Category: imidazoles-derivatives

Catalytic Behavior of Au Confined in Ionic Liquid Film: A Kinetics Study for the Hydrochlorination of Acetylene was written by Wang, Bolin;Zhang, Haifeng;Yue, Yuxue;Li, Changlin;Zhao, Jia. And the article was included in Catalysts in 2022.Recommanded Product: 79917-89-8 This article mentions the following:

A systematic study of the kinetics of supported-ionic-liquid-phase (SILP) Au catalysis (Au-IL/AC) has been established in the continuous gas-phase hydrochlorination of acetylene. We reveal that the effect of ionic liquid (IL) film on substrate diffusion can be eliminated. The reaction order of the catalyst indicates that Au is confirmed to exist as a monomer in the IL film of the Au-IL/AC system, which is different from the fast equilibrium of the “Au dimer and monomer” for the classical Au/AC catalyst. The homogeneous reaction micro-environment is confirmed for Au-IL/AC since the activation energy was little changed under both heterogeneous and homogeneous catalysis, further verifying the monat. characteristics of Au in Au-IL/AC. Due to the supported IL film, the reaction order of hydrogen chloride was decreased from 1 to 0.5 while creating a hydrogen chloride enrichment system around Au, which provides the possibility of producing vinyl chloride with an equal substrates feed ratio. This kinetic-perspective-based revelation of the catalytic behavior of the metal active sites confined in IL film enriches and expands the SILP catalytic system for acetylene hydrochlorination. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Recommanded Product: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Interaction of Ionic Liquids with a Lipid Bilayer: A Biophysical Study of Ionic Liquid Cytotoxicity was written by Jing, Benxin;Lan, Nan;Qiu, Jie;Zhu, Yingxi. And the article was included in Journal of Physical Chemistry B in 2016.Related Products of 404001-48-5 This article mentions the following:

Ionic liquids (ILs) have been widely considered and used as “green solvents” for more than two decades. However, their ecotoxicity results have contradicted this view, as ILs, particularly hydrophobic ones, are reported to exhibit high toxicity. Yet the origin of their toxicol. remains unclear. In this work, we have investigated the interaction of amphiphilic ILs with a lipid bilayer as a model cell membrane to understand their cytotoxicity at a mol. level. By employing fluorescence imaging and light and X-ray scattering techniques, we have found that amphiphilic ILs could disrupt the lipid bilayer by IL insertion, end-capping the hydrophobic edge of the lipid bilayer, and eventually disintegrating the lipid bilayer at high IL concentration The insertion of ILs to cause the swelling of the lipid bilayer shows strong dependence on the hydrophobicity of IL cationic alky chain and anions and is strongly correlated with the reported IL cytotoxicity. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Related Products of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Related Products of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electrophilic properties of nitroheterocyclic compounds. was written by Zieba-Mizgala, Anna;Puszko, Aniela;Regiec, Andrzej;Kuduk-Jaworska, Janina. And the article was included in Bioelectrochemistry in 2005.Reference of 3034-41-1 This article mentions the following:

Investigation of the reduction potential and calculation of the partition coefficient n-octanol/water allow the assessment of the potential suitability of nitropyridine N-oxide compounds in radiotherapy of cancer. Experiments were carried out using cyclic voltammetry with HMDE as working electrode. The electrode reduction of the investigated compounds is quite irreversible and strongly dependent on pH. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Reference of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electrospun nylon 6 nanofibers incorporated with 2-substituted N-alkylimidazoles and their silver(I) complexes for antibacterial applications was written by Kleyi, Phumelele;Frost, Carminita L.;Tshentu, Zenixole R.;Torto, Nelson. And the article was included in Journal of Applied Polymer Science in 2014.Application of 21252-69-7 This article mentions the following:

The article presents the incorporation of biocides [2-substituted N-alkylimidazoles and their silver(I) complexes] into electrospun nylon 6 nanofibers for application as antimicrobial materials. The electrospun nylon 6/biocides nanofiber composites were characterized by IR spectroscopy (ATR-FTIR) and SEM (SEM-EDX). The antimicrobial activity of the electrospun nylon 6/biocides nanofiber composites was evaluated against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis subsp. spizizenii using the disk diffusion method, the American Association for Textile Chemists and Colorists test method 100-2004 and the dynamic shake flask method (American Society for Testing and Materials E2149-10). The electrospun nylon 6 nanofibers incorporated with 2-substituted N-alkylimidazoles displayed moderate to excellent levels of growth reduction against S. aureus (73.2-99.8%). For the electrospun nylon 6 nanofibers incorporated with silver(I) complexes, the levels of growth reduction were >99.99%, for both E. coli and S. aureus, after the antimicrobial activity evaluation using the shake flask method. The study demonstrated that the electrospun nanofibers, fabricated using the incorporation strategy, have the potential to be used as attractive antimicrobial materials. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Application of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives was written by Bellina, Fabio;Biagetti, Matteo;Guariento, Sara;Lessi, Marco;Fausti, Mattia;Ronchi, Paolo;Rosadoni, Elisabetta. And the article was included in RSC Advances in 2021.COA of Formula: C8H8N2 This article mentions the following:

A variety of 2-alkynyl(benzo)imidazoles I (R = Ph, n-hexyl, 2-chlorophenyl, etc.; R¹ = R² = H; R¹R² = -CH=CH-CH=CH-) have been synthesized by dehydrogenative alkynation of N-methylimidazole or 1-methyl-1H-1,3-benzodiazole with terminal alkynes RCCH in NMP under air in the presence of Ag₂CO₃ as the oxidant and Pd(OAc)₂ as the catalyst precursor. The data obtained in this study support a reaction mechanism involving a non-concerted metalation deprotonation (n-CMD) pathway. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3COA of Formula: C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and properties of amides of 2-[(4-methylphenyl)(2-thienylsulfonyl)amino]acetic acid was written by Tyuneva, I. V.;Filimonov, S. I.;Balakin, K. V.;Skorenko, A. V.;Kravchenko, D. V.;Dorogov, M. V.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2004.Recommanded Product: 24134-26-7 This article mentions the following:

A series of [(4-methylphenyl)(2-thienylsulfonyl)amino]acetamides I (R¹ = H, R² = cyclopentyl, 2-ClC₆H₄CH₂, PhCHMe, 4-ClC₆H₄CH₂CH₂, etc.; R¹R²N = 4-benzyl-1-piperidinyl, 2,3-dihydro-1-indolyl, etc.) was synthesized by reaction of 2-thiophenesulfonyl chloride with Me (4-methylphenylamino)acetate followed by the ether group hydrolysis and amination with various primary and secondary amines. Some important physico-chem. properties of I, such as partition coefficient, solubility, amount of non-terminal rotating bonds and the total number of hydrogen bond donors and acceptors, were calculated In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Recommanded Product: 24134-26-7).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 24134-26-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

All-Solid-State Polymer Electrolyte with Efficiency and Stability Superior to Its Smectic Precursor for Photoelectrochemical Devices was written by Zhou, Jiwen;Wang, Caihong;Zhang, Xiaoqian;Luo, Jie;Ji, Junyi;Wu, Yong;Tan, Shuai. And the article was included in Industrial & Engineering Chemistry Research in 2021.Category: imidazoles-derivatives This article mentions the following:

All-solid-state electrolytes have attracted wide interest for versatile energy devices owing to their stability improvement toward sustainable applications; however, the low conductivity and interfacial contact remain to be addressed. Herein, a facile method was proposed for preparing superior all-solid-state electrolytes from ionic liquid crystals. A vinylimidazolium thiolate/disulfide redox-based lamellar nanostructured electrolyte showing a smectic mesophase was prepared as a precursor, and flexible polyethylene oxide (PEO) was introduced to gel the smectic domains of the precursor to form a microphase segregation nanostructure. The PEO chains assembled at domain interfaces could significantly improve the charge transport through the smectic domain boundaries in the electrolyte. The dynamic liquid crystal gel was first assembled in a dye-sensitized solar cell (DSSC) to provide good interfacial contact, and then, in situ polymerization was performed to fabricate an all-solid-state electrolyte. The microphase segregation nanostructure was well maintained within the polymerized electrolytes for efficient charge transport. Thus, the all-solid-state electrolytes exhibited ion conductivity, thermal stability, and DSSC efficiency much superior to its smectic precursor despite the loss of fluidity. The work here sheds new light on developing desirable all-solid-state electrolytes from ionic liquid crystals for energy devices. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Category: imidazoles-derivatives).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic PMMA/nanosilica interfaces from grafting ionic liquids under supercritical CO₂ conditions was written by Fedosse Zornio, Clarice;Livi, Sebastien;Jestin, Jacques;Duchet, Jannick;Gerard, Jean-Francois. And the article was included in European Polymer Journal in 2018.Product Details of 21252-69-7 This article mentions the following:

Supercritical carbon dioxide (scCO₂) was considered as an environmental friendly medium for grafting the surface of silica nanoparticles with a series of reactive imidazolium-based ionic liquids (IL), denoted as IL-silanes. The effects of the reaction conditions on the resulting IL-grafted layers on the silica surface were characterized from thermogravimetric (TGA) and transmission electronic microscopy (TEM) analyses. The IL-grafted nanoparticles were introduced into poly(Me methacrylate) (PMMA) via melt mixing in order to design nanocomposites and to demonstrate the ability of IL-grafted nanoparticles to be dispersed into a polymer medium. The role of the IL-grafted surfaces on the morphol. of PMMA-based nanocomposites was evidenced by TEM and small angle neutron scattering (SANS). It was demonstrated that longer the alkyl chain length of the IL-silane, better the state of dispersion of nanoparticles within PMMA. In addition, better thermal stabilities and mech. performances, as well as new surface properties were observed for the designed PMMA-based nanocomposites. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Product Details of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Product Details of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In situ generation of hydrophobic magnetic ionic liquids in stir bar dispersive liquid-liquid microextraction coupled with headspace gas chromatography was written by Trujillo-Rodriguez, Maria J.;Anderson, Jared L.. And the article was included in Talanta in 2019.Reference of 21252-69-7 This article mentions the following:

For the first time, an in situ stir bar dispersive liquid-liquid microextraction approach has been developed and coupled with headspace gas chromatog.-mass spectrometry for the determination of a group of organic pollutants. The method exploits a new generation of magnetic ionic liquids (MILs) that contain paramagnetic cations based on Ni²⁺ or Co²⁺ metal centers coordinated with either N-butylimidazole or N-octylimidazole ligands and chloride anions. The reactants are added to an aqueous solution containing a high field neodymium rod magnet, followed by the addition of the bis[(trifluoromethyl)sulfonyl]imide anion that promotes a metathesis reaction for the in situ generation of a hydrophobic MIL. Concurrently, a high stirring rate is maintained to exceed the magnetic field of the rod magnet and disperse the generated MIL in the sample solution When stirring is stopped, the MIL coats the rod magnet due to its paramagnetic nature, facilitating the MIL transfer and subsequent desorption and anal. Under optimum conditions, the method required a 2.5-18% (w/v) aqueous solution of sodium chloride, 10 mL of sample, 20 or 30 mg of MIL, the addition of a small volume of dispersive solvent, and stirring for 5-7.5 min, depending on the MIL. The method provided limits of detection (LODs) down to 10μg L^-1, adequate reproducibility (with relative standard deviation values lower than 10% for a spiked level of 80μg L^-1), and relative recoveries between 72.5% and 102%. Furthermore, the method was successfully applied in the anal. of tap and mineral water. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The effects of structural changes on the anti-microbial and anti-proliferative activities of diimidazolium salts was written by Cancemi, Patrizia;Buttacavoli, Miriam;D’Anna, Francesca;Feo, Salvatore;Fontana, Rosa Maria;Noto, Renato;Sutera, Alberto;Vitale, Paola;Gallo, Giuseppe. And the article was included in New Journal of Chemistry in 2017.Formula: C11H20N2 This article mentions the following:

An array of diimidazolium salts has been synthesized and used to investigate their anti-microbial and anti-proliferative activities. In particular, salts based on the 3,3′-di-n-alkyl-1,1′-(1,n-phenylenedimethylene)diimidazolium cation and differing in the alkyl chain length on the imidazolium ion, the isomeric substitution on the aromatic spacer and in the anion nature were used. The anti-proliferative activity was evaluated against cervical (HeLa), colon adenocarcinoma (HT-29) and breast (SKBR3) cancer cell lines. In the latter case, also a morphol. assessment after treatment with salts was performed. All salts were tested for their hemolytic activity against human erythrocytes. On the other hand, the anti-microbial activity was investigated using both Gram-neg. (Escherichia coli) and Gram-pos. (Kokuria rhizophila, Staphylococcus aureus and Bacillus subtilis) strains. On the whole, the data collected demonstrate that biol. activity is the result of the combined action of both cation and anion structures. In general, the cation hydrophobicity plays the most significant role with structural features of the anion becoming more relevant in the presence of a shorter alkyl chain on the cationic head. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem