Category: imidazoles-derivatives

Related Products of 930-62-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 930-62-1, name is 2,4-Dimethylimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

a. 8-(2,4-Dimethyl-1H-imidazol-1-yl)-7-trifluoromethyl[1,2,4]triazolo-[4,3-a]quinoxaline-1,4(2H,5H)-dione The title compound was prepared from 4-amino-2-chloro-5-nitrobenzotrifluoride and 2,4-dimethylimidazole by a method analogous to the method described in example 4. M.p.>330 C. 1 H-NMR (DMSO-d6): delta2.02 (s, 3H), 2.11 (s, 3H), 6.91 (s, 1H), 7.69 (s, 1H), 8.44 (s, 1H), 12.15 (br.s, 1H), 13.15 (br. s, 1H). MS (m/e): 364 (M+, 100%).

The synthetic route of 2,4-Dimethylimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Novo Nordisk A/S; US5532236; (1996); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 52099-72-6, name is 1-(Prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C10H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-(Prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one

Added to the reaction container 1-allyl benzimidazol-2-one (2) 0.19mol, glycol 140 ml, sodium sulfite 0.28mol, raising the temperature of the solution to 40 C, control the stirring speed 130rpm, dropwise 1-amino-3-bromo-propane 0.25mol, dropping time control in 3h, reaction 5h, the mass fraction of the reactants are poured into 25% sodium chloride solution, used for quality fraction of 65% cyclohexanol extracting 7 times, cyclohexanol extracted solution with calcium oxide drying, evaporate the solvent, get oily 1-allyl-3 – (3-chloro-propyl) benzimidazole-2-one

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 52099-72-6, its application will become more common.

Reference:
Patent; Chengdu Cardiff Science and Techn Co., Ltd; Liao, Ruer; (5 pag.)CN105439960; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3314-30-5, name is 1H-Benzo[d]imidazole-2-carbaldehyde, A new synthetic method of this compound is introduced below., Recommanded Product: 3314-30-5

A mixture of methyl phosphonoacetate(7.77 g, 0.037 mmol), potassium carbonate (9.38 g, 0.068 mmol) was dissolved100 mL of tetrahydrofuran, and the mixture was stirred at room temperature for half an hour and then slowly added dropwise to the above tetrahydrofuran solution. The temperature was raised to 66 CStir for 24 hours. After completion of the reaction, filtration was carried out, and most of the tetrahydrofuran was distilled off under reduced pressure. 300 mL of ethyl acetate was added, washed with waterTimes, saturated sodium chloride solution washed once, anhydrous sodium sulfate drying overnight. The solvent was concentrated under reduced pressure and the column chromatography gave pale yellowThe yield was 65%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shenyang Pharmaceutical University; Zhao Linxiang; Liu Dan; Li Kun; Ma Tianyi; Jing Yongkui; (13 pag.)CN107118249; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 33529-02-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33529-02-1, name is 1-Decyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Briefly, a mixture of alkylimidazoles such as 1-methyl-1H-imidazole (MIM), 1-hexyl-1H-imidazole(HIM), 1-octyl-1H-imidazole (OIM), and 1-decyl-1H-imidazole (DIM) (1 mmol), as well as cinnamylchloride (1 mmol) solvent-free were microwaved to 200 MW at 80 C for 5 min (optimumreaction condition). Reaction completion was marked by separation of dense IL. Products suchas 1-methyl-3-cinnamylimidazolium chloride [CMIM]Cl, 1-hexyl-3-cinnamylimidazolium chloride[CHIM]Cl, 1-octyl-3-cinnamylimidazolium chloride [COIM]Cl, and 1-decyl-3-cinnamylimidazolium chloride [CDIM]Cl were isolated by decanting toluene to remove any unreacted starting materialsand solvents. Subsequently, ILs were rinsed with diethyl ether (4 10 mL) separating afterward thislatter layer by decantation. In each case, ILs were finally dried under reduced pressure to get rid of thevolatile organic compounds.

The synthetic route of 1-Decyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Doria, Oscar Forero; Castro, Ricardo; Gutierrez, Margarita; Valenzuela, Diego Gonzalez; Santos, Leonardo; Ramirez, David; Guzman, Luis; Molecules; vol. 23; 9; (2018);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 120781-02-4,Some common heterocyclic compound, 120781-02-4, name is Methyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate, molecular formula is C6H7BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1. To a mixture of the Ex 3 hydrochloride (100 mg, 0.243 mol), 2-bromo-3-methyl-3H-imidazole-4- carboxylic acid methyl ester (56 mg, 0.243 mmol), DIPEA (83 uL, 0.486 mmol), 18-crown-6 (1.29 g, 4.86 mmol) and CsF (38 mg, 0.243 mmol) is heated to 120C overnight. The mixture is then evaporated and the residue is purified by prep. HPLC (Prep-HPLC-3 conditions) to give methyl 2-(3-((2-(difluoromethoxy)-6-methylpyridin-3- yl)carbamoyl)-3-(2-isopropylphenyl)azetidin-1 -yl)-1 -methyl-1 H-imidazole-5-carboxylate Ex 18-35 (20 mg, 16%) as a yellow oil. LCMS-1 : tR = 1.16 min, [M+1]+ 514.19.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate, its application will become more common.

Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; BOLLI, Martin; BROTSCHI, Christine; LESCOP, Cyrille; WILLIAMS, Jodi T.; (0 pag.)WO2019/234115; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 2849-93-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2849-93-6, name is 1H-Benzimidazole-2-carboxylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

1 H-Benzimidazole-2-carboxylic acid (500 tng, 3.08 mmol) was suspended in EtOH (5 mL), treated with thionyl chloride (1.12 mL, 15.4 mmol), and heated to reflux overnight. The reaction mixture was concentrated in vacuo, yielding 644 mg (99%) of the crude product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Benzimidazole-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2006/121588; (2006); A2;; ; Patent; BAYER PHARMACEUTICALS CORPORATION; WO2006/121860; (2006); A2;; ; Patent; BAYER PHARMACEUTICALS CORPORATION; WO2006/121904; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67085-11-4, name is 4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C13H15ClN2O

(1) 5 kg of 1-(2-hydroxy-4-(4-chlorophenyl)butyl)-1H-imidazole, fully dissolved in 35 kg of methylene chloride,5kg of thionyl chloride was added dropwise at a rate of 1.5ml/s at 20C, and the temperature was slowly raised to 32C and the reaction was incubated for 1 hour.Then reflux at 60 C for 1 hour, slowly cooled to 15 C to obtain the reaction solution;(2) In the reaction solution obtained in step (1), add 10C water at a rate of 0.5 ml/s while stirring.The volume ratio of liquid to water is 0.005:1, and then anhydrous sodium carbonate is added at 1.3 kg/L, suction filtration,The solid was discarded, and the liquid was concentrated at 55 C until no dichloromethane was distilled off.Dry, that is, too. Upon detection, the yield of the product of this example was 99.18%.The target product and impurity levels were determined using HPLC and standards. After testing,The target product, 1-(2-chloro-4-(4-chlorophenyl)butyl)-1H-imidazole, has a content of 99.17%.

According to the analysis of related databases, 67085-11-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhuzhou Qianjin Pharmaceutical Co., Ltd.; Li Fujun; Bai Lu; Peng Kaifeng; Wen Fengqiu; Li Sanxin; Gong Yun; (10 pag.)CN105198814; (2018); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 7189-69-7, These common heterocyclic compound, 7189-69-7, name is 1,1′-Sulfonyldiimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A 1-[(1-Aziridinyl)methyl]-2(S)-butyl-4-(1-naphthoyl) piperazine A solution of 1-(2(R)-butoxycarbonylamino-3-hydroxypropyl)-2(S)-butyl-4-(1-naphthoyl)piperazine (1.67 g, 3.56 mmol) in dimethylformamide (10 mL) was cooled to 0 C. under nitrogen. Sodium hydride (0.427 g, 10.6 mmol, 60% dispersion in oil) was added, followed by 1,1′-sulfonyldiimidazole (0.704 g, 3.56 mol). The reaction was warmed to 20 C. for 1 h, cooled to 0 C. and quenched with water. Dimethylformamide was distilled in vacuo, and the residue partitioned between ethyl acetate and water. The organic phase was washed with saturated brine and dried over magnesium sulfate. The crude product was chromatographed on silica gel with 70% ethyl acetate in hexane, followed by 5% methanol in chloroform. The title compound was obtained as the major product, FAB ms (m+1) 352. A lesser amount of 1-[(1-butoxycarbonylaziridinyl)methyl]-2(S)-butyl-4-(1-naphthoyl)piperazine was also isolated.

Statistics shows that 1,1′-Sulfonyldiimidazole is playing an increasingly important role. we look forward to future research findings about 7189-69-7.

Reference:
Patent; Merck & Co., Inc.; US5856326; (1999); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 10597-52-1, name is 7-Nitro-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10597-52-1, Product Details of 10597-52-1

4-Nitrobenzimidazole (41.7 mmoles, 6.8 g) was dissolved in 200 ml DMF. Sodium hydride (47.5 mmoles, 1.9 g of 60% in mineral oil) was added portionwise. The reaction was stirred for 30 minutes. Ethyl 2-bromooctanoate was added. The reaction stirred at room temperature for 3 hours and concentrated. Ethyl acetate and water were added; and the layers separated. The organic layer was washed with brine, dried over sodium sulfate and concentrated. The intermediate was purified by HPLC over silica gel eluted with a gradient of 0-50% ethyl acetate in hexane. The reaction yielded 10.3 g of ethyl 2-(4-nitro-1H-benzimidazol-1-yl) octanoate. (MS) M. Pt.: 86-89 C. Calculated for C17 H23 N3 O4: C, 61.25; H, 6.95; N, 12.60. Found: C, 61.52; H, 7.06; N, 12.21.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Eli Lilly and Company; US5612360; (1997); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 3012-80-4, name is 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3012-80-4, COA of Formula: C9H8N2O

100.4 mg of the compound obtained in Synthesis Example 19-2 was dissolved in 1 ml of methanol, and then 1 ml of a 4 mol/l hydrochloric acid/dioxane was added to the solution and the whole was stirred for 3 hours at room temperature. On completion of the reaction, the solvent was distilled off and the residue was then dissolved in methanol, followed by neutralizing with amberlite IRA-410 and distilling the solvent off. The residue was dissolved in 1 ml of anhydrous methanol, and 53.8 mg of 1-methyl-2-formyl benzimidazole was then added to the solution, allowing the reaction thereof for 1.5 hours at room temperature. A reaction solution was concentrated and dried under a reduced pressure, followed by dissolving in 2 ml of methanol again. Subsequently, 25.6 mg of sodium cyanoborohydride was added to the solution and the whole was reacted for 0.5 hour at room temperature. On completion of the reaction, the solvent was concentrated, and the residue was then dissolved in chloroform, followed by washing with distilled water and a saturated salt solution. After the solution was dried with anhydrous sodium sulfate, the solvent was distillated off and the resulting residue was then purified by means of silica gel column chromatography (5 g, chloroform/methanol/water = 7/3/0.5). A 1 mol/l hydrochloric acid was added to the resulting compound, and the mixture was then concentrated and azeotropically co-distilled, and 28.2 mg of hydrochloride of the above-mentioned compound was obtained as a white solid product. MS(FAB,Pos.):m/z=693[M+H]+1H-NMR(500MHz,DMSO-d6):delta=1.87-1.97(4H,m),3.93(3H,s),3.97(3H,s) ,4.46(2H,s),4.55-4.62(1H,m),4.64(2H,s),4.67(2H,s),4.76(2H,d,J =5.6Hz),7.36-7.58(6H,m),7.71-7.79(7H,m),7.93-7.95(1H,m),8.01 (2H,d,J=8.5Hz),8.05-8.08(1H,m),8.73-8.76(2H,m),9.94(2H,brs).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Kureha Chemical Industry Co., Ltd.; EP1389460; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem