Category: imidazoles-derivatives

Nsc-mediated solid-phase synthesis of polyamides containing pyrrole amino acid was written by Choi, Jin Seok;Lee, Hwa-Sun;Lee, Younjoo;Jeong, Nakcheol;Kim, Hack-Joo;Kim, Young-Deug;Han, Hogyu. And the article was included in Tetrahedron Letters in 2002.Quality Control of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate This article mentions the following:

The synthesis of the Nsc-protected amino acid, Nsc-Py-OH (I) [Nsc = 2-(4-nitrophenylsulfonyl)ethoxycarbonyl] and its oligomerization on solid-phase are described. The suitability of the Nsc methodol. for preparation of polyamides containing heteroaromatic amino acids was demonstrated. In the experiment, the researchers used many compounds, for example, Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9Quality Control of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate).

Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Quality Control of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of 2-alkyl-substituted benzimidazoles by thermal decomposition of 2-azidobenzenamines in the presence of an aldehyde was written by Wallace, Jeffery M.;Soderberg, Bjorn C. G.;Hubbard, Jeremiah W.. And the article was included in Synthetic Communications in 2006.SDS of cas: 4887-83-6 This article mentions the following:

2-Substituted benzimidazoles, e.g., I, were prepared by reaction of 2-azidoaminobenzenes, e.g., II, with with aldehydes under thermal conditions. The reaction probably proceeds via a sequential imine formation, azide decomposition forming a nitrene, and electrocyclization. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6SDS of cas: 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. SDS of cas: 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dynamic wetting of imidazolium-based ionic liquids on gold and glass was written by Delcheva, I.;Beattie, D. A.;Ralston, J.;Krasowska, M.. And the article was included in Physical Chemistry Chemical Physics in 2018.Synthetic Route of C18H31F6N3O4S2 This article mentions the following:

The present study explores the dynamic wetting of three ionic liquids (with a different length of hydrocarbon chain in the cation) on gold and glass substrates, both of which are relevant for nano- and micromech. machine applications, under well-controlled environmental conditions. The form of data capture (Wilhelmy plate) allows for a direct anal. using anal. expressions for the two dominant approaches for dynamic wetting: the hydrodynamic and mol. kinetic models. All ionic liquids yield data that are described best by the mol. kinetic model. Substrate-ionic liquid and water-ionic liquid interactions contribute to the mechanisms involved in the wetting process. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Synthetic Route of C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Synthetic Route of C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Properties and catalytic activity of magnetic and acidic ionic liquids: Experimental and molecular simulation was written by Zhou, Cunshan;Yu, Xiaojie;Ma, Haile;Huang, Xingyi;Zhang, Henan;Jin, Jian. And the article was included in Carbohydrate Polymers in 2014.Safety of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

The exploitation of dual functional magnetic and acidic ionic liquids (MAILs) for hydrolysis of cellulose to platform chems. can solve some practical challenges through easy separation of products and efficient catalyst recyclability. In this work, seven C_nmim/FeCl₄ MAILs were synthesized and investigated with combined exptl. and mol. dynamics. The MAILs contained FeCl^–₄ anions and exhibited a typical hard magnetic materials behavior with rather strong magnetic susceptibilities. These MAILs were stable up to 250-310 °C, the decomposition was started up at 250/310-480-810 °C in two steps with the formation of the undecomposed residue. The Gibbs energy for the reaction of glucose/xylose conversion to 5-hydroxymethylfurfural by metal chlorides in the C_nmimCl ionic liquid was studied using the d. functional theory calculations and the results that C₃mim/WCl₃ may be the most hopeful catalyst. The MAILs have the potential to open up promising new catalytic systems because of their easy product separation and efficient catalyst recyclability. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Safety of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Safety of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lubrication Properties of the Ionic Liquid Dodecyl-3 Methylimidazolium bis(trifluoromethylsulfonyl)imide was written by Battez, A. Hernandez;Ramos, D.;Blanco, D.;Gonzalez, R.;Fernandez-Gonzalez, A.;Viesca, J. L.. And the article was included in Tribology Letters in 2018.Product Details of 404001-48-5 This article mentions the following:

The ionic liquid (IL) dodecyl-3 methylimidazolium bis(trifluoromethylsulfonyl)imide was tested as neat lubricant and as additive (at 1 and 4 wt%) in a polar oil (diester). Tribol. tests were performed using a reciprocating configuration for 90 min at 30 and 70 N, 10 Hz, 4 mm stroke length, and at room temperature and 100°C. Wear volume and surface-IL interaction were determined by confocal microscopy, SEM, and XPS. The main findings were: Neat ionic liquid showed the best tribol. behavior; the IL-containing mixtures had similar behavior than the base oil at the lower load; meanwhile, the mixture with 4 wt% of IL outperformed the antiwear behavior of the neat base oil at the higher load; surface-IL chem. interaction was found mainly at 100°C. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Product Details of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Product Details of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of tin nanocrystals in room temperature ionic liquids was written by Le Vot, Steven;Dambournet, Damien;Groult, Henri;Ngo, Anh-tu;Petit, Christophe;Rizzi, Cecile;Salzemann, Caroline;Sirieix-Plenet, Juliette;Borkiewicz, Olaf J.;Raymundo-Pinero, Encarnacion;Gaillon, Laurent. And the article was included in Dalton Transactions in 2014.Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

The aim of this work was to study the synthesis of tin nanoparticles (NPs) or tin/carbon composites, in room temperature ionic liquids (RTILs), that could be used as structured anode materials for Li-ion batteries. An innovative route for the synthesis of Sn nanoparticles in such media is successfully developed. Compositions, structures, sizes and morphologies of NPs were characterized by high-energy x-ray diffraction (HEXRD), XPS and high-resolution TEM (HRTEM). (i) metallic tetragonal β-Sn was obtained and (ii) the particle size could be tailored by tuning the nature of the RTILs, leading to nano-sized spherical particles with a diameter ranging from 3 to 10 nm depending on synthesis conditions. To study carbon composite materials for Li-ion batteries, Sn nanoparticles were successfully deposited on the surface of multi-wall carbon nanotubes (MWCNT). Also, electrochem. properties were studied in relation to a structural study of the nanocomposites. The poor electrochem. performances as a neg. electrode in Li-ion batteries is due to a significant amount of RTIL trapped within the pores of the nanotubes as revealed by XPS studies. This dramatically affected the gravimetric capacity of the composites and limited the diffusion of lithium. The findings of this work however offer valuable insights into the exciting possibilities for synthesis of novel nano-sized particles and/or alloys (e.g. Sn-Cu, Sn-Co, Sn-Ni, etc.) and the importance of carbon morphol. in metal pulverization during the alloying/dealloying process as well as prevention of ionic liquid trapping. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Transition-metal and oxidant-free approach for the synthesis of diverse N-heterocycles by TMSCl activation of isocyanides was written by Luo, Liangliang;Li, Hongyan;Liu, Jinxin;Zhou, Yuan;Dong, Lin;Xiao, You-Cai;Chen, Fen-Er. And the article was included in RSC Advances in 2020.Formula: C8H8N2 This article mentions the following:

A highly efficient TMSCl-mediated addition of N-nucleophiles to isocyanides was achieved. This transition-metal and oxidant-free strategy was applied to the construction of various N-heterocyles such as quinazolinone, benzimidazole and benzothiazole derivatives by the use of distinct amino-based binucleophiles. The notable feature of this protocol includes its mild reaction condition, broad functional group tolerance and excellent yield. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Formula: C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Carbohydrates-tailored phase tunable systems composed of ionic liquids and water. [Erratum to document cited in CA153:297068] was written by Chen, Yuhuan;Wang, Yige;Cheng, Qingyan;Liu, Xiaoli;Zhang, Suojiang. And the article was included in Journal of Chemical Thermodynamics in 2010.Reference of 79917-89-8 This article mentions the following:

On page 1056, the first Author’s name should read: Yuhuan Chen. The correct version of the Author line has been corrected On page , in Figure 5, D of phenol in {[C3mim]BF4 + glucose + H2O} system is 2.51, not 13.04. The correct version of Figure 5 is given. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Reference of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Reference of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Identification of Prazosin as a Potential Flagellum Attachment Zone 1(FAZ1) Inhibitor for the Treatment of Human African Trypanosomiasis was written by Orahoske, Cody M.;Afrin, Marjia;Li, Yaxin;Hanna, Jovana;Marbury, Myah;Li, Bibo;Su, Bin. And the article was included in ACS Infectious Diseases in 2022.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

Human African trypanosomiasis (HAT) remains a health threat to sub-Saharan Africa. The current treatments suffer from drug resistance and life-threatening side effects, making drug discovery for HAT still important. A high-throughput screening of the library of pharmaceutically active compounds identified prazosin, an α-adrenoceptor antagonist, that showed selective activity toward Trypanosoma brucei brucei. Furthermore, a series of prazosin analogs were examined, and overall, the new analogs had improved activity and selectivity. To elucidate the binding partner, a biotin-conjugated probe was synthesized, and a protein pulldown assay combined with a proteomic anal. identified the flagellum attachment zone 1 (FAZ1) filament as an interacting partner. Addnl., prazosin treatment resulted in dysfunction of the flagellum of trypanosome cells, which is indicative of a FAZ1 irregularity. We also examined the drug distribution by utilizing immunofluorescence with a designed fluorescent analog that showed partial colocalization with FAZ1. With the activity of the prazosin analogs, a structure-activity relationship (SAR) was summarized for future lead optimization. Our findings provide a new group of FAZ1 inhibitors as novel antitrypanosomal agents. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Transition-metal-free, direct C-H radical trifluoromethylation of nitroimidazoles with Togni’s reagent was written by Wang, Hezhen;Wei, Chunyong;Zou, Haiyan;Linghu, Chengcheng;Wang, Zhiyuan;Wang, Jing;Chen, Yongzheng;Zhang, Lei. And the article was included in Tetrahedron Letters in 2022.HPLC of Formula: 169770-25-6 This article mentions the following:

In present study, a green, mild and practical method which allows for the transition-metal-free, direct C-H radical trifluoromethylation of nitroimidazoles with Togni’s regent II as the CF₃ radical precursor was described. Diverse nitroimidazoles and their drug mols. were smoothly transformed into trifluoromethylated compounds in moderate to good yields under mild conditions. This new method provided an alternative approach for the prepare of trifluoromethylated compounds, as well as late-stage modification of bioactive nitroimidazoles. In the experiment, the researchers used many compounds, for example, Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6HPLC of Formula: 169770-25-6).

Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 169770-25-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem