Imidazoles-derivatives

Formulation development and evaluaation of Candesartan Cilexetil immediate release tablets was written by Challa, Yellareddy;Banavath, Sujatha.;Swathi, Alle.;Eslavath, Ragya;Ramakrishna, Ubbani;Suthakaran, R.;Jyothirmai, Kalyankar Manasvi. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2018.Electric Literature of C33H34N6O6 This article mentions the following:

The tablets were prepared and evaluated using wet granulation technique. In order to optimize the product, different formulations were developed. And pre compression and post compression were evaluated. To check the compatibility of drug with various polymers,. FTIR spectra of Candesartan Cilexetil were recorded, The IR spectral anal. of Candesartan Cilexetil pure drug alone showed that principal peaks were observed at wave numbers 2939.13 cm-1, 1752.03 cm-1, 1546.56 cm-1, 1713.38 cm-1 and 1573.01 cm the major peaks were observed at 2937.48 cm-1, 1752.22 cm-1, 1546.30 cm-1, 1713.10 cm-1 and 1573.28 cm-1.. All the formulations were evaluated for phys. characteristics, Disintegration, in-vitro Dissolution and Stability studies. The Formulation F8 showed fair flow properties when compared to the reference product.From the obtained in vitro results of the above formulation Trials, We selected F – 8 as the optimized formulation because it showed total drug release with in 30 min than all other formulations and reference product. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Electric Literature of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and biological evaluation of benzimidazole phenylhydrazone derivatives as antifungal agents against phytopathogenic fungi was written by Wang, Xing;Chen, Yong-Fei;Yan, Wei;Cao, Ling-Ling;Ye, Yong-Hao. And the article was included in Molecules in 2016.Formula: C9H8N2O This article mentions the following:

A series of benzimidazole phenylhydrazone derivatives I (R¹ = H, CH₃, Cl; R² = H, CH₃; R³ = 2,4-F₂, 3,5-Cl₂, 2,6-Cl₂, etc.) was synthesized. The structure of I (R¹ = H; R² = H; R² = 2-F) was further confirmed by single crystal X-ray diffraction as (E)-configuration. All the compounds were screened for antifungal activity against Rhizoctonia solani and Magnaporthe oryzae employing a mycelium growth rate method. Compound I (R¹ = H; R² = H; R² = 2,4-F₂) exhibited significant inhibitory activity against R. solani and M. oryzae with the EC₅₀ values of 1.20 and 1.85 μg/mL, resp. In vivo testing demonstrated that I (R¹ = H; R² = H; R² = 2,4-F₂) could effectively control the development of rice sheath blight (RSB) and rice blast (RB) caused by the above two phytopathogens. This work indicated that the compound I (R¹ = H; R² = H; R² = 2,4-F₂) with a benzimidazole phenylhydrazone scaffold could be considered as a leading structure for the development of novel fungicides. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Formula: C9H8N2O).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Formula: C9H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of methylimidazolium amine ionic liquid for ATRP polymerization system was written by Xue, Teng;Zhou, Jian;Fu, Tantan;Tang, Erjun;Zhao, Dishun. And the article was included in Huagong Xuebao (Chinese Edition) in 2016.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

1-(Pr amine)ethyl-3-Me chloride ionic liquid ([N₂C₃MIM]Cl) was prepared on the base of N-methylimidazole by 1,2-dichloroethane to obtain the intermediates 1-chloro-ethyl-3-Me chloride ionic liquid ([CeMIM]Cl) and then reacting with 1,3-propanediamine. The chem. structure of [N₂C₃MIM]Cl was confirmed by FT-IR and ¹H NMR. [N₂C₃MIM]Cl possessed a lower REDOX potential (-0.522 V) through cyclic voltammetry measurement, [N₂C₃MIM]Cl presented a perfect coordination property compared with organic ligands. The obtained ionic liquid [N₂C₃MIM]Cl coordinated with CuBr was used to catalyze atom transfer radical polymerization (ATRP) of Me methacrylate (MMA) and it indicated by gel permeation chromatog. (GPC) that the coordination ionic liquid [N₂C₃MIM]Cl presented the perfect controllability to the ATRP reactions. The residues of Cu²⁺ in polymerization product PMMA was only 270 mg·kg^-1 by at. absorption spectrometry determination It showed that [N₂C₃MIM]Cl was conducive to the separation of catalyst from the obtained product compared with the traditional organic ligands. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Additions of Aldehyde-Derived Radicals and Nucleophilic N-Alkylindoles to Styrenes by Photoredox Catalysis was written by Lux, Marcel;Klussmann, Martin. And the article was included in Organic Letters in 2020.Recommanded Product: 1-Methylbenzimidazole This article mentions the following:

The consecutive addition of acyl radicals and N-alkylindole nucleophiles to styrenes was established, as well as some addnl. radical-nucleophile combinations. Both aryl and aliphatic aldehydes give reasonable yields. The reaction proceeds best for α-substituted styrenes, effectively creating a quaternary all-carbon center. Some iridium-based photoredox systems are catalytically active; furthermore, a base is needed in this transformation. Radicals are formed by reductive perester cleavage and hydrogen atom transfer. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Interfacial activity and micellar morphology of an imidazolium ring containing zwitterionic surfactants was written by Ali, Hazrat;Khan, Azim;Ahmad, Tauqeer;Dervisi, Athanasia;Fallis, Ian;Shoetan, Ibrahim O.;Khan, Abbas;Hussain, Arshad;Griffiths, Peter. And the article was included in Journal of Surfactants and Detergents in 2022.Name: 1-Octyl-1H-imidazole This article mentions the following:

Zwitterionic surfactants based on 3-(1-alkyl-3-imidazolio) propane-sulfonate ([ImS3-R] where R is octyl or dodecyl) is an emerging and important class of amphiphile due to their relevance as nano reactors for the synthesis of metallic nanoparticles and accelerated acid hydrolysis. The physicochem. properties of such synthesized imidazolium ring-containing zwitterionic surfactants have been characterized by surface tension and small-angle neutron scattering (SANS) techniques. Surface tension measurements were used to calculate several thermodn. parameters over a range of concentrations and temperatures (298-313 K). The results obtained showed a weak signature representing the critical micelle concentration (CMC) for ImS3-8, however, by increasing the alkyl length of the hydrophobic group to dodecyl, i.e., ImS3-8 to ImS3-12, the signature of the CMC was much more evident. As expected, the CMC for ImS3-12 shifted to a lower concentration An increase in temperature increased the surface activity and decreased the CMC of both zwitterionic surfactants, although the changes were small. Compared to classical surfactants, i.e., sodium dodecyl sulfate and dodecyl trimethylammonium bromide, the CMC of ImS3-12 is much lower. Modeling of SANS data demonstrated that the morphol. of the micelles formed by these amphiphiles may be described by the “classical” model, a central hydrophobic core, with a shell of hydrated headgroups. Due to their widespread applications in colloidal and interfacial science, the present study adds new insight to the fundamental understanding of these interesting imidazolium-based surface-active ionic liquids (ImS3-R). In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Name: 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Name: 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ribosides and Ribotide of a Fairy Chemical, Imidazole-4-carboxamide, as Its Metabolites in Rice was written by Choi, Jae-Hoon;Matsuzaki, Nobuo;Wu, Jing;Kotajima, Mihaya;Hirai, Hirofumi;Kondo, Mitsuru;Asakawa, Tomohiro;Inai, Makoto;Ouchi, Hitoshi;Kan, Toshiyuki;Kawagishi, Hirokazu. And the article was included in Organic Letters in 2019.Application In Synthesis of 1H-Imidazole-4-carboxamide This article mentions the following:

The metabolism of imidazole-4-carboxamide (ICA) in plants has been unknown. Two metabolites (1 and 2) were isolated from ICA-treated rice, and their structures were determined by spectroscopic anal. including the single-crystal X-ray diffraction technique and synthesis. The ribotide of ICA (3), whose existence was predicted, was also synthesized and detected from the treated rice by LC-MS/MS. These results indicated that rice might interconvert ICA, 1, and 3 to regulate the biol. activity. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Application In Synthesis of 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and properties of imidazolium-derived biocidals was written by Li, Bingzhen;Li, Yihe;Zhang, Zhe;Xiao, Hua;Jiang, Zhenhua;Li, Gong Yi;Ahn, Kwang-Duk. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2013.Category: imidazoles-derivatives This article mentions the following:

Synthesis and antibacterial activity evaluation of 1-alkyl-3-(4-vinylbenzyl)imidazolium chlorides (alkyl = Me, n-Bu, n-C₆H₁₃, n-C₈H₁₇, n-C₁₂H₂₅) with hydrophobic alkyl substituents are reported. In antibacterial activity study of these imidazolium salts by minimal inhibitory concentrations (MICs) on E. coli., the dodecyl-substituted product showed promising antibacterial activity with MICs at 2.4 μg/mL. It was found that the MIC value of the synthesized imidazole derivatives increased as the number of alkyl substituent carbons increased up to 12 carbons. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Category: imidazoles-derivatives).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Semi-Transparent and Stable Solar Cells for Building Integrated Photovoltaics: The Confinement Effects of the Polymer Gel Electrolyte inside Mesoporous Films was written by Zhou, Huawei;Cui, Jiawen;Guo, Junxue;Tao, Siwen;Gao, Xiaorui;Liu, Meiqian;Wang, Miaomiao;Yu, Ning;Wang, Xiaojun;Gong, Haoyu;Li, Yanmin;Wang, Ziang;Liu, Tian;Sun, Xun;Chen, Yan;Yin, Jie;Zhang, Xianxi;Zhang, Chunyang;Shi, Yantao. And the article was included in ACS Omega in 2019.Computed Properties of C8H8N2 This article mentions the following:

The semi-transparent solar cells are promising to be applied in building integrated photovoltaic (BIPV) and tandem solar cells. In this study, semi-transparent and stable solar cells are fabricated for BIPV by utilizing a poly (ethylene oxide) electrolyte and controlling the size of TiO₂ nanoparticles and the thickness of the TiO₂ film. The power conversion efficiency of the semi-transparent (> 50% transmittance at 620-750 nm) and quasi-solid solar cells is 5.78% under standard AM1.5G, 100 mW cm^-2. The higher conductivity and smaller diffusion resistance of the quasi-solid electrolyte inside the mesoporous TiO₂ film indicate the confinement effects of the polymer electrolyte inside a mesoporous TiO₂ film. The unsealed semi-transparent and quasi-solid solar cell retains its initial efficiency during 1000 h irradiation in humid air. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Computed Properties of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Computed Properties of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reactions of N-aryl-N-(4,5-dihydro-1H-imidazol-2-yl)hydroxylamines with methanesulfonyl chloride. Synthesis and acylation of 2,3-dihydro-1H-imidazo[1,2-a]benzimidazoles was written by Saczewski, F.;Debowski, T.. And the article was included in Polish Journal of Chemistry in 1998.Safety of 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole This article mentions the following:

Reactions of N-aryl-N-(4,5-dihydro-1H-imidazo-2-yl)hydroxylamines with methanesulfonyl chloride in the presence of triethylamine afforded 2,3-dihydroimidazo[1,2-a]benzimidazoles. The latter compounds, treated with acetic anhydride, methane or phenylsulfonyl chlorides, gave N-acetyl or N-methane or N-phenylsulfonyl derivatives In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Safety of 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Safety of 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Evaluation of the surface properties of poly(ionic liquid) materials by inverse gas chromatography was written by Wang, Qiang. And the article was included in European Polymer Journal in 2020.Recommanded Product: 915358-85-9 This article mentions the following:

Inverse gas chromatog. (IGC) was used as a tool to evaluate the surface parameters of three poly(1-alkyl-3-vinylimidazolium hexafluorophosphate) (P[C_nVIM][PF₆], n = 2, 4, 6) materials that were obtained by a free-radical polymerization IGC characterization was carried out at temperatures ranging between 303.15 and 343.15 K for determining the dispersive free energy (γ_ds) as well as the Lewis acidity and basicity parameters of the three materials. The retention behavior of the probes on the surfaces of the three materials was analyzed by plotting the net retention volumes (Vn) of the probes as a function of temperature The dispersive free energy results revealed that all three materials have high γds values and that the γds value decreases in an almost linear fashion with increasing temperature The acid-base data for the three materials confirmed that the surfaces of all three materials can be considered to be amphoteric with a predominantly basic character and that the basicity decreases with increasing alkyl side chain length on the imidazolium backbone. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Recommanded Product: 915358-85-9).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 915358-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem