Category: imidazoles-derivatives

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Category: imidazoles-derivatives.

Dende, Satheesh Kumar;Korupolu, Raghu Babu;Leleti, Krishnakanth Reddy research published 《 Design and Synthesis of Sulfonamide-Attached 2-(Isoxazol-3-yl)-1H-imidazoles as Anticancer Agents》, the research content is summarized as follows. Library of 2-(isoxazol-3-yl)-1H-imidazole sulfonamides I [R = H, 4-Me, 3,4-di-Cl, etc.] were synthesized and structures were confirmed by ¹HNMR, ¹³CNMR and mass spectral anal. Further these compounds I were tested for their anticancer activity against four human cancer cell lines, such as MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) and A2780 (ovarian cancer) by MTT assay and etoposide used as pos. control. Among them, compounds I [R = 2,3,5-tri-MeO, 3,5-di-Cl, 4-MeO, 4-Cl, 4-CN, 4-NO₂, 3-NO₂] showed more potent anticancer activity against human cancer cell lines.

Category: imidazoles-derivatives, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Safety of 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride.

Deng, Hao;Dong, Yujie;Shangguan, Yu;Yang, Fazhou;Han, Sheng;Wu, Jiaqi;Liang, Bo;Guo, Hongchao;Zhang, Cheng research published 《 Copper-Catalyzed Three-Component Carboboronation of Allenes Using Highly Strained Cyclic Ketimines as Electrophiles》, the research content is summarized as follows. A diastereoselective copper and NHC-ligand-catalyzed three-component difunctionalization of allenes RCH:C:CH₂ with bis(pinacolato)diboron and 2H-azirines Ar¹CHC(N)CAr² to afford borylated allylaziridines Ar¹CHC(NH)CAr²CHRC(Bpin):CH₂ is described. The reaction exhibits complete diastereoselectivity and good yields, and the further chlorination of the corresponding borylated products was also performed. It is believed that the high ring-strain force of 2H-azirines facilitates the reaction. More chem. transformations of borylated allylaziridines are also reported.

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., Safety of 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Application of C4H6N2S.

Deshayes, Samuel;Dolladille, Charles;Dumont, Anael;Martin Silva, Nicolas;Chretien, Basile;De Boysson, Hubert;Alexandre, Joachim;Aouba, Achille research published 《 A Worldwide Pharmacoepidemiologic Update on Drug-Induced Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in the Era of Targeted Therapies》, the research content is summarized as follows. The literature supporting the role of a specific drug in the onset of drug-induced antineutrophil cytoplasmic antibody-associated vasculitis (AAV) mainly relies on case reports or short series and implicates old treatments. The advent of new treatments may have modified the epidemiol. of these adverse drug reactions. This study was undertaken to update the list of drugs associated with AAV by using a pharmacovigilance-based data mining approach. We collected data on adverse drug reactions reported using the Medical Dictionary for Regulatory Activities preferred term anti-neutrophil cytoplasmic antibody pos. vasculitis up to Nov. 2020 from the World Health Organization pharmacovigilance database (VigiBase). For each retrieved drug, a case-noncase anal. was performed, and disproportionate reporting was calculated by using the information component (IC). A pos. IC025 value, which is the lower end of the 95% credibility interval, was considered significant. A total of 483 deduplicated individual case safety reports of drug-induced AAV involving 15 drugs with an IC025 >0 were retrieved. Of the individuals with drug-induced AAV for whom data on sex were available (n = 371), 264 (71.2%) were women. The median age at onset of drug-induced AAV was 62 years (quartile 1 [Q1]-Q3 45-72 years), and the median time from the introduction of the suspected drug to the onset of drug-induced AAV was 9 mo (Q1-Q3 1-36 mo). Drug-induced AAV was considered serious in 472 (98.1%), and was fatal in 43 (8.9%), of 481 cases. The drugs associated with the highest disproportionate reporting were hydralazine, propylthiouracil, thiamazole, sofosbuvir, minocycline, carbimazole, mirabegron, and nintedanib. Our findings strengthen the evidence of an association of AAV with previously suspected drugs, but also identify 3 new drugs that may cause drug-induced AAV. Particular attention should be given to these drugs by prescribers and in exptl. studies.

60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.

Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).

Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., Application of C4H6N2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Recommanded Product: 1H-Imidazole-2-carbaldehyde.

Devlin, Rory;Jones, David J.;McGlacken, Gerard P. research published 《 One-Pot, Tandem Wittig Hydrogenation: Formal C(sp³)-C(sp³) Bond Formation with Extensive Scope》, the research content is summarized as follows. A one-pot, tandem Wittig hydrogenation of aldehydes with stabilized ylides is reported, representing a formal C(sp³)-C(sp³) bond construction. The tandem reaction operates under mild conditions, is high yielding, and is broad in scope. Chemoselectivity for olefin reduction is observed, and the methodol. is demonstrated in the synthesis of lapatinib analogs and a formal synthesis of (±)-cuspareine. Early insights suggest that the chemoselectivity observed in the reduction step is due to partial poisoning of the catalyst, after step one, thus adding to the power of the one-pot procedure.

Recommanded Product: 1H-Imidazole-2-carbaldehyde, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Formula: C5H8N2.

Deyko, Grigory S.;Glukhov, Lev M.;Kustov, Leonid M. research published 《 Hydrogen storage in organosilicon ionic liquids》, the research content is summarized as follows. New structures of ionic liquids have been studied as liquid organic hydrogen carriers. The hydrogenation of organosilicon compounds containing a carbazole fragment was carried out for the first time. The N-(CH₂)₃-Si fragment in the composition of the hydrogen carrier based on organosilicon moieties was found to be more suitable than the N-CH₂-Si bond. Ionic liquids with a carbazole fragment containing silicon atoms were synthesized for the first time. It was possible to significantly reduce the m.p. of such ionic liquids by introducing an organosilicon linker between carbazole nitrogen and imidazolium ion. The synthesized ionic liquid is a liquid at room temperature Hydrogenation-dehydrogenation experiments demonstrated that such ionic liquids are thermally stable up to at least 220°C, and nearly quant. conversion can be achieved. Both the hydrogenation and dehydrogenation processes were carried out using the same Pd/C catalyst. The theor. total gravimetric hydrogen capacities for synthesized ionic liquids are 2.05% and 1.58%.

Formula: C5H8N2, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Safety of 1-Methyl-1H-imidazole-2(3H)-thione.

di Filippo, Luigi;Castellino, Laura;Giustina, Andrea research published 《 Occurrence and response to treatment of Graves’ disease after COVID vaccination in two male patients》, the research content is summarized as follows. COVID-19 had dramatic impact worldwide and various vaccines anti-SARS-CoV-2 were rapidly developed. Despite a good safety profile in clin. trials, rare and severe side effects of vaccines have been reported, including thyroid dysfunctions. In particular, occurrence of Graves’ disease (GD) post-vaccination with Tozinameran (Pfizer-BioNTech) was reported in three female subjects and only one male prevalently in young-adult age somewhat reflecting the epidemiol. age and sex distribution of the disease. Reported here is the occurrence and the response to treatment of GD in two male patients after Vaxzevria (Oxford-AstraZeneca) SARS-CoV-2 vaccinations. Case 1 is of a previously healthy, past-smoker, 32-yr-old male patient, without any personal or family history of endocrine and autoimmune diseases, ten days after the second dose of Vaxzevria vaccine developed anxiety, tachycardia and palpitations, without signs of orbitopathy or local pain. Tyroid-function tests revealed decreased TSH with elevated free-T4 and free-T3 levels and elevated thy rotropin recept or-antibodies (TRAbs). After three months of therapy his thyroid function is currently normal and TRAbs levels halved on 100 mg/daily dose of propylthiouracil. Case 2 is of a reviously healthy, past-smoker, 35-yr-old male patient, without any personal or family history of endocrine and autoimmune disease, 5 days after the first dose of Vaxzevria vaccine developed headache, nausea, asthenia, palpitations, tachycardia, mild eyes-redness and superior palpebral retraction. Thyroid-function tests revealed sup- pressed TSH with elevated free-T4 and free-T3 levels and elevated TRAbs. After three months of therapy his thyroid function and TRAbs levels are currently normal on 5 mg/daily dose of thiamazole. It cannot be excluded also a possible influence of vitamin D status on GD occurrence after COVID-19 vaccination, although data on VD status in our patients were not available. In conclusion, although COVID-19 vaccination is currently not contraindicated in patients with stable autoimmune endocrine diseases,this data suggest a note of caution in administering a further vaccine dose to patients that developed GD in the first weeks after vaccination. Moreover, it is suggested to carefully consider if submitting patients with recent onset or non-stable GD to all types of COVID-19 vaccination.

60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.

Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).

Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., Safety of 1-Methyl-1H-imidazole-2(3H)-thione

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Computed Properties of 3034-50-2.

Ding, Chong-Wei;Luo, Wenzhi;Zhou, Jie-Yi;Ma, Xin-Jie;Chen, Guang-Hui;Zhou, Xiao-Ping;Li, Dan research published 《 Hydroxo Iron(III) Sites in a Metal-Organic Framework: Proton-Coupled Electron Transfer and Catalytic Oxidation of Alcohol with Molecular Oxygen》, the research content is summarized as follows. Metalloenzymes are powerful biocatalysts that can catalyze particular chem. reactions with high activity, selectivity, and specificity under mild conditions. Metal-organic frameworks (MOFs) composed of metal ions or metal clusters and organic ligands with defined cavities have the potential to impart enzyme-like catalytic activity and mimic metalloenzymes. Here, a new metal-organic framework implanted with hydroxo iron(III) sites with the structural and reactivity characteristics of iron-containing lipoxygenases is reported. Similar to lipoxygenases, the hydrogen atoms and electrons of the substrate can transfer to the hydroxo iron(III) sites, showing typical proton-coupled electron transfer behavior. In the reactivity mimicking biol. system, similar to alc. oxidase, the material also catalyzes the oxidation of alc. into aldehyde by using O₂ with a high yield and 100% selectivity under mild conditions, without the use of a radical cocatalyst or photoexcitation. These results provide strong evidence for the high structural fidelity of enzymically active sites in MOF materials, verifying that MOFs provide an ideal platform for designing biomimetic heterogeneous catalysts with high conversion efficiency and product selectivity.

Computed Properties of 3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Name: 1H-Imidazole-2-carbaldehyde.

Ding, Zhongpeng;Li, Feifei;Zhong, Changjiang;Li, Feng;Liu, Yuqian;Wang, Shixiao;Zhao, Jianchun;Li, Wenbao research published 《 Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer》, the research content is summarized as follows. To developed more potent anti-microtubule and cytotoxic derivatives, the co-crystal complexes of plinabulin derivatives (I) [R = H, Me, cyclopropyl, iso-Pr, tert-butyl; X = O, CO] and (II) [R¹= 2-furyl, cyclohexyl, 2-benzoimidazolyl, etc.; X = O; R¹= 5-methyl-2-furyl, 5-methoxymethyl-2-furyl; X = CO] were summarized and analyzed. The further modifications were performed the tert-Bu moiety or C-ring of imidazole-type derivatives to build a library of mols. through the introduction of different groups for novel skeletons. Our structure-activity relationship study indicated that compounds (II) [R¹= 5-methoxymethyl-2-furyl, X = O] (IC₅₀= 14.0 nM, NCI-H460) and [R¹= 5-methoxymethyl-2-furyl, X = CO] (IC₅₀= 2.9 nM, NCI-H460) with furan groups exhibited potent cytotoxic activities at the nanomolar level against various human cancer cell lines. In particular, the 5-Me or methoxymethyl substituent of furan group could replace the alkyl group of imidazole at the 5-position to maintain cytotoxic activity, contradicting previous reports that the tert-Bu moiety at the 5-position of imidazole was essential for the activity of such compounds Immunofluorescence assay indicated that compounds II [R¹= 5-methoxymethyl-2-furyl, X = O, CO] could efficiently inhibited microtubule polymerization Overall, the novel furan-diketopiperazine-type derivatives I and II could be considered as a potential scaffold for the development of anti-cancer drugs.

Name: 1H-Imidazole-2-carbaldehyde, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). HPLC of Formula: 3034-50-2.

Ding, Zhongpeng;Li, Feifei;Zhong, Changjiang;Li, Feng;Liu, Yuqian;Wang, Shixiao;Zhao, Jianchun;Li, Wenbao research published 《 Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer》, the research content is summarized as follows. To developed more potent anti-microtubule and cytotoxic derivatives, the co-crystal complexes of plinabulin derivatives (I) [R = H, Me, cyclopropyl, iso-Pr, tert-butyl; X = O, CO] and (II) [R¹= 2-furyl, cyclohexyl, 2-benzoimidazolyl, etc.; X = O; R¹= 5-methyl-2-furyl, 5-methoxymethyl-2-furyl; X = CO] were summarized and analyzed. The further modifications were performed the tert-Bu moiety or C-ring of imidazole-type derivatives to build a library of mols. through the introduction of different groups for novel skeletons. Our structure-activity relationship study indicated that compounds (II) [R¹= 5-methoxymethyl-2-furyl, X = O] (IC₅₀= 14.0 nM, NCI-H460) and [R¹= 5-methoxymethyl-2-furyl, X = CO] (IC₅₀= 2.9 nM, NCI-H460) with furan groups exhibited potent cytotoxic activities at the nanomolar level against various human cancer cell lines. In particular, the 5-Me or methoxymethyl substituent of furan group could replace the alkyl group of imidazole at the 5-position to maintain cytotoxic activity, contradicting previous reports that the tert-Bu moiety at the 5-position of imidazole was essential for the activity of such compounds Immunofluorescence assay indicated that compounds II [R¹= 5-methoxymethyl-2-furyl, X = O, CO] could efficiently inhibited microtubule polymerization Overall, the novel furan-diketopiperazine-type derivatives I and II could be considered as a potential scaffold for the development of anti-cancer drugs.

3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, HPLC of Formula: 3034-50-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Recommanded Product: 1,2-Dimethyl-1H-imidazole.

Domanski, Michal;Zurauskas, Jonas;Barham, Joshua P. research published 《 Tunable Microwave Flow System for Scalable Synthesis of Alkyl Imidazolium-type Ionic Liquids》, the research content is summarized as follows. A continuous flow auto-frequency tuning single-mode microwave reactor is disclosed as a powerful platform to synthesize alkyl imidazolium salts, e.g., I and II, as ionic liquids/ionic liquid precursors in up to near-quant. yields, 100-600 g h^-1 productivities with record space-time yields. Challenges faced, including viscosity changes, dielec. property changes, and phase separation, were addressed by different operation modes of the reactor without reactor redesigning. Depending on the purpose, this highly productive method could prove to be useful for intensive applications of ionic liquids

1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., Recommanded Product: 1,2-Dimethyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem