Category: imidazoles-derivatives

In vitro studies on the antioxidant and protective effect of 2-substituted-8-hydroxyquinoline derivatives against H₂O₂-induced oxidative stress in BMSCs was written by Wang, Ting-Ting;Zeng, Gong-Chang;Li, Xi-Can;Zeng, He-Ping. And the article was included in Chemical Biology & Drug Design in 2010.Synthetic Route of C9H8N2O This article mentions the following:

Novel 2-vinyl-8-hydroxyquinoline derivatives as potential antioxidants and regulators of H₂O₂-induced oxidative stress in rat bone marrow mesenchymal stem cells (MSCs) are first reported. The antiradical properties and the reducing power of these compounds were assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and auto-oxidation of pyrogallol method, resp. The activity against lipid peroxidation was determined using ammonium thiocyanate method. The results revealed that introduction of electron-donating groups at 2nd position decreased the antioxidant activities of 8-hydroxyquinoline derivatives In addition, compound 4, the structure of which is similar to melatonin, exhibited superior antioxidant activities in scavenging DPPH free radical,.O₂ free radical, and anti-LPO activities. Except for compounds 7, 12, and 15, the other compounds exhibited a stimulatory effect on MSCs growth. Using hydrogen peroxide (H₂O₂), we also investigated the protective efficacy of 2-vinyl-8-hydroxyquinoline derivatives against oxidative stress-induced cell death of MSCs. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Synthetic Route of C9H8N2O).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Synthetic Route of C9H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Molecular Control of the Catalytic Properties of Rhodium Nanoparticles in Supported Ionic Liquid Phase (SILP) Systems was written by Bordet, Alexis;Moos, Gilles;Welsh, Calum;Licence, Peter;Luska, Kylie L.;Leitner, Walter. And the article was included in ACS Catalysis in 2020.HPLC of Formula: 21252-69-7 This article mentions the following:

Rhodium nanoparticles (NPs) immobilized on imidazolium-based supported ionic liquid phases (Rh@SILP) act as effective catalysts for the hydrogenation of biomass-derived furfuralacetone. The structure of ionic liquid-type (IL) mol. modifiers was systematically varied regarding spacer, side chain, and anion to assess the influence on the NP synthesis and their catalytic properties. Well-dispersed Rh NPs with diameters in the range of 0.6-2.0 nm were formed on all SILP materials, whereby the actual size was dependent significantly on the IL structure. The resulting variations in catalytic activity for hydrogenation of the C=O moiety in furfuralacetone allowed control of the product selectivity to obtain either the saturated alc. or the ketone in high yield. Experiments conducted under batch and continuous flow conditions demonstrated that Rh NPs immobilized on SILPs with suitable IL structures are more active and much more stable than Rh@SiO₂ catalyst synthesized on unmodified silica. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7HPLC of Formula: 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. HPLC of Formula: 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis, characterizations and anticorrosion applications of three new gemini ionic liquids. was written by Nessim, M. I.;Zaky, M. T.;Deyab, M. A.. And the article was included in Journal of Molecular Liquids in 2018.Related Products of 21252-69-7 This article mentions the following:

Three gemini ionic liquids namely, 3,3′-(1,4-phenylenebis(methylene))bis(1-alkyl-1H-imidazol-3-ium)bromide IL1, IL2, and IL3, were prepared and characterized via the conventional tools of anal., elemental anal., IR, and ¹H NMR spectroscopy. The thermal stability of these compounds was studied, using thermogravimetric anal. (TGA) technique. The gemini ionic liquids were tested as corrosion inhibitors for stainless steel (304 SS) in 0.5 M H2SO4 solution using electrochem. techniques. The Results showed that gemini ionic liquids were effective with optimal corrosion inhibition values of 90.7%, 97.3% and 82.6% for IL1, IL2 and IL3, resp. The data confirmed also gemini ionic liquids are mixed type inhibitors. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Related Products of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Related Products of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole analogues of resveratrol: synthesis and cancer cell growth evaluation was written by Bellina, Fabio;Guazzelli, Nicola;Lessi, Marco;Manzini, Chiara. And the article was included in Tetrahedron in 2015.SDS of cas: 25676-75-9 This article mentions the following:

Novel trans-restricted analogs of resveratrol in which the C-C double bond of the natural derivative was replaced by diaryl substituted imidazole analogs were designed. The syntheses of 1,4-, 2,4-, and 2,5-diarylimidazoles, in which the two aryl moieties are linked to the heteroaromatic core in a 1,3 fashion to preserve the trans stereochem., were successfully carried out by regioselective sequential transition metal-catalyzed arylations of simple, com. available imidazole precursors. The anticancer activity of selected analogs was evaluated in vitro against the NCI-60 human tumor cell lines panel. From this screening, the authors were able to select a synthetic candidate that resulted more active than its natural lead. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9SDS of cas: 25676-75-9).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 25676-75-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Phenotypic and transcriptomic response of auxotrophic Mycobacterium avium subsp. paratuberculosis leuD mutant under environmental stress was written by Chen, Jenn-Wei;Scaria, Joy;Chang, Yung-Fu. And the article was included in PLoS One in 2012.Product Details of 26832-08-6 This article mentions the following:

Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of severe gastroenteritis in cattle. To gain a better understanding of MAP virulence, we investigated the role of leuD gene in MAP metabolism and stress response. For this, we have constructed an auxotrophic strain of MAP by deleting the leuD gene using allelic exchange. The wildtype and mutant strains were then compared for metabolic phenotypic changes using Biolog phenotype microarrays. The responses of both strains to physiol. relevant stress conditions were assessed using DNA microarrays. Transcriptomic data was then analyzed in the context of cellular metabolic pathways and gene networks. Our results showed that deletion of leuD gene has a global effect on both MAP phenotypic and transcriptome response. At the metabolic level, the mutant strain lost the ability to utilize most of the carbon, nitrogen, sulfur, phosphorus and nutrient supplements as energy source. At the transcriptome level, more than 100 genes were differentially expressed in each of the stress condition tested. Systems level network anal. revealed that the differentially expressed genes were distributed throughout the gene network, thus explaining the global impact of leuD deletion in metabolic phenotype. Further, we find that leuD deletion impacted metabolic pathways associated with fatty acids. We verified this by exptl. estimating the total fatty acid content of both mutant and wildtype. The mutant strain had 30% less fatty acid content when compared to wildtype, thus supporting the results from transcriptional and computational analyses. Our results therefore reveal the intricate connection between the metabolism and virulence in MAP. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Product Details of 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Product Details of 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

An elegant method for the preparation of 3-cyanomethyl derivatives of imidazo[1,2-a]pyridines was written by Chinnapillai, Rajendiran;Nallamaddi, Ravikumar Reddy;Daliparthi, Eswaraprasad Rao;Poguri, Eswaraiah. And the article was included in Pharma Chemica in 2012.Quality Control of N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine This article mentions the following:

A series of 3-(cyanomethyl)imidazo[1,2-a]pyridines were synthesized by using ClCO₂Et as alkylating agent for the generation of quaternary ammonium salts from 3-[(dimethylamino)methyl]imidazo[1,2-a]pyridines and subsequent cyanation. This novel process is elegant and simple with excellent yields. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5Quality Control of N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine).

N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Organic energy devices from ionic liquids and conducting polymers was written by Brooke, Robert;Fabretto, Manrico;Krasowska, Marta;Talemi, Pejman;Pering, Samuel;Murphy, Peter J.;Evans, Drew. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2016.Product Details of 404001-48-5 This article mentions the following:

The use of smart technologies in the daily lives, from smart phones to auto-dimming windows to touch sensors, has become pervasive. With growing desire for these devices to be conformable and flexible, traditional materials are being replaced to create a class of products known as active organic electronic devices (OEDs). These new devices owe their ability to switch elec. and/or optical function to the intimate interaction between an inherently conducting polymer and electrolyte, typically an ionic liquid Herein, the authors provide the 1st observations that specific ionic liquids can reduce or oxidize conducting polymers upon intimate contact in the absence of any elec. stimuli. The ability to reduce or oxidize the inherently conducting polymer depends on the cation and anion pair within the ionic liquid Extending the utility of this phenomenon is made by fabricating OEDs such as prototype fuel cells, supercapacitors and smart windows. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Product Details of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Product Details of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic Liquid Modified Electrochemical Capacitor with Long-Term Performance was written by Znaniecki, Szymon;Szwabinska, Katarzyna;Wojciechowski, Jaroslaw;Skrzypczak, Andrzej;Lota, Grzegorz. And the article was included in ChemElectroChem in 2021.Reference of 21252-69-7 This article mentions the following:

Ionic liquids are used, for example, as corrosion inhibitors for metals, steel, and metal alloys. The method of preventing corrosion through the whole group of these kinds of compounds, called inhibitors, is to use them as additives to aggressive environments, including aqueous electrolytes. In this article, we present the inhibitive effect of imidazolium ionic liquids with 2,5-dihydroxybenzenesulfonate anion on the corrosion of 316L stainless steel in neutral medium. In addition, we demonstrate that when the ionic liquid is used as an additive to the electrolyte solution (1 M Na₂SO₄) of a sym. carbon/carbon electrochem. capacitor with 316L stainless-steel current collectors, the capacitor lifetime is significantly extended. The ionic-liquid additive inhibits corrosion of the current collector surface and, in effect, prevents activated carbon porous space from being blocked by corrosion products. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Organosolv and ionosolv processes for autohydrolyzed poplar fractionation: Lignin recovery and characterization was written by Ovejero-Perez, Antonio;Rigual, Victoria;Dominguez, Juan Carlos;Alonso, M. Virginia;Oliet, Mercedes;Rodriguez, Francisco. And the article was included in International Journal of Biological Macromolecules in 2022.Synthetic Route of C4H7ClN2 This article mentions the following:

Biomass fractionation plays a major role in the search for competitive biorefineries, where the isolation and recovery of the three woody fractions is key. In this sense, we have used autohydrolyzed hemicellulose-free poplar as feedstock to compare two fractionation processes, organosolv and ionosolv, oriented to lignin recovery. The recovered lignins were then characterize by different techniques (NMR, GPC, TGA). Both treatments were tested at different temperatures to analyze temperature influence on lignin recovery and properties. The highest lignin recovery was obtained with the ionosolv process at 135°C, reaching a solid yield of ∼70%. Lignin characterization showed differences between both treatments. Lignins enriched in C-O linkages and G units were recovered with the organosolv process, where increasing temperature led to highly depolymerized lignins. However, lignins with higher C-C linkages and S units contents were obtained with the ionosolv process, producing more thermically stable lignins. In addition, increasing temperature caused lignin repolymn. when employing ionic liquids as solvents. Therefore, this work outlines the most important differences between ionosolv and organosolv processes for biomass fractionation, focusing on lignin recovery and its properties, which is the first step in order to valorize all biomass fractions. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Synthetic Route of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Synthetic Route of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Advancing the Therapeutic Efficacy of Bioactive Molecules by Delivery Vehicle Platforms was written by Tsiailanis, Antonis D.;Tzakos, Andreas G.;Mavromoustakos, Thomas. And the article was included in Current Medicinal Chemistry in 2021.Recommanded Product: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

Drugs have to overcome numerous barriers to reach their desired therapeutic targets. In several cases, drugs, especially the highly lipophilic mols., suffer from low solubility and bioavailability and therefore their desired targeting is hampered. In addition, undesired metabolic products might be produced or off-targets could be recognized. Along these lines, nanopharmacol. has provided new technol. platforms, to overcome these boundaries. Specifically, numerous vehicle platforms such as cyclodextrins and calixarenes have been widely utilized to host lipophilic drugs such as antagonists of the angiotensin II AT1 receptor (AT₁R), as well as quercetin and silibinin. The encapsulation of these drugs in supramols. or other systems refines their solubility and metabolic stability, increases their selectivity and therefore decreases their ED and improves their therapeutic index. In this mini review we report on the formulations of silibinin and AT₁R antagonist candesartan in a 2-HP-β-cyclodextrin host mol., which displayed enhanced cytotoxicity and increased silibinin′s and candesartan′s stability, resp. Moreover, we describe the encapsulation of quercetin in gold nanoparticles bearing a calixarene supramol. host. Also, the encapsulation of temozolomide in a calixarene nanocapsule has been described. Finally, we report on the activity enhancement that has been achieved upon using these formulations as well as the anal. and computational methods we used to characterize these formulations and explore the mol. interactions between the host and quest mols. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Recommanded Product: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem