Category: imidazoles-derivatives

Li, Deyu; Delaney, James C.; Page, Charlotte M.; Chen, Alvin S.; Wong, Cintyu; Drennan, Catherine L.; Essigmann, John M. published an article in 2010, the title of the article was Repair of DNA alkylation damage by the Escherichia coli adaptive response protein AlkB as studied by ESI-TOF mass spectrometry.HPLC of Formula: 55662-66-3 And the article contains the following content:

DNA alkylation can cause mutations, epigenetic changes, and even cell death. All living organisms have evolved enzymic and non-enzymic strategies for repairing such alkylation damage. AlkB, one of the Escherichia coli adaptive response proteins, uses an α-ketoglutarate/Fe(II)-dependent mechanism that, by chem. oxidation, removes a variety of alkyl lesions from DNA, thus affording protection of the genome against alkylation. In an effort to understand the range of acceptable substrates for AlkB, the enzyme was incubated with chem. synthesized oligonucleotides containing alkyl lesions, and the reaction products were analyzed by electrospray ionization time-of-flight (ESI-TOF) mass spectrometry. Consistent with the literature, but studied comparatively here for the first time, it was found that 1-methyladenine, 1,N6-ethenoadenine, 3-methylcytosine, and 3-ethylcytosine were completely transformed by AlkB, while 1-methylguanine and 3-methylthymine were partially repaired. The repair intermediates (epoxide and possibly glycol) of 3,N4-ethenocytosine are reported for the first time. It is also demonstrated that O6-methylguanine and 5-methylcytosine are refractory to AlkB, lending support to the hypothesis that AlkB repairs only alkyl lesions attached to the nitrogen atoms of the nucleobase. ESI-TOF mass spectrometry is shown to be a sensitive and efficient tool for probing the comparative substrate specificities of DNA repair proteins in vitro. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).HPLC of Formula: 55662-66-3

The Article related to dna alkylation repair escherichia alkb, Biochemical Genetics: Genomic Processes and other aspects.HPLC of Formula: 55662-66-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bartholomew, David G.; Dea, Phoebe; Robins, Roland K.; Revankar, Ganapathi R. published an article in 1975, the title of the article was Imidazo[1,2-c]pyrimidine nucleosides. Synthesis of N-bridgehead inosine monophosphate and guanosine monophosphate analogs related to 3-deazapurines.Application In Synthesis of Imidazo[1,2-c]pyrimidin-5(6H)-one And the article contains the following content:

Cyclization of 4-amino-6-chloro-2-pyrimidinol with BrCH2CH(OEt)2 gave 7-chloroimidazo[1,2-c]pyrimidin-5-one (I). Direct glycosylation of the trimethylsilyl derivative of I with 2,3,5-tri-O-acetyl-D-ribofuranosyl bromide in MeCN gave an anomeric mixture of 7-chloro-1-(2,3,5-tri-O-acetyl-D-ribofuranosyl)imidazo[1,2-c]pyrimidin-5-one, which on deacetylation and separation of anomers furnished 7-chloro-1-β-D-ribofuranosylimidazo[1,2-c]pyrimidin-5-one (II) and its α anomer (III). However, the glycosylation of trimethylsilylated I with tetra-O-acetyl-β-D-ribofuranose in dichloroethane containing SnCl4, followed by aminolysis gave only II. Catalytic dehalogenation of II and III gave 1-β-D-ribofuranosylimidazo[1,2-c]pyrimidin-5-one (IV) and its α anomer (V), resp. Amination of II gave 7-amino-1-β-D-ribofuranosylimidazo[1,2-c]pyrimidin-5-one (VI). Phosphorylation of IV, V, and VI gave 1-β-D-ribofuranosylimidazo[1,2-c]pyrimidin-5-one 5′-monophosphate, the IMP analog α anomer and 7-amino-1-β-D-ribofuranosylimidazo[1,2-c]pyrimidin-5-one 5′-monophosphate, resp. The ribosylation site was determined by using 13C NMR and the anomeric configurations were established by using PMR of the 2′,3′-O-isopropylidene derivatives of II and III. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Application In Synthesis of Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to imidazopyrimidine nucleoside analog, Carbohydrates: Nucleosides, Nucleotides and other aspects.Application In Synthesis of Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On November 21, 2017, Moutzouri, Pinelopi; Kiraly, Peter; Phillips, Andrew R.; Coombes, Steven R.; Nilsson, Mathias; Morris, Gareth A. published an article.SDS of cas: 73590-85-9 The title of the article was 13C Satellite-Free 1H NMR Spectra. And the article contained the following:

A new NMR experiment (Destruction of Interfering Satellites by Perfect Echo Low-pass filtration, DISPEL) is introduced that facilitates the anal. of low-level components in high dynamic range mixtures by suppressing one-bond 13C satellite signals in 1H spectra. Since the natural abundance of 13C is around 1.1%, these satellites appear at 0.54% of the intensity of a parent peak, mimicking and often masking impurity signals. The new experiment suppresses one-bond 13C satellite signals, with high efficiency, at negligible cost in signal-to-noise ratio, and over a wide range of one-bond coupling constants, without the need for broadband 13C decoupling. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).SDS of cas: 73590-85-9

The Article related to dispel nmr one bond satellite signal suppression, Magnetic Phenomena: Nuclear Resonances and other aspects.SDS of cas: 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Boulias, Konstantinos; Greer, Eric Lieberman published an article in 2021, the title of the article was Detection of DNA Methylation in Genomic DNA by UHPLC-MS/MS.Formula: C6H7N5 And the article contains the following content:

DNA methylation serves to mark DNA as either a directed epigenetic signaling modification or in response to DNA lesions. Methods for detecting DNA methylation have become increasingly more specific and sensitive over time. Conventional methods for detecting DNA methylation, ranging from paper chromatog. to differential restriction enzyme digestion preference to dot blots, have more recently been supplemented by ultrahigh performance liquid chromatog. coupled with mass spectrometry (UHPLC-MS/MS) to accurately quantify specific DNA methylation. Methylated DNA can also be sequenced by either methylated DNA immunoprecipitation followed by sequencing (MeDIP-seq) or single-mol. real-time sequencing (SMRTseq) for identifying genomic locations of DNA methylation. Here we describe a protocol for the detection and quantification of epigenetic signaling DNA methylation modifications including, N6-methyladenine (6mA), N4-methylcytosine (4mC) and C5-methylcytosine (5mC) in genomic DNA by triple quadrupole liquid chromatog. coupled with tandem mass spectrometry (QQQ-LC-MS/MS). The high sensitivity of the UHPLC-MS/MS methodol. and the use of calibration standards of pure nucleosides allow for the accurate quantification of DNA methylation. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Formula: C6H7N5

The Article related to genomic dna methylation uhplc ms, 4mc, 5mc, 6ma, c5-methylcytosine, n4-methylcytosine, n6-methyladenine, uhplc-ms/ms, methylated dna, Biochemical Methods: Chromatographic and other aspects.Formula: C6H7N5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Revankar, Ganapathi R.; Matthews, Thomas R.; Robins, Roland K. published an article in 1975, the title of the article was Synthesis and antimicrobial activity of certain imidazo[1,2-a]pyrimidines.Computed Properties of 57473-33-3 And the article contains the following content:

A series of 5-substituted and 5,7-disubstituted imidazo[1,2-a]pyrimidines (I) were prepared and the in vitro antimicrobial activity of these compounds against a variety of microorganisms tested. 5-N-octylaminoimidazo[1,2-a]pyrimidine [57473-44-6] exhibited significant activity against all the microorganisms tested. The experimental process involved the reaction of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one(cas: 57473-33-3).Computed Properties of 57473-33-3

The Article related to bactericide imidazopyrimidine derivative, bactericide methylsulfinyl nitrofuran analog, Pharmacodynamics: Structure-Activity and other aspects.Computed Properties of 57473-33-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 20, 2021, Si, Zhangyong; Hou, Zheng; Vikhe, Yogesh Shankar; Thappeta, Kishore Reddy Venkata; Marimuthu, Kalisvar; De, Partha Pratim; Ng, Oon Tek; Li, Peng; Zhu, Yabin; Pethe, Kevin; Chan-Park, Mary B. published an article.Synthetic Route of 5036-48-6 The title of the article was Antimicrobial Effect of a Novel Chitosan Derivative and Its Synergistic Effect with Antibiotics. And the article contained the following:

Cationic polymers are promising antibacterial agents because bacteria have a low propensity to develop resistance against them, but they usually have low biocompatibility because of their hydrophobic moieties. Herein, we report a new biodegradable and biocompatible chitosan-derived cationic antibacterial polymer, 2,6-diamino chitosan (2,6-DAC). 2,6-DAC shows excellent broad-spectrum antimicrobial activity with min. inhibitory concentrations (MICs) of 8-32μg/mL against clin. relevant and multidrug-resistant (MDR) bacteria including Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Furthermore, 2,6-DAC shows an excellent synergistic effect with various clin. relevant antibiotics proved by decreasing the MICs of the antibiotics against MDR A. baumannii and methicillin-resistant Staphylococcus aureus to <1μg/mL. In vivo biocompatibility of 2,6-DAC is proved by a dosage of 100 mg/kg compound via oral administration and 25 mg/kg compound via i.p. injection to mice; 2,6-DAC does not cause any weight loss and any significant change in liver and kidney biomarkers or the important blood electrolytes. The combinations of 2,6-DAC together with novobiocin and rifampicin show >2.4 log10 reduction of A. baumannii in murine i.p. and lung infection models. The novel chitosan derivative, 2,6-DAC, can be utilized as a biocompatible broad-spectrum cationic antimicrobial agent alone or in synergistic combination with various antibiotics. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6

The Article related to antimicrobial chitosan derivative synergistic antibiotic, antibacterial, biocompatible, chitosan derivatives, nanoparticle, synergistic effect with antibiotics, Industrial Carbohydrates: Nonsugars and other aspects.Synthetic Route of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 28, 1991, Debnath, Asim Kumar; Lopez de Compadre, Rosa L.; Debnath, Gargi; Shusterman, Alan J.; Hansch, Corwin published an article.Product Details of 5709-67-1 The title of the article was Structure-activity relationship of mutagenic aromatic and heteroaromatic nitro compounds. Correlation with molecular orbital energies and hydrophobicity. And the article contained the following:

A survey of the literature yielded data on over 200 aromatic and heteroaromatic nitro compounds tested for mutagenicity in the Ames test using S. typhimurium TA98. From the data, a QSAR has been derived for 188 congeners. The main determinants of mutagenicity are the hydrophobicity (modeled by octanol/water partition coefficients) and the energies of the lowest unoccupied mol. orbitals calculated using the AM1 method. It is also shown that chems. possessing three or more fused rings possess much greater mutagenic potency than compounds with one or two fused rings. Since the QSAR is based on a very wide range in structural variation (aromatic rings from benzene to coronene are included as well as many different types of heterocycles), it is a significant step toward a predictive toxicol., with value in the design of less mutagenic bioactive compounds The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Product Details of 5709-67-1

The Article related to mutagenicity qsar aromatic heteroaromatic nitro compound, hydrophobicity nitro compound mutagenicity, lumo nitro compound mutagenicity, Physical Organic Chemistry: General and other aspects.Product Details of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 1, 2001, Privezentzev, C. V.; Saparbaev, M.; Laval, J. published an article.Name: Imidazo[1,2-c]pyrimidin-5(6H)-one The title of the article was The HAP1 protein stimulates the turnover of human mismatch-specific thymine-DNA-glycosylase to process 3,N4-ethenocytosine residues. And the article contained the following:

When present in DNA, 3,N4-ethenocytosine (εC) residues are potentially mutagenic and carcinogenic in vivo. The enzymic activity responsible for the repair of the εC residues in human cells is the hTDG protein, the human thymine-DNA-glycosylase that removes thymine in a T/G base pair [Proc. Natl. Acad. Sci., U.S.A., 95 (1998) 8508]. One of the distinctive properties of the hTDG protein is that it remains tightly bound to the AP-site resulting from its glycosylase activity. In this paper we report that the human AP endonuclease, the HAP1 (Ape1, APEX Ref-1) protein, stimulates the processing of εC residues by the hTDG protein in vitro, in a dose-dependent manner. This property of HAP1 protein is specific since E.coli Fpg, Nfo and Nth proteins, all endowed with an AP nicking activity, do not show similar features. The results suggest that the HAP1 protein displaces the hTDG protein bound to the AP-site and therefore increases the turnover of the hTDG protein. However, using a variety of techniques including gel retardation assay, surface plasmon resonance and two-hybrid system, it was not possible to detect evidence for a complex including the substrate, the hTDG and HAP1 proteins. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Name: Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to hap1 ap endonuclease ethenocytosine dna excision repair, thymine dna glycosylase ref1 endonuclease ethenocytosine mutagen, Mammalian Biochemistry: Metabolism and other aspects.Name: Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 5, 1997, Wang, Ge; Rahman, M. Sayeedur; Humayun, M. Zafri published an article.Name: Imidazo[1,2-c]pyrimidin-5(6H)-one The title of the article was Replication of M13 Single-Stranded Viral DNA Bearing Single Site-Specific Adducts by Escherichia coli Cell Extracts: Differential Efficiency of Translesion DNA Synthesis for SOS-Dependent and SOS-Independent Lesions. And the article contained the following:

To characterize mutagenic translesion DNA synthesis in UVM-induced Escherichia coli, we have developed a high-resolution DNA replication system based on E. coli cell extracts and M13 genomic DNA templates bearing mutagenic lesions. The assay is based on the conversion of M13 viral single-stranded DNA (ssDNA) bearing a single site-specific DNA lesion to the double-stranded replicative form (RF) DNA, and permits one to quant. measure the efficiency of translesion synthesis. DNA replication is most strongly inhibited by an abasic site, a classic SOS-dependent noninstructive lesion. In contrast, the efficiency of translesion synthesis across SOS-independent lesions such as O6-methylguanine and DNA uracil is around 90%, very close to the values obtained for control DNA templates. The efficiency of translesion synthesis across 3,N4-ethenocytosine and 1,N6-ethenoadenine is around 20%, a value that is similar to the in vivo efficiency deduced from the effect of the lesions on the survival of transfected M13 ssDNA. Neither DNA polymerase I nor polymerase II appears to be required for the observed translesion DNA synthesis because essentially similar results are obtained with extracts from polA- or polB-defective cells. The close parallels in the efficiency of translesion DNA synthesis in vitro and in vivo for the five site-specific lesions included in this study suggest that the assay may be suitable for modeling mutagenesis in an accessible in vitro environment. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Name: Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to dna replication system development escherichia, Biochemical Methods: Immunological and other aspects.Name: Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Maggiali, C. A.; Mingiardi, M. R.; Morini, G.; Ronchini, F.; Mossini, F. published an article in 1982, the title of the article was Biological properties of imidazopyrimidines.COA of Formula: C6H5N3O And the article contains the following content:

Fifteen imidazo[1,2-a]pyrimidine derivatives I (R = OH, Cl, alkylamino, etc.; R1 = H or Cl) and 7 imidazo[1,2-c]pyrimidine derivatives II (R and R1 = as above) were prepared and tested for herbicidal activity against Sorghum vulgare, Hordeum hexastichum, and Pisum sativum. II (R = R1 = Cl) [85989-61-3] was the most active. I (R = R1 = Cl) [57473-32-2] was very active against S. vulgare and H. hexastichum, and moderately phytotoxic to P. sativum. Structure-activity relations are discussed. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).COA of Formula: C6H5N3O

The Article related to imidazopyrimidine herbicide, Agrochemical Bioregulators: Plant and other aspects.COA of Formula: C6H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem