Category: imidazoles-derivatives

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Safety of 1H-Imidazole-2-carbaldehyde.

Martin, Sebastian;Maus, Stephan;Stemler, Tobias;Rosar, Florian;Khreish, Fadi;Holland, Jason P.;Ezziddin, Samer;Bartholomae, Mark D. research published 《 Proof-of-Concept Study of the NOTI Chelating Platform: Preclinical Evaluation of ⁶⁴Cu-Labeled Mono- and Trimeric c(RGDfK) Conjugates》, the research content is summarized as follows. We recently developed a chelating platform based on the macrocycle 1,4,7-triazacyclononane with up to three five-membered azaheterocyclic arms for the preparation of ⁶⁸Ga- and ⁶⁴Cu-based radiopharmaceuticals. Based on this platform, the chelator scaffold NOTI-TVA with three addnl. carboxylic acid groups for bioconjugation was synthesized and characterized. The primary aims of this proof-of-concept study were (1) to evaluate if trimeric radiotracers on the basis of the NOTI-TVA 6 scaffold can be developed, (2) to determine if the addnl. substituents for bioconjugation at the non-coordinating NH atoms of the imidazole residues of the building block NOTI influence the metal binding properties, and (3) what influence multiple targeting vectors have on the biol. performance of the radiotracer. The cyclic RGDfK peptide that specifically binds to the αvβ3 integrin receptor was selected as the biol. model system. Two different synthetic routes for the preparation of NOTI-TVA 6 were explored. Three c(RGDfK) peptide residues were conjugated to the NOTI-TVA 6 building block by standard peptide chem. providing the trimeric bioconjugate NOTI-TVA-c(RGDfK)39. Labeling of 9 with [⁶⁴Cu]CuCl2 was performed manually at pH 8.2 at ambient temperature Binding affinities of Cu-8, the Cu²⁺ complex of the previously described monomer NODIA-Me-c(RGDfK) 8, and the trimer Cu-9 to integrin αvβ3 were determined in competitive cell binding experiments in the U-87MG cell line. The pharmacokinetics of both ⁶⁴Cu-labeled conjugates [⁶⁴Cu]Cu-8 and [⁶⁴Cu]Cu-9 were determined by small-animal PET imaging and ex vivo biodistribution studies in mice bearing U-87MG xenografts. Depending on the synthetic route, NOTI-TVA 6 was obtained with an overall yield up to 58%. The bioconjugate 9 was prepared in 41% yield. Both conjugates [⁶⁴Cu]Cu-8 and [⁶⁴Cu]Cu-9 were radiolabeled quant. at ambient temperature in high molar activities of Am ∼ 20 MBq nmol^-1 in less than 5 min. Competitive inhibitory constants IC₅₀ of c(RDGfK) 7, Cu-8, and Cu-9 were determined to be 159.5 ± 1.3 nM, 256.1 ± 2.1 nM, and 99.5 ± 1.1 nM, resp. In small-animal experiments, both radiotracers specifically delineated αvβ3 integrin-pos. U-87MG tumors with low uptake in non-target organs and rapid blood clearance. The trimer [⁶⁴Cu]Cu-9 showed a ∼ 2.5-fold higher tumor uptake compared with the monomer [⁶⁴Cu]Cu-8. Functionalization of NOTI at the non-coordinating NH atoms of the imidazole residues for bioconjugation was straightforward and allowed the preparation of a homotrimeric RGD conjugate. After optimization of the synthesis, required building blocks to make NOTI-TVA 6 are now available on multi-gram scale. Modifications at the imidazole groups had no measurable impact on metal binding properties in vitro and in vivo suggesting that the NOTI scaffold is a promising candidate for the development of 64Cu-labeled multimeric/multifunctional radiotracers.

Safety of 1H-Imidazole-2-carbaldehyde, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Safety of 1-Methyl-1H-imidazole-2(3H)-thione.

Liao, Sha-Sha;Liu, Wei;Cao, Jing;Zhao, Zhi-Jun research published 《 Territory aggression and energy budget in food-restricted striped hamsters》, the research content is summarized as follows. Food resource availability is one of the most important factors affecting interindividual competition in a variety of animal species. However, the energy budget and territory aggression strategy of small mammals during periods of food restriction remain uncertain. In this study, metabolic rate, body temperature, territory aggression behavior, and fat deposit were measured in male striped hamster (Cricetulus barabensis) restricted by 20% of ad libitum food intake with or without supplementary methimazole. Serum thyroid hormone (tri-iodothyronine, T3 and thyroxine, T4), and cytochrome c oxidase (COX) activity in liver, brown adipose tissue, and skeletal muscle, were also measured. Attack latency, total attack times and duration, and the interval duration between attacks of resident hamsters were not significantly changed during food restriction, which was not significantly affected by supplementary methimazole. Metabolic rate and body temperature was significantly increased in food-restricted hamsters following introduction of an intruder, which was not completely blocked by supplementary methimazole. Serum T3 and T4 levels and BAT COX activity were not significantly changed following aggression, and were significantly decreased by supplementary methimazole. These findings suggest that striped hamsters increase energy expenditure for territory aggression during food restriction, and consequently lead to excessive energy depletion. Territory aggression behavior may decrease the capacity to cope with food shortage, which may be independent of thyroid hormone.

60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.

Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).

Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., Safety of 1-Methyl-1H-imidazole-2(3H)-thione

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Quality Control of 250285-32-6.

Lin, Jin;Liang, Guanfeng;Wu, Chaoyi;Tian, Xu research published 《 Direct Synthesis of Naphthalenes by Nickel-Catalyzed Cascade Cyclization of o-Vinyl Chlorobenzenes with Internal Alkynes》, the research content is summarized as follows. An efficient nickel-catalyzed arylnickelation of alkyne/Heck cyclization of challenging o-vinyl chlorobenzenes with internal alkynes was developed. This protocol enabled synthesis of a wide variety of substituted naphthalenes in a cascade process from readily available starting materials. Mechanistic studies indicated the radical pathway was not involved in the cascade catalytic system.

Quality Control of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Related Products of 250285-32-6.

Lin, Jin;Wu, Chaoyi;Tian, Xu research published 《 Nickel-Catalyzed Cascade Reaction of 2-Vinylanilines with gem-Dichloroalkenes》, the research content is summarized as follows. An efficient nickel-catalyzed cascade reaction of 2-vinylanilines with gem-dichloroalkenes was developed to deliver diversely substituted quinolines I [R¹ = Me, Ph, 4-MeC₆H₄, etc.; R² = H, 6-Me, 7-Me, 5,7-di-Me, R³ = Ph, 4-MeC₆H₄, octyl, etc.] in good to high yields. This protocol enabled effective access to quinolines bearing various functional groups in the cascade process from readily available feedstock chems. Mechanistic studies suggest that two plausible pathways were involved in the IPr-nickel catalytic system.

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., Related Products of 250285-32-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. SDS of cas: 3034-50-2.

Lin, Junqi;Chen, Xin;Wang, Nini;Liu, Shanshan;Ruan, Zhijun;Chen, Yanmei research published 《 Electrochemical water oxidation by a copper complex with an N₄-donor ligand under neutral conditions》, the research content is summarized as follows. Herein, electrochem. water oxidation catalyzed by a copper(II) complex [Cu^II(H₂L)](NO₃)₂ with the redox-active salophen-like N₄-donor ligand N,N′–bis-(1H-imidazol-4-yl)methylidene-o-phenylenediamine is demonstrated. Oxygen evolution with a high turnover frequency of 11.09 s^-1 and a low onset overpotential of only 580 mV is achieved in neutral phosphate buffer solution, and [Cu^II(H₂L)]²⁺ is confirmed as an efficient mol. water oxidation catalyst with long-term stability. The results of electrochem. tests provide evidence that the Cu center undergoes a water nucleophilic attack process and participates in the catalytic cycle. The subsequent one-step proton-coupled electron transfer (PCET) process of the Cu center and the two-step PCET process of the ligand are both critical for efficient water oxidation This work indicates that the ligand assisted catalytic cycle is a favorable method for the accumulation of intermediate species that account for electrochem. water oxidation

3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, SDS of cas: 3034-50-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Name: 1H-Imidazole-2-carbaldehyde.

Lin, Yuqing;Wu, Hao-Chen;Shen, Qin;Zhang, Lei;Guan, Kecheng;Shintani, Takuji;Tung, Kuo-Lun;Yoshioka, Tomohisa;Matsuyama, Hideto research published 《 Custom-tailoring metal-organic framework in thin-film nanocomposite nanofiltration membrane with enhanced internal polarity and amplified surface crosslinking for elevated separation property》, the research content is summarized as follows. A polyamide (PA) thin-film nanocomposite (TFN) membrane embedded with post-synthetically functionalized metal-organic framework (MOF) nanofillers of imidazole-2-carbaldehyde (ICA) decorated UiO-66-NH₂ nanofillers (ICA_d_UiO-66-NH₂) was developed using the interfacial polymerization method. The ICA_d_UiO-66-NH₂ nanofiller couples a surface water-capturing ICA decoration, facilitating the rapid transport of water mols. owing to the enhanced internal polarity, while achieving an amplified crosslinking between the terminal amine groups of ICA and trimesoyl chloride, enabling the perfect incorporation of MOF nanofillers within the PA matrix. The resultant ICA_d_UiO-66-NH₂@PA TFN membrane with elevated separation property performed comparably high water permeance of 9.4 l m^-2 h^-1 bar^-1 (achieving a nearly 2-fold increase from the initial value of the thin-film composite membrane), and a favorable rejection ratio of 97.4% (Na₂SO₄). Owing to the unique hierarchical surface microstructure embedded with the intrinsically hydrophilic ICA_d_UiO-66-NH₂ nanofillers, the newly-developed TFN membrane exhibited superior antifouling properties. Furthermore, the ICA_d_UiO-66-NH₂@PA TFN membrane also retained excellent reusability and durability without significant compromise even after long-term salt, and acid/alkali treatments. Overall, this work provides an insight into the embedding of different functionalized nanofillers inside TFN membranes with elevated separation properties.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Name: 1H-Imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. HPLC of Formula: 250285-32-6.

Ling, Bo;Yang, Wenjun;Wang, Yan-En;Mao, Jianyou research published 《 Cooperative N-Heterocyclic Carbene/Palladium-Catalyzed Umpolung 1,4-Addition of Vinyl Bromides to Enals》, the research content is summarized as follows. A highly stereoselective umpolung 1,4-addition of vinyl bromides to enals is enabled by NHC/palladium cooperative catalysis, generating various valuable γ,δ-unsaturated carbonyl derivatives in excellent yields (up to 90%). A detailed mechanism investigation indicates the NHC act as both organocatalyst and ligand for palladium during this system.

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., HPLC of Formula: 250285-32-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Application of C4H4N2O.

Ling, Danping;Li, Haihong;Xi, Wensong;Wang, Zhuo;Bednarkiewicz, Artur;Dibaba, Solomon T.;Shi, Liyi;Sun, Lining research published 《 Heterodimers made of metal-organic frameworks and upconversion nanoparticles for bioimaging and pH-responsive dual-drug delivery》, the research content is summarized as follows. Developing multifunctional nanocomposites for a pH-responsive controlled dual-drug delivery is still a huge challenge. Herein, we report a gentle and simple method for growing metal-organic frameworks (MOFs) that can load two anticancer drugs, namely DOX and 5-FU (doxorubicin and 5-fluorouracil), on the surface of upconversion nanoparticles (UCNPs) by the reactions of Schiff bases and electrostatic adsorption. The resulting pH-responsive UCMOFs@D@5 nanosystem showed effective dual-drug release by the cleavage of chem. bonds and the disruption of the MOF structure under acidic conditions. Moreover, the final nanosystem UCMOFs@D@5 showed much higher cytotoxicity in comparison with UCMOFs@D and UCMOFs@5, which loaded only one kind of drug, resp., after being incubated with human cervical cancer (HeLa) cells, indicating that Dox and 5-FU released from the final nanosystem had synergistic effects on cytotoxicity. Cellular uptake studies showed that UCMOFs@D@5 was well uptaken by HeLa cells and has potential for bioimaging applications in intracellular fluorescence imaging with high-contrast, and is beneficial for the intracellular localization of anti-cancer drugs. In addition, the nanosystem can be successfully applied in T₁-weighted magnetic resonance imaging. Therefore, we developed a visualized tracking agent combined with MOFs to load two anticancer drugs to form a nanosystem for diagnosis and synergistic treatment, thus achieving the bioimaging and stimulation-responsive dual-drug release.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Application of C4H4N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Formula: C4H4N2O.

Liu, Chenguang;Wang, Mingyang;Liu, Shihan;Wang, Yujie;Peng, Yong;Lan, Yu;Liu, Qiang research published 《 Manganese-Catalyzed Asymmetric Hydrogenation of Quinolines Enabled by π-π Interaction**》, the research content is summarized as follows. The non-noble metal-catalyzed asym. hydrogenation of N-heteroaromatics, quinolines, is reported. A new chiral pincer manganese catalyst showed outstanding catalytic activity in the asym. hydrogenation of quinolines, affording high yields and enantioselectivities (up to 97% ee). A turnover number of 3840 was reached at a low catalyst loading (S/C=4000), which is competitive with the activity of most effective noble metal catalysts for this reaction. The precise regulation of the enantioselectivity were ensured by a π-π interaction.

Formula: C4H4N2O, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Computed Properties of 10111-08-7.

Liu, Chenguang;Wang, Mingyang;Xu, Yihan;Li, Yibiao;Liu, Qiang research published 《 Manganese-Catalyzed Asymmetric Hydrogenation of 3H-Indoles》, the research content is summarized as follows. A Mn-catalyzed AH of 3H-indoles e.g., 2,3,3-trimethyl-3H-indole with excellent yields and enantioselectivities was reported. The kinetic resolution of racemic 3H-indoles by AH was also achieved with high s-factors to construct quaternary stereocenters e.g., 3,3-dimethyl-2-phenyl-3H-indole. Many acid-sensitive functional groups, which cannot be tolerated when using a state-of-the-art ruthenium catalyst, were compatible with manganese catalysis. This new process expands the scope of this transformation and highlights the uniqueness of earth-abundant metal catalysis. The reaction could proceed with catalyst loadings at the ppm (ppm) level with an exceptional turnover number of 72 350. This is the highest value yet reported for an earth-abundant metal-catalyzed AH reaction.

Computed Properties of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem