Category: imidazoles-derivatives

Hasan, Hiba Ali;Abdulmalek, Emilia;Abdul Rahman, Mohd Basyaruddin;Shaari, Khozirah Binti;Yamin, Bohari Mohd.;Chan, Kim Wei published 《Microwave synthesis, crystal structure, antioxidant, and antimicrobial study of new 6-heptyl-5,6-dihydrobenzo[4,5]imidazo[1,2-c] quinazoline compound》 in 2018. The article was appeared in 《Chemistry Central Journal》. They have made some progress in their research.Synthetic Route of C13H11N3 The article mentions the following:

A comparative study between two methods, (microwave-assisted and conventional heating approaches), was performed to synthesize a new quinazoline derivative from 2-(2-aminophenyl)-1H-benzimidazole and octanal to produce 6-heptyl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline (OCT). The compound was characterised using FTIR, ¹H and ¹³C NMR, DIMS, as well as X-ray crystallog. The most significant peak in the ¹³C NMR spectrum is C-7 at 65.5 ppm which confirmed the cyclization process. Crystal structure anal. revealed that the mol. growed in the monoclinic crystal system P2₁/n space group and stabilized by an intermol. hydrogen bond between the N1-H1A···N3 atoms. The crystal packing anal. showed that the mol. adopts zig-zag one dimensional chains. Fluorescence study of OCT revealed that it produced blue light when expose to UV-light and its quantum yield equal to 26%. Antioxidant activity, which included DPPH· and ABTS^·+ assays was also performed and statistical anal. was achieved via a paired T-test using Minitab 16 software with P < 0.05. Also, the antimicrobial assay against two Gram-pos., two Gram-neg., and one fungus was screened for these derivatives Using microwave to synthesize OCT have drastically reduced reaction time, and increased yield. OCT showed good antioxidant activity in one of the tests and moderate antimicrobial activity. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Synthetic Route of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Leal, Jorge;Santos, Lucia;Fernandez-Aroca, Diego M.;Cuevas, J. Vicente;Martinez, M. Angeles;Massaguer, Anna;Jalon, Felix A.;Ruiz-Hidalgo, M. Jose;Sanchez-Prieto, Ricardo;Rodriguez, Ana M.;Castaneda, Gregorio;Dura, Gema;Carrion, M. Carmen;Barrabes, Silvia;Manzano, Blanca R. published 《Effect of the aniline fragment in Pt(II) and Pt(IV) complexes as anti-proliferative agents. Standard reduction potential as a more reliable parameter for Pt(IV) compounds than peak reduction potential》. The research results were published in《Journal of Inorganic Biochemistry》 in 2021.Electric Literature of C13H11N3 The article conveys some information:

The problems of resistance and side effects associated with cisplatin and other chemotherapeutic drugs have boosted research aimed at finding new compounds with improved properties. The use of platinum(IV) prodrugs is one alternative, although there is some controversy regarding the predictive ability of the peak reduction potentials. In the work described here a series of fourteen chloride Pt(II) and Pt(IV) compounds was synthesized and fully characterized. The compounds contain different bidentate arylazole heterocyclic ligands. Their cytotoxic properties against human lung carcinoma (A549), human breast carcinoma (MCF7) and human colon carcinoma (HCT116 and HT29) cell lines were studied. A clear relationship between the type of ligand and the anti-proliferative properties was found, with the best results obtained for the Pt(II) compound that contains an aniline fragment, (13), thus evidencing a pos. effect of the NH₂ group. Stability and aquation studies in DMSO, DMF and DMSO/water mixtures were carried out on the active complexes and an in-depth anal. of the two aquation processes, including DFT anal., of 13 was undertaken. It was verified that DNA was the target and that cell death occurred by apoptosis in the case of 13. Furthermore, the cytotoxic derivatives did not exhibit haemolytic activity. The reduction of the Pt(IV) compounds whose Pt(II) congeners were active was studied by several techniques. It was concluded that the peak reduction potential was not useful to predict the ability for reduction However, a correlation between the cytotoxic activity and the standard reduction potential was found.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Electric Literature of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Seyednejhad, Sajedeh;Khalilzadeh, Mohammad A.;Zareyee, Daryoush;Sadeghifar, Hasan;Venditti, Richard published 《Cellulose nanocrystal supported palladium as a novel recyclable catalyst for Ullmann coupling reactions》. The research results were published in《Cellulose (Dordrecht, Netherlands)》 in 2019.Application of 5805-39-0 The article conveys some information:

A new Pd catalyst chem. bonded to cellulose nanocrystals surfaces was developed. 2-(1H-benzo[d]imidazol-2-yl)aniline (BIA), tosylated cellulose nanocrystals (CNC-TOS) and PdCl₂ were the reactants for the synthesis of the new catalyst designed to be used for the Ullmann reaction. The modified cellulose nano catalyst was characterized with various anal. tools. The catalyst had excellent selectivity and activity in a short reaction time (45 min) and outstanding TON (490) and TOF (1960) values. The nano catalyst was determined to be reusable for at least eight cycles. The Pd catalyst chem. bonded to cellulose nanocrystals surface indicated excellent catalytic efficiency for the Ullmann C-O reaction when it was compared to com. palladium catalysts.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Application of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Today I want to share an article with you. The article is 《An efficient and stable magnetic nano-biocatalyst for biodiesel synthesis in recyclable ionic liquids》,you can find this article in 《Biomass Conversion and Biorefinery》. The following contents are mentioned:

Abstract: The process of jatropha oil transesterification was studied for biodiesel production Rhizomucor miehei lipase (RML) immobilized on 3-aminopropyltriethoxysilane functionalized magnetic Fe₃O₄ was employed as a biocatalyst. The immobilized lipase was confirmed by scanning electron microcopy (SEM), Fourier transform IR spectra (FT-IR), thermogravimetric anal. (TGA), vibrating sample magnetometer (VSM), and confocal laser scanning microscopy (CLSM) techniques. The efficient biodiesel synthesis in ionic liquids using immobilized RML was demonstrated. Fifteen kinds of ionic liquids based on different alkyl chain lengths of the Me imidazolium cation ([C₂MIM], [C₄MIM], [C₈MIM], [C₁₂MIM], and [C₁₆MIM]) combined with [NTf₂], [N(CN)₂], [PF₆] or [BF₄] anions were assayed as reaction media for RML producing biodiesel. The highest synthetic activity of immobilized RML appeared in [BMIM][PF₆], which is more than five times higher than the free enzyme. The enzyme catalytic activity remained 60even after the magnetic nano-biocatalyst and ionic liquid had been reused 5 times in a 48-h reaction cycle. In addition, the immobilized enzyme exhibited excellent storage stability with almost no decrease in catalytic activity after storing at -20 °C for 98 days.1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) were involved in the experimental procedure.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.Safety of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formula: C13H11N3In 2018, Matysiak, Joanna;Skrzypek, Alicja;Glaszcz, Urszula;Matwijczuk, Arkadiusz;Senczyna, Bogdan;Wietrzyk, Joanna;Krajewska-Kulak, Elzbieta;Niewiadomy, Andrzej published 《Synthesis and biological activity of novel benzoazoles, benzoazines and other analogs functionalized by 2,4-dihydroxyphenyl moiety》. 《Research on Chemical Intermediates》published the findings. The article contains the following contents:

Novel benzoazoles, benzoazines, benzothiazoles, benzothiazines and other related compounds possessing a 2,4-dihydroxyphenyl moiety were prepared The compounds were obtained by the reaction of sulfinylbis[(2,4-dihydroxyphenyl)methanethione]s with the appropriate heterocyclic amines or hydrazines. Human cancer lines, Candida species and phytopathogenic fungi were used for the evaluation of biol. potency of compounds Addnl., drug-like properties were estimated in silico. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Formula: C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kumar, Amit;Kumar, Ashish;Gupta, Rakesh Kumar;Paitandi, Rajendra Prasad;Singh, Krishna Beer;Trigun, Surendra Kumar;Hundal, Maninder Singh;Pandey, Daya Shankar published 《Cationic Ru(II), Rh(III) and Ir(III) complexes containing cyclic π-perimeter and 2-aminophenyl benzimidazole ligands: Synthesis, molecular structure, DNA and protein binding, cytotoxicity and anticancer activity》. The research results were published in《Journal of Organometallic Chemistry》 in 2016.Product Details of 5805-39-0 The article conveys some information:

Synthesis, characterization, DNA and protein binding as well as anticancer activity of the organometallic complexes [(η⁶-C₆H₆)RuCl(APBI)]Cl (1), [(η⁶-p-MeC₆H₄Prⁱ)RuCl(APBI)]Cl (2), [(η⁶-C₆Me₆)RuCl(APBI)]Cl (3), [(η⁵-C₅Me₅)RhCl(APBI)]Cl·H₂O (4) and [(η⁵-C₅Me₅)IrCl(APBI)]Cl·H₂O (5) containing 2-aminophenyl benzimidazole (APBI) have been described. The complexes 1–5 exhibited strong DNA, protein binding and anticancer activity against cervical cancer (SiHa) cell line. Their binding with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) have been examined by absorption and emission spectral studies. Strong interactions between complexes and CT-DNA have been affirmed by absorption spectral and EthBr displacement studies, while interaction with BSA via static quenching explored by fluorescence titration, synchronous and 3D fluorescence spectroscopy. The interactions between 1–5 and DNA has also been scrutinized by ¹H NMR spectral studies using guanosine as a model for DNA. These results have been supported by DFT calculations and mol. docking studies. Cytotoxicity, apoptosis and in vitro anticancer activity of 1–5 toward SiHa cell line have been investigated by MTT assay and acridine (AO)/ethidium bromide (EthBr) fluorescence staining. Overall results revealed that DNA and protein binding, as well as anticancer activity of 1–5 follows the order as 5 > 3 > 2 > 1 > 4. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Product Details of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of C13H11N3In 2019, Teker, Mine Sen;Karaca, Erhan;Pekmez, Nuran Oezcicek;Tamer, Ugur;Pekmez, Kadir published 《An Enzyme-Free H₂O₂ Sensor Based on Poly(2-Aminophenylbenzimidazole)/Gold Nanoparticles Coated Pencil Graphite Electrode》. 《Electroanalysis》published the findings. The article contains the following contents:

A poly(2-aminophenylbenzimidazole)/gold nanoparticles (P2AB/AuNPs) coated disposable pencil graphite electrode (PGE) was fabricated as an enzyme-free sensor for the H₂O₂ determination P2AB/AuNPs and P2AB were successfully synthesized electrochem. on PGE in acetonitrile for the first time. The coatings were characterized by SEM, X-ray diffraction spectroscopy, Energy-dispersive X-ray spectroscopy, Surface-enhanced Raman spectroscopy, and UV-Vis spectroscopy. AuNPs interacted with P2AB as carrier enhances the electrocatalytic activity towards reduction of H₂O₂. The anal. performance was evaluated in a 100 mM phosphate buffer solution at pH 6.5 by amperometry. The steady state current vs. H₂O₂ concentration is linear in the range of 0.06 to 100 mM (R²=0.992) with a limit of detection 3.67×10^-5 M at -0.8 V vs. SCE and no interference is caused by ascorbic acid, dopamine, uric acid, and glucose. The examination for the sensitive determination of H₂O₂ was conducted in com. available hair oxidant solution The results demonstrate that P2AB/AuNPs/PGE has potential applications as a sensing material for quant. determination of H₂O₂. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Synthetic Route of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)aniline《Novel ion imprinted polymer electrochemical sensor for the selective detection of lead(II)》 was published in 2020. The authors were Dahaghin, Zohreh;Kilmartin, Paul A.;Mousavi, Hassan Zavvar, and the article was included in《Food Chemistry》. The author mentioned the following in the article:

The application of a novel Pb²⁺ selective sensor based on the ionic imprinted polymer in determining trace levels of lead in natural water and in fruit juice was investigated using differential pulse voltammetry (DPV). The new and selective magnetic ion-imprinted polymer (Fe₃O₄@SiO₂@IIP) was synthesized using 2-(2-aminophenyl)-1H-benzimidazole and 4-vinyl pyridine as a ligand and functional monomer, resp. The new polymer was utilized for modifying a GCE to generate a new electrochem. sensor. Box-Behnken design (BBD) was utilized for optimizing the parameters influencing the peak current. Extremely suitable voltammetric performance was demonstrated for the electrochem. detection of lead with a low detection limit (0.05 ng mL^-1), over a wide linear concentration range (0.1-80 ng mL^-1). This modified electrode as a novel sensor was utilized for determining Pb(II) ions in natural water and in fruit juice with very reasonable outcomes. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Shahinfard, Hamed;Shabani-Nooshabadi, Mehdi;Reisi-Vanani, Adel;Ansarinejad, Hanieh published 《A novel platform based on CoMn₂O₄-rGO/1-ethyl-3-methylimidazolium chloride modified carbon paste electrode for voltammetric detection of pethidine in the presence morphine and olanzapine》 in 2022. The article was appeared in 《Chemosphere》. They have made some progress in their research.Computed Properties of C6H11ClN2 The article mentions the following:

The present work focuses on the development of a new electrochem. platform based on CoMn2O4-rGO/1-ethyl-3-methylimidazolium chloride modified carbon paste electrode (CoMn2O4-rGO/IL/CPE) for electrochem. determination of pethidine in the presence of biol. species. For the first time, the electrooxidation mechanism of pethidine in presences of morphine and olanzapine is investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) technologies. The as-synthesized CoMn2O4-rGO nanocomposites are characterized by physicochem. measurements such as X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), Field emission SEM (FE-SEM), and Fourier transform IR (FT-IR). The obtained results illustrated synergistic interactions between rGO and CoMn2O4 structures. Also, to investigate the electrode charge-transfer resistances, electrochem. features of the resulting nanocomposites are studied via electrochem. impedance spectroscopy (EIS) anal. Based on the result, three segmented linear ranges are observed over the range 0.08-900μM and detection limit of 0.024μM. Over the 10.0-40.0μM ranges of pethidine in phosphate buffer solution (PBS-pH 7.0), suitable diffusion coefficient of 5.67 x 10-7 cm2 s-1 is evaluated by chronoamperometry technique (CHA). Finally, the CoMn2O4-rGO/IL/CPE with high sensitivity, selectivity and repeatability is successfully used for determination of pethidine in real sample and drug formulation.1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) were involved in the experimental procedure.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.Computed Properties of C6H11ClN2

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lian, Kai;Liu, Yang;Teng, Bo;Zhao, Yongjie published 《Phase equilibrium and ionic liquid partitioning in aqueous two-phase system composed of alcohol and small molecule compound》 in 2022. The article was appeared in 《Journal of the Iranian Chemical Society》. They have made some progress in their research.Application In Synthesis of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride The article mentions the following:

In this study, liquid-liquid equilibrium data of an aqueous two-phase system (ATPS) composed of alcs. (ethanol, 1-propanol, or 2-propanol) and small-mol. organic compound (sodium citrate, sodium tartrate, sucrose, maltose, and lactose) was extensively investigated at 298.1 K ± 0.1 K. The binodal curves were summarized through the empirical nonlinear equations with the lowest standard deviation. The contents of alcs. and organic salts in ATPS were accurately determined by gas chromatog. and UV spectrophotometer. The phase-forming abilities of alcs. were ranked in the following order, 1-propanol > 2-propanol > ethanol, resp. The ATPS composed of saccharides was difficult to form two phases due to the high viscosity. The salting-out abilities of sodium citrate (C₆H₅Na₃O₇) were better than sodium tartrate. 1-propanol/ C₆H₅Na₃O₇ATPS had larger biphase areas, it was further applied to concentrate various ionic liquids including [C₂mim]BF₄, [C₄mim]BF₄, [C₄mim]Cl and [C₈mim]Cl. The results showed that alc./organic salt ATPS had a better extraction rate to imidazole-type ionic liquids Ionic liquids were mainly distributed in the top phase (alc.-rich phase). And 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) was used in the research process.

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.Application In Synthesis of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem