imidazoles-derivatives Archives - Page 464 of 1008

Application of cas: 65039-09-0 | Meng, Pengyu et al. published an article in 2022

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a solvent as well as catalyst for the depolymerization of oak wood lignin; a solvent in the hydrolysis of hemicellulose (xylan) to xylose using Brønsted acid catalysts.Product Details of 65039-09-0

Meng, Pengyu;Huang, Jian;Yang, Zhaohui;Wang, Fei;Lv, Teng;Zhang, Jiao;Fu, Chaopeng;Xiao, Wei published 《A Low-Cost and Air-Stable Rechargeable Aluminum-Ion Battery》 in 2022. The article was appeared in 《Advanced Materials (Weinheim, Germany)》. They have made some progress in their research.Product Details of 65039-09-0 The article mentions the following:

Rechargeable aluminum-ion batteries (AIBs) are promising for large-scale energy storage due to the abundant reserves, low cost, and high capacity of the Al anode. However, the development of AIBs is currently hindered by the usage of AlCl₃/1-ethyl-3-methylimidazolium chloride electrolyte, which is expensive, highly corrosive, and extremely air-sensitive. Herein, a new hydrated eutectic electrolyte (HEE) composed of hydrated aluminum perchlorate and succinonitrile for low-cost, noncorrosive, and air-stable AIBs is reported. Crystal water in the hydrated aluminum perchlorate plays a vital role in forming the HEE, in which one H₂O and five succinonitrile mols. coordinate with one Al³⁺ ion. The optimized ratio of Al(ClO₄)₃·₉H₂O to succinonitrile is 1:12. When combining with the self-doped polyaniline cathode, the associated AIB delivers a high discharge capacity of 185 mAh g^-1 over 300 cycles; and the charge/discharge mechanism in the HEE is studied exptl. and theor. The HEE is nonflammable, air-stable, and noncorrosive, thus enabling good air tolerance and facile fabrication of AIBs. To complete the study, the researchers used 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Xie, Caixia et al. published new progress in experiments with the help of cas: 5805-39-0

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Synthetic Route of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Xie, Caixia;Zhang, Zeyuan;Li, Danyang;Gong, Jian;Han, Xushuang;Liu, Xuan;Ma, Chen published 《Dimethyl Sulfoxide Involved One-Pot Synthesis of Quinoxaline Derivatives》. The research results were published in《Journal of Organic Chemistry》 in 2017.Synthetic Route of C13H11N3 The article conveys some information:

An efficient, green, and novel method for the synthesis of N-heterocycle-fused quinoxalines is reported herein. DMSO was used as both a reactant and a solvent in this reaction. A wide range of products in moderate to excellent yields were obtained, including pyrrolo[1,2-a]quinoxalines, indolo[1,2-a]quinoxalines, 1H-pyrrolo[3,2-c]quinolines, and benzo[4,5]imidazo[1,2-c]quinazolines. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Learn more about cas: 5805-39-0 | Acta Chimica Slovenica 2018

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Odame, Felix;Hosten, Eric C. published 《Synthesis, characterization and computational studies of two triazaspiro tetracycles》 in 2018. The article was appeared in 《Acta Chimica Slovenica》. They have made some progress in their research.Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

Synthesis of two new triazaspiro tetracycles I (R = 3-Me, 4-Me) and their characterization using spectroscopy, microanal. and single crystal X-ray diffractometry are discussed. The DFT computed bond angles were obtained for both compounds and compared to exptl. results for the compound I (R = 4-Me). The HOMO-LUMO anal. of both compounds has been carried out. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Li, Jia-Bin et al. published new progress in experiments with the help of cas: 5805-39-0

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Category: imidazoles-derivatives) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Category: imidazoles-derivativesIn 2019, Li, Jia-Bin;Liu, Yang;Zheng, Xiang-Jun;Wang, Dan published 《An off-on chemosensor for Hg²⁺ based on the excimer emission of anthracene》. 《Microchemical Journal》published the findings. The article contains the following contents:

A quinazoline derivative 6-anthracenyl-5,6-2H-benzimidazo[1,2-c]quinazoline (L) was obtained and characterized by elemental anal., IR spectroscopy, ¹H NMR and single-crystal X-ray diffraction. L shows very weak emission in DMSO, but can respond to Hg²⁺ ion intensively in off-on mode. Job’s plot and titration experiments show that Hg²⁺ ion binds L in 1:1 stoichiometry. The detection limit for Hg²⁺ is 6.34μM. ¹H NMR titration experiments indicate that only one benzimidazo nitrogen atom coordinates with Hg2+. And the fluorescence emission spectra imply that an excimer formed in the Hg²⁺-L system, and the detection of Hg²⁺ was realized by excimer emission of anthracene moiety. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cas: 5805-39-0 | Shaikh, Irfan N. et al. made new progress in 2018

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Product Details of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Shaikh, Irfan N.;Bagwan, Umar Farooq;Hunagund, Shirajahammad M.;Shaikh, Imran N.;Afzal, Mohammed published 《Cu-catalyzed Rapid Synthesis of Novel Fluorinated Indole Derivatives Under Microwave Irradiation》 in 2018. The article was appeared in 《Chemistry Africa》. They have made some progress in their research.Product Details of 5805-39-0 The article mentions the following:

Herein, a simple microwave-assisted synthesis of novel fluorinated indole derivatives I [R = (1H-benzimidazol-2-yl)phenyl, 6-chloro-7H-purin-2-yl, 3-amino-2,2-dimethyl-3-phenylpropyl, etc.] have been developed by the reaction of 5-fluoroindoline-2,3-dione with various anilines RNH₂. The reaction could be conducted using readily available substrates within short periods of 9-15 min under microwave irradiation with good to excellent yields of the product (64-92%). This approach exploits the synthetic potential of microwave irradiation and copper dipyridine dichloride (CuPy₂Cl₂) combination and offers many advantages such as full reaction control, excellent product yields, shorter reaction time, eco-friendly procedure and rapid feedback. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Green Chemistry | Cas: 65039-09-0 was involved in experiment

1-Ethyl-3-methyl-1H-imidazol-3-ium chloride(cas: 65039-09-0) is an imidazolium chloride ionic liquid that can be used as:a starting material for the preparation of 1-ethyl-3-methylimidazolium chloride/tetrafluoroborate (EMI.Cl.BF4) molten salt for electrochemical studies; a solvent as well as catalyst for the depolymerization of oak wood lignin.Category: imidazoles-derivatives

Category: imidazoles-derivatives《A porous thienyl cyclodextrin polymer synthesized in a homogeneous ionic liquid catalytic system for the rapid removal of pharmaceuticals and personal care products (PPCPs)》 was published in 2022. The authors were Tu, Yizhou;Wang, Huimin;Yang, Pingping;Xu, Guizhou;Hu, Xuejiao;Li, Aimin;Xie, Xianchuan, and the article was included in《Green Chemistry》. The author mentioned the following in the article:

Pharmaceuticals and personal care products (PPCPs) are widely distributed in aquatic environments due to their large consumption and low biodegradability, causing ecol. risks. In this study, a porous thienyl cyclodextrin polymer (Th-CDP) with a sp. surface area of 730 m² g^-1 was synthesized in an ionic liquid system for the first time to remove PPCPs. The green and recyclable 1-ethyl-3-methylimidazolium chloride/ferric chloride ([EMIm]Cl/FeCl₃) ionic liquid was synthesized as a solvent and catalyst, superior to traditional toxic organic solvents and heterogeneous catalysts. In Th-CDP synthesis, thienyl cyclodextrin (ThCD) was synthesized, followed by polymerization with the three-dimensional crosslinking agent tri-Me orthoformate (Tmof) in [EMIm]Cl/FeCl₃ via the Friedel-Crafts alkylation reaction. Th-CDP shows excellent adsorption towards the studied PPCPs (diclofenac, ibuprofen, carbamazepine, and sulfamethoxazole) due to the rich pore structure. In particular, Th-CDP achieved 90% removal of hydrophobic diclofenac and ibuprofen in 5 min, and the rate constants were 16.7 and 10.5 times higher than those of activated carbon, resp. The adsorption capacity of Th-CDP is related to the mol. weight and pKa of the compound, and is about twice that of activated carbon. Th-CDP has more pronounced adsorption advantages over activated carbon for acidic compounds due to its pos. charge under neutral conditions. In addition, multiple mechanisms, including hydrophobic interaction caused by thiophene and cyclodextrin, electrostatic interaction, and heteroatom interaction (24.8% S content), enable Th-CDP to efficiently remove PPCPs. Moreover, Th-CDP has great application potential due to its excellent regenerability, anti-interference ability, and green synthesis process. The experimental procedure involved many compounds, such as 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rajh, Ava et al. published new experimental results with the assistance of cas: 65039-09-0

Rajh, Ava;Arcon, Iztok;Bucar, Klemen;Zitnik, Matjaz;Petric, Marko;Vizintin, Alen;Bitenc, Jan;Kosir, Urban;Dominko, Robert;Gretarsson, Hlynur;Sundermann, Martin;Kavcic, Matjaz published 《Characterization of electrochemical processes in metal-organic batteries by x-ray Raman spectroscopy》 in 2022. The article was appeared in 《Journal of Physical Chemistry C》. They have made some progress in their research.Safety of 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride The article mentions the following:

X-ray Raman spectroscopy (XRS) is an emerging spectroscopic technique that utilizes inelastic scattering of hard X-rays to study X-ray absorption edges of low Z elements in bulk material. It was used to identify and quantify the amount of carbonyl bonds in a cathode sample, in order to track the redox reaction inside metal-organic batteries during the charge/discharge cycle. XRS was used to record the oxygen K-edge absorption spectra of organic polymer cathodes from different multivalent metal-organic batteries. The amount of carbonyl bond in each sample was determined by modeling the oxygen K-edge XRS spectra with the linear combination of two reference compounds that mimicked the fully charged and the fully discharged phases of the battery. To interpret exptl. XRS spectra, theor. calculations of oxygen K-edge absorption spectra based on d. functional theory were performed. Overall, a good agreement between the amount of carbonyl bond present during different stages of battery cycle, calculated from linear combination of standards, and the amount obtained from electrochem. characterization based on measured capacity was achieved. The electrochem. mechanism in all studied batteries was confirmed to be a reduction of double carbonyl bond and the intermediate anion was identified with the help of theor. calculations X-ray Raman spectroscopy of the oxygen K-edge was shown to be a viable characterization technique for accurate tracking of the redox reaction inside metal-organic batteries. And 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) was used in the research process.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Explore more uses of cas: 65039-09-0 | Chemosphere

Chang, Ken-Lin;Muega, Sherwin C.;Ofrasio, Bjorn Ivan G.;Chen, Wei-Hsin;Barte, Emely G.;Abarca, Ralf Ruffel M.;de Luna, Mark Daniel G. published 《Synthesis of 5-hydroxymethylfurfural from glucose, fructose, cellulose and agricultural wastes over sulfur-doped peanut shell catalysts in ionic liquid》 in 2022. The article was appeared in 《Chemosphere》. They have made some progress in their research.SDS of cas: 65039-09-0 The article mentions the following:

In this study, waste peanut shells were sulfur-impregnated and used as acid catalysts in the presence of an ionic liquid for the conversion of fructose, glucose, and cellulose into 5-hydroxymethylfurfural, a useful chem. intermediate for biofuel production Effects of sulfur-doping duration (1 h and 5 h), solvent type and proportion, reaction temperature (130°C, 140°C, and 150°C), time (30-240 min), catalyst-to-substrate ratio (1-2.5 m/m), and agricultural residue (peanut shell, Canada wheat straw, water hyacinth, stalk, and reed) on HMF yields were investigated. Monophasic and biphasic ionic liquids such as [amim]Cl, [bmim]HSO₄, and [emim]Cl were employed in combination with choline chloride and DMSO to improve HMF yields. Results show that peanut shells subjected to prolonged sulfur impregnation produced higher HMF yields. At 130°C and 2 h, HMF yields from fructose and glucose reached 94.6% and 55.1%, resp. Higher reaction temperatures improved HMF yields and accelerated conversion rates for the sugar substrates. Moreover, HMF production from waste biomass namely, peanut shells, peanut stalk, Canadian wheat straw, reed, and water hyacinth were examined in sep. one-pot catalytic reactions. Overall, the study showed the effectiveness of sulfur-doped peanut shells as solid acid catalysts for the synthesis of HMF from various sources and the results may be used in designing large-scale production of furanic biofuel precursors from agricultural wastes. The experimental procedure involved many compounds, such as 1-Ethyl-3-methyl-1H-imidazol-3-ium chloride (cas: 65039-09-0) .

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jiang, Binyang team published research on Chinese Journal of Chemistry in 2022 | 250285-32-6

Computed Properties of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Computed Properties of 250285-32-6.

Jiang, Binyang;Shi, Shi-Liang research published 《 Pd-Catalyzed Cross-Coupling of Alkylzirconocenes and Aryl Chlorides》, the research content is summarized as follows. The first Pd-catalyzed aryl-alkyl cross-coupling of alkylzirconocenes and aryl halides was reported. A com. available N-heterocyclic carbene (IPr) as the ligand for palladium catalyst was critical to enable the challenging process. This mild protocol does not require base additives and tolerated a broad scope of both coupling partners bearing various functional groups and heterocycles. Moreover, both terminal and internal alkenes were applicable, and the latter underwent “chain walking”, giving the terminal coupling product exclusively. Preliminary mechanistic studies revealed a precatalyst activation pathway and inhibited β-H elimination due to steric bulk of NHC ligand.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jiang, Chenglin team published research on Molecular Plant in | 60-56-0

60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.

Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).

Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., Product Details of C4H6N2S

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Product Details of C4H6N2S.

Jiang, Chenglin;Sun, Ju;Li, Rui;Yan, Shijuan;Chen, Wei;Guo, Liang;Qin, Guochen;Wang, Pengcheng;Luo, Cheng;Huang, Wenjie;Zhang, Qinghua;Fernie, Alisdair R.;Jackson, David;Li, Xiang;Yan, Jianbing research published 《 A reactive oxygen species burst causes haploid induction in maize》, the research content is summarized as follows. Haploid induction (HI) is an important tool in crop breeding. Phospholipase A1 (ZmPLA1)/NOT LIKE DAD (NLD)/MATRILINEAL (MTL) is a key gene controlling HI in maize; however, the underlying mol. mechanism remains unclear. In this study, to dissect why loss of ZmPLA1 function could mediate HI we performed a comprehensive multiple omics anal. of zmpla1 mutant anthers by integrating transcriptome, metabolome, quant. proteome, and protein modification data. Functional classes of significantly enriched or differentially abundant mol. entities were found to be associated with the oxidative stress response, suggesting that a reactive oxygen species (ROS) burst plays a critical role in HI. In support of this, we further discovered that a simple chem. treatment of pollen with ROS reagents could lead to HI. Moreover, we identified ZmPOD65, which encodes a sperm-specific peroxidase, as a new gene controlling HI. Taken together, our study revealed a likely mechanism of HI, discovered a new gene controlling HI, and created a new method for HI in maize, indicating the importance of ROS balance in maintaining normal reproduction and providing a potential route to accelerate crop breeding.

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem