Category: imidazoles-derivatives

Adsorption and purification of baicalin from Scutellaria baicalensis georgi extract by Ionic liquids (ILs) grafted silica was written by Fan, Yunchang;Wu, Di;Zhang, Sheli. And the article was included in Molecules in 2021.Recommanded Product: 79917-89-8 This article mentions the following:

Baicalin which has multiple biol. activities is the main active component of the root of Scutellaria baicalensis Georgi (SBG). Although its isolation and purification by adsorption methods have aroused much interest of the scientific community, it suffered from the poor selectivity of the adsorbents. In this work, an environmentally benign method was developed to prepare ionic liquids (ILs) grafted silica by using IL 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([C₂mim]NTf₂) and ethanol as reaction media. The IL 1-propyl-3-methylimidazolium chloride ([C₃mim]Cl) grafted silica ([C₃mim]+Cl-@SiO₂) was used to adsorb and purify baicalin from the root extract of Scutellaria baicalensis Georgi (SBG). Exptl. results indicated that the adsorption equilibrium can be quickly achieved (within 10 min). The adsorption behavior of [C₃mim]+Cl-@SiO₂ for baicalin was in good agreement with Langmuir and Freundlich models and the adsorption was a physisorption process as suggested by Dubinin-Radushkevich model. Compared with com. resins, [C₃mim]+Cl-@SiO₂ showed the strongest adsorption ability and highest selectivity. After desorption and crystallization, a purity of baicalin as high as 96.5% could be obtained. These results indicated that the ILs grafted silica materials were promising adsorbents for the adsorption and purification of baicalin and showed huge potential in the purification of other bioactive compounds from natural sources. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Recommanded Product: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formulation and evaluation of candesartan cilexetil loaded solid lipid nanoparticles with improved bioavailability was written by Bagul, U. S.;Tagalpallewar, A. A.;Kshirsagar, A. A.. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2022.Recommanded Product: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

In this present work, BCS class II Candesartan celexitil, as an angiotensin receptor blocker used mainly for the treatment of high blood pressure and congestive heart failure, was successfully loaded in the solid lipid nanoparticles (SLNs) by using hot high-speed homogenization method. The SLN formulations were prepared and optimized by Box Benhken design study. The SLN was characterized by Nanophox size analyzer and Delsa nano C zetameter. The SLN was also evaluated for particle size, zeta potential, entrapment efficiency, drug loading, surface morphol., and in-vitro dissolution study. The average particle size, zeta potential, percentage entrapment efficiency, and drug loading were found to be 177nm, -8.23 mV, 95.72%, and 8.23%, resp. The dissolution study of SLN showed 92.07% released in six hours compared to 46.89% release from the pure drug, which indicates a significant improvement in the bioavailability. The release of the drug from SLN showed zero-order kinetics. The stability study was also carried out and found to be stable after three months. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Recommanded Product: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of Hetaryl-Substituted Asymmetric Porphyrins and Their Affinity to SARS-CoV-2 Helicase was written by Syrbu, S. A.;Kiselev, A. N.;Lebedev, M. A.;Gubarev, Yu. A.;Yurina, E. S.;Lebedeva, N. Sh.. And the article was included in Russian Journal of General Chemistry in 2021.Category: imidazoles-derivatives This article mentions the following:

Novel porphyrin compounds containing benzothiazole, benzoxazole, and benzimidazole moieties have been prepared and their structures have been confirmed. Mol. docking of non-sym. hetaryl-substituted porphyrins and chlorin e6 with SARS-CoV-2 helicase has been carried out. The affinity of hetaryl-substituted porphyrins to this protein has been found significantly higher than that of the drugs approved by the FDA and chlorin e6. The structure of the complexes of SARS-CoV-2 helicase with the considered macroheterocyclic compounds has been analyzed. Possible ways to inhibit and photoinactivate SARS-CoV helicase have been suggested basing on the localization of porphyrins and chlorin e6 in the helicase domains. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Category: imidazoles-derivatives).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation of 1-methyl-2,4,5-trinitroimidazole from derivatives of 1-methylimidazole and its oxidation under nitration conditions was written by Lian, Peng-Bao;Chen, Jian;Chen, Li-Zhen;Zhao, Chong-Yang;Wang, Jian-Long;Shen, Fen-Fen. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2020.Product Details of 3034-41-1 This article mentions the following:

1-Methylimidazole, 1-methyl-4-nitroimidazole, 1-methyl-5-nitroimidazole, or 1-methyl-4,5-dinitroimidazole gave a mixture of 1-methyl-4,5-dinitroimidazole and 1-methyl-2,4,5-trinitroimidazole under the volume ratio of HNO₃ to H₂SO₄ of 1:3 at 80° temperature for 2.5 h, and the highest unisolated yield of 1-methyl-2,4,5-trinitroimidazole was 2.4%. 1-Methyl-2,4,5-trinitroimidazole was prepared from 1-methyl-2-nitroimidazole, 1-methyl-2,4-dinitroimidazole, or 1-methyl-2,5-dinitroimidazole under the same conditions, and the yields were 65, 76, and 82%, resp. However, when the ratio of HNO₃ to H₂SO₄ was 1:5 and reaction was carried out at 120° for 2.5 h, only 1-methyl-4,5-dinitroimidazole was obtained from 1-methylimidazole, 1-methyl-4-nitroimidazole, or 1-methyl- 5-nitroimidazole in yields 43, 64, and 81%, resp. 1-Methyl-2-nitroimidazole, 1-methyl-2,4-dinitroimidazole, or 1-methyl- 2,5-dinitroimidazole gave 1-methylimidazolidine-2,4,5-trione under the same conditions, the yields were 61, 63, and 65%, resp. Meanwhile, 1-methylimidazolidine-2,4,5-trione was obtained from 1-methyl-2,4,5-trinitroimidazole. Under strong nitration conditions, the nitro group at the C-2 position is a key substituent to promote oxidation of the imidazole ring. The possible reaction mechanism for the formation of 1-methylimidazolidine-2,4,5-trione from 1-methyl-2,4,5-trinitroimidazole is given. The structure of 1-methylimidazolidine-2,4,5-trione was further confirmed by single crystal X-ray diffraction. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Product Details of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Product Details of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Selection, synthesis, and structure-activity relationship of tetrahydropyrido[4,3-d]pyrimidine-2,4-diones as human GnRH receptor antagonists was written by Lanier, Marion C.;Feher, Miklos;Ashweek, Neil J.;Loweth, Colin J.;Rueter, Jaimie K.;Slee, Deborah H.;Williams, John P.;Zhu, Yun-Fei;Sullivan, Susan K.;Brown, Michael S.. And the article was included in Bioorganic & Medicinal Chemistry in 2007.Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

Tetrahydropyrido[4,3-d]pyrimidine-2,4-diones are prepared as potential human gonadotropin-releasing hormone receptor (hGnHR) antagonists; the choice of the tetrahydropyridopyrimidine core for hGnHR antagonists was determined computionally, with the highest scoring templates used for the preparation of potential hGnHR antagonists. Virtual templates were tested using three computational methods; the outputs of the methods were combined to yield a consensus score which is used to order the templates. The 5% of templates which scored most highly were further evaluated in silico and assessed for novelty and synthetic accessibility. After two rounds of optimization, tetrahydropyrido[4,3-d]pyrimidine-2,4-diones such as the trifluoroacetate salts of I (R = 4-Cl-2-MeC₆H₃CH₂, 2,4-Me₂C₆H₃) are prepared with K_i values for inhibition of the human gonadotropin-releasing hormone receptor of < 10 nM. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enzymatic Production of Biodiesel from Millettia pinnata Seed Oil in Ionic Liquids was written by Huang, Ze-Lin;Yang, Tao-Xiang;Huang, Jian-Zi;Yang, Zhen. And the article was included in BioEnergy Research in 2014.COA of Formula: C18H31F6N3O4S2 This article mentions the following:

Millettia pinnata seed oil has been identified as a promising sustainable feedstock for biodiesel production Oils extracted from the seeds grown in freshwater and seawater habitats showed no significant differences in their physicochem. properties. The enzymic methanolysis of the oil has been investigated in the ionic liquid (IL) [BMIm][PF₆] (1-butyl-3-methylimidazolium hexafluorophosphate) as compared to tert-butanol, catalyzed by Penicillium expansum lipase (PEL) and Candida antarctica lipase B (Novozym 435). Under optimal conditions, PEL induced much higher yields in the IL than in tert-butanol, while in the IL PEL-catalyzed conversions were higher than those catalyzed by Novozym 435. The catalytic processes were improved by recycling both the enzyme (Novozym 435) and the IL ([BMIm][PF₆]) and by searching for new enzymes and new ILs. The impact of ILs on biodiesel production has been discussed, and the interactions between the IL, the substrate, and the enzyme are believed to play an important role in governing the conversion. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5COA of Formula: C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of dielectric constant on estimation of properties of ionic liquids: an analysis of 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide was written by Olmo, Lourdes del;Lage-Estebanez, Isabel;Lopez, Rafael;Garcia de la Vega, Jose M.. And the article was included in RSC Advances in 2015.Reference of 404001-48-5 This article mentions the following:

A series of different cationic structures based on 1-alkyl-3-methylimidazolium were combined with a single anion, bis(trifluoromethylsulfonyl)imide (C_nmimNTf₂, n = 1 to 12) for analyzing the quality of COSMO-RS based estimations For this purpose, we have studied the structure as well as the estimations of several properties of one ionic liquid (IL). These estimations are obtained from polarization charge distribution in which the IL is embedded. Special attention has been paid to the effect of the dielec. constant value in the predictions. For this purpose, polarization charge d. has been modeled using several values of dielec. constant, and properties have been estimated in each case. Thus, σ-profiles and, σ-potentials have been computed and used with COSMO-RS for estimating vapor pressure, as a function of temperature, as well as theor. values of vaporization enthalpy, d., and viscosity at 298.15 K. The influence of the length of the alkyl chain of ionic liquid in the estimation of these properties has also been tested. Finally, the results have been compared with exptl. data. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Reference of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In Situ Formation of Frustrated Lewis Pairs in a Water-Tolerant Metal-Organic Framework for the Transformation of CO₂ was written by Shyshkanov, Serhii;Nguyen, Tu N.;Ebrahim, Fatmah Mish;Stylianou, Kyriakos C.;Dyson, Paul J.. And the article was included in Angewandte Chemie, International Edition in 2019.Category: imidazoles-derivatives This article mentions the following:

Herein, a bulky Lewis acid-functionalized ligand incorporated into a water-tolerant metal-organic framework (MOF), named SION-105 and employing Lewis basic diamine substrates for the in situ formation of FLPs within the MOF. Using CO₂ as a C1-feedstock, this combination allowed for the efficient transformation of a variety of diamine substrates into benzimidazoles. SION-105 could be easily recycled by washing with MeOH and reused multiple times without losing its identity and catalytic activity, highlighting the advantage of the MOF approach in FLP chem. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Category: imidazoles-derivatives).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of O,C-dilithium derivatives of 2-(α-hydroxyalkyl)-1-methylbenzimidazoles was written by Morkovnik, A. S.;Tertov, B. A.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) in 2001.Related Products of 3012-80-4 This article mentions the following:

Methylbenzimidazoles reacted with lithionaphthalene and lithium in THF forming dilithiated methylbenzimidazole derivatives which reacted with benzaldehyde yielding (methylbenzimidazolyl)phenylalkyldiols. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Related Products of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Odd-even effect on the formation of aqueous biphasic systems formed by 1-alkyl-3-methylimidazolium chloride ionic liquids and salts was written by Belchior, Diana C. V.;Sintra, Tania E.;Carvalho, Pedro J.;Soromenho, Mario R. C.;Esperanca, Jose M. S. S.;Ventura, Sonia P. M.;Rogers, Robin D.;Coutinho, Joao A. P.;Freire, Mara G.. And the article was included in Journal of Chemical Physics in 2018.Product Details of 79917-89-8 This article mentions the following:

This work provides a comprehensive evaluation of the effect of the cation alkyl side chain length of the 1-alkyl-3-methylimidazolium chloride series ([C_nC₁i.m.]Cl, n = 2-14) of ionic liquids (ILs) on their capability to form aqueous biphasic systems (ABSs) with salts and self-aggregation derived properties. The liquid-liquid phase behavior of ternary systems composed of [C_nC₁i.m.]Cl, water, and K₃PO₄ or K₂CO₃ and the resp. Setschenow salting-out coefficients (k_s), a quant. measure of the two-phase formation ability, were determined An odd-even effect in the k_s values along the number of methylene groups of the longest IL cation alkyl side chain was identified for the ABS formed by K₂CO₃, a weaker salting-out agent where the phenomenon is clearly identified. In general, cations with even alkyl side chains, being likely to display higher molar volumes, are more easily salted-out and thus more prone to undergo phase separation The odd-even effect in the k_s values is, however, more significant in ILs up to n = 6, where the nanostructuration/nanosegregation of ILs plays a less relevant role. Still, with the [C_nC₁i.m.]Cl (n = 7-14) series of ILs, an odd-even effect was also identified in the ILs’ ionization degree, molar conductivity, and conductivity at infinite dilution In summary, it is shown here that the ILs’ odd-even effect occurs in IL aqueous solutions and not just in neat ILs, an already well-established phenomenon occurring in a series of ILs’ properties described as a result of the orientation of the terminal Me groups to the imidazolium ring cation and consequent effect in the ILs’ cohesive energy. (c) 2018 American Institute of Physics. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Product Details of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Product Details of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem