Category: imidazoles-derivatives

Related Products of 2620-76-0, These common heterocyclic compound, 2620-76-0, name is 2-(4-Bromophenyl)-1-phenyl-1H-benzoimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1-7) Synthesis of Compound (1); Into a 300 ml three-necked flask, 2.0 g (5.0 mmole) of Intermediate 6, 3.9 g (11 mmole) of 2-(4-bromophenyl)-1-phenylbenzimidazole, 0.23 g (0.20 mmole) of tetrakis(triphenylphosphine)palladium(0), 50 ml of 1,2-dimethoxyethane and 15 ml (30 mmole) of a 2 M aqueous solution of sodium carbonate were placed under the stream of argon, and the resultant mixture was heated under the refluxing condition for 8 hours. After the reaction was completed, the organic layer was washed with water and dried with magnesium sulfate, and the solvent was removed by distillation using a rotary evaporator. The obtained crude crystals were washed with 50 ml of toluene and 100 ml of methanol, and 3.4 g of a light yellow powder substance was obtained. The obtained substance was identified to be Compound (1) by the measurement of the field desorption mass spectrum (FD-MS) (the yield: 80percent).

The synthetic route of 2620-76-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; US8058450; (2011); B2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 16042-25-4, name is 2-Imidazolecarboxylic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16042-25-4, name: 2-Imidazolecarboxylic acid

General procedure: Ligand 1 was prepared by refluxing equimolar solution of imidazole- 2-carboxylic acid (0.112 g; 1 mM) and benzhydrazide (0.136 g; 1 mM) (HL1) in 50 mL of methanol. After 24 h, the reaction mixture was cooled to room temperature and the product formed was filtered, washed several times with water and then recrystallized from methanol to afford the desired product in pure form. Other Ligands 2-4 (HL2-HL4) were also prepared by adopting the similar procedure as in the caset of ligand, using the respective hydrazides i.e., isonicotinic acid hydrazide (0.137 g; 1 mM), furoic acid hydrazide (0.126 g; 1 mM) and thiophene-2-carboxylic acid hydrazide (0.142 g; 1 mM as summarized in Scheme 1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Imidazolecarboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sathyadevi, Palanisamy; Krishnamoorthy, Paramasivam; Butorac, Rachel R.; Cowley, Alan H.; Dharmaraj, Nallasamy; Inorganica Chimica Acta; vol. 409; PART B; (2014); p. 185 – 194;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C5H6N2O2

A solution of Intermediate II (30 mg, 0.092 mmol) and 1-methyl-1H-imidazole- 2-carboxylic acid (14 mg, 0.11 mmol) in 1 mE of DMF was treated at 0 C with i-Pr2NEt (0.10 mL, 0.57 mmol) and propane phosphonic acid anhydride (T3P; 0.11 mL, 0.25 mmol). The vialwas sealed and stirred at room temperature ovemight. The reaction mixture was filtered, washing the filter with DMSO (1 niL). The crude product dissolved in 2 mL of DMSO/DMF was purified by reverse phase HPLC. The desired fraction was concentrated under reduced pressure to yield 2-39. ?Ii NMR (600 MHz, DMSO-d6) 3 8.48 (m, 1 H), 7.96 (m, 1 H), 7.28 (m, 1 H), 6.96 (m, 1 H), 5.88 (s, 1 H), 4.14 (q, J= 7.2 Hz, 2 H), 3.82 (s, 3 H), 3.80 (s, 3 H), 4.00-3.60(m, 4 H), 2.53-2.52 (m, 3 H), 2.35-2.20 (m, 2 H), 1.32 (t, J= 7.3 Hz, 3 H); MS (El) Calc?d for C21H26N902 [M+Hfb, 436; found 436.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 20485-43-2.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ACHAB, Abdelghani Abe; ALTMAN, Michael D.; DENG, Yongqi; GUZI, Timothy; KATTAR, Solomon; KATZ, Jason D.; METHOT, Joey L.; ZHOU, Hua; MCGOWAN, Meredeth; CHRISTOPHER, Matthew P.; GARCIA, Yudith; ANTHONY, Neville John; FRADERA LLINAS, Francesc Xavier; MU, Changwei; ZHANG, Sixing; ZHANG, Rong; FONG, Kin Chiu; LENG, Xiansheng; WO2014/75392; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-(1-Trityl-4-imidazolyl)benzaldehyde

5 (3.3 g, 7.7 mmol) was dissolved in dichloromethane (10 mL)Aqueous NaOH (0.6 g, 15.4 mmol) (1 mL) was added at 0 C,Stir at room temperature for 40 minutes.2- (1-Trityl- 1 H-imidazole) benzaldehyde (3.2 g, 7.7 mmol) was dissolved in dichloromethane (1 mL)0 C slowly dripped into the above system,After stirring for 12 hours at room temperature,Water (50 mL) was added,Dichloromethane extraction,Dried over anhydrous magnesium sulfate,Purification by column chromatography gave a pale yellow solid,Yield 77.5%.

The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; China Pharmaceutical University; Nanjing University; Lai Yisheng; Sun Qirui; Zou Yi; Xu Qiang; Guo Wenjie; Wang Yan; Wang Fang; Li Yuezhen; (23 pag.)CN107501272; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 13750-62-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13750-62-4 as follows.

General procedure: An appropriate imidazole (0.2 mmol) was added to the mixtureof [Pd(mu-X)X(bmim-y)]2 (0.1 mmol) in CH2Cl2 (1-2 ml). The colorchanged from orange to yellow immediately (in case of iodidecomplex from dark red to red). The mixture was stirred for 1 h atroom temperature. After this time 8ml of a hexane was added tothe solution and clouding of the mixturewas observed. The mixturewas left for 24 h and the yellow solid was formed. The product wasfiltrated, washed with hexane and dried. The complexes were obtainedwith the yield of 80-90%.

According to the analysis of related databases, 13750-62-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Sikorski; Zawartka; Trzeciak; Journal of Organometallic Chemistry; vol. 867; (2018); p. 323 – 332;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1H-Imidazole

General procedure: A mixture of aryl halide (1.0 mmol), Het-NH (1.2mmol) or amine (4 mmol), KOH (2 mmol), Cu2O/nano-CuFe2O4 magnetic composite (0.010 g) and anhydrous DMSO (2 mL) was stirred at 100 C. After completion of the reaction as indicated by TLC, the reaction mixture was cooled to room temperature and with diluted ethyl acetate and the catalyst was separated by an external magnet from the mixture, washed with acetone, dried in an oven at 80 C for 3 h and re-used for a consecutive run under the same reaction conditions. The combined ethyl acetate layer was washed with water, dried over anhydrous MgSO4, The residue was purified by recrystallization or short column chromatography on silica gel to afford the target products in excellent yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 288-32-4, its application will become more common.

Reference:
Article; Elhampour, Ali; Nemati, Firouzeh; Kaveh, Mahdieh; Chemistry Letters; vol. 45; 2; (2016); p. 223 – 225;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 68282-47-3, These common heterocyclic compound, 68282-47-3, name is 2-Phenyl-1H-imidazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

COMPOUND 12.1. 36: 1-{4-[(DIETHYLAMINO)CARBONYL]PHENYL}-2-[(2- PHENYL-1N-IMIDAZOL-5-Y ; L) METHYL1-L23, 4- TETRAHYDROISOQUINOLIN-6-YL DIMETHYLSULFAMATE; INTERMEDIATE 6.4. 2 (12 mg, 0.028 mmol) and 2-phenyl-4 (5)- imidazolecarbaldehyde (10 mg, 0.056 mmol) were dissolved in 1,2-dichloroethane (3 mL) and sodium triacetoxyboronhydride (18 mg, 0. 084 mmol) was added. The mixture was stirred for 18 h after which ethyl acetate and 1 M aqueous sodium hydroxide solution were added. After phase separation the aqueous phase was extracted with more ethyl acetate and the combined organic phases were washed with water and brine. Resin-bound tosylhydrazine (147 mg, 1.5 mmol/g) was added and the mixture was stirred for 2 h. After filtration and thorough washing of the resin, the filtrate was evaporated and the residue was purified by flash chromatography to yield the product (11 mg, 0.019 mmol, 67%). 1H NMR (500 MHz, CDCl3) : 1.14, 1.27 (2 brs, 6H), 2.67, 2.86, 3.05, 3.17 (4 m, 4H), 2.97 (s, 6H), 3.18, 3.60 (2 brs, 4H), 3. 51, 3.60 (2 d, J 12.0 Hz, 2H), 4.72 (s, 1H), 6.69 (d, 8.5 Hz, 1H), 6.92 (s, 1H), 6.94 (dd, J 8. 5,2. 0 Hz, 1H), 7.08 (d, J 2.0 Hz, 1H), 7.34 (m, 7H), 7.86 (d, J 7.5 Hz, 2H). (+) LRESIMS m/z 559 (100) [M+H] +.

The synthetic route of 68282-47-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2005/61484; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 96797-15-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 96797-15-8 name is 4-Iodo-1-trityl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[270] To a solution of (2-forrnylphenyl)boronic acid (2.0 g, 13.3 rnrnol) in a rnixed solvent of N,N- dirnethylforrnarnide (DMF) (60 rnL) and water (12 rnL) was successively added 4-iodo-1- trityl-1H-irnidazole (6.1 g, 14.0 rnrnol), and potassiurn phosphate (5.6 g, 26.6 rnrnol). After degassing with nitrogen, the resulted rnixture was added tetrakis(triphenylphosphine)palladiurn(0) (Pd(PPh3)4) (300 rng, 0.26 rnrnol). The resulted rnixture was degassed with nitrogen and stirred at 90C for overnight under nitrogen. And then the rnixture was cooled down to roorn ternperature and filtered, the filtrate was added water (60 rnL), extracted with ethyl acetate (100 rnLx2). The cornbined organic phase was washed with brine (25 rnL), dried over sodiurn sulfate, filtered and concentrated. The residue was purifiedby colurnn chrornatography on silica gel (petroleurn ether: ethyl acetate= 6:1) to afford cornpound 1.1 (3.3 g, yield: 60%) as a white solid.[271] rn/z: [M+H]415

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Iodo-1-trityl-1H-imidazole, and friends who are interested can also refer to it.

Reference:
Patent; SHANGHAI DE NOVO PHARMATECH CO.,LTD.; LI, Qun; GAO, Daxin; (158 pag.)WO2016/131380; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 492-98-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 492-98-8, name is 1H,1’H-2,2′-Biimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Compound 2 was synthesized hydrothermally by reaction of H3PW12O40 xH2O (0.075g, 0.026 mmol), AgNO3 (0.051g, 0.3 mmol), H2biim (0.008g, 0.06 mmol) and 10 mL distilled water in a 25 ml Teflon-lined autoclave. The pH was adjusted to 2 with 1.0 mol L-1 HNO3. The mixture was heated under autogenous pressure at 160 C for 5 days and then was left to cool to room temperature. Red crystals could be isolated in about 60% yield and dried at room temperature for the further characterization. Anal.Calcd for 2: C7.13,H0.50, N6.23. Found: C7.02,H0.45,N6.42%. IR(ITR mode,cm1): 1502(s),1412(w),1352(s),1243(w),1153(s),1075(s),968(s),890(s),793(s).The IR spectrum of compound 2 is shown in the Supporting information (Fig. S6).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H,1’H-2,2′-Biimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lu, Xin-Xin; Luo, Yu-Hui; Lu, Chen; Chen, Xin; Zhang, Hong; Journal of Solid State Chemistry; vol. 232; (2015); p. 123 – 130;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 68282-53-1, name is 5-Methyl-1H-imidazole-4-carbaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 68282-53-1, SDS of cas: 68282-53-1

COMPOUND 12.1. 19: 4-f6, {6s7-DIMETHOXY-2-r (4-METHYL-lH-IMIDAZOL-5- YL)METHYL]-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YL}-N,N- DIETHYLBENZAMIDE; INTERMEDIATE 5.1. 7 (50 mg, 0.14 mmol) and 4-methyl-5-imidazolecarbaldehyde (30 mg, 0.27 mmol) were dissolved in DCE (3.0 mL). After stirring for 10 min at room temperature, sodium triacetoxyborohydride (86 mg, 0.41 mmol) was added and the mixture was stirred for 18 h at room temperature. DCM and 1 M sodium hydroxide solution were added and the mixture was passed through a Whatman 1PS silicon-treated filter paper. The organic phase was evaporated and the crude product was purified by flash chromatography to yield the product (57 mg, 0.12 mmol, 91%). 1H NMR (500 MHz, CDC13): 1. 08, 1.22 (2 brs, 6H), 2.07 (s, 3H), 2.54, 2.72, 2.90, 3.06 (4 m, 4H), 3.25, 3.54 (2 brs, 4H), 3.39, 3.59 (2 d, J 13 Hz, 2H), 4.56 (s, 1H), 6.16, 6.59 (2 s, 2H), 7.29 (s, 4H), 8.38 (brs, lH). l3C NMR (125 MHz, CDC13) : 11.14, 13.43, 14.03, 28.07, 39.69, 43.67, 46.67, 49. 48, 56.04, 56.06, 67.48, 111.2, 112.0, 126.5, 129.9, 127.2, 127.3, 129.3, 130.2, 136.1, 133. 3, 145.9, 147.6, 147.7, 171. 8. (+) LRESIMS mlz 369 (100), 463 (35).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; ASTRAZENECA AB; WO2005/61484; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem