Category: imidazoles-derivatives

Naumchuk, V. M.; Volynets, G. P.; Gorbatiuk, O. B.; Lukashov, S. S.; Bdzhola, V. G.; Yarmoluk, S. M. published an article in 2015, the title of the article was Investigation of inhibitory activity of imidazolone derivatives and their precursors toward human protein kinase CK2.Formula: C12H9N3O And the article contains the following content:

We have investigated inhibitory activity of imidazolone derivatives and their precursors toward protein kinase CK2. As a result, we have found seven inhibitors with IC50 values in the range from 8 to 30 μM. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Formula: C12H9N3O

The Article related to protein kinase imidazolone derivative non cyclic precursor inhibition, Enzymes: Other and other aspects.Formula: C12H9N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 31, 2020, Zhang, Shuming; Li, Bianbian; Du, Ke; Liang, Tingting; Dai, Mengyuan; Huang, Wenxin; Zhang, Huizhi; Ling, Yihui; Zhang, Huidong published an article.Application of 443-72-1 The title of the article was Epigenetically modified N6-methyladenine inhibits DNA replication by human DNA polymerase iota. And the article contained the following:

Among human four Y-family DNA polymerases, hPol ι is exceptionally error-prone in DNA synthesis. 6 mA plays significant roles in epigenetic regulation of numerous biol. processes. Nonetheless, its effects on DNA replication by hPol ι is still unclear. In this work, we found that 6 mA and Hyp, the intermediate of 6 mA, inhibited the replication of DNA by hPol ι. 6 mA lost priority in extension beyond 6 mA:T pair, partially reducing dTTP incorporation efficiency and inhibiting next-base extension. Hyp was prone to dCTP incorporation and extension beyond Hyp:C instead of Hyp:T pair. Statistically, 6 mA primarily reduced the burst incorporation rate (kpol) and slightly increased the dissociation constant (Kd,dTTP). However, Hyp mainly increased the Kd,dCTP yet did not affect the kpol, both reducing the burst incorporation efficiency (kpol/Kd,dCTP). 6 mA together with Hyp weakened the binding affinity of hPol ι to DNA in binary or ternary complex. The misincorporation opposite 6 mA or Hyp further weakened this binding affinity. The Me group in 6 mA doesn′t almost affect the H-bond formation with dTTP, therefore mildly inhibiting dTTP incorporation. As an analog of G, Hyp can form only two H-bonds with dCTP, thus reducing dCTP incorporation. This work provides a new insight in how the epigenetically modified 6 mA and its intermediate Hyp affect replication of DNA by human DNA polymerase ι. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Application of 443-72-1

The Article related to dna polymerase, dna replication, human dna polymerase ι, hypoxanthine (hyp), n(6)-methyladenine (6 ma), steady-state and pre-steady-state kinetics, and other aspects.Application of 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Shan, Li; Lu, Ye; Song, Yihua; Zhu, Xiaoli; Xiang, Cheng-Cheng; Zuo, Er-Dong; Cheng, Xu published an article in 2022, the title of the article was Identification of nine M6A-related long noncoding RNAs as prognostic signatures associated with oxidative stress in oral cancer based on data from the cancer genome atlas.Synthetic Route of 443-72-1 And the article contains the following content:

Objective. Although the expression of long noncoding RNAs (lncRNAs) and N6-methyladenosine (M6A) is correlated with different tumors, it remains unclear how M6A-related lncRNA functioning affects the initiation and progression of oral squamous cell carcinoma (OSCC). Materials and Methods. Gene expression and clin. data were retrieved from The Cancer Genome Atlas. The prognostic value of M6A-related lncRNAs was determined using univariate Cox regression analyses. Gene set enrichment anal. of OSCC patient clusters revealed the pathways that elucidate the mechanism. Furthermore, a risk-based model was established. The difference in the overall survival (OS) between groups, including low-/high-risk groups, was determined by Kaplan-Meier anal. Relationships among immune cells, clusters, clinicopathol. characteristics, and risk scores were explored. Results. Among 1,080 M6A-related lncRNAs, 36 were prognosis-related. Patients with OSCC were divided into two clusters. T stage and the pathol. grade were noticeably lower in cluster 2 than in cluster 1. Epithelial-mesenchymal transition showed greater enrichment in cluster 1. Nine hub M6A-related lncRNAs were identified for the model of risk score for predicting OSCC prognosis. The OS was longer in patients with a low-risk score than in patients with a high-risk score. The risk score was an independent prognostic factor of OSCC and was associated with the infiltration of different immune cells. T stages and the American Joint Committee on Cancer (AJCC) stages were more advanced in the high-risk score group than in the low-risk score group. Finally, expression correlation anal. showed that the risk score is associated with the expression of oxidative stress markers. Conclusion. M6A-related lncRNAs play an important role in OSCC progression. Immune cell infiltration was related to the risk score model in OSCC and could accurately predict OSCC prognosis. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Synthetic Route of 443-72-1

The Article related to adenine: analogs & derivatives, biomarkers, tumor: genetics, biomarkers, tumor: metabolism, carcinoma, squamous cell: diagnosis, carcinoma, squamous cell: genetics, carcinoma, squamous cell: pathology, gene expression regulation, neoplastic, head and neck neoplasms: diagnosis, head and neck neoplasms: genetics, humans and other aspects.Synthetic Route of 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Guo, Ye; Pei, Yuqing; Li, Kexin; Cui, Wei; Zhang, Donghong published an article in 2020, the title of the article was DNA N6-methyladenine modification in hypertension.Synthetic Route of 443-72-1 And the article contains the following content:

DNA methylation has a role in the pathogenesis of essential hypertension. DNA N6-methyladenine (6mA) modification as a novel adenine methylation exists in human tissues, but whether it plays a role in hypertension development remains unclear. Here, we reported that the global 6mA DNA level in leukocytes was significantly reduced in patients with hypertension and was reversed with successful treatment. Age, systolic blood pressure, and serum total cholesterol and high-d. lipoprotein levels were associated with decreased leukocyte 6mA DNA level. Elevated ALKBH1 (AlkB homolog 1), a demethylase of 6mA, level mediated this dynamic change in 6mA level in leukocytes and vascular smooth muscle cells in hypertension mouse and rat models. Knockdown of ALKBH1 suppressed angiotensin II-induced vascular smooth muscle phenotype transformation, proliferation and migration. ALKBH1-6mA directly and neg. regulated hypoxia inducible factor 1 α (HIF1α), which responded to angiotensin II-induced vascular remodeling. Collectively, our results demonstrate a potential epigenetic role for ALKBH1-6mA regulation in hypertension development, diagnosis and treatment. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Synthetic Route of 443-72-1

The Article related to adenine: analogs & derivatives, adenine: metabolism, alkb homolog 1, histone h2a dioxygenase: genetics, angiotensin ii: metabolism, animals, dna methylation, dna repair enzymes, epigenesis, genetic, hypertension: blood, hypertension: metabolism, hypertension: therapy, leukocytes: metabolism, mice, muscle, smooth and other aspects.Synthetic Route of 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chen, Luyang; Zhang, Meiying; Guo, Mingzhou published an article in 2020, the title of the article was DNA N6-methyladenine increased in human esophageal squamous cell carcinoma..Product Details of 443-72-1 And the article contains the following content:

Esophageal cancer is one of the most common malignancies worldwide. DNA N6-methyladenine (6mA) has been well-studied in prokaryotes, while the distribution and biological functions of DNA 6mA in eukaryotic cells remain to be elucidated. Recently, DNA 6mA epigenetic modification was found in human gastric and liver cancers. To explore the status of DNA 6mA epigenetic modification in esophageal cancer, 101 cases of human esophageal squamous cell carcinoma (ESCC) and matched adjacent normal tissue samples were analyzed by dot blot assay. The levels of genomic DNA 6mA were significantly higher in ESCC tissue samples than in matched adjacent normal tissue samples (P<0.001). Increased DNA 6mA was associated with poor tumor differentiation (P<0.05), while no association was found between 6mA modification and gender, age, tumor size, TNM stage, lymph node metastasis, smoking, alcohol intake, or family history (all P>0.05). In conclusion, DNA 6mA epigenetic modification increased in human ESCC and may serve as a prognostic marker. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Product Details of 443-72-1

The Article related to adenine: analogs & derivatives, adenine: analysis, adenine: metabolism, adult, aged, aged, 80 and over, biomarkers, tumor: analysis, biomarkers, tumor: metabolism, dna methylation, epigenesis, genetic, esophageal mucosa: pathology, esophageal neoplasms: diagnosis, esophageal neoplasms: genetics and other aspects.Product Details of 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 17, 2021, Mathur, Lavina; Jung, Sunhee; Jang, Cholsoon; Lee, Gina published an article.Safety of N-Methyl-7H-purin-6-amine The title of the article was Quantitative analysis of m6A RNA modification by LC-MS. And the article contained the following:

N6-adenosine methylation (m6A) of mRNA (mRNA) plays key regulatory roles in gene expression. Accurate measurement of m6A levels is thus critical to understand its dynamic changes in various biol. settings. Here, we provide a protocol to quantitate the levels of adenosine and m6A in cellular mRNAs. Using nuclease and phosphatase, we digest mRNA into nucleosides, which are subsequently quantified using liquid chromatog. mass spectrometry. For complete details on the use and execution of this protocol, please refer to Cho et al. (2021). The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Safety of N-Methyl-7H-purin-6-amine

The Article related to adenine: analogs & derivatives, adenine: analysis, adenine: chemistry, adenosine: analogs & derivatives, adenosine: chemistry, adenosine: metabolism, biochemical phenomena, chromatography, liquid: methods, methylation, nucleosides: analysis, rna: chemistry, rna, messenger: chemistry, rna and other aspects.Safety of N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sutton, W. B.; Gordee, R. S.; Wick, W. E.; Stanfield, La Veda published an article in 1966, the title of the article was In vitro and in vivo laboratory studies on the antituberculous activity of capreomycin.Product Details of 5709-67-1 And the article contains the following content:

The in vitro and in vivo spectrum of the activity of capreomycin (I) was exclusively antimycobacterial. No synergistic effect was found in vitro; however, I in combination with p-amino-salicylic acid (PAS) in vivo was more effective than the use of these agents alone. The emergence of resistance of Mycobacterium tuberculosis H37Rv, Mycobacterium ATCC 607 and M. avium ATCC 7992 to I in vitro was delayed. Induced I-, streptomycin (II)-, isoniazid-, and viomycin- resistant strains of M. tuberculosis H37Rv did not demonstrate cross-resistance with each other or PAS. II and I cross-resistance was not observed with other mycobacteria. Orally administered, I exhibited a low order of activity. Subcutaneous treatment with I was effective against M. tuberculosis strain H37Rv and M. kanasii in exptl. mouse tuberculosis. The antibiotic had significant activity against exptl. bovine tuberculosis in mice. I was effective against II-resistant M. tuberculosis H37Rv in vivo. Resistant organisms were not isolated following prolonged I treatment. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Product Details of 5709-67-1

The Article related to animals, anti-bacterial agents: pharmacology, antitubercular agents: pharmacology, bacteria: drug effects, in vitro techniques, infections: drug therapy, mice, mycobacterium: drug effects, mycobacterium tuberculosis: drug effects and other aspects.Product Details of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pozharskii, A. F.; Zvezdina, E. A.; Simonov, A. M. published an article in 1967, the title of the article was Unexpected formation of 2-nitro- and 2,2′-azobenzimidazoles.Related Products of 5709-67-1 And the article contains the following content:

Readily accessible 1-benzy-2-aminobenzimidazole (I) (CA 55: 16520f) treated with 2 moles Na in liquid NH3 yielded 60% of the expected 2-aminobenzimidazole (II) and 32% orange-red 2,2′-azobenzimidazole (III), m. >350°. With 4 moles Na in liquid NH3, 43% 2-nitrobenzimidazole (IV), m. 258°, and 55% III were produced. The structures of III and IV were established by reduction with Sn and HCl to II. IV is strongly acidic and gives a stable Na salt, m. 350°, readily alkylated to 1-alkyl-2-nitrobenzimidazoles. III is less acidic than IV and this facilitates their separation I is debenzylated with Na in liquid NH3 to give disodio (V) and trisodio (VI) derivatives, which when oxidized by atm. O gave III and IV. Treatment of I with 4 moles Na in liquid NH3 in a stream of dry N yielded 78% II. Treatment of 1-methyl- and 1-ethyl-2-aminobenzimidazoles with 4 moles Na in liquid NH3 gave only 1.5 and 0.7% of the corresponding 2,2′-azo derivatives, m. 289-90° (alc.) and 197° (EtOAc), resp. Sodio derivatives from 1-alkyl-2-aminobenzimidazoles gave the corresponding azo products only on long contact with air. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Related Products of 5709-67-1

The Article related to azobenzimidazoles, benzimidazoles, anti-infective agents, azo compounds, benzimidazoles, chemical phenomena, chemistry, chemistry, organic, nitrobenzenes, organic chemistry phenomena and other aspects.Related Products of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pozharskii, A. F.; Zvezdina, E. A.; Simonov, A. M. published an article in 1966, the title of the article was Synthesis of 2-nitrobenzimidazole (benzazomycin).Recommanded Product: 5709-67-1 And the article contains the following content:

Reaction of 1-benzyl-2-aminobenzimidazole with 4 g. at. Na in liquid NH3 gave 43% 2-nitrobenzimidazole, decomposed at 258°, and 55% 2,2′-azobenzimidazole (I), red-orange, m. above 350°. With 2 g. atoms Na the reaction gave 32% azo compound and 60% 2-aminobenzimidazole, m. 226.5°. When air is totally excluded, the latter is formed in 78% yield as the sole product. The di-Na derivative of aminobenzimidazole is very easily attacked by air to form the above oxidation products, both of which gave the amino derivative after reduction with Sn-HCl. The nitro derivative was devoid of basic properties and was acidic as it readily formed a Na salt which was easily alkylated in the 1-position. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Recommanded Product: 5709-67-1

2-Nitro-1H-benzo[d]imidazole(cas:5709-67-1) belongs to imidazoles. It is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Recommanded Product: 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 13, 1967, Pozharskii, A F.; Zvezdina, E. A.; Simonov, A. M. published a patent.Quality Control of 2-Nitro-1H-benzo[d]imidazole The title of the patent was Simultaneous preparation of 2-nitrobenzimidazole and 2,2′-azobenzimidazole. And the patent contained the following:

1-Benzyl-2-aminobenzimidazole is treated with an excess of Na in liquid NH3 at -70° followed by separation of 2,2′-azobenzimidazole by acidifying with concentrated HCl, filtrating, acidifying the filtrate, and purifying the product. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Quality Control of 2-Nitro-1H-benzo[d]imidazole

2-Nitro-1H-benzo[d]imidazole(cas:5709-67-1) belongs to imidazoles. It is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Quality Control of 2-Nitro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem