Category: imidazoles-derivatives

NMR Quantification of Halogen-Bonding Ability To Evaluate Catalyst Activity was written by Chang, Yun-Pu;Tang, Teresa;Jagannathan, Jake R.;Hirbawi, Nadia;Sun, Shaoming;Brown, Jonah;Franz, Annaliese K.. And the article was included in Organic Letters in 2020.Safety of 1-Methylbenzimidazole This article mentions the following:

Quantification of halogen-bonding abilities is described for a series of benzimidazolium-, imidazolium- and bis(imidazolium) halogen-bond donors (XBDs) using ³¹P NMR spectroscopy. The measured Δδ(³¹P) values correlate with calculated activation free energy ΔG^{â€?/sup> and catalytic activity for a Friedel-Crafts indole addition This rapid method also serves as a sensitive indicator for Bronsted acid impurities. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Safety of 1-Methylbenzimidazole).}

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Safety of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dichlorophenylacrylonitriles as AhR Ligands That Display Selective Breast Cancer Cytotoxicity in vitro was written by Baker, Jennifer R.;Gilbert, Jayne;Paula, Stefan;Zhu, Xiao;Sakoff, Jennette A.;McCluskey, Adam. And the article was included in ChemMedChem in 2018.Category: imidazoles-derivatives This article mentions the following:

Knoevenagel condensation of 3,4-dichloro- and 2,6-dichlorophenylacetonitriles gave a library of dichlorophenylacrylonitriles. Our leads (Z)-2-(3,4-dichlorophenyl)-3-(1H-pyrrol-2-yl)acrylonitrile (5) and (Z)-2-(3,4-dichlorophenyl)-3-(4-nitrophenyl)acrylonitrile (6) displayed 0.56±0.03 and 0.127±0.04 μM growth inhibition (GI₅₀) and 260-fold selectivity for the MCF-7 breast cancer cell line. A 2,6-dichlorophenyl moiety saw a 10-fold decrease in potency; addnl. nitrogen moieties (-NO₂) enhanced activity (Z)-2-(2,6-dichloro-3-nitrophenyl)-3-(2-nitrophenyl)acrylonitrile (26) and (Z)-2-(2,6-dichloro-3-nitrophenyl)-3-(3-nitrophenyl)acrylonitrile (27), with the corresponding -NH₂ analogs (Z)-2-(3-amino-2,6-dichlorophenyl)-3-(2-aminophenyl)acrylonitrile (29) and (Z)-2-(3-amino-2,6-dichlorophenyl)-3-(3-aminophenyl)acrylonitrile (30) being more potent. Despite this, both 29 (2.8±0.03 μM) and 30 (2.8±0.03 μM) were found to be 10-fold less cytotoxic than 6. A bromine moiety effected a 3-fold enhancement in solubility with (Z)-3-(5-bromo-1H-pyrrol-2-yl)-2-(3,4-dichlorophenyl)acrylonitrile 18 relative to 5 at 211 μg mL^-1. Modeling-guided synthesis saw the introduction of 4-aminophenyl substituents (Z)-3-(4-aminophenyl)-2-(3,4-dichlorophenyl)acrylonitrile (35) and (Z)-N-(4-(2-cyano-2-(3,4-dichlorophenyl)vinyl)phenyl)acetamide (38), with resp. GI₅₀ values of 0.030±0.014 and 0.034±0.01 μM. Other analogs such as 35 and 36 were found to have sub-micromolar potency against our panel of cancer cell lines (HT29, colon; U87 and SJ-G2, glioblastoma; A2780, ovarian; H460, lung; A431, skin; Du145, prostate; BE2-C, neuroblastoma; MIA, pancreas; and SMA, murine glioblastoma), except compound 38 against the U87 cell line. A more extensive evaluation of 38 ((Z)-N-(4-(2-cyano-2-(3,4-dichlorophenyl)vinyl)phenyl)acetamide) in a panel of drug-resistant breast carcinoma cell lines showed 10-206 nM potency against MDAMB468, T47D, ZR-75-1, SKBR3, and BT474. Mol. Operating Environment docking scores showed a good correlation between predicted binding efficiencies and observed MCF-7 cytotoxicity. This supports the use of this model in the development of breast-cancer-specific drugs. In the experiment, the researchers used many compounds, for example, 1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4Category: imidazoles-derivatives).

1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On the relation between reorientation and diffusion in glass-forming ionic liquids with micro-heterogeneous structures was written by Becher, Manuel;Steinruecken, Elisa;Vogel, Michael. And the article was included in Journal of Chemical Physics in 2019.Recommanded Product: 404001-48-5 This article mentions the following:

We investigate complex structure-dynamics relations in glass-forming ionic liquids comprising 1-alkyl-3-methylimidazolium cations and bis(trifluoromethylsulfonyl)imide anions. In doing so, we exploit the microheterogeneous structures emerging when the alkyl length is increased in the range n = 1-12 and use that ^1H and ²H NMR give information about cation dynamics, while ¹⁹F NMR reports on anion motions. Furthermore, we combine spin-lattice relaxation anal., including field-cycling relaxometry, with stimulated-echo experiments to follow reorientation dynamics related to structural relaxation in wide dynamic ranges and we apply static field gradients to probe translational diffusion. The resulting correlation times τ and diffusion coefficients D show Vogel-Fulcher-Tammann temperature dependence. Moreover, they indicate a moderate slowdown of both cation and anion dynamics with increasing alkyl length n. However, the relative diffusivities of the ionic species depend on the cation size, where cations are more mobile for n < 6 and anions for n > 6. Finally, we relate rotational and translational motions in the framework of the Stokes-Einstein-Debye (SED) approach. We find that the SED relation is obeyed for anion dynamics in all samples, while it breaks down for cation dynamics when n is increased. The origin of this SED breakdown is shown to differ fundamentally from that reported previously for conventional glass formers. We argue that an emergence of cation clusters causes a retardation of cation diffusion relative to cation reorientation upon cooling, i.e., the studied ionic liquids show a complex interplay of structural and dynamical properties. (c) 2019 American Institute of Physics. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Recommanded Product: 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Connection between dielectric constant and total number of hydrogen-bond groups per cation-anion pair in ionic liquids was written by Shi, Baoli. And the article was included in Journal of Molecular Liquids in 2020.Application of 35487-17-3 This article mentions the following:

This paper reports a quant. connection between the dielec. constant and calculated total number of hydrogen-bond groups per cation-anion pair for 44 ionic liquids, including 15 ionic liquids with high dielec. constants exceeding 20. The total number of hydrogen-bond groups per cation-anion pair was equal to the addition of the hydrogen-bond group number per cation and per anion. The methylene group could reduce the group number capable of forming hydrogen bonds, and one methylene group caused a decrease of 1 hydrogen-bond number Regardless of whether a liquid was ionic or non-ionic liquid, approx. linear relationship were observed between dielec. constant and total hydrogen-bond number per mol. For ionic liquids, an increase of 1 in the total number of hydrogen-bond groups per cation-anion pair resulted in an increase of approx. 8.5 in the dielec. constant For non-ionic liquids, the value was approx. 21.9. The average molar d. of nine hydrogen-bonded ionic liquids with high dielec. constants was 9.3 x 10³ mol/m³, while the average molar d. of eight non-ionic liquids with hydrogen-bonds was 21.1 x 10³ mol/m³. The 21.1 M d. coefficient of the non-ionic liquids was almost equal to the 21.9 coefficient in the dielec. constant equation, and the 9.3 M d. coefficient of the ionic liquids was very close to the 8.5 coefficient in its dielec. constant equation. This result indicated that the effect mechanisms of the intermol. hydrogen-bond structure on dielec. constant were similar for the two types of liquids In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Application of 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nitroimidazole-based ‘extruded mustards’ designed as reductively activated hypoxia-selective cytotoxins was written by Hay, Michael P.;Denny, William A.;Wilson, William R.. And the article was included in Anti-Cancer Drug Design in 1996.Synthetic Route of C5H5N3O4 This article mentions the following:

A new class of nitroimidazole alkanoic acid amides, designed to extrude para-aminophenyl mustard by intramol. cyclization following reduction of the nitro group, have been prepared and evaluated for their ability to function as bioreductively activated prodrugs. The mechanism of activation following (bio)reduction was studied using the model compounds and the related mustard analogs. However, the reduced forms of these compounds were relatively stable and not susceptible to intramol. cyclization. This is in contrast to the corresponding 2-nitrophenylalkyl amides, where the hydroxylamino or amino reduction products undergo intramol. cyclization via a tetrahedral intermediate, resulting in cleavage of the amide and release of an activated aromatic mustard. One of the 2-nitroimidazole mustards (I) had 20-fold greater toxicity towards aerobic AA8 cells than RB 6145, and a 51-fold greater toxicity towards UV4 cells (which are defective in DNA cross-link repair and thus hypersensitive to crosslinking agents). The cytotoxicity of I against AA8 cells was enhanced 3.3-fold under hypoxic conditions, but the compound was inactive against the hypoxic subfraction of cells in KHT tumors in vivo. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Synthetic Route of C5H5N3O4).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Synthetic Route of C5H5N3O4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Development and evaluation of rapidly disintegrating tablets of Candesartan was written by Ansari, Mohammad Pravej;Iqbal, Majid Md.;Saraswat, Rohit. And the article was included in World Journal of Pharmaceutical Research in 2019.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

In the present work, Rapidly disintegrating tablets of Cadesartan cilexetil were designed with a view to enhance patient compliance by direct compression method. In the direct compression method, crospovidone, croscarmellose sodium, sodium starch glycolate as superdisintegrants were used along with Sweeteners and flavours were used to enhance the organoleptic properties of tablet. Tablets were prepared by direct compression technique. Directly compressible microcrystalline cellulose to enhance mouth feel. Prepared tablets were evaluated for thickness, uniformity of weight, hardness, friability, wetting time, in -vitro disintegration time, drug content and in vitro drug release. Short-term stability (40°C / 75% RH for 3 mo) and drug-excipient interaction study (IR spectroscopy) are also were studied. Disintegration time and drug release were taken as the basis to optimize the rapidly disintegrating tablet. All the formulations were evaluated for the influence of disintegrates and their concentrations on the characteristics of rapid disintegrating tablets mainly in terms of disintegration time and dissolution studies. The disintegration time of all formulation showed less than 37 s. Among the three superdisintegrants used, Crospovidon showed less disintegrating time followed by croscarmellose sodium and sodium starch gycolate. The relative efficiency of different superdisintegrants to improve the drug rate of tablets was in order, crospovidon > Croscarmellose sodium > sodium starch gycolate. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex was written by Harrison, David E.;Strong, Randy;Reifsnyder, Peter;Kumar, Navasuja;Fernandez, Elizabeth;Flurkey, Kevin;Javors, Martin A.;Lopez-Cruzan, Marisa;Macchiarini, Francesca;Nelson, James F.;Bitto, Alessandro;Sindler, Amy L.;Cortopassi, Gino;Kavanagh, Kylie;Leng, Lin;Bucala, Richard;Rosenthal, Nadia;Salmon, Adam;Stearns, Timothy M.;Bogue, Molly;Miller, Richard A.;Markewych, Adrian. And the article was included in Aging Cell in 2021.Reference of 145040-37-5 This article mentions the following:

In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the “non-feminizing” estrogen, 17-α-estradiol (17aE2), extended median male lifespan by 19% (p < 0.0001, log-rank test) and 11% (p = 0.007) when fed at 14.4 ppm starting at 16 and 20 mo, resp. 90th percentile lifespans were extended 7% (p = 0.004, Wang-Allison test) and 5% (p = 0.17). Body weights were reduced about 20% after starting the 17aE2 diets. Four other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranylacetone, and MIF098. Despite some data suggesting that nicotinamide riboside would be effective, neither it nor the other three increased lifespans significantly at the doses tested. The 17aE2 results confirm and extend our original reports, with very similar results when started at 16 mo compared with mice started at 10 mo of age in a prior study. The consistently large lifespan benefit in males, even when treatment is started late in life, may provide information on sex-specific aspects of aging. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Reference of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic liquids and cyclodextrin inclusion complexes: limitation of the affinity capillary electrophoresis technique was written by Mofaddel, Nadine;Fourmentin, Sophie;Guillen, Frederic;Landy, David;Gouhier, Geraldine. And the article was included in Analytical and Bioanalytical Chemistry in 2016.Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

The state of the art of inclusion complex formation between cyclodextrins and ionic liquids is reported. Mechanisms, stoichiometries, and binding constants are summarized and classified by anion. We investigated the supramol. interactions between the β-cyclodextrin cavity and six ionic liquids based on 1-dodecyl-3-methylimidazolium by affinity capillary electrophoresis and compared the results with those obtained by isothermal titration calorimetry. We show that the presence of basic or acidic buffers leads to a metathesis reaction, underlining the limitation of the affinity capillary electrophoresis technique. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New class of non-symmetrical homo-dibenzimidazolium salts and their dinuclear Silver(I) di-NHC complexes was written by Haziz, Umie F. M.;Haque, Rosenani A.;Amirul, A. A.;Aidda, O. Noor;Razali, Mohd. R.. And the article was included in Journal of Organometallic Chemistry in 2019.Electric Literature of C8H8N2 This article mentions the following:

This work describes the synthesis of an uncommon non-sym. dibenzimidazolium salts as a precursor for the dinuclear Ag(I) di-NHC complexes with a formula of [Ag₂L₂]·2PF₆ (L = NHC = bis-N-heterocyclic carbene). Through the reaction of 3-(2-bromoethyl)-1-butylbenzimidazole bromide with n-alkylbenzimidazole (alkyl = Me, Et, Pr, pentyl, hexyl, heptyl, benzyl), seven non-sym. dibenzimidazolium bromide salts, 1–3 and 5–8 were obtained. The sym. dibenzimidazolium bromide salt 4 was obtained either as a minor product or through the reaction between n-butylbenzimidazole with 1,2-dibromoethane in 2:1 M ratio. Salts 1–8 were then reacted with Ag₂O via in-situ deprotonation method to facilitate the formation of dinuclear Ag(I) di-NHC complexes, 9–16. The formation of these complexes is confirmed by the disappearance of both H2′ peaks in ¹H NMR and the presence of carbene peaks in the range of 187-191 ppm in the ¹³C NMR of the complexes. From single crystal X-ray diffraction study, complex 16 is determined to be a dinuclear complex bearing dicarbene ligands which is further stabilized by significant argentophilic interaction with the separation of Ag···Ag being 3.358(5) Å. All the bis-benzimidazolium salts 1–8 show no activities while all dinuclear Ag(I) di-NHC complexes, 9–16 show medium to higher activities against E. coli (ATCC 25922) and S. aureus (ATCC 12600) compared to the standard antibiotic drug, Ampicillin. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lewis Acid Induced Toggle from Ir(II) to Ir(IV) Pathways in Photocatalytic Reactions: Synthesis of Thiomorpholines and Thiazepanes from Aldehydes and SLAP Reagents was written by Hsieh, Sheng-Ying;Bode, Jeffrey W.. And the article was included in ACS Central Science in 2017.Category: imidazoles-derivatives This article mentions the following:

The authors report that the inclusion of Lewis acids in photocatalytic reactions of organosilanes allows access to a distinct reaction pathway featuring an Ir(III)^*/Ir(IV) couple instead of the previously employed Ir(III)^*/Ir(II) pathway, enabling the transformation of aromatic and aliphatic aldehydes to thiomorpholines and thiazepanes. The role of the Lewis acid in accepting an electron-either directly or via coordination to an imine-can be extended to other classes of photocatalysts and transformations, including oxidative cyclizations. The combination of light induced reactions and Lewis acids therefore promises access to new pathways and transformations that are not viable using the photocatalysts alone. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Category: imidazoles-derivatives).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem