Category: imidazoles-derivatives

Pharmacokinetics of a new fixed-dose combination of candesartan cilexetil, hydrochlorothiazide, and rosuvastatin in healthy adult subjects was written by Yerino, Gustavo A.;Feleder, Ethel C.;Halabe, Emilia K.;Diaz, Liliana;Sakson, Mario;Iglesias, Mariana;Haddad, Tobias;Roldan, Emilio;Mondelo, Nelida. And the article was included in International Journal of Clinical Pharmacology and Therapeutics in 2022.Safety of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

A fixed-dose combination (FDC) of candesartan cilexetil, hydrochlorothiazide and rosuvastatin (CC/ HCTZ/RSV) has been developed to enhance patient compliance in the primary prevention of cardiovascular diseases. To evaluate if the combination of the product components in the new FDC capsule formulation affects their resp. pharmacokinetic and in vitro dissolution patterns. Materials and methods: In vitro dissolution profiles were compared in USP-43 and in biorelevant dissolution media. In vivo comparisons were obtained in a randomized, open-label, single-dose, two-treatment, two-way crossover study in 24 healthy subjects. During each treatment period, subjects received the test formulation (FDC hard capsule containing CC/HCTZ/RSV) or the reference formulation (co-administration of a FDC CC/HCTZ tablet and a RSV tablet). Plasma samples were collected periodically over 48 h post-dose. Safety and tolerability were assessed. Dissolution profiles of all active drugs in the Test (capsule) and Reference Products (as tablets) were within the tolerance dissolution criteria of USP-43 conditions. HCTZ dissolution profiles were closely similar whereas those for RSV and CC did not match at specific pHs. In the pharmacokinetic study, the 90% confidence intervals (CIs) for the geometric least-square mean ratios of Cmax, AUC0-last, and AUC0-inf were 0.95 – 1.18, 0.95 – 1.15 and 0.95 – 1.13 (CC); 0.91 – 1.10, 0.96 – 1.08, and 0.96 – 1.09 (HCTZ) and 0.82 – 1.23, 0.81 – 1.13, and 0.82 – 1.12 (RSV), resp. All adverse events were mild. The new FDC product (Sinlip Prevent), a stable FDC hard capsule, was bioequivalent (similar pharmacokinetics) when compared to the coadministration of the components and may be considered as a suitable and simplified medication for cardiovascular disease management. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Safety of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Safety of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation and in vivo evaluation of candesartan cilexetil solid dispersions was written by Kumar, Uppuluru Ashok;Suresh, Gande. And the article was included in Asian Journal of Pharmaceutical and Clinical Research in 2021.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

The present study aims at development of solid dispersions (SD) of candesartan cilexetil for enhanced solubility and bioavailability. About 18 SD formulations of candesartan cilexetil were prepared by solvent evaporation technique and evaluated. The in vitro release studies were conducted and the best formulation chosen was further characterized for Fourier transform IR spectroscopy, Scanning electron microscope, X-ray, and stability. The in vivo evaluation study conducted in rats. The formulation SD16 containing drug and Soluplus in 1:3 ratio along with 2% selective laser sintering was chosen optimal based on drug content (99.08%), and drug release (99.7%). In vivo studies conducted on SD16 showed that mean time to peak concentration (T_max) was 2.0±0.05 and 4±0.2 h for the optimized and pure drug, resp., while mean maximum drug concentration (C_max) was 570.63±2.65 ng/mL and was significant as compared to the candesartan pure drug 175.146±0.07 ng/mL. Area under curve AUC_0-∞ infinity for candesartan SD16 was higher (4860.61±1.05 ng.h/mL) than pure drug suspension 1480±1.72 ng.h/mL. Hence, the developed SD formulations enhanced the bioavailability of drug by 3 folds. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2 was written by D’Alessandro, Pier L.;Corti, Corrado;Roth, Adelheid;Ugolini, Annarosa;Sava, Anna;Montanari, Dino;Bianchi, Federica;Garland, Stephen L.;Powney, Ben;Koppe, Emma L.;Rocheville, Magalie;Osborne, Greg;Perez, Paloma;de la Fuente, Jesus;De Los Frailes, Maite;Smith, Paul W.;Branch, Clive;Nash, David;Watson, Stephen P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.HPLC of Formula: 3012-80-4 This article mentions the following:

The optimization of an HTS hit series (1) leading to the identification of structurally novel, selective, orally bioavailable mGluR2 pos. modulators GSK1331258 and GSK1331268 is described. Structure-activity relationships, attenuation of dopaminergic activity, and potentiation of mGluR2 responses in rat hippocampal MPP-DG synapses are also reported. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4HPLC of Formula: 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.HPLC of Formula: 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A facile and convenient synthesis of new substituted heteroarylchalcones and flavones by microwave irradiated Suzuki-Miyaura cross coupling reaction in aqueous medium was written by Joshi, Vidya;Hatim, Jaywant Govind. And the article was included in Indian Journal of Heterocyclic Chemistry in 2012.COA of Formula: C4H5BrN2 This article mentions the following:

Chalcones I (R = heteroaryl) and corresponding flavones II (same R) having various heteroaryl substituents have been synthesized. The starting compound 5-formyl-2-methoxyphenylboronic acid (III) was prepared by a series of reactions; bromination of 4-methoxybenzaldehyde with catalyst anhydrous AlCl₃ in DCE (1,2-dichloroethane) gave 3-bromo-4-methoxybenzaldehyde. The aldehydic in 3-bromo-4-methoxybenzaldehyde was protected by acetalization with 1,3-propanediol and Et orthoformate with phase transfer catalyst tetrabutylammonium tribromide producing the corresponding 2-(3-bromo-4-methoxyphenyl)-1,3-dioxane, which on treatment with tri-Me borate [(MeO)₃B] in presence of n-butyllithium at 70° gave III. Suzuki-Miyaura coupling of III with different heteroaryl bromides in presence of [(C₆H₅)₃P]₄Pd(0) catalyst, aqueousNa₂CO₃ (2N) as base, and aqueous DMF as solvent and microwave irradiation for 1 to 2.5 min. in a Panasonic microwave set at 1000 W and 80% microwave power yielded 3-heteroaryl-4-methoxybenzaldehydes. Claisen-Schmidt condensation of the latter with 2-hydroxyacetophenone in presence of ethanolic KOH produced 3-heteroaryl-2′-hydroxy-4-methoxychalcones (I, R = heteroaryl). Cyclizing I with a mixture of I₂ and DMSO gave 3′-heteroaryl-4′-methoxyflavones (II, same R). In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9COA of Formula: C4H5BrN2).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C4H5BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design, formulation, and characterization of stearic acid-based solid lipid nanoparticles of candesartan cilexetil to augment its oral bioavailability was written by Mahajan, Anu;Kaur, Satvinder. And the article was included in Asian Journal of Pharmaceutical and Clinical Research in 2018.Reference of 145040-37-5 This article mentions the following:

Objective: Poor aqueous solubility and suboptimal oral bioavailability hamper the therapeutic efficacy of candesartan cilexetil (CDC). This study is designed to prepare solid lipid nanoparticle (SLN) of CDC and to enhance the oral absorption of CDC compared with free drug suspension. The development and characterization of CDC-loaded SLN, using stearic acid as main encapsulating lipid, stabilized with poloxamer188 using “modified emulsification-ultrasonication technique.” Results: CDC-SLN with a total drug content of 88.33 ± 1.23% and entrapment efficiency of 78.28 ± 1.91%, with an average particle size of 197.9 nm and zeta potential value -21.3 mV, was prepared Differential scanning calorimetry and powder X-ray diffraction (PXRD) results confirmed the mol. encapsulation of the drug in amorphous state. CDC-SLN released 60.43% of drug in comparison to 17.11% released by CDC suspension in 24 h (p<0.05). The results of pharmacoKinetic studies in rat showed that AUC0-t of CDC-SLN was significantly enhanced over 3-folds than that of free drug suspension (p<0.05). Conclusion: SLN of CDC could be successful in improving the oral bioavailability of poorly soluble CDC. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Reference of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dissolution of Maize Starch in Aqueous Ionic Liquids: The Role of Alkyl Chain Length of Cation and Water:Ionic Liquid Ratio was written by Ren, Fei;Wang, Jinwei;Yu, Jinglin;Xiang, Fengjuan;Wang, Shuo;Wang, Shujun;Copeland, Les. And the article was included in ACS Sustainable Chemistry & Engineering in 2019.Recommanded Product: 79917-89-8 This article mentions the following:

The dissolution behavior of maize starch in water:ionic liquid (IL) mixtures at ambient temperature (22-23 °C) was studied. The ionic liquids used were 1-butyl-3-methylimidazolium chloride ([C₄ mim][Cl]), 1-propyl-3-methylimidazolium chloride ([C₃ mim][Cl]), and 1-ethyl-3-methylimidazolium chloride ([C₂ mim][Cl]). Structural analyses indicated that long- and short-range mol. order in the starch decreased with decreasing water:IL ratio. At water:IL ratios of 10:1 and 5:1, the extent of disruption of starch structure followed the order [C₄ mim][Cl] > [C₃ mim][Cl] > [C₂ mim][Cl]. At lower water:IL ratio (2:1), the complete disruption of starch granule morphol. and ordered structures in water:[C₃ mim][Cl] and water:[C₂ mim][Cl] mixtures indicated these mixtures were more effective in dissolving starch than water:[C₄ mim]Cl mixture Results from rheol., FTIR, and ¹H NMR analyses of water:IL mixtures showed that as water:IL ratio decreased, the viscosity of solutions increased, the interaction between IL and water decreased, and the interaction between the cation and the anion increased. Stronger interaction between the IL and water and higher viscosity of water:IL mixtures were noted for cations with longer alkyl chains. Our results clearly showed that both the alkyl chain length of cations and water:IL ratio played key roles in the dissolution of starch, predominantly by affecting the interaction between ILs and water and viscosity of water:IL mixtures In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Recommanded Product: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Representation of phase behavior of ionic liquids and their mixtures using various forms of cubic-two-state equation of state was written by Haghtalab, Ali;Shojaeian, Abolfazl. And the article was included in Fluid Phase Equilibria in 2017.Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

In this work, in addition of Soave-Redlich-Kwong (SRK) equation of state, two other alternative cubic models such as Peng- Robinson (PR) and Cubic Square Well (CSW) EoSs are combined with the Two-State Association Model (TSAM) and the new forms of the Cubic-Two-State equation of state (CTS EoS) as PR-TS and CSW-TS are presented. In the beginning, the present models are used to correlate the saturated vapor pressure and liquid d. of pure water, alcs. and phenol. The models are also employed to predict vapor molar volume and second virial coefficients of pure compounds to explore the predictability of the different type of the CTS models. Also, the liquid d. of different pure ionic liquids (ILs) at various temperatures from 298.15 K up to 500 K and pressure from 0.1 MPa up to 59.59 MPa is correlated and the parameters of the CTS models are obtained. Following successful application of the models for the pure components, using one temperature independent binary interaction parameter, the SRK-TS and PR-TS models are applied to predict the vapor-liquid equilibrium of the several binary mixtures consists of IL with non-association and association components at various temperatures from 298.15 K up to 363.15 K and pressure from 0.09 kPa up to 216 kPa. The results of the SRK-TS and PR-TS models for pure and binary systems containing ILs are in very good agreement with experiments and also are compared with various equations of states that show better results. In overall for the systems that are presented in this work, the PR-TS model shows slightly better results with respect to the SRK-TS model specially in prediction, and PR-TS and SRK-TS models present superiority with respect to the CSW-TS EoS. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

β-Carotene: A green, inexpensive, and convenient solvatochromic probe for the determination of solvent polarizability was written by Loffredo, Carina;Pires, Paulo Augusto R.;Imran, Muhammad;El Seoud, Omar A.. And the article was included in Dyes and Pigments in 2013.Application of 21252-69-7 This article mentions the following:

Solvent polarizability has been previously determined by using the solvatochromic probe 3,20-di-tert-butyl-2,2,21,21-tetramethyl-3,5,7,9,11,13,15,17,19-docosanonaene whose synthesis involves 15 steps. We show here that the natural dye β-carotene, 1,1′-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis[2,6,6-trimethylcyclohexene], can be conveniently employed for the accurate determination of the same solvent property. This conclusion is based on both theor. calculations and exptl. data. The former includes free energies of solvation, and the wavenumber of the longest wavelength (i.e., the solvatochromic) transition. Both quantities for β-carotene correlate linearly with the corresponding values of the docosanonaene, with slopes and correlation coefficients of practically unity. The plot of exptl. calculated solvent polarizability of β-carotene vs. that of the docosanonaene was found to be linear for 68 solvents. Previously unknown solvent polarizability values are reported for eight ROCH₂CH₂OH (R = C₁ to C₁₀) and four 1-allyl-3-R-imidazolium chloride ionic liquids (R = C₆ to C₁₀). The dependence of solvent polarizability on the number of carbon atoms in the hydrocarbon chains of several classes of solvents is calculated, it shows the importance of van der Waals interactions in ionic liquids In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Application of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pharmacokinetics of liposomal curcumin (Lipocurc) infusion: effect of co-medication in cancer patients and comparison with healthy individuals was written by Bolger, Gordon T.;Licollari, Albert;Tan, Amin;Greil, Richard;Vcelar, Brigitta;Greil-Ressler, Sigrun;Weiss, Lukas;Schonlieb, Charlotte;Magnes, Teresa;Radl, Bianca;Majeed, Muhammed;Sordillo, Peter P.. And the article was included in Cancer Chemotherapy and Pharmacology in 2019.Related Products of 145040-37-5 This article mentions the following:

Purpose: Investigation of the impact of co-medication on the plasma levels of curcumin and tetrahydrocurcumin (THC) in cancer patients and a comparison of the pharmacokinetics of curcumin and plasma levels of THC between cancer patients and healthy individuals following i.v. infusion of Lipocurc (liposomal curcumin). Methods: Correlation anal. was used to determine the impact of co-medication on infusion rate normalized plasma levels of curcumin and THC in cancer patients and to compare the plasma levels of curcumin and THC at different infusion rates between cancer patients and healthy individuals. In vitro hepatocyte and red blood cell distribution experiments were conducted with Lipocurc to support clin. findings. Plasma concentration time data were analyzed by the non-compartmental method to determine and compare the pharmacokinetic parameters of curcumin in cancer patients and healthy individuals. Results: Of 44 co-medications studied, three medications targeting the renin-angiotensin system, Lisinopril, Ramipril, and Valsartan elevated plasma levels of curcumin and THC in three cancer patients infused with Lipocurc. Cell distribution experiments indicated that the disposition of curcumin in red blood cells may be a target for elevation of the plasma levels of curcumin. Plasma levels of curcumin in cancer patients increased to a greater extent with increased infusion rate compared to healthy individuals. Upon termination of infusion, the elimination phase for curcumin was shorter with a shorter terminal half-life and smaller volume of distribution for curcumin in cancer patients compared to healthy individuals. Conclusion: Either co-medications or health status, or both, can impact the pharmacokinetics of curcumin infusion (as Lipocurc) in cancer patients. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Related Products of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Related Products of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enhancing onset of action of candesartan cilexetil by the preparation of fast dissolving film containing loaded Candesartan cilexetil nanoemulsion was written by Sahil;Malviya, Sarvesh Jain;Khune, Kalyani;Jain, Puspendra Kumar. And the article was included in World Journal of Pharmaceutical Research in 2019.COA of Formula: C33H34N6O6 This article mentions the following:

Candesartan cilexetil has limitation both in less bioavailability and onset of action. Therefor formulation to optimized the use of candesartan cilexetil. The purpose of this study was to develop nanoemulsion by using an appropriate oils, surfactant and co surfactant. Nanoemulsion was prepared by the spontaneous mixture of labrafil 2125, kolliphor RH 40 and PEG 400 with the ratio (0.5:9:5). The nanoemulsions were prepared by aqeous titration method. The solubility of drug was checked in different solvents, surfactant, oils and co surfactant in regulate to select the best solubilizing componenets for the preparation of nanoemulsion and then pseudoternary phase diagram was used as a useful device to evaluate the nanoemulsion area. The film was prepared by using a polymers (HPMC 5, HPMC 6, HPMC 15, and HPMC 50) and plasticizers. The method used for the preparation of film was petri plate method. It is an easy and low cost price method. The main purpose behind for the preparation of film was enhanced the onset of action and reduce the side effect. The evaluation of film was Invitro dissolution release, weight variation, folding endurance, film thickness, disintegration time, drug content release determination by used a zero order, first order, higuchi, koshmeyer plot graphs. The serious feature was type and ratio of oils, surfactant, co surfactant, and polymer and plasticizer concenteration influenced the film characters. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5COA of Formula: C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.COA of Formula: C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem