Category: imidazoles-derivatives

Today I want to share an article with you. The article is 《DMSO as C1 Source under Metal- and Oxidant-free Conditions: NH₄SCN-mediated Synthesis of Quinazolinone and Dihydroquinazolin-4(1H)-one Derivatives》,you can find this article in 《Asian Journal of Organic Chemistry》. The following contents are mentioned:

A new and efficient strategy for the development of quinazolinones I(R = iso-Pr, cyclohexyl, 4-methylphenyl, thiophen-2-ylmethyl, etc.) and dihydroquinazolin-4(1H)-ones II (R¹ = Me, Ph, Bn, etc.; R² = H, Bu, 4-chlorophenyl, pyridin-4-yl, etc.) promoted by ammonium thiocyanate is reported. Most remarkably, DMSO is used for solvent as well as methine and bridged methylene source to obtain a wide variety of new N,N-disubstituted 2,3-dihydroquinazolin-4(1H)-ones II. This transformation possesses significant advantages such as metal- and oxidant-free, non-acidic medium, simple condition, good functional group tolerance and broad substrate scope. Besides, this process could be readily scaled up and applied to drug mols. synthesis. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Formula: C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kaur, Narinder;Singh, Jasminder;Raj, Pushap;Singh, Narinder;Singh, Harpreet;Sharma, Sanjeev K.;Kim, Deuk Young;Kaur, Navneet published 《ZnO decorated with organic nanoparticles based sensor for the ratiometric selective determination of mercury ions》 in 2016. The article was appeared in 《New Journal of Chemistry》. They have made some progress in their research.Computed Properties of C13H11N3 The article mentions the following:

ZnO nanoparticles decorated with organic receptor, 2-[[[2-(1H-benzimidazol-2-yl)phenyl]imino]methyl]phenol, were prepared and the resultant compound (N1) was studied for its metal recognition ability. N1 is selective for mercury ions (Hg²⁺) in a DMSO/water mixture in a ratio of 7 : 3 and possessed no interference from any of the potential interferent metal ions. The crystal size and morphol. of ZnO was characterized using various spectroscopic and diffraction techniques like SEM, XRD, dynamic light scattering (DLS), etc. Surface decoration of the ZnO with receptor 1 is confirmed using NMR spectroscopy. On successive additions of Hg²⁺ ions, the fluoroscence intensity of the compound was quenched at 427 nm with enhancement of the peak at 482 nm, which led to ratiometric sensor development for the recognition of mercury ions having a detection limit of 0.19 nM. The prepared receptor was also tested for real sample application by preparing a known concentration of Hg²⁺ solution and it was found to respond well with an accuracy >90%. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Computed Properties of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Computed Properties of C13H11N3《Synthesis, characterization and biological evaluation of benzimidazole derivatives》 was published in 2018. The authors were Anand, Keshav;Wakode, Sharad, and the article was included in《International Journal of Pharmaceutical Sciences and Research》. The author mentioned the following in the article:

A series of benzimidazole derivatives were synthesized by a single step process by reacting o-phenylenediamine and benzoic acid. The purity and structure confirmation of the synthesized compounds were done by TLC and ¹H-NMR. The compounds were evaluated for anti-microbial, anti-fungal and antioxidant activity. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Computed Properties of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Joshi, P. P.;Dodkey, A. M. published 《Synthesis and characterization of new substituted 2-(2-aryl-diazenyl)-H-benzo(d)-imidazole derivatives》. The research results were published in《World Journal of Pharmaceutical Research》 in 2017.Related Products of 5805-39-0 The article conveys some information:

A series of new substituted 2-(2-aryl-diazenyl)benzo(d)imidazoles I [R = H, Cl, CH₃; R¹ = H, Cl, NO₂; Ar = 2-HOC₆H₄, 2-hydroxy-1-naphthyl] was synthesized via coupling reaction of substituted 2-[(1H)-benzo(d)imidazol-2-yl]anilines with 2-naphthol and phenol. The structures of the products were confirmed from ¹H-NMR, ¹³C-NMR and IR spectra. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Related Products of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Safety of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride《Synthesis of adamantane by ionic liquid-promoted isomerization of tricyclo[5.2.1.0^2,6]decane and H₂SO₄-mediated hydroisomerization of pentacyclo[4.4.0.0^2,4.0^3,7.0^8,10]decane》 was published in 2022. The authors were Aminov, R. I.;Ramazanov, I. R.;Khusnutdinov, R. I., and the article was included in《Russian Chemical Bulletin》. The author mentioned the following in the article:

Adamantane was synthesized by skeletal isomerization of endo- and exo-tricyclo[5.2.1.0^2,6]^–decanes in the presence of ionic liquid [Et₃NH]⁺[Al₂Cl₇]^–-CuSO₄. A new method to synthesize adamantane in 75% yield by H₂SO₄-mediated hydroisomerization of its new precursor, pentacyclo[4.4.0.0^2,4.0^3,7.0^8,10]decane, was developed. And 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) was used in the research process.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Safety of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride《Deep eutectic solvents coupled with (NH₄)₃H₆CoMo₆O₂₄ trigger aerobic oxidation of 5-hydroxymethylfurfural to 5-formyl-2-furancarboxylic acid》 was published in 2022. The authors were Sun, Yanbin;Yang, Kaixuan;Zhu, Zhiguo;Su, Ting;Ren, Wanzhong;Lu, Hongying, and the article was included in《Chemical Communications (Cambridge, United Kingdom)》. The author mentioned the following in the article:

An Anderson-type polyoxometalate (NH4)3H6CoMo6O24 in deep eutectic solvents exhibited outstanding catalytic performance for the selective aerobic oxidation of HMF to FFCA. It is potentially a promising and highly environmentally friendly approach for biomass conversion. And 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) was used in the research process.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Reference of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zhang, Yinhang;Fan, Yuan;Kamran, Urooj;Park, Soo-Jin published 《Improved thermal conductivity and mechanical property of mercapto group-activated boron nitride/elastomer composites for thermal management》. The research results were published in《Composites, Part A: Applied Science and Manufacturing》 in 2022.Computed Properties of C6H11ClN2 The article conveys some information:

Ionic liquid 1-Ethyl-3-methylimidazolium chloride was employed to promote the exfoliation of hexagonal boron nitride (BN) to fabricate the boron nitride nanosheets (BNNSs). The BNNSs were then surface activated by covalently attaching mercapto groups on their surfaces. The surface-activated BNNS nanoparticles (S@BNNSs) were incorporated in a carboxylated styrene-butadiene rubber matrix for preparing thermal management materials. The developed material was provided with superior mech. properties, satisfied thermal conductivity and strong storage modulus attributing to the two-dimensional structure of the filler and the enhanced interfacial interaction between the filler and matrix. The filler-filler and filler-matrix networks in the composite system were comprehensively analyzed. The thermal management applications were also demonstrated using an IR camera and a com. thermoelec. generator. All the performances demonstrated their potential use as thermal management materials in electronic devices. To complete the study, the researchers used 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Computed Properties of C6H11ClN2

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kanlayakan, Narissa;Kerdpol, Khanittha;Prommin, Chanatkran;Salaeh, Rusrina;Chansen, Warinthon;Sattayanon, Chanchai;Kungwan, Nawee published 《Effects of different proton donor and acceptor groups on excited-state intramolecular proton transfers of amino-type and hydroxy-type hydrogen-bonding molecules: theoretical insights》. The research results were published in《New Journal of Chemistry》 in 2017.Related Products of 5805-39-0 The article conveys some information:

The effect of proton donors, namely NH-type and OH-type, on the excited-state intramol. proton transfer (ESIPT) of hydrogen-bonding (H-bond) mols. was investigated using d. functional theory (DFT) and time-dependent DFT (TD-DFT) at the B3LYP level with the TZVP basis set. The important parameters for bond distances involved in the intramol. H-bond revealed that H-bonds of OH-type are stronger than those of NH-type and this was supported by the greater red-shift of O-H vibrational modes in the excited-state. The potential energy surfaces along the proton transfer (PT) reaction show that the ESIPT of O-H type occurs with a small barrier or barrierless in the excited-state whereas those of N-H type have higher PT barriers except for the one with a stronger proton acceptor, resulting in a smaller barrier. On-the-fly dynamic simulations on the first excited-state were further carried out to provide the important dynamic information on PT time and probability. The results of dynamic simulations are in accordance with the potential energy surfaces in which the N-H type shows no PT in APBT but slow PT in APBI and fast PT in HNHPIP, while the O-H type (HBI, HBT and HPIP) exhibits ultrafast PT within 80 fs. Moreover, the occurrence of the ESIPT process is strongly dependent on reaction energy and activation energy, in which the H-bond mols. with thermodynamically and kinetically favorable characters always provide the ESIPT. Therefore, the type of proton donor and proton acceptor of H-bond mols. is very important to hinder or effectively facilitate the ESIPT process. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Related Products of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Name: 1-Ethyl-3-methyl-1H-imidazol-3-ium chlorideIn 2022, Hou, Qidong;Bai, Chuanyunlong;Bai, Xinyu;Qian, Hengli;Nie, Yifan;Xia, Tianliang;Lai, Ruite;Yu, Guanjie;Rehman, Mian Laiq Ur;Ju, Meiting published 《Roles of Ball Milling Pretreatment and Titanyl Sulfate in the Synthesis of 5-Hydroxymethylfurfural from Cellulose》. 《ACS Sustainable Chemistry & Engineering》published the findings. The article contains the following contents:

Production of 5-hydroxymethylfurfural (HMF) from cellulose has been expected for a long time, but most catalytic systems generally give low yield and selectivity due to the difficulty of balancing cellulose deconstruction with the uncontrollable degradation of the target product under harsh conditions. Here we show that the ball milling pretreatment could markedly facilitate the conversion of microcrystalline cellulose to HMF by titanyl sulfate (TiOSO₄). The ball milling pretreatment remarkably decreases the degree of crystallinity of microcrystalline cellulose with a reduction of mol. weight via disrupting the hydrogen bond and partially breaking the β-1,4-glycosidic bond. TiOSO₄ functions as both Lewis and Bronsted acid to catalyze the efficient conversion of cellulose with high HMF yield (45.4%), far exceeding that (14.1%) from untreated cellulose. The reaction pathway was revealed by liquid chromatograph-mass spectra anal. In addition, phosphorylated titanium dioxide also afforded a notable HMF yield (21.8%), showcasing the great potential of Ti-based heterogeneous catalyst.1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) were involved in the experimental procedure.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.Name: 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Jing;Li, Qing;Li, Kuncai;Sun, Xu;Wang, Yizhuo;Zhuang, Tiantian;Yan, Junjie;Wang, Hong published 《Ultra-High Electrical Conductivity in Filler-Free Polymeric Hydrogels Toward Thermoelectrics and Electromagnetic Interference Shielding》. The research results were published in《Advanced Materials (Weinheim, Germany)》 in 2022.Application In Synthesis of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride The article conveys some information:

Conducting hydrogels have attracted much attention for the emerging field of hydrogel bioelectronics, especially poly(3,4-ethylenedioxythiophene): poly(styrene sulfonate) (PEDOT:PSS) based hydrogels, because of their great biocompatibility and stability. However, the elec. conductivities of hydrogels are often lower than 1 S cm^-1 which are not suitable for digital circuits or applications in bioelectronics. Introducing conductive inorganic fillers into the hydrogels can improve their elec. conductivities. However, it may lead to compromises in compliance, biocompatibility, deformability, biodegradability, etc. Herein, a series of highly conductive ionic liquid (IL) doped PEDOT:PSS hydrogels without any conductive fillers is reported. These hydrogels exhibit high conductivities up to ≈305 S cm^-1, which is ≈8 times higher than the record of polymeric hydrogels without conductive fillers in literature. The high elec. conductivity results in enhanced areal thermoelec. output power for hydrogel-based thermoelec. devices, and high specific electromagnetic interference (EMI) shielding efficiency which is about an order in magnitude higher than that of state-of-the-art conductive hydrogels in literature. Furthermore, these stretchable (strain >30%) hydrogels exhibit fast self-healing, and shape/size-tunable properties, which are desirable for hydrogel bioelectronics and wearable organic devices. The results indicate that these highly conductive hydrogels are promising in applications such as sensing, thermoelecs., EMI shielding, etc. And 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) was used in the research process.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.Application In Synthesis of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem