pathol. of an organism, including cancer. DNA is constantly damaged by reactive oxygen species (ROS) and reactive nitrogen species (RNS) directly and also by products of lipid peroxidation (LPO), which form exocyclic adducts to DNA bases. A wide variety of oxidatively-generated DNA lesions are present in living cells. 8-Oxoguanine (8-oxoGua) is one of the best known DNA lesions due to its mutagenic properties. Among LPO-derived DNA base modifications the most intensively studied are ethenoadenine and ethenocytosine, highly miscoding DNA lesions considered as markers of oxidative stress and promutagenic DNA damage. Although at present it is impossible to directly answer the question concerning involvement of oxidatively damaged DNA in cancer etiol., it is likely that oxidatively modified DNA bases may serve as a source of mutations that initiate carcinogenesis and are involved in aging (i.e. they may be causal factors responsible for these processes). To counteract the deleterious effect of oxidatively damaged DNA, all organisms have developed several DNA repair mechanisms. The efficiency of oxidatively damaged DNA repair was frequently found to be decreased in cancer patients. The present work reviews the basis for the biol. significance of DNA damage, particularly effects of 8-oxoGua and ethenoadduct occurrence in DNA in the aspect of cancer development, drawing attention to the multiplicity of proteins with repair activities. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Category: imidazoles-derivatives

The Article related to review oxidative stress dna damage repair cancer aging, Mammalian Pathological Biochemistry: Reviews and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem