Category: imidazoles-derivatives

Poly(ionic liquid)-Coated Meshes with Opposite Wettability for Continuous Oil/Water Separation was written by Deng, Xi;Zhang, Jingshun;Zhang, Liren;Cheng, Guiren;Chen, Bihua;Zhang, Yongya;Gao, Guohua. And the article was included in Industrial & Engineering Chemistry Research in 2020.Application of 915358-85-9 This article mentions the following:

A series of oil/water separation membranes with tunable surface wettability based on poly(ionic liquid)s (PILs) were prepared via a facile one-step photopolymerization of N-vinylimidazolium ionic liquids and divinylbenzene on meshes. The wettability of PIL-based membranes (PILMs) was adjusted by the structures of PILs, specifically the alkyl chain length of imidazolium (Bu and octyl) and anion species (acrylic anion, Br^–, and PF₆^–). Tunability of wettability resulted in the hydrophilic or hydrophobic property of PILMs. The hydrophilic poly(1-vinyl-3-butylimidazolium acrylate)-based membrane (PILM-1) transported water and intercepted oil, while the hydrophobic poly(1-vinyl-3-octylimidazolium hexafluorophosphate)-based membrane (PILM-5) removed oil and rejected water. The two membranes with opposite wettability showed excellent oil/water separation efficiency (above 99%) in batch processes. Continuous oil/water separation was also achieved by assembling PILM-1 and PILM-5 on the fabricated devices. A T-type device could sep. various oil/water mixtures continuously, and a tank-type device could sep. dispersed oil/water mixtures, with a handling capacity of 46 L within 12 h. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Application of 915358-85-9).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application of 915358-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Semi-heterogeneous photo-Cu-dual-catalytic cross-coupling reactions using polymeric carbon nitrides was written by Zhang, Zhaofei;Xu, Yangsen;Zhang, Qitao;Fang, Shaofan;Sun, Hongli;Ou, Wei;Su, Chenliang. And the article was included in Science Bulletin in 2022.Safety of 1-Methylbenzimidazole This article mentions the following:

A merger of copper catalysis and semiconductor photocatalysis using polymeric carbon nitride (PCN) for multi-type cross-coupling reactions was developed. This dual catalytic system enables mild C-H arylation, chalcogenation, and C-N cross-coupling reactions under visible light irradiation with a broad substrate scope. Good to excellent yields were obtained with appreciable site selectivity and functional group tolerance. Metal-free and low-cost PCN photocatalyst can easily be recovered and reused several times. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Safety of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Safety of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Structure-Activity Relationships of a Novel Capsid Targeted Inhibitor of HIV-1 Replication was written by Kortagere, Sandhya;Xu, Jimmy P.;Mankowski, Marie K.;Ptak, Roger G.;Cocklin, Simon. And the article was included in Journal of Chemical Information and Modeling in 2014.Recommanded Product: 5496-35-5 This article mentions the following:

Despite the considerable successes of highly active antiretroviral therapy (HAART) for the treatment of HIV/AIDS, cumulative drug toxicities and the development of multidrug-resistant virus necessitate the search for new classes of antiretroviral agents with novel modes of action. The HIV-1 capsid (CA) protein has been structurally and functionally characterized as a druggable target. We have recently designed a novel small mol. inhibitor I-XW-053 using the hybrid structure based method to block the interface between CA N-terminal domains (NTD-NTD interface) with micromolar affinity. In an effort to optimize and improve the efficacy of I-XW-053, we have developed the structure activity relationship of I-XW-053 compound series using ligand efficiency methods. Fifty-six analogs of I-XW-053 were designed that could be subclassified into four different core domains based on their ligand efficiency values computed as the ratio of binding efficiency (BEI) and surface efficiency (SEI) indexes. Compound 34 belonging to subcore-3 showed an 11-fold improvement over I-XW-053 in blocking HIV-1 replication in primary human peripheral blood mononuclear cells (PBMCs). Surface plasmon resonance experiments confirmed the binding of compound 34 to purified HIV-1 CA protein. Mol. docking studies on compound 34 and I-XW-053 to HIV-1 CA protein suggested that they both bind to NTD-NTD interface region but with different binding modes, which was further validated using site-directed mutagenesis studies. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Recommanded Product: 5496-35-5).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 5496-35-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of new ionic liquids based on dicationic imidazolium and their anti-corrosion performances was written by Zaky, M. T.;Nessim, M. I.;Deyab, M. A.. And the article was included in Journal of Molecular Liquids in 2019.Synthetic Route of C11H20N2 This article mentions the following:

Ionic liquids with high environmental value and adsorption properties are a requirement for the new trend for corrosion inhibitors. Here, we synthesis three new ionic liquids based on dicationic imidazolium (IL1, IL2 and IL3) to produce green inhibitors for stainless steel corrosion in acidic environment. The anionic portion of all prepared ionic liquids is BF-4. New ionic liquids were recognized by means of element inspection, FT-IR, TGA and 1H NMR spectroscopy. All prepared ionic liquids work as good corrosion inhibitors. Where their efficiencies are 91.5%, 98.4% and 83.3% for IL1, IL2 and IL3, resp. at 100 ppm. The counter portion of ILs (BF-4) has a great role in the adsorption process. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Synthetic Route of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Synthetic Route of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Polybenzimidazoles based on methylated benzene tetraamines was written by Korshak, V. V.;Teplyakov, M. M.;Fedorova, R. D.. And the article was included in Vysokomolekulyarnye Soedineniya, Seriya B: Kratkie Soobshcheniya in 1967.Product Details of 4887-83-6 This article mentions the following:

3,3′-Diaminotolidine (I) and 2,3′,4,4′-tetraaminoditolylmethane (II) were synthesized and were used to prepare polybenzimidazoles with di-Ph isophthalate (III), di-Ph terephthalate (IV), di-Ph adipate (V), and di-Ph sebacate (VI). The polybenzimidazoles obtained had the following properties (amine, ester, intrinsic viscosity in HCO2H, and decomposition temperature given): I, V, 0.76, -; I, VI, 0.80, -; I, III, 0.40, 490°; I, IV, 0.42, 500°; II, III-IV, 0.51, 490°; II, III, 0.64, -; II, III, 0.47, 400°; II, IV, 0.41, 450°. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Product Details of 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Product Details of 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Comparative effects of amlodipine and candesartan on blood pressure and metabolic profile in non-diabetic hypertensive patients was written by Althanoon, Zeina A.;Thanoon, Imad AJ. And the article was included in Pharmacognosy Journal in 2022.Electric Literature of C33H34N6O6 This article mentions the following:

Introduction: The present study aimed to compare the effects of the angiotensin II receptor blocker candesartan and the calcium channel blocker amlodipine on blood pressure and metabolic profile in non-diabetic hypertensive patients. Methods: The study involved non-diabetic patients with mild to moderate hypertension. They were randomly assigned to receive candesartan or amlodipine for 24 wk, parameters were evaluated at baseline and after 12 wk and 24 wk for each patient group. Results: Candesartan and amlodipine both reduced blood pressure and the HOMA-IR index significantly (P < 0.05, 24 wk vs. baseline). Candesartan was more effective than amlodipine in lowering blood pressure and HOMA-IR, although the difference was not significant statistically. Conclusion: Both candesartan and amlodipine are extremely effective at reducing blood pressure in moderate hypertension patients. Candesartan cilexetil has a major benefit in terms of tolerability, as it reduces the risk of developing metabolic dysregulation. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Electric Literature of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Unusual synthesis of stable pyridinium dinitromethylides was written by Andreasson, Eva;Newton, Christopher G.;Ollis, W. David;Rees, Charles W.;Smith, David I.;Wright, Derek E.. And the article was included in Journal of the Chemical Society, Chemical Communications in 1983.Formula: C9H8N2O2 This article mentions the following:

Nitration of imidazo[1,2-a]pyridines with concentrated HNO₃ and H₂SO₄ at room temperature gave pyridinium dinitromethylides in 51-85% yield; these compounds have orthogonal pyridinium and dinitromethylide groups. E.g., treatment of ester I with fuming HNO₃-concentrated H₂SO₄ at room temperature gave 61% ylide II. Reaction mechanisms involving sequential nitration and ring cleavage are discussed. In the experiment, the researchers used many compounds, for example, Methyl imidazo[1,2-a]pyridine-5-carboxylate (cas: 88047-55-6Formula: C9H8N2O2).

Methyl imidazo[1,2-a]pyridine-5-carboxylate (cas: 88047-55-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Formula: C9H8N2O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Graphene oxide supported chlorostannate (IV) ionic liquid: Bronsted-Lewis acidic combined catalyst for highly efficient Baeyer-Villiger oxidation in water was written by Xing, Chen;Tan, Rong;Hao, Pengbo;Gao, Mengqiao;Yin, Donghong;Yin, Dulin. And the article was included in Molecular Catalysis in 2017.Related Products of 79917-89-8 This article mentions the following:

Lewis acidic chlorostannate(IV)-based imidazolium ionic liquid ([PmimCl][SnCl₄]_x IL) was post-grafted on graphene oxide (GO) nanosheets through a silylation process. Characterization results suggested the coexistence of intrinsic carboxylic acid on GO edges and the post-grafted Lewis acidic IL on GO planes in the catalysts. The Bronsted-Lewis acidic combined catalysts of GO/[PmimCl][SnCl₄] were highly efficient and universal in Baeyer-Villiger (BV) oxidation in water due to the high water-dispersion, diminished diffusion limitation, enriched surface acid sites, as well as the concerted effects between Bronsted and Lewis acid sites. Only 3.0 mol% of GO/[PmimCl][SnCl₄]_x (x = 0.5, 1.0, 1.5) was sufficient for affording almost quant. yield of a wide range of lactones in water without the need of any organic solvents and cocatalysts, whereas Lewis acidic IL of [PmimCl][SnCl₄]_1.0 itself was far less efficient. More importantly, the heterogeneous catalysts were perfectly stable and could be reused several times without significant loss of activity and selectivity. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Related Products of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Related Products of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Copper-mediated oxidative cyclization of heterocyclically substituted aldimines was written by Pufky-Heinrich, Daniela;Ciesielski, Michael;Gharnati, Loubna;Walter, Olaf;Doering, Manfred. And the article was included in Heterocycles in 2010.Product Details of 85692-37-1 This article mentions the following:

Cu-mediated cascade reactions were performed with heteroaryl aldimines. These oxidative heterocyclizations include sequences of oxidations and cycloadditions or nucleophilic additions, which take place in the coordination sphere of Cu ions. When 2 heteroaryl aldimines were reacted in the presence of Cu(II) under air, pyridines were produced. In one case, a 5,8-di-1H-imidazol-2-yl-3,7-dipyridin-2-yl-1,4-diazatricyclo[3.2.1.0^2,7]oct-3-ene was also formed. The basic structure of this new tetracyclic compound contains 5 new chiral C atoms. Its cage-like structure was revealed by x-ray crystallog. [orthorhombic, space group Pna(2), a 20.2315(15), b 10.0265(7), c 11.2033(8) Å, V 2272.6(3) ų, Z 4]. The synthesis of 2H-pyrroles by Cu-assisted conversions of the aldimines with acetylenedicarboxylate or quinones was also described. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Product Details of 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Product Details of 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In silico Drug Repurposing for COVID-19: Targeting SARS-CoV-2 Proteins through Docking and Consensus Ranking was written by Cavasotto, Claudio N.;Di Filippo, Juan I.. And the article was included in Molecular Informatics in 2021.HPLC of Formula: 145040-37-5 This article mentions the following:

In Dec. 2019, an infectious disease caused by the coronavirus SARS-CoV-2 appeared in Wuhan, China. This disease (COVID-19) spread rapidly worldwide, and on March 2020 was declared a pandemic by the World Health Organization (WHO). Today, over 21 million people have been infected, with more than 750.000 casualties. Today, no vaccine or antiviral drug is available. While the development of a vaccine might take at least a year, and for a novel drug, even longer; finding a new use to an old drug (drug repurposing) could be the most effective strategy. We present a docking-based screening using a quantum mech. scoring of a library built from approved drugs and compounds undergoing clin. trials, against three SARS-CoV-2 target proteins: the spike or S-protein, and two proteases, the main protease and the papain-like protease. The S-protein binds directly to the Angiotensin Converting Enzyme 2 receptor of the human host cell surface, while the two proteases process viral polyproteins. Following the anal. of our structure-based compound screening, we propose several structurally diverse compounds (either FDA-approved or in clin. trials) that could display antiviral activity against SARS-CoV-2. Clearly, these compounds should be further evaluated in exptl. assays and clin. trials to confirm their actual activity against the disease. We hope that these findings may contribute to the rational drug design against COVID-19. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5HPLC of Formula: 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem