Category: imidazoles-derivatives

Li, Hao; Zhang, Ning; Wang, Yuechen; Xia, Siyuan; Zhu, Yating; Xing, Chen; Tian, Xuefeng; Du, Yinan published an article in 2022, the title of the article was DNA N6-methyladenine modification in eukaryotic genome.Name: N-Methyl-7H-purin-6-amine And the article contains the following content:

A review. DNA methylation is treated as an important epigenetic mark in various biol. activities. In the past, a large number of articles focused on 5 mC while lacking attention to N6-methyladenine (6 mA). The presence of 6 mA modification was previously discovered only in prokaryotes. Recently, with the development of detection technologies, 6 mA has been found in several eukaryotes, including protozoans, metazoans, plants, and fungi. The importance of 6 mA in prokaryotes and single-celled eukaryotes has been widely accepted. However, due to the incredibly low d. of 6 mA and restrictions on detection technologies, the prevalence of 6 mA and its role in biol. processes in eukaryotic organisms are highly debated. In this review, we first summarize the advantages and disadvantages of 6 mA detection methods. Then, we conclude existing reports on the prevalence of 6 mA in eukaryotic organisms. Next, we highlight possible methyltransferases, demethylases, and the recognition proteins of 6 mA. In addition, we summarize the functions of 6 mA in eukaryotes. Last but not least, we summarize our point of view and put forward the problems that need further research. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Name: N-Methyl-7H-purin-6-amine

The Article related to review dna methyladenine modification eukaryotic genome, dna modification, n6-methyladenine, epigenetics, eukaryotic genome, methylation, Mammalian Biochemistry: Reviews and other aspects.Name: N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tsukiyama, Sho; Hasan, Mehedi Md; Deng, Hong-Wen; Kurata, Hiroyuki published an article in 2022, the title of the article was BERT6mA: prediction of DNA N6-methyladenine site using deep learning-based approaches.Recommanded Product: 443-72-1 And the article contains the following content:

N6-methyladenine (6mA) is associated with important roles in DNA replication, DNA repair, transcription, regulation of gene expression. Several exptl. methods were used to identify DNA modifications. However, these exptl. methods are costly and time-consuming. To detect the 6mA and complement these shortcomings of exptl. methods, we proposed a novel, deep leaning approach called BERT6mA. To compare the BERT6mA with other deep learning approaches, we used the benchmark datasets including 11 species. The BERT6mA presented the highest AUCs in eight species in independent tests. Furthermore, BERT6mA showed higher and comparable performance with the state-of-the-art models while the BERT6mA showed poor performances in a few species with a small sample size. To overcome this issue, pretraining and fine-tuning between two species were applied to the BERT6mA. The pretrained and fine-tuned models on specific species presented higher performances than other models even for the species with a small sample size. In addition to the prediction, we analyzed the attention weights generated by BERT6mA to reveal how the BERT6mA model extracts critical features responsible for the 6mA prediction. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Recommanded Product: 443-72-1

The Article related to dna n6 methyladenine deep learning, 6ma modification prediction, bert, cnn, gru, lstm, word2vec, Biochemical Methods: Biological and other aspects.Recommanded Product: 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 5, 2004, Food and Drug Administration published an article.HPLC of Formula: 65896-14-2 The title of the article was Implantation or injectable dosage form new animal drugs; romifidine. And the article contained the following:

The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect approval of a new animal drug application (NADA) field by Boehringer Ingelheim Vetmedica, Inc. The NADA provides for the veterinary prescription use of romifidine hydrochloride injectable solution in horses as a sedative and analgesic, and as a preanesthetic agent. The experimental process involved the reaction of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride(cas: 65896-14-2).HPLC of Formula: 65896-14-2

The Article related to romifidine standard injection horse, Pharmaceuticals: Drug Standards and other aspects.HPLC of Formula: 65896-14-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fernandes, Sara B.; Grova, Nathalie; Roth, Sarah; Duca, Radu Corneliu; Godderis, Lode; Guebels, Pauline; Meriaux, Sophie B.; Lumley, Andrew I.; Bouillaud-Kremarik, Pascaline; Ernens, Isabelle; Devaux, Yvan; Schroeder, Henri; Turner, Jonathan D. published an article in 2021, the title of the article was N6-methyladenine in eukaryotic DNA: tissue distribution, early embryo development, and neuronal toxicity.Product Details of 443-72-1 And the article contains the following content:

DNA methylation is one of the most important epigenetic modifications and is closely related with several biol. processes such as regulation of gene transcription and the development of non-malignant diseases. The prevailing dogma states that DNA methylation in eukaryotes occurs essentially through 5-methylcytosine (5mC) but recently adenine methylation was also found to be present in eukaryotes. In mouse embryonic stem cells, 6-methyladenine (6mA) was associated with the repression and silencing of genes, particularly in the X-chromosome, known to play an important role in cell fate determination Here, we have demonstrated that 6mA is a ubiquitous eukaryotic epigenetic modification that is put in place during epigenetically sensitive periods such as embryogenesis and fetal development. In somatic cells there are clear tissue specificity in 6mA levels, with the highest 6mA levels being observed in the brain. In zebrafish, during the first 120 h of embryo development, from a single pluripotent cell to an almost fully formed individual, 6mA levels steadily increase. An identical pattern was observed over embryonic days 7-21 in the mouse. Furthermore, exposure to a neurotoxic environmental pollutant during the same early life period may led to a decrease in the levels of this modification in female rats. The identification of the periods during which 6mA epigenetic marks are put in place increases our understanding of this mammalian epigenetic modification, and raises the possibility that it may be associated with developmental processes. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Product Details of 443-72-1

The Article related to methyladenine eukaryotic dna early embryo development neuronal toxicity, 6-methyladenine, dna methylation, brain, developmental neurotoxicity, embryo development, stress, Pharmaceuticals: Pharmaceutics and other aspects.Product Details of 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 31, 2022, Hui, Wenyan; Zhang, Wenyi; Li, Jing; Kwok, Lai-Yu; Zhang, Heping; Kong, Jian; Sun, Tiansong published an article.HPLC of Formula: 443-72-1 The title of the article was Functional analysis of the second methyltransferase in the bacteriophage exclusion system of Lactobacillus casei Zhang. And the article contained the following:

The antiphage ability is an important feature of fermentation strains in the dairy industry. Our previous work described the bacteriophage exclusion (BREX) system in the probiotic strain, Lactobacillus casei Zhang. The function of L. casei Zhang pglX gene in mediating 5′-ACRCm6AG-3′ methylation was also confirmed. This study aimed to further dissect the function of the BREX system of L. casei Zhang by inactivating its second methyltransferase gene (LCAZH_2054). The methylome of the mutant, L. casei Zhang Δ2054, was profiled by single-mol. real-time sequencing. Then, the cell morphol., growth, plasmid transformation efficiency, and stability of the wildtype and mutant were compared. The mutant did not have an observable effect in microscopic and colony morphol., but it reached a higher cell d. after entering the exponential phase without obvious increase in the cell viability. The mutant had fewer 5′-ACRCm6AG-3′ methylation compared with the wildtype (1835 vs. 1906). Interestingly, no significant difference was observed in the transformation efficiency between the 2 strains when plasmids without cognate recognition sequence (pSec:Leiss:Nuc and pG+host9) were transformed, contrasting to transforming cells with cognate recognition sequence-containing plasmids (pMSP3535 and pTRKH2). The efficiency of transforming pMSP3535 into the LCAZH_2054 mutant was significantly lower than the wildtype, whereas an opposite trend was seen in pTRKH2 transformation. Moreover, compared with the wildtype, the mutant strain had higher capacity in retaining pMSP3535 and lower capacity in retaining pTRKH2, suggesting an unequal tolerance level to different foreign DNA. In conclusion, LCAZH_2054 was not directly responsible for 5′-ACRCm6AG-3′ methylation in L. casei Zhang, but it might help regulate the function and specificity of the BREX system. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).HPLC of Formula: 443-72-1

The Article related to methyltransferase bacteriophage lactobacillus, lactobacillus casei zhang, bacteriophage exclusion system, methyltransferase, phage infection, transformation efficiency, Food and Feed Chemistry: Other and other aspects.HPLC of Formula: 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 31, 2020, Hasan, Mehedi Md.; Manavalan, Balachandran; Shoombuatong, Watshara; Khatun, Mst. Shamima; Kurata, Hiroyuki published an article.Name: N-Methyl-7H-purin-6-amine The title of the article was i6mA-Fuse: improved and robust prediction of DNA 6 mA sites in the Rosaceae genome by fusing multiple feature representation. And the article contained the following:

DNA N6-methyladenine (6 mA) is one of the most vital epigenetic modifications and involved in controlling the various gene expression levels. With the avalanche of DNA sequences generated in numerous databases, the accurate identification of 6 mA plays an essential role for understanding mol. mechanisms. Because the exptl. approaches are time-consuming and costly, it is desirable to develop a computation model for rapidly and accurately identifying 6 mA. To the best of our knowledge, we first proposed a computational model named i6mA-Fuse to predict 6 mA sites from the Rosaceae genomes, especially in Rosa chinensis and Fragaria vesca. We implemented the five encoding schemes, i.e., mononucleotide binary, dinucleotide binary, k-space spectral nucleotide, k-mer, and electron-ion interaction pseudo potential compositions, to build the five, single-encoding random forest (RF) models. The i6mA-Fuse uses a linear regression model to combine the predicted probability scores of the five, single encoding-based RF models. The resultant species-specific i6mA-Fuse achieved remarkably high performances with AUCs of 0.982 and 0.978 and with MCCs of 0.869 and 0.858 on the independent datasets of Rosa chinensis and Fragaria vesca, resp. In the F. vesca-specific i6mA-Fuse, the MBE and EIIP contributed to 75% and 25% of the total prediction; in the R. chinensis-specific i6mA-Fuse, Kmer, MBE, and EIIP contribute to 15%, 65%, and 20% of the total prediction. To assist high-throughput prediction for DNA 6 mA identification, the i6mA-Fuse is publicly accessible at https://kurata14.bio.kyutech.ac.jp/i6mA-Fuse/. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Name: N-Methyl-7H-purin-6-amine

The Article related to methyladenine fuse dna genome rosa fragaria, dna 6 ma, feature encoding, machine learning, sequence analysis, Biochemical Methods: Apparatus and other aspects.Name: N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 30, 2007, El Alaoui, Abdessamad; Schmidt, Frederic; Amessou, Mohamed; Sarr, Marianne; Decaudin, Didier; Florent, Jean-Claude; Johannes, Ludger published an article.Recommanded Product: 901770-40-9 The title of the article was Shiga toxin-mediated retrograde delivery of a topoisomerase I inhibitor prodrug. And the article contained the following:

A retrograde strategy: An innovative cancer-cell delivery concept exploits the naturally evolved characteristics of the Shiga toxin B-subunit (STxB) for the intracellular activation of a newly synthesized prodrug at the level of the biosynthetic/secretory pathway. Retrograde prodrug targeting allows its slow release, which should sustain the presence of the active principle in dividing tumor cells. The experimental process involved the reaction of N-(4-Hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide(cas: 901770-40-9).Recommanded Product: 901770-40-9

The Article related to shiga toxin retrograde delivery topoisomerase i inhibitor prodrug, Pharmaceuticals: Pharmaceutics and other aspects.Recommanded Product: 901770-40-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nalwade, Santaji Uttam; Reddy, Vangala Ranga; Rao, Dantu Durga; Morisetti, Nagendra kumar published an article in 2011, the title of the article was A validated stability indicating ultra performance liquid chromatographic method for determination of impurities in Esomeprazole magnesium gastro resistant tablets.Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:

A novel gradient reversed-phase ultra performance liquid chromatog. method has been developed for quant. determination of Esomeprazole magnesium and its seven impurities in pharmaceutical dosage forms. Chromatog. separation has been achieved on an Acquity BEH C18, 50 mm × 2.1 mm, 1.7 μm with buffered mobile phase consisting solvent A (0.04 M (M) glycine (pH 9.0) buffer) and solvent B (mixture of acetonitrile and Milli-Q water in the ratio 90: 10 (volume/volume); resp.) delivered at flow rate of 0.21 mL min-1 and the detection wavelength 305 nm. Resolution of Esomeprazole magnesium and all the seven potential impurities has been achieved greater than 2.0 for all pairs of compounds The drug was subjected to the stress conditions of oxidative, acid, base, hydrolytic, thermal and photolytic degradation Esomeprazole magnesium was found to degrade significantly in oxidative and acid hydrolysis stress conditions and stable in base, hydrolytic and photolytic degradation conditions. The degradation products were well resolved from main peak and its impurities, thus proved the stability indicating power of the method. The stress samples were assayed against a reference standard and the mass balance was found to be close to 99.1%. So this method was also suitable for Assay determination of Esomeprazole magnesium in pharmaceutical dosage forms. The developed method was validated as per ICH guidelines with respect to specificity, linearity, limit of detection, limit of quantification, accuracy, precision and robustness. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to liquid chromatog impurity esomeprazole magnesium tablet stress, Pharmaceuticals: Pharmaceutics and other aspects.Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 11, 2021, Pennington, Lewis D.; Woods, James R.; Huynh, Hoan; Aquila, Brian M.; Mugge, Ingo Andreas; Hu, Yuan; Choi, Younggi; Wynn, Thomas Andrew; Gerard, Baudouin; Bosanac, Todd; Vantangoli, Nicholas J. published a patent.Application of 40644-16-4 The title of the patent was Lactam-containing compounds for the treatment of pain. And the patent contained the following:

Provided herein are compounds I (R1= (halogen-substituted) C1-6 alkyl, C1-4 alkoxy; R2, R3, R4= H, (halogen-substituted) C1-4 alkyl, C1-4 alkoxy, OH, halogen; R5= H, C1-4 alkyl; X and R6 as defined in text) that are useful in the treatment of pain in a subject. Also provided herein is a pharmaceutical composition comprising compounds or pharmaceutically acceptable salts thereof, and a pharmaceutically acceptable carrier and methods of treating pain in a subject in need thereof. The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Application of 40644-16-4

The Article related to pharmaceutical composition pain, Pharmaceuticals: Pharmaceutics and other aspects.Application of 40644-16-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 1, 2020, Wu, Kou-Juey published an article.Computed Properties of 443-72-1 The title of the article was The epigenetic roles of DNA N6-Methyladenine (6mA) modification in eukaryotes. And the article contained the following:

A review. The DNA N6-methyladenine (6mA) modification is a prevalent epigenetic mark in prokaryotes, but the low abundance of 6mA in eukaryotes has recently received attention. The possible role of 6mA as an epigenetic mark in eukaryotes is starting to be recognized. This review article addresses the epigenetic roles of 6mA in eukaryotes. The existence of 6mA in metazoans and plants, the correlation of 6mA with gene expression, the enzymes catalyzing the deposition and removal of the 6mA modification, the relationship of 6mA to nucleosome positioning, the 6mA interaction with chromatin, its role in tumorigenesis and other physiol. conditions/diseases and tech. issues in 6mA detection/profiling and bioinformatics anal. are described. New directions and unresolved issues (e.g., the base-pair-resolution 6mA-sequencing method and gene activation vs. repression) in 6mA research are discussed. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Computed Properties of 443-72-1

The Article related to review epigenetic mark n6methyladenine tumorigenesis, chromatin, demethylase, epigenetic mark, gene expression, methyltransferase, nucleosome positioning, Biochemical Genetics: Reviews and other aspects.Computed Properties of 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem