Category: imidazoles-derivatives

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Synthetic Route of 10111-08-7.

Imyen, Thidarat;Znoutine, Emilie;Suttipat, Duangkamon;Iadrat, Ploychanok;Kidkhunthod, Pinit;Bureekaew, Sareeya;Wattanakit, Chularat research published 《 Methane Utilization to Methanol by a Hybrid Zeolite@Metal-Organic Framework》, the research content is summarized as follows. The development of an effective approach for methane utilization, especially methane conversion to methanol is a crucial challenge that has remained unsolved satisfactorily. Herein, we propose an alternative concept of methane utilization to methanol over a Fe-ZSM-5@ZIF-8. The concept is to use the designed composite as a dual catalyst, in which ZIF-8 and Fe-ZSM-5 act simultaneously as gas adsorbent and catalytic function, resp. In this case, methane can be adsorbed on ZIF-8 at 50°C, and subsequently converted to methanol at a moderate temperature (150°C) on Fe-ZSM-5. Interestingly, the promising catalytic performance is observed on Fe-ZSM-5@ZIF-8, whereas only trace amount of produced methanol is detected on isolated Fe-ZSM-5 and ZIF-8. Moreover, the designed composite also benefits a facile methanol desorption at hydrophobic surface of the composite. This first example opens new promising horizons in combined perspectives for gas storage and catalytic process applications.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Synthetic Route of 10111-08-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . HPLC of Formula: 60-56-0.

Iñiguez-Ariza, Nicole M;Cuenca, Dalia;Franco-Granillo, Juvenal;Villalobos-Prieto, Alberto;Pineda-Díaz, Janet;Baquera-Heredia, Javier research published 《 Severe thyrotoxicosis as initial presentation of gastric choriocarcinoma: a case report.》, the research content is summarized as follows. BACKGROUND: Extragonadal choriocarcinoma is rare and can be associated with hyperthyroidism when producing very high levels of human chorionic gonadotropin. CASE PRESENTATION: A 62-year-old Hispanic female presented with a 3-week history of shortness of breath, palpitations, extreme weakness, new-onset hot flashes, and right flank pain. Her physical examination was remarkable for tachycardia, hepatomegaly, hyperreflexia, and tremor; goiter was absent. Laboratory studies revealed increased lactate dehydrogenase, alkaline phosphatase, suppressed thyroid stimulating hormone, very elevated T4, and absent thyroid stimulating immunoglobulin. ¹⁸F-fluorodeoxyglucose positron emission tomography-computed tomography exhibited hepatomegaly with multiple large fluorodeoxyglucose-avid liver masses and a focus of fluorodeoxyglucose avidity in the stomach with no structural correlate. A thyroid scan (^99mTcO ₄^– ) showed diffusely increased tracer uptake. She was started on propranolol and methimazole. Upon stabilization of severe thyrotoxicosis, upper endoscopy was performed, showing a ~ 5 cm bleeding lesion in the greater stomach curvature body; biopsy was consistent with choriocarcinoma; beta-human chorionic gonadotropin hormone was 2,408,171 mIU/mL. The patient received methotrexate followed by etoposide and cisplatin. Methimazole was titrated down, and upon liver failure the medication was stopped. The thyrotoxicosis was effectively controlled with antithyroid drug and concurrent chemotherapy. At ~ 1.5 months after initial diagnosis, the patient died due to bleeding/acute liver failure with coagulation defects followed by multiple organ failure. CONCLUSIONS: Severe thyrotoxicosis can represent an unusual initial presentation of metastatic choriocarcinoma in the setting of extreme elevation of beta-human chorionic gonadotropin. Primary gastric choriocarcinoma is an aggressive malignancy with very poor outcomes. The co-occurrence of severe thyrotoxicosis with advanced primary gastric choriocarcinoma and imminent liver failure complicates management options.

HPLC of Formula: 60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.

Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).

Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., 60-56-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Recommanded Product: Imidazole-4-carbaldehyde.

Jaafar, Amani;Platas-Iglesias, Carlos;Bilbeisi, Rana A. research published 《 Thiosemicarbazone modified zeolitic imidazolate framework (TSC-ZIF) for mercury(II) removal from water》, the research content is summarized as follows. Zeolitic imidazolate frameworks (ZIF-8), and their derivatives, have been drawing increasing attention due to their thermal and chem. stability. The remarkable stability of ZIF-8 in aqueous and high pH environments renders it an ideal candidate for the removal of heavy metals from wastewater. In this study, we present the preparation of novel aldehyde-based zeolitic imidazolate frameworks (Ald-ZIF) through the integration of mixed-linkers: 2-methylimidazole (MIM) and imidazole-4-carbaldehyde (AldIM). The prepared Ald-ZIFs were post-synthetically modified with bisthiosemicarbazide (Bisthio) and thiosemicarbazide (Thio) groups, incorporating thiosemicarbazone (TSC) functionalities to the core of the framework. This modification results in the formation of TSC-functionalized ZIF derivatives (TSC-ZIFs). Thiosemicarbazones are versatile metal chelators, hence, adsorption properties of TSC-ZIFs for the removal of mercury(II) from water were explored. Removal of mercury(II) from homoionic aqueous solutions, binary and tertiary systems in competition with lead(II) and cadmium(II) under ambient conditions and neutral pH are reported in this study. MIM3.5:Thio1:Zn improved the removal efficiency of mercury(II) from water, up to 97% in two hours, with an adsorption capacity of 1667 mg g-1. Desorption of mercury(II) from MIM3.5:Thio1:Zn was achieved under acidic conditions, regenerating MIM3.5:Thio1:Zn for five cycles of mercury(II) removal. TSC-ZIF derivatives, designed and developed here, represent a new class of dynamically functionalized adsorption material displaying the advantages of simplicity, efficiency, and reusability.

3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, Recommanded Product: Imidazole-4-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Quality Control of 1739-84-0.

Jablonski, Piotr;Nikjoo, Dariush;Warna, Johan;Irgum, Knut;Mikkola, Jyri-Pekka;Khokarale, Santosh Govind research published 《 Sustainable, highly selective, and metal-free thermal depolymerization of poly-(3-hydroxybutyrate) to crotonic acid in recoverable ionic liquids》, the research content is summarized as follows. Valorization of renewable and biodegradable biopolymers to value added chems. and green fuels is currently considered as an important research topic aiming at reducing the dependency on fossil derived feedstocks as well as their neg. consequences on the environment. In this report, we are introducing an ionic liquid (IL) mediated, sustainable, and green synthesis of crotonic acid (CA) from poly-(3-hydroxybutyrate, PHB), a biopolymer derived from microbial fermentation In this actual case, imidazolium cation comprising ILs have been used in the synthesis, where the influence of various reaction parameters such as reaction temperature and types of ILs as well as the amount of polymer, water, and IL in the reaction mixture were examined The conversion of PHB to CA in IL took place by a base catalyzed depolymerization with formation of crotonyl terminated polymeric entities as intermediates, a mechanism that was confirmed by NMR anal. of the reaction mixtures sampled when the reactions were carried out at various temperatures The rate of CA formation via the IL mediated base catalyzed depolymerization increased with increasing temperature in the tested interval, and 97% yield of CA was obtained after 90 min at 140°C. The [EMIM][AcO] IL applied as solvent and catalyst is capable of completely depolymerizing PHB to CA in 5 h at 120°C up to a polymer loading of 40 wt%. At higher loadings the depolymerization became incomplete, which is attributed to a deactivation of the IL due to hydrogen bonding interactions with the in situ formed CA, confirmed by NMR and DSC techniques. Since the depolymerization is base catalyzed, the only tested ILs that were able to form CA were based on acetate anions, whereas the less basic or neutral [EMIM][Cl] IL was found to be inactive. Finally, more than 90% of CA as well as [EMIM][AcO] IL were recovered in high purity by solvent extraction with brine (saturated aqueous NaCl) and 2-Me THF (2-Me-THF). Most importantly, here we introduce a sustainable, metal free, and single solvent based reaction approach for selective depolymerization of PHB to industrially valuable CA in basic and recoverable ILs.

Quality Control of 1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Computed Properties of 250285-32-6.

Jenkins, Aireal D.;Robo, Michael T.;Zimmerman, Paul M.;Montgomery, John research published 《 Nickel-Catalyzed Three-Component Cycloadditions of Enoates, Alkynes, and Aldehydes》, the research content is summarized as follows. A method for the three-component cycloaddition of aldehydes R¹CHO (R¹ = Ph, i-Pr), enoates PhOC(O)C(R²)=CHR³ (R² = H, Me; R³ = H, Me, Ph), and alkynes R⁴CCR⁵ (R⁴ = Me, n-Pr, (CH₂)₃OTBS, (CH₂)₂C(O)₂Me; R⁵ = Ph, n-Pr) has been developed. Building upon previous work by this group in which stoichiometrically generated metallacycles undergo alkylation, a catalytic, alkylative [3+2] cycloaddn was reported. From simple starting materials, structurally complex cyclopentenones I may be rapidly assembled. Computational investigation of the mechanism (ωB97X-D3/cc-pVTZ // ωB97X/6-31G(d)) identified three energetically feasible pathways. Based on the relative rates of ketene formation compared to isomerization to a 7-membered metallacycle, the most likely mechanism has been determined to occur “ketene-first”, with carbocyclization prior to aldol addition Deuterium labeling studies suggest that formation of the 7-membered metallacycle becomes possible when an α-substituted enoate is used. This observed change in selectivity is due to the increased difficulty of phenoxide elimination with the inclusion of addnl. steric bulk of the α-substituent. The net transformation results in a [3+2] cycloaddition accompanied by an alkylation of the enoate substituent.

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., Computed Properties of 250285-32-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Name: 1,2-Dimethyl-1H-imidazole.

Jheng, Li-Cheng;Cheng, Cheng-Wei;Ho, Ko-Shan;Hsu, Steve Lien-Chung;Hsu, Chung-Yen;Lin, Bi-Yun;Ho, Tsung-Han research published 《 Dimethylimidazolium-Functionalized Polybenzimidazole and Its Organic-Inorganic Hybrid Membranes for Anion Exchange Membrane Fuel Cells》, the research content is summarized as follows. A quaternized polybenzimidazole (PBI) membrane was synthesized by grafting a dimethylimidazolium end-capped side chain onto PBI. The organic-inorganic hybrid membrane of the quaternized PBI was prepared via a silane-induced crosslinking process with triethoxysilylpropyl dimethylimidazolium chloride. The chem. structure and membrane morphol. were characterized using NMR, FTIR, TGA, SEM, EDX, AFM, SAXS, and XPS techniques. Compared with the pristine membrane of dimethylimidazolium-functionalized PBI, its hybrid membrane exhibited a lower swelling ratio, higher mech. strength, and better oxidative stability. However, the morphol. of hydrophilic/hydrophobic phase separation, which facilitates the ion transport along hydrophilic channels, only successfully developed in the pristine membrane. As a result, the hydroxide conductivity of the pristine membrane (5.02 x 10^-2 S cm^-1 at 80°C) was measured higher than that of the hybrid membrane (2.22 x 10^-2 S cm^-1 at 80°C). The hydroxide conductivity and tensile results suggested that both membranes had good alk. stability in 2M KOH solution at 80°C. Furthermore, the maximum power densities of the pristine and hybrid membranes of dimethylimidazolium-functionalized PBI reached 241 mW cm^-2 and 152 mW cm^-2 at 60°C, resp. The fuel cell performance result demonstrates that these two membranes are promising as AEMs for fuel cell applications.

Name: 1,2-Dimethyl-1H-imidazole, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Product Details of C5H8N2.

Jia, Hu;Kang, Zheng;Li, Zhijie research published 《 Using 1,2 dimethylimidazole to improve gel thermalstability for wellbore plugging in ultra-high temperature fractured reservoirs》, the research content is summarized as follows. Working fluid loss as well as formation damage is usually encountered as a big challenge during well completion and workover for fossil-fuel production Polymer gel is widely used for wellbore plugging to isolate the working fluid and the reservoir for controlling fluid loss and protecting the reservoir. However, with the increasing number of ultra-high temperature well (>180 °C) operations, the thermal stability of the gel plug is increasingly required. In this paper, 1,2 dimethylimidazole (C₅H₈N₂) is first used to prepare a gel plug. The effects of C₅H₈N₂on gel gelation at dynamic heating mode, viscosity, elasticity, thermal stability and temporary plugging performances are evaluated at 190 °C. It is found that the addition of C₅H₈N₂does not affect the gelation, while a slightly viscosity-reducing effect is exhibited. At 190 °C, the gel without C₅H₈N₂ broke down within 4 h and lost its temporary plugging performance, while the gel with 20% imidazole remained unbroken after 60 h. For the fractured core (5 cm in length) plugging experiments, the addition of 15% C₅H₈N₂ significantly increased the breakthrough pressure of gels from 0.2 MPa to 1.9 MPa compared to pure gels (without C₅H₈N₂). The enhancement mechanism of C₅H₈N₂is investigated. Recommendations for the application of gels with C₅H₈N₂ are given in the paper. This paper provides an avenue for the development of gel plug to deal with wellbore temporary plugging jobs in ultra-high temperature fractured reservoirs.

Product Details of C5H8N2, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Name: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride.

Jia, Jie;Yuan, Fushan;Zhang, Zihao;Song, Xuejiao;Hu, Fangdong;Xia, Ying research published 《 Copper-Catalyzed Ring-Opening Defluoroborylation of gem-Difluorinated Cyclobutenes: A General Route to Bifunctional 1,3-Dienes and Their Applications》, the research content is summarized as follows. The exploration of the reactivity of gem-difluorinated small-size rings has continuously drawn attention in recent years but is limited to three-membered carbocycles. Herein, the authors report a Cu-catalyzed reaction of gem-fluorinated cyclobutenes with bis(pinacolato)diboron (B₂pin₂). A sequence of defluoroborylation and ring opening process produces B,F-bifunctional 1,3-dienes in a stereoselective manner. The transformation together with the efficient downstream coupling of the boronate and the fluoride moiety collectively constitutes a modular route to highly functionalized and stereocontrolled 1,3-dienes.

Name: 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Application In Synthesis of 60-56-0.

Giuliani, Cesidio;Verrocchio, Sara;Verginelli, Fabio;Bucci, Ines;Grassadonia, Antonino;Napolitano, Giorgio research published 《 Hormonal Regulation of the MHC Class I Gene in Thyroid Cells: Role of the Promoter “Tissue-Specific” Region.》, the research content is summarized as follows. In previous studies we have demonstrated that the expression of the Major Histocompatibility Complex (MHC) class I gene in thyrocytes is controlled by several hormones, growth factors, and drugs. These substances mainly act on two regions of the MHC class I promoter a “tissue-specific” region (-800 to -676 bp) and a “hormone/cytokines-sensitive” region (-500 to -68 bp). In a previous study, we have shown that the role of the “tissue-specific” region in the MHC class I gene expression is dominant compared to that of the “hormone/cytokines-sensitive” region. In the present report we further investigate the dominant role of the “tissue-specific” region evaluating the effect of thyroid stimulating hormone (TSH), methimazole (MMI), phenylmethimazole (C10), glucose and thymosin-α1. By performing experiments of electrophoretic mobility shift assays (EMSAs) we show that TSH, MMI and C10, which inhibit MHC class I expression, act on the “tissue-specific” region increasing the formation of a silencer complex. Glucose and thymosin-α1, which stimulate MHC class I expression, act decreasing the formation of this complex. We further show that the silencer complex is formed by two distinct members of the transcription factors families activator protein-1 (AP-1) and nuclear factor-kB (NF-kB), c-jun and p65, respectively. These observations are important in order to understand the regulation of MHC class I gene expression in thyroid cells and its involvement in the development of thyroid autoimmunity.

Application In Synthesis of 60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.

Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).

Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., 60-56-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). COA of Formula: C4H4N2O.

Gong, Pei-Xue;Xu, Fangning;Cheng, Lu;Gong, Xu;Zhang, Jie;Gu, Wei-Jin;Han, Wei research published 《 Iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabled aldehyde C-H methylation》, the research content is summarized as follows. A practical and general iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabling aldehyde C-H methylation for the synthesis of Me ketones has been developed. This mild, operationally simple method uses ambient air as the sole oxidant and tolerates sensitive functional groups for the late-stage functionalization of complex natural-product-derived and polyfunctionalized mols.

3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, COA of Formula: C4H4N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem