Category: imidazoles-derivatives

Assessment of atomic partial charge schemes for polarisation and charge transfer effects in ionic liquids was written by Rigby, Jason;Izgorodina, Ekaterina I.. And the article was included in Physical Chemistry Chemical Physics in 2013.Synthetic Route of C7H13ClN2 This article mentions the following:

In this work, we assess several popular at. partial charge schemes with the view of accurately quantifying charge distribution, dipole moments and charge transfer in routinely used ionic liquids (ILs). We investigated a series of ion pairs of imidazolium-based ILs such as [C_(1-4)mim]X (where X = Cl, BF₄ and NTf₂) and ionic clusters of [NMe₄][BF₄], [C₁mim][BF₄] and [C₁mim]Cl that were composed of two, four and eight ion pairs. Assessed partial charge schemes include restrained electrostatic potentials (RESP) employing ChelpG, Connolly and Geodesic point selection algorithms, as well as d. matrix partitioning schemes including Mulliken, Loewdin and Natural Population Anal. (NPA). The quality of charge distribution was analyzed using the following criteria: (1) treatment of symmetry identical atoms, (2) invariance of charge in the imidazolium ring with increasing alkyl chain and (3) recalcn. to dipole moments as a measure of electronic polarization. The RESP schemes such as Connolly and Geodesic clearly outperform the ChelpG scheme as well as the d. matrix-based schemes for these three criteria. Calculated partial charges reveal that dipole moments were best represented by the RESP schemes and confirmed the presence of charge transfer in ILs to a various degree. The degree of charge transfer was dependent on anions as well as cluster size. In the ion pairs, the chloride anion showed the largest charge transfer, followed by the NTf₂ and BF₄ anions. In ionic clusters the charge transfer was shown to gradually converge from two to eight ion pairs in the case of the [NMe₄][BF₄] and [C₁mim][BF₄] ILs to a value, close to that for corresponding ion pairs. In contrast, charge transfer in the [C₁mim]Cl clusters converges to a lower value, showing an unusually strong inter-ionic bond with the chloride anion. NPA charges were found to perform poorly, with near-unity charges being retained on the anions and cations in ion pairs and ionic clusters. Mulliken and Loewdin charges were shown to be highly basis set dependent and unpredictable with marked fluctuations in partial charges and therefore their use for ILs is particularly discouraged. Ability of the partial charge schemes to capture fluctuations in the dipole moment within the ionic clusters was also examined The Connolly and Geodesic RESP schemes were found to slightly outperform ChelpG. Evidence to suggest that chloride-based ILs might be poor model systems for ILs is also presented. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Synthetic Route of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Synthetic Route of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Blue Photosensitizer with Copper(II/I) Redox Mediator for Efficient and Stable Dye-Sensitized Solar Cells was written by Ren, Yameng;Flores-Diaz, Natalie;Zhang, Dan;Cao, Yiming;Decoppet, Jean-David;Fish, George Cameron;Moser, Jacques-E.;Zakeeruddin, Shaik Mohammed;Wang, Peng;Hagfeldt, Anders;Graetzel, Michael. And the article was included in Advanced Functional Materials in 2020.Application of 1632-83-3 This article mentions the following:

Dye-sensitized solar cells (DSCs) based on copper(II/I) redox mediators have recently achieved notable performance progress through tailoring the ligand structure of the copper complexes, exploiting cosensitization, and introducing an advanced device structure. In order to further improve the power conversion efficiency (PCE), it is imperative to develop wide spectral-response photosensitizers compatible with the copper(II/I) redox mediators while attaining a high Voc. Herein, a blue photosensitizer coded R7 is reported, which is purposely designed for highly efficient DSCs with copper-based electrolytes. R7 features a strong electron-donating segment of 9,19-dihydrobenzo[1′,10′ ]phenanthro[3′,4′:4,5]thieno[3,2-b]benzo[1,10]phenanthro[3,4-d]thiophene conjugated with a bulky auxiliary donor N-(2,4′-bis(hexyloxy)-[1,1′-biphenyl]-4-yl)-2,4′-bis(hexyloxy)-N-methyl-[1,1′-biphenyl]-4-amine and the electron acceptor 4-(7-ethynylbenzo[c][1,2,5]thiadiazol-4-yl)benzoic acid. The blue dye R7 with bulkier auxiliary donor moiety in the DSC largely outperforms the reference dye R6, which has a smaller bis(4-(hexyloxy)phenyl)amine donor unit. Transient absorption spectroscopy and electrochem. impedance spectroscopy measurements show that the R7 based DSC has a higher charge separation yield, a higher charge collection efficiency, and lower charge recombination with the copper electrolyte than the R6 based counterpart. A cosensitized system of R7 and Y123 for the DSC presents an outstanding PCE of 12.7% and retains 90% of its initial value after 1000 h of light soaking under 1 sun at 45 °C. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Orthogonality and compatibility between Tsc and Fmoc amino-protecting groups was written by Choi, Jin Seok;Kang, Hunhui;Jeong, Nakcheol;Han, Hogyu. And the article was included in Tetrahedron in 2005.Reference of 109012-23-9 This article mentions the following:

New deprotection conditions that provide a complete orthogonality between Tsc [2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl] and Fmoc amino-protecting groups are described. The potential of these orthogonal deprotection conditions was then demonstrated by the efficient solid-phase synthesis of branched peptides I (n = 0 or 3) using doubly protected amino acids such as Tsc-Lys(Fmoc)-OH and Fmoc-Lys(Tsc)-OH. In the experiment, the researchers used many compounds, for example, Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9Reference of 109012-23-9).

Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 109012-23-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A re-examination of the genotoxicity and carcinogenicity of azathioprine. Comments was written by Rosenkranz, Herbert S.;Klopman, Gilles. And the article was included in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1991.Product Details of 3034-41-1 This article mentions the following:

CASE, a novel artificial intelligence structure-activity relational method of anal., was used to study the structural basis of carcinogenicity of azathioprine. The criteria that were analyzed predicted azathioprine to be a genotoxic carcinogen. In addition, 6-mercaptopurine and 1-methyl-4-nitroimidazole, both moieties of azathioprine, were predicted to have mutagenic potential. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Product Details of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Product Details of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Expanding the Chemical Space of Benzimidazole Dicationic Ionic Liquids was written by Mezzetta, Andrea;Guglielmero, Luca;Mero, Angelica;Tofani, Giorgio;D’Andrea, Felicia;Pomelli, Christian Silvio;Guazzelli, Lorenzo. And the article was included in Molecules in 2021.Electric Literature of C8H8N2 This article mentions the following:

Benzimidazole dicationic ionic liquids (BDILs) have not yet been widely explored in spite of their potential. Therefore, two structurally related families of BDILs, paired with either bromide or bistriflimide anions and bearing alkyl spacers ranging from C3 to C6, have been prepared Their thermal properties have been studied by thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC), while their elec. properties have been assessed by cyclic voltammetry (CV). TG anal. confirmed the higher stability of the bistriflimide BDILs over the bromide BDILs, with minor variation within the two families. Conversely, DSC and CV allowed for ascertaining the role played by the spacer length. In particular, the thermal behavior changed dramatically among the members of the bistriflimide family, and all three possible thermal behavior types of ILs were observed Furthermore, cyclic voltammetry showed different electrochem. window (C₃(C₁BenzIm)₂/2Tf₂N < C₄(C₁BenzIm)₂/2Tf₂N, C₅(C₁BenzIm)₂/2Tf₂N < C₆(C₁BenzIm)₂/2Tf₂N) as well as a reduction peak potential, shape, and intensity as a function of the spacer length. The results obtained highlight the benefit of accessing a more structurally diverse pool of compounds offered by dicationic ILs when compared to the parent monocationic ILs. In particular, gains are to be found in the ease of fine-tuning their properties, which translates in facilitating further investigations toward BDILs as designer solvents and catalysts. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dimethyl phosphorothioate and phosphoroselenoate ionic liquids as solvent media for cellulosic materials was written by Hummel, Michael;Froschauer, Carmen;Laus, Gerhard;Roeder, Thomas;Kopacka, Holger;Hauru, Lauri K. J.;Weber, Hedda K.;Sixta, Herbert;Schottenberger, Herwig. And the article was included in Green Chemistry in 2011.Name: 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

A series of novel ionic liquids comprising two asym. phosphate-derived anions, namely di-Me phosphorothioate and di-Me phosphoroselenoate, and several imidazolium and non-imidazolium-based cations was prepared via a facile synthetic route. Thermal degradation was studied by dynamic thermogravimetric anal. (TGA) revealing a slightly higher stability of the imidazolium ionic liquids and an overall low thermal stability for the phosphoroselenoate salts. Long-term moisture sorption anal. showed correlation with the polarity of the cation and differences in absorption and desorption kinetics. Finally, a Eucalyptus globulus kraft paper grade pulp was dissolved and subsequently regenerated to assess the degradation of the various mol. weight fractions by size exclusion chromatog. In addition, pre-extracted xylan was subjected to the same dissolution procedure to examine the degradation of low-mol. weight components in more detail. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Name: 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Name: 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A facile ionic liquid approach to prepare cellulose-rich aerogels directly from corn stalks was written by Li, Xiaoqian;Lu, Xingmei;Yang, Jiming;Ju, Zhaoyang;Kang, Ying;Xu, Junli;Zhang, Suojiang. And the article was included in Green Chemistry in 2019.Name: 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Aerogels derived from corn stalks are promising materials for wide use, due to their biodegradability and biocompatibility. However, preparation of cellulose-rich aerogels directly from corn stalks is a tedious and complicated process. In this study, generation of cellulose-rich aerogels was achieved by a facile approach relying on an ionic liquid and amido-sulfonic acid used as solvents. By this method, cellulose-rich aerogels were directly obtained from corn stalks through a process whereby lignin was separated from the other components of the corn stalks in one step, an approach simplifying the traditional fabrication processes. The composition, morphol. and thermal stability of the obtained aerogels were investigated as they were related to the ionic liquid solvent systems used. Furthermore, the dye adsorption mechanism of cellulose-rich aerogels was simulated. In the most favorable case, the obtained aerogel was free of lignin and had the cellulose content as high as 88.1%. In addition, the aerogel possessed a porous three-dimensional structure with a high specific area (201 m² g^-1) and good thermal stability. Owing to its excellent properties, this cellulose-rich porous aerogel is expected to have a potential use in dye adsorption and other fields. This aerogel displayed an absorption capacity of 549 mg g^-1 for Congo red and 302 mg g^-1 for Coomassie brilliant blue. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Name: 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Age-Related Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction. was written by Tromp, Jasper;Shen, Li;Jhund, Pardeep S;Anand, Inder S;Carson, Peter E;Desai, Akshay S;Granger, Christopher B;Komajda, Michel;McKelvie, Robert S;Pfeffer, Marc A;Solomon, Scott D;Køber, Lars;Swedberg, Karl;Zile, Michael R;Pitt, Bertram;Lam, Carolyn S P;McMurray, John J V. And the article was included in Journal of the American College of Cardiology in 2019.Application In Synthesis of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

BACKGROUND: Although heart failure with preserved ejection fraction (HFpEF) is considered a disease of the elderly, younger patients are not spared from this syndrome. OBJECTIVES: This study therefore investigated the associations among age, clinical characteristics, and outcomes in patients with HFpEF. METHODS: Using data on patients with left ventricular ejection fraction ≥45% from 3 large HFpEF trials (TOPCAT [Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function], I-PRESERVE [Irbesartan in Heart Failure With Preserved Systolic Function], and CHARM Preserved [Candesartan Cilexetil in Heart Failure Assessment of Reduction in Mortality and Morbidity]), patients were categorized according to age: ≤55 years (n = 522), 56 to 64 years (n = 1,679), 65 to 74 years (n = 3,405), 75 to 84 years (n = 2,464), and ≥85 years (n = 398). This study compared clinical and echocardiographic characteristics, as well as mortality and hospitalization rates, mode of death, and quality of life across age categories. RESULTS: Younger patients (age ≤55 years) with HFpEF were more often obese, nonwhite men, whereas older patients with HFpEF were more often white women with a higher prevalence of atrial fibrillation, hypertension, and chronic kidney disease (eGFR <60 ml/min/1.73 m²). Despite fewer comorbidities, younger patients had worse quality of life compared with older patients (age ≥85 years). Compared with patients age ≤55 years, patients age ≥85 years had higher mortality (hazard ratio: 6.9; 95% confidence interval: 4.2 to 11.4). However, among patients who died, sudden death was, proportionally, the most common mode of death (p < 0.001) in patients age ≤55 years. In contrast, older patients (age ≥85 years) died more often from noncardiovascular causes (34% vs. 20% in patients age ≤55 years; p < 0.001). CONCLUSIONS: Compared with the elderly, younger patients with HFpEF were less likely to be white, were more frequently obese men, and died more often of cardiovascular causes, particularly sudden death. In contrast, elderly patients with HFpEF had more comorbidities and died more often from noncardiovascular causes. (Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function [TOPCAT]; NCT00094302; Irbesartan in Heart Failure With Preserved Systolic Function [I-PRESERVE]; NCT00095238; Candesartan Cilexetil in Heart Failure Assessment of Reduction in Mortality and Morbidity [CHARM Preserved]; NCT00634712). In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Application In Synthesis of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application In Synthesis of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On the Colossal and Highly Anisotropic Thermal Expansion Exhibited by Imidazolium Salts was written by de Pedro, I.;Garcia-Saiz, A.;Dupont, J.;Migowski, P.;Vallcorba, O.;Junquera, J.;Rius, J.;Rodriguez Fernandez, J.. And the article was included in Crystal Growth & Design in 2015.Computed Properties of C7H13ClN2 This article mentions the following:

The imidazolium salts 1-ethyl-2,3-dimethylimidazolium chloride, Edimim[Cl], and bromide, Edimim[Br], exhibit neg. and pos. thermal expansions, as determined by variable-temperature synchrotron powder x-ray diffraction experiments Both compounds crystallize in the same monoclinic centrosym. space group, showing an anisotropic H-bonding network and imidazolium-imidazolium π⁺-π⁺ interactions, which were corroborated by d. functional theory studies. The chloride derivative displays a highly anisotropic thermal expansion with a colossal pos. coefficient along one direction. Replacement of Cl^– by Br^– in the same crystal structure produces an increase of the colossal coefficient and induces a biaxial neg. thermal expansion. By studying the mol. vibration factors and the H-bonding framework in their crystals as a function of temperature, it was possible to rationalize at the mol. level the mechanism for the observed anomalies in thermal expansion. Crystallog. data and at. coordinates are given. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Computed Properties of C7H13ClN2).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Computed Properties of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design and synthesis of vandetanib derivatives containing nitroimidazole groups as tyrosine kinase inhibitors in normoxia and hypoxia was written by Wei, Huiqiang;Li, Deguan;Yang, Xiangbo;Shang, Haihua;Fan, Saijun;Li, Yiliang;Song, Dan. And the article was included in Molecules in 2016.Quality Control of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid This article mentions the following:

Sixteen novel epidermal growth factor receptor (EGFR)/vascular endothelial growth factor (VEGF)-2 inhibitors (nitroimidazole-substituted 4-anilinoquinazoline derivatives) I (R¹ = H, CH₃, NO₂; R² = H, NO₂; X¹ = H, F, Cl; X² = H, F, Br, Cl; X³ = H, Br, F, Me, Cl; n = 1, 2, 3) were designed and prepared via the introduction of a nitroimidazole group in the piperidine side chain and modification on the aniline moiety of vandetanib. Preliminary biol. tests showed that comparing with vandetanib, some target compounds exhibited excellent EGFR inhibitory activities and anti-proliferative over A549/H446 cells in hypoxia. Meanwhile, several of the above compounds demonstrated better bioactivity than vandetanib in VEGF gene expression inhibition. Owing to the excellent IC₅₀ value (1.64 μmol/L), the inhibition ratios of compound I (R¹ = H; R² = NO₂; X¹ = F; X² = H; X³ = Br; n = 1) over A549 and H446 cells were 62.01% and 59.86% at the concentration of 0.5 μM in hypoxia, resp. All of these results indicated that compound I (R¹ = H; R² = NO₂; X¹ = F; X² = H; X³ = Br; n = 1) was a potential cancer therapeutic agent in hypoxia and was worthy of further development. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Quality Control of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Quality Control of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem