Category: imidazoles-derivatives

On April 30, 1991, Seela, F.; Rosemeyer, H.; Gumbiowski, R.; Mersmann, K.; Muth, H. P.; Roeling, A. published an article.Formula: C6H4ClN3O The title of the article was Base-modified purine 2′,3′-dideoxyribonucleosides: synthesis via deoxygenation or direct nucleobase anion glycosylation. And the article contained the following:

A symposium report. 5-Aza-7-deazapurine, 5-aza-1,7-dideazapurine, and 8-azapurine 2′,3′-dideoxy-D-ribonucleosides were synthesized and inhibitory activity against HIV reverse transcriptase and DNA-polymerases was evaluated. The experimental process involved the reaction of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one(cas: 57473-33-3).Formula: C6H4ClN3O

The Article related to purine dideoxyribonucleoside base modified symposium, deoxygenation nucleoside symposium, nucleobase anion glycosylation symposium, hiv reverse transcriptase inhibitor symposium, dna polymerase inhibitor symposium, aids inhibitor purine dideoxyribonucleoside symposium, azadeazapurine dideoxyribonucleoside symposium and other aspects.Formula: C6H4ClN3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 31, 2008, Meira, Lisiane B.; Bugni, James M.; Green, Stephanie L.; Lee, Chung-Wei; Pang, Bo; Borenshtein, Diana; Rickman, Barry H.; Rogers, Arlin B.; Moroski-Erkul, Catherine A.; McFaline, Jose L.; Schauer, David B.; Dedon, Peter C.; Fox, James G.; Samson, Leona D. published an article.Application of 55662-66-3 The title of the article was DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. And the article contained the following:

Chronic inflammation increases cancer risk. While it is clear that cell signaling elicited by inflammatory cytokines promotes tumor development, the impact of DNA damage production resulting from inflammation-associated reactive oxygen and nitrogen species (RONS) on tumor development was not directly tested. RONS induce DNA damage that can be recognized by alkyladenine DNA glycosylase (Aag) to initiate base excision repair. Using a mouse model of episodic inflammatory bowel disease by repeated administration of dextran sulfate Na in the drinking water, we show that Aag-mediated DNA repair prevents colonic epithelial damage and reduces the severity of dextran sulfate sodium-induced colon tumorigenesis. Importantly, DNA base lesions expected to be induced by RONS and recognized by Aag accumulated to higher levels in Aag-deficient animals following stimulation of colonic inflammation. Finally, as a test of the generality of this effect we show that Aag-deficient animals display more severe gastric lesions that are precursors of gastric cancer after chronic infection with Helicobacter pylori. These data demonstrate that the repair of DNA lesions formed by RONS during chronic inflammation is important for protection against colon carcinogenesis. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Application of 55662-66-3

The Article related to dextran sulfate sodium colon inflammation carcinogenesis dna damage, alkyladenine dna glycosylase colon inflammation carcinogenesis dna damage, reactive oxygen species colon inflammation carcinogenesis dna damage, nitrogen reactive species colon inflammation carcinogenesis dna damage and other aspects.Application of 55662-66-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 1, 2022, Nikitin, E. A.; Shpakovsky, D. B.; Tyurin, V. Yu; Kazak, A. A.; Gracheva, Yu A.; Vasilichin, V. A.; Pavlyukov, M. S.; Mironova, E. M.; Gontcharenko, V. E.; Lyssenko, K. A.; Antonets, A. A.; Dubova, L. G.; Shevtsov, P. N.; Shevtsova, E. F.; Shamraeva, M. A.; Shtil, A. A.; Milaeva, E. R. published an article.Recommanded Product: 5036-48-6 The title of the article was Novel organotin complexes with phenol and imidazole moieties for optimized antitumor properties. And the article contained the following:

A series of novel imidazole-containing ligands and their organotin complexes were synthesized and characterized by NMR, IR, MALDI and elemental anal. Redox behavior was studied by cyclic voltammetry (CV). Antioxidant properties were estimated in model reactions of single-electron reduction (CUPRAC-test), scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and O-.2 radical anion, enzymic oxidation of linoleic acid by lipoxygenase and Fe3+-induced lipid peroxidation of rat liver homogenates. It was found that ligands and complexes both possess radical scavenging activity of prolonged action type. Compounds exhibited notable antioxidant activity in lipid peroxidation Cytotoxicity was estimated in standard MTT-test on multiple cell lines. Compounds demonstrated high toxicity on colon carcinoma and breast cancer cells and based on obtained data, lead compound was proposed. Addnl. assays were carried out for the lead compound, including regular MTT-test on cancer cells possessing various resistant mechanisms and modified MTT-test on tumor tissue samples, obtained from patients as well as apoptosis and cell cycle studies. All organotin complexes were also studied for their influence on tubulin polymerization It was demonstrated that obtained compounds demonstrate unorthodox activity, promoting microtubules assembly rate instead of inhibiting it. Significant influence of compound 5 on G2/M phase of cell cycle is in accordance with influence on tubulin polymerization and lets us to mark synthesized compounds as mitotic poisons. The results open up the scopes for the search of novel antitumor agents for treatment of advanced forms of cancer. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: 5036-48-6

The Article related to organotin complex phenol imidazole human antitumor breast colon ovary, electrochem preparation organotin complex phenol imidazole, cytotoxicity antioxidant organotin complex phenol imidazole preparation, crystal structure mol optimized organotin complex phenol imidazole moiety and other aspects.Recommanded Product: 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 31, 2020, Ding, Wen; Yu, Tao; Du, Yingxiang; Sun, Xiaodong; Feng, Zijie; Zhao, Shiyuan; Ma, Xiaofei; Ma, Mingxuan; Chen, Cheng published an article.Product Details of 5036-48-6 The title of the article was A metal organic framework-functionalized monolithic column for enantioseparation of six basic chiral drugs by capillary electrochromatography. And the article contained the following:

Poly(glycidyl methacrylate)-co-(ethylene dimethacrylate) [poly(GMA-co-EDMA)] monoliths were used as a support to grow a zeolitic imidazolate framework-8 (ZIF-8) via layer-by-layer self-assembly. Pepsin, acting as as chiral selector, was covalently linked to the surface of the amino-modified ZIF-8 through the Schiff base method. The material was characterized by SEM, thermogravimetric anal., X-ray diffraction, Fourier transform IR spectroscopy and elemental anal. The pepsin-ZIF-8-poly(GMA-co-EDMA) column was utilized to the enantioseparation of the racemic forms of hydroxychloroquine (HCQ), chloroquine (CHQ), hydroxyzine (HXY), nefopam (NEF), clenbuterol (CLE) and amlodipine (AML). In comparison with a pepsin-poly(GMA-co-EDMA) monolithic column (without self-assembled ZIF-8 nanoparticles), the resolution is strongly enhanced (HCQ: 0.34 → 2.50; CHQ: 0.45 → 1.97; HXY: 0.39 → 1.43; NEF: 0.27 → 0.81; CLE: 0 → 0.81; AML: 0.16 → 0.72). Effects of self-assembly layers of ZIF-8, pepsin concentration, buffer pH values and applied voltage were investigated with hydroxychloroquine as the model analyte. The reproducibility of run-to-run, day-to-day and column-to-column were explored, and found to be satisfactory. [Figure not available: see fulltext.]. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6

The Article related to metal organic framework monolithic column enantioseparation capillary electrochromatog, basic drugs, capillary electrochromatography, enantioseparation, glycidyl methacrylate, metal-organic framework, monolithic column, nanoparticles, pepsin, self assembly, zif-8 and other aspects.Product Details of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Boix, C.; Ibanez, M.; Sancho, J. V.; Niessen, W. M. A.; Hernandez, F. published an article in 2013, the title of the article was Investigating the presence of omeprazole in waters by liquid chromatography coupled to low and high resolution mass spectrometry: degradation experiments.Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:

Omeprazole is one of the most consumed pharmaceuticals around the world. However, this compound is scarcely detected in urban wastewater and surface water. The absence of this pharmaceutical in the aquatic ecosystem might be due to its degradation in wastewater treatment plants, as well as in receiving water. Different laboratory-controlled degradation experiments were carried out on surface water to elucidate omeprazole transformation products (TPs). Surface water spiked with omeprazole was subjected to hydrolysis, photo-degradation under both sunlight and UV radiation and chlorination. Analyses by liquid chromatog. coupled to quadrupole time-of-flight mass spectrometry (LC-QTOF MS) permitted identification of ≤17 omeprazole TPs. In a subsequent step, the TPs identified were sought in surface water and urban wastewater by LC-QTOF MS and by LC coupled to tandem mass spectrometry with triple quadrupole. The parent omeprazole was not detected in any of the samples, but 4 TPs were found in several water samples. The most frequently detected compound was OTP 5 (omeprazole sulfide), which might be a reasonable candidate to be included in monitoring programs rather than the parent omeprazole. Copyright pr 2013 John Wiley & Sons, Ltd. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to omeprazole water liquid chromatog mass spectrometry degradation, omeprazole, surface water, time-of-flight mass spectrometry, transformation/degradation products, triple quadrupole mass spectrometry, ultra-high-performance liquid chromatography, urban wastewater and other aspects.Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 31, 2020, Currie, Sarah; Kim, Seungil; Gu, Xiaochen; Ren, Xiaoou; Lin, Francis; Liu, Shangxi; Yang, Chengbo; Kim, Ji-Heung; Liu, Song published an article.Quality Control of N-(3-Aminopropyl)-imidazole The title of the article was Mucus-penetrating PEGylated polysuccinimide-based nanocarrier for intravaginal delivery of siRNA battling sexually transmitted infections. And the article contained the following:

Intravaginal delivery of siRNA for prevention of sexually transmitted infections faces obstacles such as the acidic environment and vaginal mucus barrier. To achieve effective protection and delivery of siRNA, we developed a polysuccinimide (PSI)-based nanocarrier (PSI-PEG-API-PMA, PPAP) by conjugating methoxy polyethylene glycol amine (Me-PEG-NH2, Mw 5000), 1-(3-aminopropyl)imidazole (API), and 1-pyrenemethylamine hydrochloride (PMA) to PSI. PPAP demonstrated a spherical self-assembled nanostructure before and after encapsulation of a model siRNA. Variable electrostatic interaction between API and siRNA at acidic vs. neutral pH accomplished significantly lower burst release at pH 4.2 (4 ± 1%) than pH 7.0 (26 ± 5%) within 1 h. PEGylation enabled siRNA-PPAP to achieve higher mucus penetration efficiency (64 ± 17%) than free siRNA (27 ± 5%) for 24 h. Moreover, in vitro study showed minimal toxicity, successful internalization of siRNA-PPAP in HeLa cells and improved gene knockdown (97.5 ± 0.4%). Overall, PPAP is promising for developing preventative treatments for battling sexually transmitted infections. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Quality Control of N-(3-Aminopropyl)-imidazole

The Article related to pegylated polysuccinimide nanocarrier intravaginal sirna sexually transmitted infections mucus, hsv-2 prevention, intravaginal nanomedicine, mucus-penetrating sirna nanocarrier, polysuccinimide (psi)-based nanocarrier, preventing sexually transmitted infections and other aspects.Quality Control of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 6, 2021, Martin-Montes, Alvaro; Kolodova, Kristina; Marin, Clotilde; Rosales-Lombardo, Maria Jose; Sanchez-Moreno, Manuel; de Andres-Gordo, Lucia; Cano, Carmen; Campayo, Lucrecia; Gomez-Munoz, Alberto; Sanz, Ana M.; Yunta, Maria J. R. published an article.Recommanded Product: N-(3-Aminopropyl)-imidazole The title of the article was In vitro Leishmanicidal and Trypanosomicidal Properties of Imidazole-Containing Azine and Benzoazine Derivatives. And the article contained the following:

Leishmaniasis and Chagas diseases are two of the most important parasitic diseases in the world. Both belong to the category of Neglected Tropical Diseases, and they cannot be prevented by vaccination. Their treatments are founded in outdated drugs that possess many pernicious side-effects and they’re not easy to administer. With the aim of discovering new compounds that could serve as anti-trypanosomal drugs, an antiparasitic study of a synthetic compound family has been conducted. A series of new 1,4-bis(alkylamino)- and 1-alkylamino-4-chloroazine and benzoazine derivatives 1-4 containing imidazole rings have been synthesized and identified. Their structures showed a possible interest based on previous work. Their in vitro anti-Leishmania infantum, anti-L. braziliensis, anti-L. donovani and anti-T. cruzi activity were tested, as well as the inhibition of Fe-SOD enzymes. It was found that some of them exhibited quite relevant values indicative of being worthy of future more detailed studies, as most of them showed activity to more than only one parasite species, especially compound 3 c was active for the three studied Leishmania species and also for T. cruzi, which is a very interesting trait as it covers a wide spectrum. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: N-(3-Aminopropyl)-imidazole

The Article related to imidazole containing azine benzoazine derivative preparation, azine benzoazine leishmanicidal trypanosomicidal property structure activity relationship, azines and benzoazines, fe-sod inhibition, imidazole, in vitro trypanosomicidal and leishmanicidal activity and other aspects.Recommanded Product: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 31, 1992, Seela, Frank; Gumbiowski, Rainer published an article.Category: imidazoles-derivatives The title of the article was Imidazo[1,2-a]pyrimidine 2′-deoxyribo- and 2′,3′-dideoxyribonucleosides: glycosylation of the nucleobase anion. And the article contained the following:

The synthesis of the imidazopyrimidine deoxyribonucleosides I (R = NH2, H, R1 = H, R2 = H, OH) via stereoselective glycosidation of the nucleobase anion of II, is described. The inhibitory activity of the dideoxynucleoside 5′-triphosphates I (R = H, NH2, R1 = P3O9H4, R2 = H) against HIV reverse transcriptase was tested. The experimental process involved the reaction of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one(cas: 57473-33-3).Category: imidazoles-derivatives

The Article related to imidazopyrimidine deoxyribonucleoside preparation phosphorylation, nucleotide dideoxy imidazopyrimidine triphosphate enzyme inhibition, nucleoside deoxy imidazopyrimidine preparation phosphorylation, stereoselective glycosidation chloroimidazopyrimidinone and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fan, Xin; Zhang, Lingling; Huang, Junwen; Zhong, Yun; Fan, Yanting; Zhou, Tong; Lu, Min published an article in 2022, the title of the article was An integrated immune-related bioinformatics analysis in glioma: prognostic signature’s identification and multi-omics mechanisms’ exploration.Electric Literature of 443-72-1 And the article contains the following content:

As the traditional treatment for glioma, the most common central nervous system malignancy with poor prognosis, the efficacy of high-intensity surgery combined with radiotherapy and chemotherapy is not satisfactory. The development of individualized scientific treatment strategy urgently requires the guidance of signature with clin. predictive value. In this study, five prognosis-related differentially expressed immune-related genes (PR-DE-IRGs) (CCNA2, HMGB2, CASP3, APOBEC3C, and BMP2) highly associated with glioma were identified for a prognostic model through weighted gene co-expression network anal., univariate Cox and lasso regression. Kaplan-Meier survival curves, receiver operating characteristic curves and other methods have shown that the model has good performance in predicting the glioma patients’ prognosis. Further combined nomogram provided better predictive performance. The signature’s guiding value in clin. treatment has also been verified by multiple anal. results. We also constructed a comprehensive competing endogenous RNA (ceRNA) regulatory network based on the protective factor BMP2 to further explore its potential role in glioma progression. Numerous immune-related biol. functions and pathways were enriched in a high-risk population. Further multi-omics integrative anal. revealed a strong correlation between tumor immunosuppressive environment/IDH1 mutation and signature, suggesting that their cooperation plays an important role in glioma progression. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Electric Literature of 443-72-1

The Article related to prognosis idh1 apobec3c casp3 linc00689 snhg16 n6 methyladenine glioma, idh1 mutation, cerna regulatory network, glioma, mechanisms’ exploration, muti-omics immune-related bioinformatics research, prognostic model, tumor immunosuppressive environment and other aspects.Electric Literature of 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 9, 2020, Bartlett, Mark J.; Corkey, Britton Kenneth; Cosman, Jennifer Leigh; Elzein, Elfatih; Li, Xiaofen published a patent.Electric Literature of 40644-16-4 The title of the patent was Preparation of indoles, azaindoles and related bicyclic nitrogen heterocycles useful in treatment of diseases. And the patent contained the following:

The invention relates to preparation of indoles, azaindoles and related bicyclic nitrogen heterocycles of formula (I), or a pharmaceutically acceptable salt thereof, as enzyme indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Compounds I wherein Y1 is O or N; the dotted line is a single bond that is present or absent; X1, X2 and X4 each independently is N or CH; X3 is N or CRa; Ra is H, halo, C1-4 alkyl; X5 is N, C or CRb; X6 is N or CRc; X7 is N or CRd; X8 is N or CRe; Rb-Re and R1 each independently is H, halo, or CN; R2 is C1-6 alkyl, C1-6 haloalkyl, C1-6 haloalkoxy; etc., are claimed. The example compound II was prepared via two-step synthesis using 4-bromo-3,3-dimethylindolin-2-one as starting material (procedure given). Compounds I were evaluated for IDO1-inhibitory activity (data given). Compounds I can be useful in mono- amd combination therapy of cancer and viral infections (e.g. HIV and HBV). The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Electric Literature of 40644-16-4

The Article related to indole preparation ido1 inhibitor antitumor hbv hiv antiviral therapy, azaindole preparation ido1 inhibitor cancer viral infection combination therapy, bicyclic nitrogen heterocycle preparation ido1 inhibitor immunotherapy anticancer antiviral and other aspects.Electric Literature of 40644-16-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem