Category: imidazoles-derivatives

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52099-72-6, name is 1-(Prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C10H10N2O

200 g of Intermediate 1 was added to 1 L of DMF, and 50 g of sodium hydroxide was added.187g of 1,2-dibromoethane was added dropwise; after the addition was completed,Stir at room temperature for 4 hours, concentrate, and add the residual liquid to water.Filtration, washing with water, drying, to obtain 284 g of intermediate 2, the yield was 87%;

According to the analysis of related databases, 52099-72-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nanjing Faen Chemical Co., Ltd.; Wang Kunpeng; Han Yuelin; (6 pag.)CN108456173; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 5465-29-2, These common heterocyclic compound, 5465-29-2, name is 2-Propylbenzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of 10.0 mmol of compound 1a-1d in 14 mL of concentrated sulfuric acid was heated to 100-105C, 14 mL (0.26 mol) of 30% aqueous hydrogen peroxide was added dropwise with stirring,and the mixture was stirred for 1 h at 130C. After cooling, the mixture was poured into water and adjusted to pH 4, and the precipitate was filtered off.

Statistics shows that 2-Propylbenzimidazole is playing an increasingly important role. we look forward to future research findings about 5465-29-2.

Reference:
Article; Brusina; Nikolaev; Ramsh; Piotrovskii; Russian Journal of Organic Chemistry; vol. 52; 10; (2016); p. 1528 – 1530; Zh. Org. Khim.; vol. 52; 10; (2016); p. 1533 – 1535,3;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 714273-83-3, name is 5-(tert-Butyl)-1H-imidazole-4-carbaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 714273-83-3, Recommanded Product: 5-(tert-Butyl)-1H-imidazole-4-carbaldehyde

Example 1 Preparation of 5-(tert-butyl)-1H-imidazole-4-carbaldehyde-d (deuterium aldehyde compound b), as Show in the Following Figure The specific process for preparing the compound comprises the following step: 5-(tert-butyl)-1H-imidazole-4-carbaldehyde (304 mg, 2 mmol) was weighed and added into a dry and round bottom flask with a volume of 50 mL, and nitrogen was aerated for protection. anhydrous EtOH (5 mL) and NaBD4 (420 mg, 10 mmol) was added into the reaction flask under nitrogen. The resultant mixture was reacted overnight at room temperature. To the quenching reaction, 10 mL water was added. The organic phase was extracted by ethyl acetate. The product was spin-dryed and to be used for the next step directly. 10 mL acetone and MnO2 (1.7 g, 20 mmol) was added, and reaction was carried out overnight at room temperature. Carrying out suction filtration via the sand core funnel, spin-drying the solvent, carrying out column chromatography isolation and purification to obtain off-white solid of 5-tert-butyl-1H-imidazole-4-carbaldehyde-d (199 mg, 1.3 mmol), with yield of 65%. 1H NMR (400 MHz, DMSO-d6) delta 6.97 (s, 1H), 6.66 (s, 1H) 1.05 (s, 9H); MS (ESI) m/z 154.10 (M+H)+ (calcd for C8H12DN2O 154.10).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD.; LI, Wenbao; SUN, Tianwen; WANG, Shixiao; ZHAO, Jianchun; CAI, Bing; GUAN, Huashi; (17 pag.)US2018/140600; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 15469-97-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15469-97-3, name is 1-Trityl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A. 2-Hydroxyethyl-N-triphenylmethylimidazole To a solution of N-triphenylmethylimidazole (15.5 g, 50 mmol) at 0°C in THF was added normal butyl lithium (nBuLi) (34.4 mL, 55 mmol) dropwise over 30 minutes. The mixture was stirred for 1 hour followed by gentle warming to 30°C over 30 minutes. The solution was cooled to 0°C, and ethylene oxide (24.4 mL, 50 mmol) was added to the mixture via a cannula. The mixture was stirred at 0°C for 2 hours and gradually warmed to ambient temperature over 16 hours. The solution was concentrated and the residue was chromatographed (flash silica, 19:1; chloroform:methanol) to yield 14.5g (82percent) of compound A as a white solid. MS (M+Na)+ 377+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Trityl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; EP675112; (1995); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 614-97-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 614-97-1, name is 5-Methyl-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Equimolar quantities of the 7-bromo alkane derivatives (2a-2c) and corresponding benzimidazole were dissolved in acetone (30 mL), and certain amount of K2CO3 was also added to the solution. The solution was then refluxed for approximately 12 h. The product was extracted by dichloromethane. Then evaporated of the solvent, the residue was purified bycolumn chromatography on silica gel, eluting with dichloromethane/methanol (30:1) to givethe compounds 3-23.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methyl-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article in Press; Wang, Zhe; Deng, Xiangping; Xiong, Shujuan; Xiong, Runde; Liu, Juan; Zou, Liu; Lei, Xiaoyong; Cao, Xuan; Xie, Zhizhong; Chen, Yanming; Liu, Yunmei; Zheng, Xing; Tang, Guotao; Natural Product Research; (2017); p. 1 – 10;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 870837-70-0, name is 4-(1H-Imidazol-1-yl)-3-methoxybenzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 4-(1H-Imidazol-1-yl)-3-methoxybenzaldehyde

2-Methyl-2-butene (5.0 mL), sodium dihydrogenphosphate dihydrate (1.55 g) and sodium chlorite (3.14 g) were added to a solution containing 4-(1H-imidazol-1-yl)-3-methoxybenzaldehyde (2 g) in water (10 mL) and tert-butanol (30 mL), and the reaction solution was stirred for two hours. The generated solid was collected by filtration to obtain the title compound (745 mg). The property values of the compound are as follows. 1H-NMR (DMSO-d6) delta (ppm): 3.89 (s, 3H), 7.09 (s, 1H), 7.54 (m, 2H), 7.63 (dd, J = 8.0, 1.6 Hz, 1H), 7.69 (d, J = 1.6 Hz, 1H), 8.05 (s, 1H).

The synthetic route of 4-(1H-Imidazol-1-yl)-3-methoxybenzaldehyde has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2019093; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 1977-72-6, These common heterocyclic compound, 1977-72-6, name is 5-Fluoro-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

CuBr 6 mg (0.04 mmol), TEMPO 5 mg (0.03 mmol), compounded in a 25 mL Schlenk reaction tube5-fluorobenzimidazole 55 mg (0.4 mmol),28 mg (0.2 mmol) of salicylic acid (0.2 mmol) and p-xylene (0.5 mL), followed by 33 muL of pyridine (0.4 mmol) were added and the reaction was stirred at 120°C for 36 hours under reflux.Cool to room temperature, transfer all to a 25 mL flask, spin off the solvent on a rotary evaporator, add an appropriate amount of silica gel to spin dry, and then use a 300-400 mesh silica gel column. The developing solvent used is petroleum ether:ethyl acetate=16: 1 to 6:1, that is, compound III-6 15 mg, yield 30percent, white solid

Statistics shows that 5-Fluoro-1H-benzo[d]imidazole is playing an increasingly important role. we look forward to future research findings about 1977-72-6.

Reference:
Patent; Southwest University; Cai Guixin; Xie Dan; (14 pag.)CN107955020; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39021-62-0, Product Details of 39021-62-0

To a flask containing 6-bromo-4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline (3.0 g, 6.97 mmol, Intermediate 5: step d) was added THF (40 mL) and the solution was cooled to -70 C. n-BuLi (2.5 M in hexanes, 2.8 mL, 7 mmol) was then added dropwise. After 2 minutes, 1-methyl-1H-imidazole-5-carbaldehyde (1.2 g, 9 mmol, in 10 mL THF) was introduced. After 15 minutes, the dry-ice bath was replaced with a 0 C. bath. After 35 minutes the reaction mixture was quenched with aqueous NH4Cl solution and the aqueous portion was extracted with EtOAc:THF (10:2, 5*50 mL). The combined organics were washed with brine, dried over Na2SO4, filtered and concentrated to dryness. Chromatography on silica gel (30% acetone-DCM increasing to 5% MeOH) provided the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Janssen Pharmaceutica NV; Leonard, Kristi A.; Barbay, Kent; Edwards, James P.; Kreutter, Kevin D.; Kummer, David A.; Maharoof, Umar; Nishimura, Rachel; Urbanski, Maud; Venkatesan, Hariharan; Wang, Aihua; Wolin, Ronald L.; Woods, Craig R.; Fourie, Anne; Xue, Xiaohua; Cummings, Maxwell D.; (53 pag.)US2017/258782; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 2-(1-Trityl-4-imidazolyl)benzaldehyde

step 1.312 mg of compound 22 was dissolved in 10 ml of tetrahydrofuran.Add 414 mg of compound 26,Add 2 drops of acetic acid dropwise, react at room temperature until the starting reaction is complete.Squeeze off most of the THF under reduced pressure, add water and ethyl acetate.The organic phase was separated, the organic phase was washed with saturated NaCI solution and dried over anhydrous NaSO4, Obtaining compound 32,Directly invest in the next step;

The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Huawei Pharmaceutical Development Co., Ltd.; Zhang Xiaoqing; Song Zhichun; Bao Jinyuan; (52 pag.)CN108689958; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 37052-78-1,Some common heterocyclic compound, 37052-78-1, name is 5-Methoxy-1H-benzo[d]imidazole-2-thiol, molecular formula is C8H8N2OS, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[Reference Example 7] Production of 4-(5-methoxybenzimidazole-2-ylthio)butanoate ester hydrogen bromide salt 6.48 g (33.2 mmol) of 4-bromobutanoate ethyl ester were added to 10 ml of an ethanol solution containing 5.0 g (27.7 mmol) of 5-methoxybenzimidazole-2-thiol followed by stirring for 1 hour at 80C and adding 90 ml of ethyl acetate. The reaction solution was returned to room temperature and the formed crystals were filtered out followed by drying to obtain 9.34 g of the target compound (yield: 90%). 1H-NMR (270 MHz, CDCl3) (ppm): 7.65 (d,1H,J=8.91 Hz), 7.24 (S,1H), 7.00 (dd,1H,J=2.43, 8.91 Hz), 4.21 (q,2H,J=7.29 Hz), 3.83 (s,3H), 3.74 (m,2H), 2.61 (m,2H), 2.10 (m,2H), 1.30 (t,3H,J=7.29 Hz)

The synthetic route of 37052-78-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TEIJIN LIMITED; EP1249450; (2002); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem