Yamaguchi, Tsuyoshi et al. published their research in Journal of Chemical Physics in 2012 | CAS: 404001-48-5

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 404001-48-5

Relationship between mesoscale dynamics and shear relaxation of ionic liquids with long alkyl chain was written by Yamaguchi, Tsuyoshi;Mikawa, Ken-ichi;Koda, Shinobu;Fujii, Kenta;Endo, Hitoshi;Shibayama, Mitsuhoro;Hamano, Hiroshi;Umebayashi, Yasuhiro. And the article was included in Journal of Chemical Physics in 2012.SDS of cas: 404001-48-5 This article mentions the following:

The shear relaxation spectra of three imidazolium-based ionic liquids, 1-methyl-3-octylimidazolium chloride (C8mimCl), 1-methyl-3-octylimidazolium hexafluorophosphate (C8mimPF6), and 1-dodecyl-3-methylimidazolium bis(trifluoromethanesulfonyl)amide (C12mimTFSA) were measured and compared with the intermediate scattering functions determined with neutron spin echo (NSE) spectroscopy. The shear relaxation is slower than that predicted from the relaxation of the main peak of the structure factor that is common to other mol. liquids, whereas it is faster than that from the relaxation of the pre-peak, that corresponds to the correlation length of about 10 nm specific to ionic liquids with an intermediately long alkyl chain. The role of the pre-peak structure in the mechanism of shear viscosity of ionic liquids is discussed based on the comparison between NSE and shear relaxations. (c) 2012 American Institute of Physics. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5SDS of cas: 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Alimchandani, H. R. et al. published their research in Journal of Bacteriology in 1957 | CAS: 26832-08-6

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C4H5N3O

The accumulation of 4-amino-5-imidazolecarboxamide in Escherichia coli was written by Alimchandani, H. R.;Sreenivasan, A.. And the article was included in Journal of Bacteriology in 1957.COA of Formula: C4H5N3O This article mentions the following:

The effects of pteroylglutamic acid (I), leucovorin (II), vitamin B12 (III), and methionine (IV) on the accumulation of 4-amino-5-imidazolecarboxamide by E. coli during sulfadiazine (V) bacteriostasis were studied. I and II were ineffective in reversing V growth inhibition or in influencing amine accumulation per unit growth to different degrees, III being the more effective. Amine accumulation, when expressed as a variable against growth, was more in the presence of IV and least in the control set without added III or IV, the III effect being intermediate. These observations are interpreted to mean that the primary effects of III or IV are on the growth and other aspects of cell metabolism that are interfered with by sulfonamides. Their involvement in amine to purine conversion is only indirect. Ethionine and a III oxidation product depressed growth, but no amine accumulation was observed. The inability of an E. coli mutant to accumulate the amine under conditions of deficiency of III or IV also suggested that these 2 metabolites are involved only indirectly in purine synthesis. 27 references. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6COA of Formula: C4H5N3O).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C4H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lee, Betty Y. T. et al. published their research in Inorganic Chemistry in 2021 | CAS: 1632-83-3

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Computed Properties of C8H8N2

Heptadentate, Octadentate, Or Even Nonadentate? Denticity in the Unexpected Formation of an All-Carbon Donor-Atom Ligand in RhIII(Cp*)(Anthracenyl-NHC) Complexes was written by Lee, Betty Y. T.;Phillips, Andrew D.;Hanif, Muhammad;Tong, Kelvin K. H.;Sohnel, Tilo;Hartinger, Christian G.. And the article was included in Inorganic Chemistry in 2021.Computed Properties of C8H8N2 This article mentions the following:

Investigations on incorporating an N-flanking anthracenyl moiety to [Rh(Cp*)(NHC)Cl2] complexes surprisingly led to the formation of an intramol. C-C bond between the Cp* and anthracenyl moieties, with addnl. auxiliary interactions between the metal and the anthracenyl ring system. In silico modeling supports a reaction mechanism whereby Rh(η4-tetramethylfulvene) intermediates undergo metallocycloaddn. and the abstraction of a chlorido ligand, affording unique cationic complexes that feature Rh centers coordinated by a nonadentate ligand with exclusively carbon donor atoms. Some Rh-C interactions were extremely weak but nevertheless exhibited covalent bonding character. These weak Rh-C interactions were readily displaced by stronger electron donors, and the nonadentate ligand reverted to the heptadentate coordination mode observed in the intermediate. As far as we are aware, this study provides the first conclusive evidence of complexes bearing a single nonadentate κ9-coordinating ligand that features only carbon donors bound to a metal center. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Computed Properties of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Computed Properties of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yang, Qiuping et al. published their research in Journal of Physics and Chemistry of Solids in 2019 | CAS: 35487-17-3

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 35487-17-3

Facile fabrication of Sc-BiOBr photocatalyst immobilized on palm bark with enhanced visible light photocatalytic performance for estradiol degradation was written by Yang, Qiuping;Zhai, Yubo;Xu, Ting;Zhao, Kexian;Li, Huizhi. And the article was included in Journal of Physics and Chemistry of Solids in 2019.Application of 35487-17-3 This article mentions the following:

A novel Sc-BiOBr photocatalyst was innovatively prepared via the dispersion of Sc-BiOBr onto the surface of palm bark with the utilization of 1-Me imidazolium chloride ionic liquid as the solvent. The crystalline phase, morphol., chem. composition and optical property of the photocatalyst were investigated by X-ray diffraction (XRD), XPS, scanning electron microscope (SEM) attached with energy dispersive spectrometer (EDS), transmittance electron microscopy (TEM), Fourier transform IR (FT-IR) spectrometry, Brunauer-Emmett-Teller (BET) surface area, photoluminescence (PL) spectra and UV-vis diffuse reflectance spectroscopy (DRS). Photocatalytic activity was evaluated by the photodegradation of estradiol. The photodegradation rate of estradiol over Sc-BiOBr/palm bark photocatalyst was 99.9% under visible light irradiation, which exhibited excellent photocatalytic efficiency than pure BiOBr. The kinetics of estradiol photodegradation catalyzed by Sc-BiOBr/palm bark photocatalyst was investigated by fitting the data with the data with pseudo-first-order model. The apparent rate constant of Sc-BiOBr/palm bark photocatalyst was 1.88 and 1.27 times higher than that of pure BiOBr and Sc-BiOBr. Meanwhile, the effect of photocatalyst loading and initial estradiol concentration was also investigated. The recycling experiments revealed that the Sc-BiOBr/palm bark photocatalyst still exhibited excellent photocatalytic activity after five recycling runs. The radical quenching experiments verified that •O2 and h+ were the dominant reactive species. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Application of 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rodriguez-Palmeiro, Iago et al. published their research in Physical Chemistry Chemical Physics in 2015 | CAS: 404001-48-5

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Related Products of 404001-48-5

Measurement and PC-SAFT modelling of three-phase behaviour was written by Rodriguez-Palmeiro, Iago;Rodriguez, Oscar;Soto, Ana;Held, Christoph. And the article was included in Physical Chemistry Chemical Physics in 2015.Related Products of 404001-48-5 This article mentions the following:

Modeling of multi-component systems with complex interactions is an ongoing challenge in thermodn. due to their great relevance in industry and academia. Systems that build three liquid phases are found in many interesting applications (separation processes, triphasic catalysis…). Among them, the surfactant flooding method for enhanced oil recovery is noticeable. In this method, a stable solution of water, surfactants, co-surfactants, salts and other components is injected into the reservoir. The optimal formulation of this surfactant system is associated with a three-phase behavior in which the interfacial tension becomes significantly low. In this work, the PC-SAFT equation of state was used for the first time to predict the equilibrium involved in triphasic systems using solely pure-component parameters. The model without any fitting parameter was able to predict the three-phase behavior. A great agreement between exptl. and predicted compositions for (water + [C10mim][NTf2] + n-dodecane) and (water + [C12mim][NTf2] + n-dodecane) ternary systems at 298.15 K and atm. pressure was found. At 348.15 K slightly higher deviations were found, which can be compensated by the introduction of just one binary interaction parameter. The success of this achievement could mean an important advancement in upstream oil operations, enabling a faster and cheaper method to carry out an initial screening of potential surfactants. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Related Products of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Related Products of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Smoll, E. J. Jr. et al. published their research in Faraday Discussions in 2018 | CAS: 404001-48-5

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Determining the composition of the vacuum-liquid interface in ionic-liquid mixtures was written by Smoll, E. J. Jr.;Tesa-Serrate, M. A.;Purcell, S. M.;D’Andrea, L.;Bruce, D. W.;Slattery, J. M.;Costen, M. L.;Minton, T. K.;McKendrick, K. G.. And the article was included in Faraday Discussions in 2018.Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

The vacuum-liquid interfaces of a number of ionic-liquid mixtures have been investigated using the combination of reactive-atom scattering with laser-induced fluorescence detection (RAS-LIF), selected surface tension measurements, and mol. dynamics (MD) simulations. The mixtures are based on the widespread 1-alkyl-3-methylimidazolium ([Cnmim]+) cation, including mixed cations which differ in chain length or chem. functionality with a common anion; and different anions for a common cation. RAS-LIF results imply that the surface compositions exhibit a general form of non-stoichiometric behavior that mimics the well-known Henry’s and Raoult’s laws at low and high mole fraction, resp. The extended Langmuir model provides a moderately good single-parameter fit, but higher-order terms are required for an accurate description. The quant. relationship between RAS-LIF and surface tension, which probes the surface composition only indirectly, is explored for mixtures of [C2mim]+ and [C12mim]+ with a common bis(trifluoromethylsulfonyl)imide ([NTf2]) anion. Extended Langmuir model fits to surface tension data are broadly consistent with those to RAS-LIF; however, several other common approaches to extracting surface compositions from measured surface tensions result in much larger discrepancies. MD simulations suggest that RAS-LIF faithfully reports on the alkyl-chain exposure at the surface, which is only subtly modified by composition-dependent structural reorganisation. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chen, Dongmei et al. published their research in Journal of Molecular Structure in 2021 | CAS: 25045-82-3

6-Nitroimidazo[1,2-a]pyridine (cas: 25045-82-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 25045-82-3

Synthesis, crystal structure and vibrational properties of N-(8-(3-(3-(tert-butyl)ureido)phenyl)imidazo[1,2-a]pyridin-6-yl)acetamide was written by Chen, Dongmei;Chen, Yumei;Wu, Qingmei;Zhang, Xiaohan;Liao, Weike;Zhou, Zhixu. And the article was included in Journal of Molecular Structure in 2021.Reference of 25045-82-3 This article mentions the following:

In this study, the title compound I was designed and synthesized from the coupling reaction of N-(8-iodoimidazo[1,2-a]pyridin-6-yl)acetamide and 1-(tert-butyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea. The crystals of the title compound I were obtained by solvent evaporation at room temperature The structure of title compound I was demonstrated by 1H NMR, 13C NMR, FT-IR and single crystal X-ray diffraction studies. Addnl., theor. calculations, based on the d. functional method B3LYP at the 6-311+G(d, p) level, were performed on the title compound I, and the mol. structure optimized using DFT was consistent with the results obtained using X-ray diffraction. In addition, hydrogen bonding, intramol. π-π stacking and the Van der Waals forces significantly stabilized the title compound I, as shown in the packing diagram. Moreover, the vibrations of the title compound I were reliably assigned on the basis of characteristic vibrational absorption bands. Finally, frontier MO (FMO) was employed to verify the charge transfer interaction involving the electron acceptor and electron donor groups. In the experiment, the researchers used many compounds, for example, 6-Nitroimidazo[1,2-a]pyridine (cas: 25045-82-3Reference of 25045-82-3).

6-Nitroimidazo[1,2-a]pyridine (cas: 25045-82-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 25045-82-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Ze et al. published their research in Tetrahedron Letters in 2021 | CAS: 85692-37-1

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 85692-37-1

Manganese catalyzed enantio- and regioselective hydrogenation of α,β-unsaturated ketones using an imidazole-based chiral PNN tridentate ligand was written by Wang, Ze;Zhao, Xianghua;Huang, An;Yang, Zehui;Cheng, Yuqi;Chen, Jiachen;Ling, Fei;Zhong, Weihui. And the article was included in Tetrahedron Letters in 2021.Product Details of 85692-37-1 This article mentions the following:

The enantioselective 1,2-reduction of α,β-unsaturated ketones has been achieved using a chiral pincer Mn catalyst. A series of PNN tridentate ligands containing benzimidazole groups were designed with ferrocene as the backbone, which coordinated with Mn to form the active catalyst. This mild process represents a general method to access chiral allyl alcs. with high catalytic activity (up to 9500 TON) and high enantioselectivity (66-86% ee). Furthermore, this catalytic system provides a novel synthesis of key pharmaceutical intermediates of cannabidiol. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Product Details of 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Li-Ya et al. published their research in Journal of Molecular Structure in 2010 | CAS: 3012-80-4

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 3012-80-4

Synthesis, crystal structures and magnetic properties of a new radical NIT-1′-MeBzIm and the corresponding complexes of Ni(II), Co(II) and Zn(II) containing NIT-1′-MeBzIm was written by Wang, Li-Ya;Sun, Xiao-Yuan;Yang, Rui-Hua;Jiang, Kai;Wang, Yu-Fang. And the article was included in Journal of Molecular Structure in 2010.SDS of cas: 3012-80-4 This article mentions the following:

A new chelating radical, ligand NIT-1′-MeBzIm (1, NIT-1′-MeBzIm = 2-(1-methylbenzimidazol-2-yl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide) and three corresponding complexes, [M(NIT-1′-MeBzIm)2(NO3)(CH3OH)]·(NO3)(CH3OH) (M = Ni (2), Co (3)) and [Zn(NIT-1′-MeBzIm)2(CH3OH)2]·(ClO4)2(H2O)2(CH3OH) (4), were prepared and structurally characterized by x-ray diffraction and variable-temperature magnetic susceptibility measurements. In the crystal structures radical 1 and complexes 3 and 4 crystallize isomorphously in monoclinic, with the space groups P2(1)/n, P2(1)/c, and P2(1), resp. Complex 2 crystallizes in orthorhombic space group Pna2(1). The metal ions of the three complexes embed in distorted octahedral geometry centers and are coordinated by two NIT-1′-MeBzIm radicals from the equatorial positions to form trans configurations; the axial positions are occupied by one methanol mol. and one nitrate anion for 2 and 3, but by two methanol mols. for 4. Magnetic measurement demonstrates that the intramol. exchange couplings in 2 and 3 are antiferromagnetic with J = -41.25 and -38.1 cm-1, where the spin Hamiltonian is defined as H^= -2J(Sr̂ad1 SM̂ + SM̂ Sr̂ad2) based on the mol. structure of radical-metal-radical, while that in 4 is weakly ferromagnetic with J = 1.65 cm-1 where the spin Hamiltonian is defined as H^= -2JS1̂S2̂ within the complexes. Intermol. exchange couplings in 1 is also weakly ferromagnetic with J = 1.32 cm-1 where the spin Hamiltonian is defined as H^= -2JS1̂S2̂ between radical and radical. Compounds 24 exhibit intermol. antiferromagnetic interactions with the zJ’ = -0.52 cm-1, θ = -0.75 K and zJ’ = -0.49 cm-1 for compounds 2, 3 and 4, resp., which should ascribe to the weak interactions. The crystal structures for 14 have intermol. hydrogen bonding interactions (and π-π piling interactions for 1 and 3) which form the single crystals into 1-dimensional, 2-dimensional and 3-dimensional structures and seems to play an important role in mol. packing and in magnetic coupling. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4SDS of cas: 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ripperger, Anne et al. published their research in Frontiers in Pharmacology in 2018 | CAS: 145040-37-5

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Pharmacogenetic aspects of the interaction of AT1 receptor antagonists with ATP-binding cassette transporter ABCG2 was written by Ripperger, Anne;Krischer, Anna;Robaa, Dina;Sippl, Wolfgang;Benndorf, Ralf A.. And the article was included in Frontiers in Pharmacology in 2018.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

The ATP-binding cassette transporter ABCG2 (BCRP and MXR) is involved in the absorption, distribution, and elimination of numerous drugs. In addition, genetic variability within the ABCG2 gene may influence the ability of the transporter to interact with ARBs. Thus, the aim of this study was to characterize the ARB-ABCG2 interaction in the light of naturally occurring variations (F489L, R482G) or amino acid substitutions with in silico-predicted relevance for the ARB-ABCG2 interaction (Y469A; M483F; Y570A). For this purpose, ABCG2 variants were expressed in HEK293 cells and the impact of ARBs on ABCG2 activity was studied in vitro using the pheophorbide A (PhA) efflux assay. First, we demonstrated that both the F489L and the Y469A substitution, resp., reduced ABCG2 protein levels in these cells. Moreover, both substitutions enhanced the inhibitory effect of candesartan cilexetil, irbesartan, losartan, and telmisartan on ABCG2-mediated PhA efflux, whereas the R482G substitution blunted the inhibitory effect of candesartan cilexetil and telmisartan in this regard. In conclusion, our data indicate that the third transmembrane helix and adjacent regions of ABCG2 may be of major importance for the interaction of ARBs with the ABC transporter. Moreover, we conclude from our data that individuals carrying the F489L polymorphism may be at increased risk of developing ABCG2-related drug-drug interactions in multi-drug regimens involving ARBs. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem