Category: imidazoles-derivatives

On March 31, 1981, Lopyrev, V. A.; Larina, L. I.; Vakul’skaya, T. I.; Larin, M. F.; Nefedova, O. B.; Shibanova E. F.; Voronkov, M. G. published an article.Recommanded Product: 5709-67-1 The title of the article was Transmission of the substituent effects in 2-substituted benzimidazoles studied by proton and carbon-13 nuclear magnetic resonance. And the article contained the following:

Substituent effects on the 1H and 13C NMR chem. shifts in 2-substituted benzimidazoles and their anions and cations were studied quant. The transmission of electron effects of substituents from C-2 to C-5(6) is approx. 20% less effective than in the opposite direction. The solvent effects on 1H chem. shifts and transmission effects in the charged forms of 2-substituted benzimidazoles were also studied. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Recommanded Product: 5709-67-1

The Article related to benzimidazole nmr substituent effect, transmission electronic effect benzimidazole substituent, solvent effect benzimidazole nmr, lfer benzimidazole nmr, Physical Organic Chemistry: Spectral and Related Studies and other aspects.Recommanded Product: 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 30, 2011, Kruger, Karin; Stegmann, George F.; Becker, Piet J. published an article.Reference of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride The title of the article was Preliminary investigation of concurrent administration of phenylbutazone and romifidine in healthy horses. And the article contained the following:

To characterize the cardiorespiratory and electrocardiog. effects of the combined administration of phenylbutazone and romifidine. Prospective four-period, four-treatment, blinded, randomized, crossover trial. Five, healthy, mixed breed horses. Prior to treatment administration, a catheter was introduced into the intra-thoracic cranial vena cava via the jugular vein and a s.c. located carotid artery was catheterised. All treatments were administered i.v. and consisted of saline placebo (PLC), phenylbutazone (PBZ, 4.4 mg/kg-1) romifidine (ROM, 80 μg/kg-1) and a combination of phenylbutazone (4.4 mg/kg-1) and romifidine (80 μg/kg-1). There was at least a 1 wk washout period between treatments. Heart rate (HR), respiratory rate (fR), systolic (SAP), diastolic (DAP) and mean (MAP) arterial pressures and central venous pressure (CVP) were recorded for baseline (prior to drug administration) and at 5 min intervals thereafter for 30 min. Electrocardiog. abnormalities were recorded. Data were analyzed by ANOVA. For the cardiovascular variables there were no statistically significant (p > 0.05) differences between horses treated with ROM and PBZ_ROM. Statistically significant (p < 0.05) differences only occurred between treatments with romifidine (ROM and PBZ_ROM) and without romifidine (PLC and PBZ). Within treatments, for ROM, changes over time were statistically significant (p < 0.05) for HR, SAP, DAP, MAP and CVP. For PBZ_ROM, changes over time were statistically significant (p < 0.05) for CVP. Sino-atrial and atrio-ventricular blocks occurred in horses treated with ROM and PBZ_ROM. The combined i.v. administration of phenylbutazone and romifidine had no statistically significant effect on cardiorespiratory variables. These limited data suggest no evidence why both agents should not be included in a preoperative medication protocol for healthy horses but do not exclude the possibility of interactions occurring in a larger population. The experimental process involved the reaction of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride(cas: 65896-14-2).Reference of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride

The Article related to phenylarthrite sedivet anesthetic combination therapy heart rate respiration horse, Pharmacology: Drug Interactions and General Pharmacology and other aspects.Reference of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

War, Javeed Ahmad; Srivastava, Santosh Kumar published an article in 2020, the title of the article was Rationale design and synthesis of some novel imidazole linked thiazolidinone hybrid molecules as DNA minor groove binders.Application In Synthesis of N-(3-Aminopropyl)-imidazole And the article contains the following content:

A new series of imidazole linked thiazolidinone hybrid mols. was designed and subsequently synthesized through a feasible, three step reaction protocol. The structures of these mols. were established using FT-IR, 1H NMR, 13C NMR and HRMS techniques. In vitro susceptibility tests against some Gram pos. (Staphylococcus aureus and Bacillus subtilis) and Gram neg. bacteria (Escherichia coli and Pseudomonas aeruginosa) exhibited broad spectrum potency of the mols. The most potent mol. (S2A7) amongst the screened mols., showed min. inhibitory concentration (MIC) value not less than 2.0μg/mL which was at par with the reference drug Streptomycin. Structure activity relationships revealed nitro and chloro groups being crucial for bioactivity when present at meta position of arylidene ring in 3-(3-(imidazol-1-yl)propyl)-5-(benzylidene)-2- (phenylimino)thiazolidin-4-one. DNA (DNA)and bovine serum albumin (BSA) binding studies for S2A7 under simulated physiol. pH were probed using UV Visible, fluorescence quenching, gel electrophoresis and mol. docking techniques. These studies established that S2A7 has strong binding affinity towards DNA and binds at the minor groove of DNA with binding constant (Kb) of 0.1287×102 L/mol. Mol. docking simulations of S2A7 with DNA and BSA predicted binding affinity of -9.2 and -7.2 kcal/mol, resp. Van der Waals forces and hydrogen bonding interactions were predicted as the main forces of interaction. With DNA, S2A7 exhibited specific binding affinity towards adenine-thiamine base pairs. The compound S2A7 forms a stable complex with BSA by binding at subdomain IIIA implying high bio-distribution of the compound The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Application In Synthesis of N-(3-Aminopropyl)-imidazole

The Article related to imidazole thiazolidinone antibiotic dna minor groove binder bacterial infection, Pharmacology: Drug Interactions and General Pharmacology and other aspects.Application In Synthesis of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Douvlataniotis, Karolos; Bensberg, Maike; Lentini, Antonio; Gylemo, Bjoern; Nestor, Colm E. published an article in 2020, the title of the article was No evidence for DNA N6 -methyladenine in mammals.HPLC of Formula: 443-72-1 And the article contains the following content:

N6 -methyladenine (6mdA) is a widespread DNA modification in bacteria. More recently, 6mdA has also been characterized in mammalian DNA. However, measurements of 6mdA abundance and profiles are often very dissimilar between studies, even when performed on DNA from identical mammalian cell types. Using comprehensive bioinformatics analyses of published data and novel exptl. approaches, we reveal that efforts to assay 6mdA in mammals have been severely compromised by bacterial contamination, RNA contamination, technol. limitations, and antibody nonspecificity. These complications render 6mdA an exceptionally problematic DNA modification to study and have resulted in erroneous detection of 6mdA in several mammalian systems. Together, our results strongly imply that the evidence published to date is not sufficient to support the presence of 6mdA in mammals. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).HPLC of Formula: 443-72-1

The Article related to dna n methyladenine mammalian cell, Mammalian Biochemistry: Classical Genetics and Phylogeny and other aspects.HPLC of Formula: 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kost, A. A.; Ermolin, S. V. published an article in 1978, the title of the article was Fluorescent derivatives of cytosine.Recommanded Product: Imidazo[1,2-c]pyrimidin-5(6H)-one And the article contains the following content:

The fluorescence of ethenocytosines, e.g., I (R = Me, H, Ph; R1 = H, Me), was investigated by PPP MO calculations The π-electronic charges of the atoms do not change appreciably on excitation of the mols. The electronic excitation of these compounds is more diffuse than that of cytosine. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Recommanded Product: Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to fluorescent ethenocytosine mo, Physical Organic Chemistry: Spectral and Related Studies and other aspects.Recommanded Product: Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 31, 1979, Larina, L. I.; Vakul’skaya, T. I.; Nefedova, O. B.; Shibanova, E. F.; Lopyrev, V. A.; Voronkov, M. G. published an article.Reference of 2-Nitro-1H-benzo[d]imidazole The title of the article was Study of electron effects of substituents in 2-substituted benzimidazole derivatives by a proton NMR method. And the article contained the following:

NMR chem. shifts (δ) were determined for the protons on C-4 and C-7 and on C-5 and C-6 of 2-substituted benzimidazoles and their anions and protonated forms. In the neutral mols. substituent effects were transmitted to positions 4 and 7 exclusively by conjugation but were transmitted to positions 5 and 6 by both field and resonance mechanisms in a 1:3 ratio. In the anions transmission to positions 5 and 6 involved only conjugation, whereas transmission to positions 4 and 7 involved inductive and resonance effects in a 1:8 ratio. The effects in the protonated forms could not be separated The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Reference of 2-Nitro-1H-benzo[d]imidazole

The Article related to nmr benzimidazole lfer, Physical Organic Chemistry: Spectral and Related Studies and other aspects.Reference of 2-Nitro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 15, 2021, Diao, Li-Ting; Xie, Shu-Juan; Yu, Pei-Jie; Sun, Yu-Jia; Yang, Fan; Tan, Ye-Ya; Tao, Shuang; Hou, Ya-Rui; Zheng, Ling-Ling; Xiao, Zhen-Dong; Zhang, Qi published an article.Formula: C6H7N5 The title of the article was N6-methyladenine demethylase ALKBH1 inhibits the differentiation of skeletal muscle. And the article contained the following:

DNA N6-methyladenine (N6-mA) was recently recognized as a new epigenetic modification in mammalian genome, and ALKBH1 was discovered as its demethylase. Knock-out mice studies revealed that ALKBH1 was indispensable for normal embryonic development. However, the function of ALKBH1 in myogenesis is largely unknown. In this study, we found that N6-mA showed a steady increase, going along with a strong decrease of ALKBH1 during skeletal muscle development. Our results also showed that ALKBH1 enhanced proliferation and inhibited differentiation of C2C12 cells. Genome-wide transcriptome anal. and reporter assays further revealed that ALKBH1 accomplished the differentiation inhibiting function by regulating a core set of genes and multiple signaling pathways, including increasing chemokine (C-X-C motif) ligand 14 (CXCL14) and activating ERK signaling. Taken together, our results demonstrated that ALKBH1 is critical for the myogenic differentiation of C2C12 cells, and suggested that N6-mA might be a new epigenetic mechanism for the regulation of myogenesis. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Formula: C6H7N5

The Article related to n6methyladenine dna methylation alkbh1 skeletal muscle differentiation, alkbh1, n(6)-methyladenine, rna-seq, skeletal muscle differentiation, Mammalian Biochemistry: General Physiological Chemistry and other aspects.Formula: C6H7N5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 1, 1994, Dosanjh, M. K.; Chenna, A.; Kim, E.; Fraenkel-Conrat, H.; Samson, L.; Singer, B. published an article.Application In Synthesis of Imidazo[1,2-c]pyrimidin-5(6H)-one The title of the article was All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase. And the article contained the following:

The authors have previously reported that human cells and tissues contain a 1,N6-ethenoadenine (εA)-binding protein, which, through glycosylase activity, releases both 3-methyladenine (m3A) and εA from DNA treated with methylating agents or the vinyl chloride metabolite chloroacetaldehyde, resp. The authors now find that both the partially purified human εA-binding protein and cell-free extracts containing the cloned human m3A-DNA glycosylase release all 4 cyclic etheno adducts – namely εA, 3,N4-ethenocytosine (εC), N2,3-ethenoguanine (N2,3-εG), and 1,N2-ethenoguanine (1,N2-εG). Base release was both time- and protein concentration-dependent. Both εA and εC were excised at similar rates, while 1,N2-εG and N2,3-εG were released much more slowly under identical conditions. The cleavage of glycosyl bonds of several heterocyclic adducts as well as those of simple methylated adducts by the same human glycosylase appears unusual in enzymol. This raises the question of how such a multiple, divergent activity evolved in humans and what may be its primary substrate. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Application In Synthesis of Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to chloroacetaldehyde cyclic etheno adduct release, methyladenine dna glycosylase human chloroacetaldehyde, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Application In Synthesis of Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 21, 2020, Billeci, Floriana; D’Anna, Francesca; Feroci, Marta; Cancemi, Patrizia; Feo, Salvatore; Forlino, Antonella; Tonnelli, Francesca; Seddon, Kenneth Richard; Gunaratne, H. Q. Nimal; Plechkova, Natalia V. published an article.COA of Formula: C6H11N3 The title of the article was When functionalization becomes useful: Ionic liquids with a “sweet” appended moiety demonstrate drastically reduced toxicological effects. And the article contained the following:

The growing number of applications of ionic liquids (ILs) in industry have brought attention to the green credentials of synthesis, as well as their cytotoxicities and ecotoxicities both for their use and accidental leakage into the environment. With the abovementioned properties in mind, we designed a class of ILs with either cations bearing a gluconamide motif and aliphatic side chains or the anion incorporating a gluconic acid (derived from food waste) moiety. An IL with an imidazolium cation with an appended gluconic amide (bearing five hydroxyl groups) moiety was also synthesized for a useful comparison. Different structural features were considered, placing emphasis on the nature and length of the alkyl chain and the nature of the anion. For comparison, two ILs, one with a hydroxyl group and another without any hydroxyl groups, were prepared Apart from the typical characterization of ILs, such as differential scanning calorimetry, thermogravimetric anal., conductivity, and viscosity measurements, the main focus was placed on the evaluation of their cytotoxicities and ecotoxicities, performing tests with three cancer cell lines (HeLa, HTC-116, and MCF-7) and fish embryos (zebrafish). Data obtained have shed light on the relationship working between the physicochem. properties and the structural features of the ILs. Interestingly, these ILs are able to inhibit cell growth only at very high concentrations (IC50 ≈ 10-3 M) and they do not affect the vitality of fish embryos, allowing them to be classified as harmless solvents. To our surprise, the data collected show that derivatization with the “sweet” residue on the imidazolium cation completely removes the well-known toxicity effects of imidazolium ILs. “Sweet” ionic liquids incorporating a moiety derived from food waste were obtained. They show good physicochem. properties and drastically reduced toxicity. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).COA of Formula: C6H11N3

The Article related to ionic liquid functionalization reducing toxicity sweet moiety appending, Toxicology: Chemicals (Household, Industrial, General) and other aspects.COA of Formula: C6H11N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 1, 2020, Usai, Gabriele; Mascagni, Flavia; Giordani, Tommaso; Vangelisti, Alberto; Bosi, Emanuele; Zuccolo, Andrea; Ceccarelli, Marilena; King, Robert; Hassani-Pak, Keywan; Zambrano, Liceth S.; Cavallini, Andrea; Natali, Lucia published an article.Recommanded Product: 443-72-1 The title of the article was Epigenetic patterns within the haplotype phased fig (Ficus carica L.) genome. And the article contained the following:

Summary : Due to DNA heterozygosity and repeat content, assembly of non-model plant genomes is challenging. Herein, we report a high-quality genome reference of one of the oldest known domesticated species, fig (Ficus carica L.), using Pacific Biosciences single-mol., real-time sequencing. The fig genome is ∼333 Mbp in size, of which 80% has been anchored to 13 chromosomes. Genome-wide anal. of N6-methyladenine and N4-methylcytosine revealed high methylation levels in both genes and transposable elements, and a prevalence of methylated over non-methylated genes. Furthermore, the characterization of N6-methyladenine sites led to the identification of ANHGA, a species-specific motif, which is prevalent for both genes and transposable elements. Finally, exploiting the contiguity of the 13 pseudomols., we identified 13 putative centromeric regions. The high-quality reference genome and the characterization of methylation profiles, provides an important resource for both fig breeding and for fundamental research into the relationship between epigenetic changes and phenotype, using fig as a model species. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Recommanded Product: 443-72-1

The Article related to ficus genome dna methylation haplotype breeding population, ficus carica l., n4-methylcytosine, n6-methyladenine, genome assembly, single-molecule real-time sequencing, Biochemical Genetics: Gene Structure and Organization and other aspects.Recommanded Product: 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem