Category: imidazoles-derivatives

On November 30, 1996, Rahman, M. Sayeedur; Dunman, Paul M.; Wang, Ge; Murphy, Holly S.; Humayun, M. Zafri published an article.Safety of Imidazo[1,2-c]pyrimidin-5(6H)-one The title of the article was Effect of UVM induction on mutation fixation at non-pairing and mispairing DNA lesions. And the article contained the following:

Mutation fixation at an ethenocytosine (εC) residue borne on transfected M13 single-stranded DNA is significantly enhanced in response to pretreatment of Escherichia coli cells with UV, alkylating agents, or hydrogen peroxide, a phenomenon that we have called UVM for UV modulation of mutagenesis. The UVM response does not require the E. coli SOS or adaptive responses, and is observed in cells defective for oxyR, an oxidative DNA damage-responsive regulatory gene. UVM may represent either a novel DNA-repair phenomenon, or an unrecognized feature of DNA replication in damaged cells that affects a specific class of non-coding DNA lesions. To explore the range of DNA lesions subject to the UVM effect, we have examined mutation fixation at 3,N4-ethenocytosine and 1,N6-ethenoadenine, as well as at O6-methylguanine (O6mG). M13 viral single-stranded DNA constructs bearing a single mutagenic lesion at a specific site were transfected into cells pretreated with UV or 1-methyl-3-nitro-1-nitroso-guanidine (MNNG). Survival of transfected viral DNA was measured as transfection efficiency, and mutagenesis at the lesion site was analyzed by a quant. multiplex sequence anal. technol. The results suggest that the UVM effect modulates mutagenesis at the two etheno lesions, but does not appear to significantly affect mutagenesis at O6mG. Because the modulation of mutagenesis is observed in cells incapable of the SOS response, these data are consistent with the notion that UVM may represent a previously unrecognized DNA damage-inducible response that affects the fidelity of DNA replication at certain mutagenic lesions in Escherichia coli. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Safety of Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to escherichia bacteriophage m13 mutation repair uv, uv induction mutation repair escherichia m13, dna damage repair uv ethenocytosine ethenoadenine, methylguanine dna damage repair uv escherichia and other aspects.Safety of Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 15, 2014, Nevado, Juan Jose Berzas; Penalvo, Gregorio Castaneda; Dorado, Rosa Maria Rodriguez; Robledo, Virginia Rodriguez published an article.COA of Formula: C17H19N3O2S The title of the article was Simultaneous determination of omeprazole and their main metabolites in human urine samples by capillary electrophoresis using electrospray ionization-mass spectrometry detection. And the article contained the following:

The authors report a novel method for the simultaneous determination of omeprazole and their main metabolites (omeprazole sulfide, omeprazole sulfone and 5-hydroxy omeprazole) in human urine samples. For this purpose, two new capillary electrophoresis (CE) methods were developed for the simultaneous determination of target compounds, using initially diode-array for optical detection and electrospray ionization-mass spectrometry (ESI-MS) for metabolites identification and identity confirmation. A new metabolite (5-hydroxysulfide omeprazole) was identified by electrospray ionization multi-stage mass spectrometry (ESI-MS2) fragment which was then used to support the proposed chem. structure. Pharmacokinetic results using CE method were compared with those obtained when a HPLC method was used. Equivalent pharmacokinetics profiles resulted when any anal. methods were carried out. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).COA of Formula: C17H19N3O2S

The Article related to omeprazole metabolite capillary electrophoresis electrospray ionization mass spectrometry, capillary electrophoresis-mass spectrometry, human urine, metabolites, omeprazole, pharmacokinetics and other aspects.COA of Formula: C17H19N3O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 10, 2017, Shen, Chao; Qiao, Jun; Zhao, Linwei; Zheng, Kai; Jin, Jianzhong; Zhang, Pengfei published an article.Related Products of 73590-85-9 The title of the article was An efficient silica supported Chitosan@vanadium catalyst for asymmetric sulfoxidation and its application in the synthesis of esomeprazole. And the article contained the following:

A new type of silica supported chitosan@vanadium complex was used as a highly active heterogeneous catalyst for asym. oxidation of aryl alkyl sulfides. With the economic aqueous H2O2 (30%) as the oxidant, the oxidation products were obtained in high yields (up to 95%) with good enantioselectivities (up to 68% ee). It was noted that the marketed drug Nexium (first proton-pump inhibitor, esomeprazole) was synthesized easily by the newly developed asym. sulfoxidation reaction. In addition, the highly active catalyst was reused five times without losing its catalytic activity. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Related Products of 73590-85-9

The Article related to reusable slica support chitosan vanadium complex catalyst preparation, aryl alkyl sulfide chitosan vanadium complex catalyst sulfoxidation, sulfoxide aryl alkyl enantioselective preparation and other aspects.Related Products of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Clark, Robert L.; Pessolano, Arsenio A.; Shen, Tsung-Ying; Jacobus, David P.; Jones, Howard; Lotti, Victor J.; Flataker, Lars M. published an article in 1978, the title of the article was Synthesis and analgesic activity of 1,3-dihydro-3-(substituted phenyl)imidazo[4,5-b]pyridin-2-ones and 3-(substituted phenyl)-1,2,3-triazolo[4,5-b]pyridines.Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one And the article contains the following content:

One hundred-thirty imidazo[4,5-b]pyridin-2-ones (I, R = H or alkyl, X = H, halo, alkyl, NH2, etc.) and 60 triazolo[4,5-b]pyridines (II, X = H, halo, alkyl, alkoxy, NO2, etc.) were prepared, eg by cyclizing 3-nitro-2-anilinopyridines with COCl2, urea, or NaNO2. I and II increased the pain threshold of both the inflammed and the normal foot in a modified Randall-Selitto test. I (R = H, X = 3,4-OCH2O), I (R = allyl, X = 3,4-OCH2O), I (R = CHMe2, X = 3,4-OCH2O), II (X = H) and II (X = F) were the most active compounds The analgesic activity of I was superior to that of codeine or D-propoxyphene, while showing no narcotic characteristics. Some I and II were effective in the carrageenin edema test. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to phenylimidazopyridinone preparation analgesic, phenyltriazolopyridine preparation analgesic, imidazopyridinone phenyl preparation analgesic, triazolopyridine phenyl preparation analgesic and other aspects.Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 31, 1992, Debnath, Asim Kumar; Lopez de Compadre, Rosa L.; Shusterman, Alan J.; Hansch, Corwin published an article.Electric Literature of 5709-67-1 The title of the article was Quantitative structure-activity relationship investigation of the role of hydrophobicity in regulating mutagenicity in the Ames test: 2: Mutagenicity of aromatic and heteroaromatic nitro compounds in Salmonella typhimurium TA100. And the article contained the following:

A quant. structure-activity relationship (QSAR) is derived for the mutagenic activity of 117 aromatic and heteroaromatic nitro compounds acting on S. typhimurium TA100. Relative mutagenic activity is bilinearly dependent on hydrophobicity, with an optimal log P of 5.44, and is linearly dependent on the energy of the LUMO of the nitro compound The dependence of mutagenic activity on hydrophobicity and electronic effects is very similar for TA98 and TA100. Mutagenic activity in TA100 does not depend on the size of the aromatic ring system, as its does in TA98. The effect of the choice of assay organism, TA98 vs. TA100, on nitroarene QSAR is similar to the effect previously found for aminoarenes. Lateral verification of QSARs is presented as a tool for establishing the significance of a new QSAR. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Electric Literature of 5709-67-1

The Article related to hydrophobicity qsar mutagenicity heteroaromatic nitro compound, structure aromatic nitro compound mutagenicity hydrophobicity, salmonella aromatic nitro compound mutagenicity structure and other aspects.Electric Literature of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 15, 2020, Huo, Siqi; Yang, Shuang; Wang, Jun; Cheng, Jianwen; Zhang, Qianqian; Hu, Yefa; Ding, Guoping; Zhang, Qiaoxin; Song, Pingan published an article.Name: N-(3-Aminopropyl)-imidazole The title of the article was Liquid phosphorus-containing imidazole derivative as flame-retardant curing agent for epoxy resin with enhanced thermal latency, mechanical, and flame-retardant performances. And the article contained the following:

The development of phosphorus-containing flame retardants combining good compatibility with matrix, low curing temperature, and mech. reinforcing effect has remained a major challenge. Herein, we reported the synthesis of a liquid flame-retardant curing agent (DA) via the nucleophilic substitution between diphenylphosphinic chloride and 1-(3-aminopropyl)-imidazole (AI). DA exhibited good blending and latency towards epoxy resin (EP) at room temperature According to DSC studies, DA could rapidly cure EP at moderate temperature Compared with EP/AI sample, EP/DA samples displayed comparable or higher glass transition temperature (Tg) and enhanced mech. properties due to the introduction of rigid diphenylphosphinyl group and improved crosslinking d. Moreover, DA improved the flame-retardant performances of EP thermoset. For instance, the LOI and UL94 rating of EP/DA-16 sample achieved 37.2% and V-0, resp. In addition, the peak of heat release rate (PHRR), average of heat release rate (AHRR), fire growth rate (FIGRA), and total heat release (THR) for EP/DA-16 sample reduced by 32%, 42%, 28% and 27% in comparison to EP/AI sample, resp. DA was characterized by its good compatibility with EP, moderate curing temperature, fast curing rate, suitable thermal latency, mech. reinforcing and flame-retardant effects, and thus it had a broad application prospect in various industrial fields. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Name: N-(3-Aminopropyl)-imidazole

The Article related to epoxy resin liquid phosphorus imidazole thermal latency flame retardancy, epoxy resin, flame retardancy, liquid phosphorus-containing imidazole, mechanical properties, thermal latency and other aspects.Name: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On November 15, 2017, Cook, James; Zusi, F. Christopher; Hill, Matthew D.; Fang, Haiquan; Pearce, Bradley; Park, Hyunsoo; Gallagher, Lizbeth; McDonald, Ivar M.; Bristow, Linda; Macor, John E.; Olson, Richard E. published an article.Name: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one The title of the article was Design and synthesis of a novel series of (1’S,2R,4’S)-3H-4′-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2′-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor. And the article contained the following:

We describe an efficient and convergent synthesis of a series of (1’S,2R,4’S)-3H-4′-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2′-bicyclo[2.2.2]octanes], such as I (R = H, 5-Cl, 6-Me, etc.) displaying potency for the α7 nicotinic acetylcholine receptor (nAChR) and good selectivity vs. the related 5-HT3A receptor. The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Name: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one

The Article related to azaspiro benzoimidazooxazole bicyclooctane preparation alpha 7 nicotinic acetylcholine receptor, 5-ht(3a) receptor, schizophrenia, spirooxazolines, α7 nicotinic acetylcholine receptor and other aspects.Name: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 15, 2022, Liu, Lin; Wu, Yan; Song, Ru; Zhang, Yu; Ma, Yafei; Wan, Jun; Zhang, Meili; Cui, Huali; Yang, Hua; Chen, Xiaoli; Wang, Jijiang published an article.Formula: C6H11N3 The title of the article was Morphology engineering and photothermal effect derived from perylene diimide based derivative for boosting photocatalytic hydrogen evolution of ZnIn2S4. And the article contained the following:

The construction of excellent photocatalysts for splitting water into hydrogen is highly desirable to realize carbon neutralization. In this work, an innovative and well-designed S-scheme photocatalyst composed of ultrathin ZnIn2S4 (ZIS) nanosheets uniformly anchored on the surface of organic semiconductor PDIIM is successfully fabricated. Within the heterojunction, perylene diimide with an imidazole group (PDIIM) is strategically applied as a structure template, which plays a crucial role in optimizing the morphol., increasing the active sites of sulfur vacancies, providing the addnl. photothermal effect, and promoting photogenerated charge separation of the catalyst. The photocatalytic H2 generation rate of the ZIS/PDIIM heterojunction with an optimized mass ratio reaches up to 13.04 mmol/g/h, which is 2.64 times and 14.02 times higher than that of pristine ZIS and PDIIM, resp. The outstanding photocatalytic activity is attributed to the synergistic effect of the above advantages. Importantly, the photothermal effect induced by PDIIM belonging to the perylene diimide-based derivative was discovered to accelerate photocatalytic H2 generation for the first time. This work provides valuable insight into the utilization of perylene diimide-based derivatives in the construction of multi-effect enhancement photocatalysts and their application in photothermal-assisted photocatalytic hydrogen evolution. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Formula: C6H11N3

The Article related to indium zinc sulfide perylene diimide hydrogen evolution reaction catalyst, organic semiconductor, perylene diimide, photocatalytic hydrogen evolution, photothermal effect, znin(2)s(4) and other aspects.Formula: C6H11N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 2, 2016, Youn, So Won; Kim, Yi Hyun published an article.Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the article was Pd(II)/Ag(I)-Promoted One-Pot Synthesis of Cyclic Ureas from (Hetero)Aromatic Amines and Isocyanates. And the article contained the following:

A simple and facile one-pot reaction has been developed to afford a diverse range of N,N’-disubstituted benzimidazolones and imidazopyridinones containing two differently substituted N atoms. A cooperative Pd(II)/Ag(I) system promotes the sequential addition/intramol. C-H amidation reaction of (hetero)aromatic amines and isocyanates, leading to the formation of two C-N bonds. A mechanism involving radical intermediates generated by single-electron transfer (SET) in the presence of a Ag2CO3 oxidant and Pd(OAc)2 Lewis acid is proposed. This protocol offers an operationally easy, simple, and robust approach with the use of readily available starting materials, good functional group tolerance, and high efficiency. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to disubstituted benzimidazolone imidazopyridinone preparation palladium silver promoted sequential reaction, cyclic urea preparation addition amidation hetero aromatic amine isocyanate and other aspects.Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem