Imidazoles-derivatives

Cobalt(II)/(imidazoline-oxazoline)-catalyzed enantioselective Michael addition of 2-acetyl azaarenes to β-CF₃-β-disubstituted nitroalkenes was written by Hao, Xin-Qi;Wang, Cong;Liu, Shuang-Liang;Wang, Xiao;Wang, Li;Gong, Jun-Fang;Song, Mao-Ping. And the article was included in Organic Chemistry Frontiers in 2017.COA of Formula: C6H8N2O This article mentions the following:

A series of chiral (imidazoline-oxazoline) N,N-bidentate ligands derived from 2,2-dimethylmalonic acid were conveniently synthesized and characterized. With the aid of the new ligands, the first Co(II)-catalyzed asym. Michael addition of 2-acetyl azaarenes to β-CF₃-β-disubstituted nitroalkenes was successfully achieved, producing chiral compounds with a trifluoromethylated all-carbon quaternary stereocenter in good yields with enantioselectivities of up to 98% ee. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1COA of Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of [¹⁸F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)acetamide], a marker for PET detection of hypoxia was written by Josse, Olivier;Labar, Daniel;Georges, Benoit;Gregoire, Vincent;Marchand-Brynaert, Jacqueline. And the article was included in Bioorganic & Medicinal Chemistry in 2001.Application of 22813-32-7 This article mentions the following:

[¹⁸F]-2-(2-Nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)acetamide ([¹⁸F]-EF3) has been prepared in 65% chem. yield and 5% radiochem. yield by coupling 2,3,5,6-tetrafluorophenyl 2-(2-nitroimidazol-1-yl)acetate with [¹⁸F]-3,3,3-trifluoropropylamine. This original radiolabeled key synthon was obtained in 40% overall chem. yield by oxidative [¹⁸F]-fluorodesulfurization of Et N-phthalimido-3-aminopropanedithioate, followed by deprotection with hydrazine of the resulting [¹⁸F]-N-phthalimido-3,3,3-trifluoropropylamine. The process was performed within 90 min, from the [¹⁸F]-HF production in the cyclotron to the purification of the final target. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Application of 22813-32-7).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 22813-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine was written by Mukherjee, Arijit;Rogers, Robin D.;Myerson, A. S.. And the article was included in CrystEngComm in 2018.Product Details of 404001-48-5 This article mentions the following:

Liquid assisted grinding using imidazolium-based ionic liquids (IL-AG) was found to be effective in isolation of cocrystals and cocrystal polymorphs. Isolation of specific polymorphs of caffeine-citric acid (CAF-CA) and caffeine-glutaric acid (CAF-GLU) cocrystals highlights the tunability of ILs in polymorphic control. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Product Details of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cluster approach to the prediction of thermodynamic and transport properties of ionic liquids was written by Seeger, Zoe L.;Kobayashi, Rika;Izgorodina, Ekaterina I.. And the article was included in Journal of Chemical Physics in 2018.Name: 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

The prediction of physicochem. properties of ionic liquids such as conductivity and m.p. would substantially aid the targeted design of ionic liquids for specific applications ranging from solvents for extraction of valuable chems. to biowaste to electrolytes in alternative energy devices. The previously published study connecting the interaction energies of single ion pairs (1 IP) of ionic liquids to their thermodn. and transport properties has been extended to larger systems consisting of two ion pairs (2 IPs), in which many-body and same-ion interactions are included. Routinely used cations, of the imidazolium and pyrrolidinium families, were selected in the study coupled with chloride, tetrafluoroborate, and dicyanamide. Their two ion pair clusters were subjected to extensive configuration screening to establish most stable structures. Interaction energies of these clusters were calculated at the spin-ratio scaled MP2 (SRS-MP2) level for the correlation interaction energy, and a newly developed scaled Hartree-Fock method for the rest of energetic contributions to interaction energy. A full geometry screening for each cation-anion combination resulted in 192 unique structures, whose stability was assessed using two criteria-widely used interaction energy and total electronic energy. Furthermore, the ratio of interaction energy to its dispersion component was correlated with exptl. observed m.ps. in 64 energetically favorable structures. These systems were also used to test the correlation of the dispersion contribution to interaction energy with measured conductivity (c) 2018 American Institute of Physics. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Name: 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Name: 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chemical Modification of siRNA Bases To Probe and Enhance RNA Interference was written by Peacock, Hayden;Kannan, Arunkumar;Beal, Peter A.;Burrows, Cynthia J.. And the article was included in Journal of Organic Chemistry in 2011.Synthetic Route of C8H8N2 This article mentions the following:

Considerable attention has focused on the use of alternatives to the native ribose and phosphate backbone of small interfering RNAs for therapeutic applications of the RNA interference pathway. In this synopsis, we highlight the less common chem. modifications, namely, those of the RNA nucleobases. Base modifications have the potential to lend insight into the mechanism of gene silencing and to lead to novel methods to overcome off-target effects that arise due to deleterious protein binding or mis-targeting of mRNA. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Synthetic Route of C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Synthetic Route of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis, Characterization, Thermal Analyses, and Spectroscopic Properties of Novel Naphthyl-Functionalized Imidazolium Ionic Liquids was written by Yao, Meihuan;Li, Qing;Xia, Yanqiu;Liang, Yongmin. And the article was included in Russian Journal of Physical Chemistry A in 2018.Product Details of 21252-69-7 This article mentions the following:

A series of novel ionic liquids based on naphthyl-functionalized imidazolium cation have been prepared Their structure was characterized by NMR. The thermal stabilities of the prepared liquids were studied by thermal gravimetric anal. The new ionic liquids containing NTf₂^– anion display significantly higher thermal stabilities (> 400°C). Anion exchange to PF₆^–, BF₄^–, and Br^– decreases the thermal stabilities of such ionic liquids Fluorescence and UV-Vis absorption spectroscopy were used to study the spectroscopic properties of the ionic liquids Compared with common ionic liquids, the described ionic liquids provide robust fluorescence properties and remarkably increased UV-Vis absorption. This research may enrich the field of functionalized ionic liquids and provide a platform for extension of ionic liquid applications. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Product Details of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Product Details of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Oxidized Charcoal-Supported Thiol-Protected Palladium Nanoparticles for Cross Dehydrogenative Coupling of Heteroarenes was written by Kumar, Sunil;Kumari, Sonu;Singh, Sohan;Boruah, Palash Jyoti;Paul, Amit Kumar;Roy, Partha;Joshi, Hemant. And the article was included in ACS Applied Nano Materials in 2022.Safety of 1-Methylbenzimidazole This article mentions the following:

This report described the synthesis of thiol-protected Pd nanoparticles (NPs) (Pd-MUA) (MUA = 11-mercaptoundecanoic acid) supported on oxidized charcoal (OC-Pd-MUA) at room temperature The Pd-MUA NPs and OC-Pd-MUA nanocomposites (NCs) were characterized with Fourier transform IR (FTIR) spectroscopy, transmission electron microscopy (TEM), energy-dispersive X-ray spectrometry (EDX), XPS and Brunauer-Emmett-Teller (BET) techniques. The size distribution curve revealed that the diameter of the nanoparticles was in the range of âˆ?-12 nm, and the surface area of the NCs was found to be 138.449 m²/g. The as-prepared OC-Pd-MUA NCs were used as a catalyst for the cross dehydrogenative coupling (CDC) of two different heteroarenes. Remarkably, the catalyst was found to be very efficient in activating various heteroarenes under mild reaction conditions. Most importantly, no homocoupled or other byproducts were observed during the heterocoupling reactions. Moreover, the catalyst can be potentially used for the homocoupling reaction of various heteroarenes. It is noteworthy that only 0.22 mol % catalyst loading was required to activate a broad substrate scope with large functional group tolerance. Notwithstanding, the efficacy of the catalyst was found to be retained even after six reaction cycles. The reusability and hot filtration tests validated the heterogeneous nature of the catalysis. In addition, the exptl. and computational studies collectively suggested that thiophene derivatives react to produce energetically stable products compared with other heteroarenes during the reaction. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Safety of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Safety of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Correlation of molecular structure and polarity of ionic liquids was written by Spange, Stefan;Lungwitz, Ralf;Schade, Alexander. And the article was included in Journal of Molecular Liquids in 2014.SDS of cas: 35487-17-3 This article mentions the following:

The empirical Kamlet-Taft solvent parameters for hydrogen bond donating (HBD) ability (α), hydrogen bond accepting (HBA) ability (β), and dipolarity/polarizability (π*) have been determined for 102 ionic liquids (ILs). α, β, and π* have been measured by means of the solvatochromic methods utilizing three specific dyes Fe(phen)₂(CN)₂ (Fe), 3-(4-amino-3-methyl-phenyl)-7-phenyl-benzo-[1,2-b:4,5-b’]-difuran-2,6-dione (ABF) and 4-tert-butyl-2-(dicyanomethylene)-5-[4-(diethylamino)benzylidene]-Δ³-thiazoline (Th) each solely sensitive to one of the Kamlet-Taft parameter. Different types of ILs with various cation structure such as 1,3-dialkyl imidazolium and 2- and 4-,5-Me substituted derivatives, pyridinium, tetraalkylammonium, trialkylsulfonium and tetraalkylphosphonium were used. In conjunction to the [C₄mim] cation, more than 20 various established anions, such as halides, tetrafluoroborate, dicyanamide, were considered in this study. The frontiers of HBA ability strength of the anions are marked by the specific anions azide (N₃^–) (large β) and FAP PF₃(C₂F₅)₃^– (lowest β). The linear intercorrelation between α and β is clearly evidenced, which shows that anion and cation interact with each other, for each type of IL used. Also correlation of mol. structure of the cation and the HBD ability can be recognized and supported by results from NMR spectroscopy. The interpretation of π* is still not satisfied because dipolarity and polarizability of each IL obviously contribute in different proportions to the value. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3SDS of cas: 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic liquid surfactants as multitasking micellar catalysts for epoxidations in water was written by Schmidt, Fabian;Zehner, Bastian;Korth, Wolfgang;Jess, Andreas;Cokoja, Mirza. And the article was included in Catalysis Science & Technology in 2020.Product Details of 21252-69-7 This article mentions the following:

We present a single-component catalyst system for the epoxidation of hydrophobic olefins in aqueous solution The aggregation of surface-active 1-alkyl-3-methylimidazolium ionic liquids (IL) containing the catalytically active tungstate dianion leads to micelles, which solubilise apolar olefins in aqueous media. The micellization of tungstate allows for the epoxidation of cyclooctene and other olefins in water, using environmentally benign hydrogen peroxide as oxidant. The structural characterization of the micelles under catalysis conditions as well as the substrate uptake have been studied by cryo-TEM. ¹⁸³W-NMR studies revealed that the catalytically active species is a tetraperoxotungstate complex. The addition of organophosphonic acids results in a significant boost of the catalytic activity by formation of a tungstate-phosphonate adduct, investigated using electrospray ionization mass spectrometry (ESI-MS). The versatile functionalisability of the imidazolium cation enables a covalent linkage of a phosphonate group, which is further increasing the catalytic activity. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Product Details of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Product Details of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Metalloporphyrin and Ionic Liquid-Functionalized Covalent Organic Frameworks for Catalytic CO₂ Cycloaddition via Visible-Light-Induced Photothermal Conversion was written by Ding, Luo-Gang;Yao, Bing-Jian;Wu, Wen-Xiu;Yu, Zhi-Gao;Wang, Xiao-Yu;Kan, Jing-Lan;Dong, Yu-Bin. And the article was included in Inorganic Chemistry in 2021.Application In Synthesis of 1-Methylbenzimidazole This article mentions the following:

We report the construction of a porphyrin and imidazolium-ionic liquid (IL)-decorated and quinoline-linked covalent organic framework (COF, abbreviated as COF-P1-1) via a three-component one-pot Povarov reaction. After post-synthetic metalization of COF-P1-1 with Co(II) ions, the metalized COF-PI-2 is generated. COF-PI-2 is chem. stable and displays highly selective CO₂ adsorption and good visible-light-induced photothermal conversion ability (ΔT = 26°). Furthermore, the coexistence of Co(II)-porphyrin and imidazolium-IL within COF-PI-2 has guaranteed its highly efficient activity for CO₂ cycloaddition Of note, the needed thermal energy for the reactions is derived from the photothermal conversion of the Co(II)-porphyrin COF upon visible-light irradiation More importantly, the CO₂ cycloaddition herein is a “window ledge” reaction, and it can proceed smoothly upon natural sunlight irradiation In addition, a scaled-up CO₂ cycloaddition can be readily achieved using a COF-PI-2@chitosan aerogel-based fixed-bed model reactor. Our research provides a new avenue for COF-based greenhouse gas disposal in an eco-friendly and energy- and source-saving way. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application In Synthesis of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application In Synthesis of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem