Category: imidazoles-derivatives

Cao, Siyu; Yoshio, Masafumi; Seki, Atsushi published an article in 2020, the title of the article was Ion-conductive nanostructured polymer films formed by photopolymerization of lyotropic columnar liquid-crystalline monomers, composed of a zwitterionic compound and a protic ionic liquid.Related Products of 5036-48-6 And the article contains the following content:

Here, we report on a new family of columnar nanostructured polymer films forming protic nanochannels that exhibit good ionic conductivities in the order of 10-4-10-3 S cm-1 at ambient temperature These polymer films were obtained by the in situ photopolymerization of lyotropic columnar liquid crystals, consisting of a polymerizable taper-shaped zwitterionic compound and a protic ionic liquid (imidazolium bis(trifluoromethylsulfonyl)imide), in the presence of 15 wt% water. The composition of the protic ionic liquid in the mixture was changed from 40 to 60 mol%. The ionic conductivities were measured by an a.c. impedance method. The ionic conductivity increased with the increase of the protic ionic liquid The conductivities of columnar nanostructured polymer films were about 2-3 orders of magnitude higher than those of amorphous polymer films prepared by photopolymerization of the corresponding monomers in an isotropic liquid state. The formation of nanochannels in the polymer matrixes significantly enhanced the ion conduction. The present two-component lyotropic liquid-crystalline self-assembly followed by photopolymerization is a promising approach to the development of high ion-conductive polymer membranes. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Related Products of 5036-48-6

The Article related to lyotropic columnar liquid crystalline monomer photopolymerization ionic conductivity, Physical Properties of Synthetic High Polymers: Physical Properties Of Polymers and other aspects.Related Products of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 27, 2022, Le, My Linh; Grzetic, Douglas J.; Delaney, Kris T.; Yang, Kai-Chieh; Xie, Shuyi; Fredrickson, Glenn H.; Chabinyc, Michael L.; Segalman, Rachel A. published an article.Safety of N-(3-Aminopropyl)-imidazole The title of the article was Electrostatic Interactions Control the Nanostructure of Conjugated Polyelectrolyte-Polymeric Ionic Liquid Blends. And the article contained the following:

Polyelectrolyte complexation offers unique opportunities to compatibilize polymers with different backbone chemistries and to control the morphol. of the resulting blend via electrostatic manipulation. In this study, we demonstrate the ability to formulate homogeneous complexes of a conjugated polyelectrolyte with a polymeric ionic liquid, utilizing the electrostatic attraction among their oppositely charged side chains. Variation of electrostatic parameters, such as counterion concentration or polymer charge fraction, tunes the morphol. of these polymer complexes from homogeneously disordered blend to weakly structured microemulsion where the local ordering arises from backbone-immiscibility-induced microphase segregation. Our exptl. observations are in qual. agreement with both field-theoretic simulation and RPA calculations Simulated morphol. snapshots suggest and exptl. evidence also indicates that the microphase-segregated complex likely takes on a cocontinuous microemulsion structure. Our findings show that ionic interactions are an effective pathway to compatibilize polymers at macroscopic length scales while achieving controlled nanostructures in these ionic blends. Such systems have great potential for engineering the nanostructure of polymers to tailor applications such as nanofiltration, catalysis, and energy storage, where local ordering can enhance the phys. properties of an otherwise macroscopically homogeneous structure. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to electrostatic nanostructure conjugated polyelectrolyte polymeric ionic liquid blend, Physical Properties of Synthetic High Polymers: Physical Properties Of Polymers and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 1, 2019, Zhang, Yan; Wu, Yin-Qi; Xu, Na; Zhao, Qian; Yu, Hui-Lei; Xu, Jian-He published an article.Category: imidazoles-derivatives The title of the article was Engineering of cyclohexanone monooxygenase for the enantioselective synthesis of (S)-omeprazole. And the article contained the following:

Enzymic asym. sulfoxidation using mol. oxygen as the oxidant is a promising green chem. approach to chiral sulfoxide production Despite the broad substrate spectrum of cyclohexanone monooxygenases (CHMOs), some unnatural substrates with bulky functional groups, such as the pharmaceutically relevant omeprazole sulfide, cannot be effectively accepted by CHMOs. Herein, we describe a set of variants derived from an Acinetobacter calcoaceticus CHMO (AcCHMO), whose active sites adjacent to the substrate tunnel were altered to shift the substrate specificity from cyclohexanone monooxygenation toward omeprazole sulfide sulfoxidation We performed homologous modeling and mol. docking to identify key residues that might affect the substrate specificity. Two libraries of residues lining the active center of AcCHMO were then constructed and screened by an effective halo-based selection method using the solubility difference between the substrate (omeprazole sulfide) and product (esomeprazole). Functional evaluation of the resultant variants showed that the substrate specificity of AcCHMO was markedly altered from the small natural substrate (cyclohexanone) toward the desired bulky substrate (omeprazole sulfide) despite the extremely poor activity detected even for the best variant, M2 (0.61 U/gprot). The crystal structure of M2 complexed with a FAD prosthetic group was determined, which provided insight into the altered substrate specificity. To improve the activity of enzyme M2 toward pharmaceutical precursor omeprazole sulfide, we performed both local and global protein engineering among the two CASTing libraries surrounding FAD+ and NADP+ prosthetic groups and an error-prone PCR library of the full-length AcCHMO. As a result, variant M6 was obtained, giving a 50-fold higher activity compared to M2. This structure-guided protein engineering of AcCHMO provided a promising candidate for converting omeprazole sulfide into (S)-omeprazole using a green biocatalytic method. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Category: imidazoles-derivatives

The Article related to cyclohexanone monooxygenase engineering enantioselective synthesis s omeprazole, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 31, 2022, Tang, Hui; Zhang, Yuanyuan; Deng, Yashan; Du, Shanshan; Li, Depeng; Wang, Zhiyong; Li, Huiling; Gao, Xin; Wang, Fanye published an article.Recommanded Product: 73590-85-9 The title of the article was Optimization of Synthesis of (S)-Omeprazole Catalyzed by Soybean Pod Peroxidase in Water-in-Oil Microemulsions Using RSM. And the article contained the following:

Response surface methodol. (RSM) was used to optimize the oxidizing the omeprazole sulfide to (S)-omeprazole catalyzed by environmentally friendly catalyst soybean pod peroxidase (SPP) in cetyltrimethylammonium bromide (CTAB)/isooctane/n-Bu alc./water water-in-oil microemulsions. With the initial concentration of SPP of 3200 U ml-1, the conversion of the omeprazole sulfide, the (S)-omeprazole yield and ee were 93.75%, 91.56% and 96.08%, resp., under the optimal conditions: Wo of 15.85, the concentration of H2O2 of 22.44 mM and reaction temperature of 49.68°C, resp. The proposed mechanism of asym. sulfoxidations catalyzed by SPP involves three concomitant mechanisms as follows: (1) a two-electron reduction of SPP-I, (2) a single-electron transfer to SPP-I and (3) nonenzymic reactions. Based on the proposed mechanism which is reasonable and can express the oxidations, the reaction system includes five enzymic and two nonenzymic reactions. With 5.44% of the average relative error, a kinetic model based on the mechanisms fitting observed data very well was established, and the SPP-catalyzed reactions including both the two-electron reduction and the single-electron transfer mechanisms obey ping-pong mechanism with substrate and product inhibition, while nonenzymic reactions follow a power law. This study has also demonstrated the feasibility of SPP as a substitute with low cost, excellent enantioselectivity and better thermal stability. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Recommanded Product: 73590-85-9

The Article related to soybean peroxidase water in oil microemulsion omeprazole optimization rsm, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.Recommanded Product: 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 18, 2022, Ueda, Yuki; Eguchi, Ayano; Tokunaga, Kohei; Kikuchi, Kei; Sugita, Tsuyoshi; Okamura, Hiroyuki; Naganawa, Hirochika published an article.Synthetic Route of 5036-48-6 The title of the article was Urea-Introduced Ionic Liquid for the Effective Extraction of Pt(IV) and Pd(II) Ions. And the article contained the following:

A urea-introduced imidazolium-based ionic liquid (IL), 1-butyl-3-{3-(3-methyl-2H-imidazol-1-yl)propyl}urea bis(trifluoromethylsulfonyl)imide (L1), whose selectivity to Pt(IV) and Pd(II) was changed only by a pH region, was synthesized, and its Pt(IV) and Pd(II) extraction behaviors were investigated. In the conventional organic extraction system, an organic extractant with a urea group, 1-butyl-3-(2-ethylhexyl)urea, in isooctane extracted Pt(IV) and Pd(II) in a similar pH range, the extraction equilibrium half-time (t1/2) of Pd(II) was 8.95 h. In contrast, in the IL extraction system, Pt(IV) and Pd(II) were extracted in the lower and higher pH regions, resp., indicating the mutual separation of Pt(IV) and Pd(II) by pH-change. Furthermore, the extraction equilibrium t1/2 of Pd(II) with the IL extraction system was 0.18 h. UV-visible and extended X-ray absorption fine structure spectroscopies of Pt(IV) and Pd(II) after extraction using the IL were conducted to determine the extraction mechanism. As a result, Pt(IV) was extracted as [PtCl6]2- via anion-exchange (outer-sphere complex). On the other hand, Pd(II) was extracted via a mixed reaction of ligand-exchange (inner-sphere complex) and anion-exchange. Finally, the IL extraction system did not produce a third phase even when loaded with a high concentration of Pt(IV). The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6

The Article related to urea introduced ionic liquid extraction platinum palladium ion, Phase Equilibriums, Chemical Equilibriums, and Solutions: Partition, Extraction and other aspects.Synthetic Route of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 31, 2021, Zhang, Yuanyuan; Lv, Kuiying; Deng, Yashan; Li, Huiling; Wang, Zhiyong; Li, Depeng; Gao, Xin; Wang, Fanye published an article.Formula: C17H19N3O2S The title of the article was Asymmetric Bio-oxidation Using Resting Cells of Rhodococcus rhodochrous ATCC 4276 Mutant QZ-3 for Preparation of (S)-Omeprazole in a Chloroform-Water Biphasic System Using Response Surface Methodology. And the article contained the following:

Abstract: (S)-Omeprazole is a very effective anti-ulcer medicine that is difficult to be prepared using whole cells at elevated substrate concentrations In the chloroform-water biphasic system, resting cells of the mutant QZ-3 of Rhodococcus rhodochrous (R. rhodochrous) ATCC 4276 were used to catalyze the bio-oxidation of omeprazole sulfide for preparation of (S)-omeprazole. Using response surface methodol. (RSM), the reaction was optimized to work at a substrate concentration of 180 mM and a cell concentration of 100 g/L. The optimal yield of (S)-omeprazole obtained was 92.9% with enantiomeric excess (ee) (> 99%), and no sulfone byproduct was detected under the optimal working conditions; reaction temperature 37°C, pH 7.3 and reaction time, 43 h. A quadratic polynomial model was established, which predicts the exptl. data with very high accuracy (R2 = 0.9990). The chloroform-water biphasic system may contribute to the significant improvement in substrate tolerance because almost all substrates are partitioned in the organic phase (water solubility of omeprazole sulfide is only about 0.5 mg/mL), resulting in little damage and inhibition to cells by substrates. The mutant QZ-3 of R. rhodochrous ATCC 4276 exhibited high enantioselectivity, activity and substrate and product tolerance. The aerated flask provides enough oxygen for a high concentration of cells. Accordingly, bio-oxidation is thus more promising for efficient preparation of chiral sulfoxides. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Formula: C17H19N3O2S

The Article related to rhodococcus s omeprazole chloroform water biphasic system, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.Formula: C17H19N3O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Babiak, Peter; Kyslikova, Eva; Stepanek, Vaclav; Valesova, Renata; Palyzova, Andrea; Maresova, Helena; Hajicek, Josef; Kyslik, Pavel published an article in 2011, the title of the article was Whole-cell oxidation of omeprazole sulfide to enantiopure esomeprazole with Lysinibacillus sp. B71.SDS of cas: 73590-85-9 And the article contains the following content:

Production of enantiopure esomeprazole by biocatalysis is of great demand by pharmaceutical industry. A Gram-pos. bacterium oxidizing omeprazole sulfide (5-methoxy-2-[((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio]-1H-benzoimidazole) to (S)-sulfoxide esomeprazole (S)-5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl]-3H-benzoimidazole was isolated from soil polluted with elemental sulfur. The strain exhibited the highest identity with the genus Lysinibacillus and catalyzed oxidation of 1a into enantiopure esomeprazole with conversion of 77% in a stirred bioreactor, fed-batch culture. No consecutive oxidation of (S)-sulfoxide to sulfone was observed during whole-cell catalysis. The unique characteristics of the catalyst provide a solid basis for further improvement and development of sustainable green bioprocess. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).SDS of cas: 73590-85-9

The Article related to lysinibacillus omeprazole sulfide oxidation enantiomer, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.SDS of cas: 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Liu, Kaixuan; Paulino, Victor; Mukhopadhyay, Arindam; Bernard, Brianna; Kumbhar, Amar; Liu, Chuan; Olivier, Jean-Hubert published an article in 2021, the title of the article was How to reprogram the excitonic properties and solid-state morphologies of π-conjugated supramolecular polymers.Application of 5036-48-6 And the article contains the following content:

The development of supramol. tools to modulate the excitonic properties of non-covalent assemblies paves the way to engineer new classes of semicondcuting materials relevant to flexible electronics. While controlling the assembly pathways of organic chromophores enables the formation of J-like and H-like aggregates, strategies to tailor the excitonic properties of pre-assembled aggregates through post-modification are scarce. In the present contribution, we combine supramol. chem. with redox chem. to modulate the excitonic properties and solid-state morphologies of aggregates built from stacks of water-soluble perylene diimide building blocks. The n-doping of initially formed aggregates in an aqueous medium is shown to produce π-anion stacks for which spectroscopic properties unveil a non-negligible degree of electron-electron interactions. Oxidation of the n-doped intermediates produces metastable aggregates where free exciton bandwidths (ExBW) increase as a function of time. Kinetic data anal. reveals that the dynamic increase of free exciton bandwidth is associated with the formation of superstructures constructed by means of a nucleation-growth mechanism. By designing different redox-assisted assembly pathways, we highlight that the sacrificial electron donor plays a non-innocent role in regulating the structure-function properties of the final superstructures. Furthermore, supramol. architectures formed via a nucleation-growth mechanism evolve into ribbon-like and fiber-like materials in the solid-state, as characterized by SEM and HRTEM. Through a combination of ground-state electronic absorption spectroscopy, electrochem., spectroelectrochem., microscopy, and modeling, we show that redox-assisted assembly provides a means to reprogram the structure-function properties of pre-assembled aggregates. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Application of 5036-48-6

The Article related to conjugated supramol polymer solid state morphol, Physical Properties of Synthetic High Polymers: Physical Properties Of Polymers and other aspects.Application of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 27, 2021, Zhang, Huan; Yang, Shijia; Yang, Zhusheng; Wang, Dong; Han, Juanjuan; Li, Cuihua; Zhu, Caizhen; Xu, Jian; Zhao, Ning published an article.Safety of N-(3-Aminopropyl)-imidazole The title of the article was An Extremely Stretchable and Self-Healable Supramolecular Polymer Network. And the article contained the following:

The construction of a single polymer network with extreme stretchability, relatively high mech. strength, and fast and facile autonomous room-temperature self-healing capability still remains a challenge. Herein, supramol. polymer networks are fabricated by synergistically incorporating metal-ligand and hydrogen bonds in poly(propylene glycol) (PPG). The representative specimen, PPG-Im-MDA-1.5-0.25-Cu, shows a combination of notable mech. properties involving an extreme stretching ratio of 346 ± 14x and a Young’s modulus of 2.10 ± 0.14 MPa, which are superior to the previously reported extremely stretchable polymeric materials. Notably, the destroyed specimen can fully recover mech. performances within 1 h. The tunability of mech. properties and self-healing capability has been actualized by merely tailoring the content of a chain extender. The application of the as-prepared supramol. PPG network in constructing a flexible and self-healable conductor has been demonstrated. This strategy provides some insights for preparing extremely stretchable and self-healable polymeric materials. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to stretchable self healable supramol polymer network, ppg, autonomous self-healing, dynamic bond, extreme stretchability, hydrogen bond, metal−ligand bond, Plastics Manufacture and Processing: Formulating Procedures and Compositions and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 31, 2021, Ma, Youwei; Liu, Zhiyong; Zhou, Shuai; Jiang, Xuesong; Shi, Zixing; Yin, Jie published an article.Safety of N-(3-Aminopropyl)-imidazole The title of the article was Aminoesterenamide Achieved by Three-Component Reaction Heading toward Tailoring Covalent Adaptable Network with Great Freedom. And the article contained the following:

Covalent adaptable networks (CANs) have recently received extensive interests due to their reprocessability and repairability. Rethinking the libraries of the published CANs, most of them are fabricated by one/two-component reactions and few cases utilize multi-component reactions to construct CANs while multi-component reactions are conductive to tailoring the properties of polymers due to their structural designability and flexible choice of raw materials. A novel kind of dynamic covalent bond named aminoesterenamide is presented through three-component reaction between acetoacetyl, amine and isocyanate. Aminoesterenamide exhibits thermal reversibility through dissociating into vinylogous urethane and isocyanate. When it is used to prepare CANs, the synthesized polymer networks can be reprocessed many times via the exchange reaction between aminoesterenamides. Moreover, the forming of aminoesterenamide involving three starting components imparts CANs with great freedom to tailor their properties. Therefore, the authors believe this method that utilizes three-component reaction to fabricate CANs would bring new stories and perspectives to the exploration of new types of CANs. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to aminoesterenamide covalent adaptable network three component reaction, aminoesterenamide, covalent adaptable networks, three-component reaction, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem