Imidazoles-derivatives

Femtosecond and nanosecond LIBS studies of nitroimidazoles: correlation between molecular structure and LIBS data was written by Rao, E. Nageswara;Mathi, P.;Kalam, S. Abdul;Sreedhar, S.;Singh, Ajay K.;Jagatap, B. N.;Rao, S. Venugopal. And the article was included in Journal of Analytical Atomic Spectrometry in 2016.Recommanded Product: 3034-41-1 This article mentions the following:

In the present study, seven novel explosive mols. (nitroimidazoles) have been investigated for laser induced breakdown (LIB) spectral signatures of mol. and at. species in air and argon atmospheres utilizing both femtosecond (fs) and nanosecond (ns) laser pulse excitation. The mol. emissions were observed to be stronger in the fs spectra whereas at. emissions were prominent in the ns spectra recorded in both air and argon atmospheres. The C₂ Swan band was strongest in an argon atm. while the CN violet band was strongest in ambient environment. The LIB spectra were analyzed for understanding (a) the influence of mol. structure i.e. type of bonds (C-C, C=C, C-N and C=N) on at. (C, H, N and O) and mol. (CN, C₂ and NH) emissions, (b) effect of surrounding atm. on the fs and ns LIB spectra, (c) correlation between stoichiometric and intensity ratios of mol. as well as at. species, (d) effect of the number of substituents and their position in the ring on the fragmentation pathways and (e) correlation between oxygen balance and LIB spectra. Furthermore, time resolved spectroscopic studies of the plasma induced by fs and ns laser pulses have been carried out to understand the temporal evolution and possible reaction mechanisms of various mol. species. An attempt has been made to correlate the spectral emission with the chem. structure for this series of energetic materials. Our detailed studies and analyses clearly suggest that the atomization/fragmentation ratio could serve as a performance metric for high energy materials. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Halogen migration in reactions of halo imidazoles with potassium amide in liquid ammonia was written by De Bie, D. A.;Van der Plas, H. C.. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1969.Category: imidazoles-derivatives This article mentions the following:

5-Bromo-1-methylimidazole (I) is treated with KNH2 to give a mixture of 4-bromo-1-methylimidazole (II) and 1-methylimidazole (III). A mixture of 4,5-dibromo-1-methylimidazole and III gives II. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Category: imidazoles-derivatives).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Catalytic synthesis of benzimidazoles and organic carbamates using a polymer supported zinc catalyst through CO₂ fixation was written by Biswas, Imdadul Haque;Biswas, Surajit;Islam, Sarikul Md;Riyajuddin, Sk;Sarkar, Priyanka;Ghosh, Kaushik;Islam, Sk Manirul. And the article was included in New Journal of Chemistry in 2019.COA of Formula: C8H8N2 This article mentions the following:

Utilization of carbon dioxide in chem. fixation for synthesis of fine chems. like benzimidazoles, organic carbamates, etc. is in high demand in recent years as carbon dioxide is a cost effective, sustainable, and green renewable C1 source. In this article we present the design and synthesis of an organically modified polystyrene bound heterogeneous [PS-Zn(II)-SALTETA] catalyst. The catalyst has been characterized thoroughly by Fourier transform IR spectroscopy, at. absorption spectroscopy, thermogravimetric anal., PXRD, SEM and EDAX studies. The catalyst was used for cyclization of o-phenylenediamines through insertion of carbon dioxide in order to produce benzimidazoles in the presence of dimethylamine borane (DMAB). The developed catalytic procedure is sustainable, economical and efficient owing to the utilization of ethanol/water as a biodegradable and environment friendly solvent system. Besides benzimidazole production the catalyst was also very active for manufacture of organic carbamates from anilines and Bu bromide under atm. CO₂ pressure under solvent free conditions at room temperature and the catalytic protocol showed outstanding functional group tolerance. Moreover the catalyst is highly recyclable and reusable. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6COA of Formula: C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.COA of Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Environmental properties of phosphonium, imidazolium and ammonium cation-based ionic liquids as potential lubricant additives was written by Oulego, P.;Blanco, D.;Ramos, D.;Viesca, J. L.;Diaz, M.;Hernandez Battez, A.. And the article was included in Journal of Molecular Liquids in 2018.Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

This research compares the environmental properties (bacterial toxicity and biodegradability) of 12 ionic liquids -ILs- (7 phosphonium, 2 imidazolium and 3 ammonium cation-based ones), potentially applicable as lubricant additive, with two types of the traditional lubricant additive ZDDP. Aquatic toxicity was determined by means of Vibrio fischeri and Escherichia coli bacteria, while biodegradability was evaluated through biol. oxygen demand (BOD₅) and COD (COD) measurements. Regarding toxicity results, [P₄₄₄₂][DEP] was the least toxic IL (acute 3 according to GHS) for both bacteria, whereas ZDDP fell into the acute 1 category (very toxic). All samples tested turned out to be poorly biodegradable, showing BOD₅/COD values below 0.1. Two ILs showed better combined tribol. and environmental properties than ZDDP. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A new class of benzoin condensation catalysts: N,N’-disubstituted o-phenylenediamines was written by Morkovnik, Anatolli S.;Khrustalev, Viktor N.;Lindeman, Sergei V.;Struchkov, Yuril T.;Morkovnik, Zinaida S.. And the article was included in Mendeleev Communications in 1995.Quality Control of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

N,N’-dialkyl(diaralkyl)-o-phenylenediamine 1-R¹NHC₆H₄NHR²-2 (R¹ = R² = Me, Et, CH₂Ph; R¹ = Et, R² = allyl) act as effective catalysts in benzoin condensation of heterocyclic aldehydes I (X = NMe, NEt, Se) to give dihydroxy alkene products II. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Quality Control of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Quality Control of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors was written by Ma, Chunlong;Wang, Jun. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2021.Electric Literature of C33H34N6O6 This article mentions the following:

Recently several study report the discovery of 16 Food and Drug Administration-approved drugs as severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) main protease (Mpro) inhibitors. They were identified from a computational virtual screening approach using the Mpro as the drug target, and their enzymic inhibition against SARS-CoV-2 M pro was validated in the fluorescence resonance energy transfer (FRET)-based enzymic assay (inhibitory constant Ki = 0.04 to 3.27μM). Here, authors highlight that among the discovered drugs dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Acidified Ionic Liquid Assisted Recovery of Vanadium and Nickel from Oilsands Bitumen was written by Chauhan, Garima;de Klerk, Arno. And the article was included in Energy & Fuels in 2021.COA of Formula: C4H7ClN2 This article mentions the following:

Extraction of vanadium and nickel from diluted oil sands bitumen was investigated. The extraction was performed using HCl acidified ionic liquids, aqueous NaCl diluted ionic liquids, and water diluted ionic liquids to evaluate the relative contributions of acidity, dilution, and ionic strength on the extraction efficiency of ionic liquids Experiments were conducted with 1-methylimidazolium chloride ([HMIM]-Cl), 1-ethyl-3-Me imidazolium chloride ([EMIM]-Cl), 1-butyl-3-Me imidazolium chloride ([BMIM]-Cl), and 1-ethyl-3-Me imidazolium di-Et phosphate ([EMIM]-DEP). Acid concentration was varied over the range 0.1-10 M, and dilution was varied over the range 2-30 wt %. The study included an evaluation of the change in viscosity on dilution, and it was found that heavy oil viscosity mixing rules could adequately describe the change in viscosity on dilution The combined effect of the dissociation equilibrium and partitioning of the resulting metal containing species between the phases provided a plausible explanation to unify all of the observations in this work. It could explain the differences between vanadium and nickel extraction, as well as the differences in extraction behavior of the ionic liquid mixtures Acidification of the ionic liquids influenced the dissociation equilibrium of the metal ions (VO²⁺ or Ni²⁺) and the organic bases, e.g., porphyrins. The anionic species in the ionic liquid (Cl^– or [PO₄(C₂H₅)₂]^–) affected the extent of metal ion exchange and its partitioning between the oil and ionic liquid phases. Nickel was efficiently extracted as the chloride salt. Diethylphosphate was a better counterion to facilitate vanadium extraction In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3COA of Formula: C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Discovery of a novel highly potent broad-spectrum heterocyclic chemical series of arenavirus cell entry inhibitors was written by Plewe, Michael B.;Gantla, Vidyasagar Reddy;Sokolova, Nadezda V.;Shin, Young-Jun;Naik, Shibani;Brown, Eric R.;Fetsko, Alexandra;Zhang, Lihong;Kalveram, Birte;Freiberg, Alexander N.;Henkel, Greg;McCormack, Ken. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2021.Recommanded Product: 6-Bromo-8-methylimidazo[1,2-a]pyridine This article mentions the following:

We identified and explored the structure-activity relationship (SAR) of a novel heterocyclic chem. series of arenavirus cell entry inhibitors. Optimized lead compounds, including diphenyl-substituted imidazo[1,2-a]pyridines, benzimidazoles, and benzotriazoles exhibited low to sub-nanomolar potency against both pseudotyped and infectious Old and New World arenaviruses, attractive metabolic stability in human and most nonhuman liver microsomes as well as a lack of hERG K + channel or CYP enzyme inhibition. Moreover, the straightforward synthesis of several lead compounds (e.g., the simple high yield 3-step synthesis of imidazo[1,2-a]pyridine I) could provide a cost-effective broad-spectrum arenavirus therapeutic that may help to minimize the cost-prohibitive burdens associated with treatments for emerging viruses in economically challenged geog. settings. In the experiment, the researchers used many compounds, for example, 6-Bromo-8-methylimidazo[1,2-a]pyridine (cas: 217435-65-9Recommanded Product: 6-Bromo-8-methylimidazo[1,2-a]pyridine).

6-Bromo-8-methylimidazo[1,2-a]pyridine (cas: 217435-65-9) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 6-Bromo-8-methylimidazo[1,2-a]pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of substituents on the electronic structure and spectral characteristics of imidazole derivatives in the ground and excited states was written by Prokop’eva, T. M.;Vysotskii, Yu. B.;Dadali, V. A.;Sokolenko, V. A.. And the article was included in Ukrainskii Khimicheskii Zhurnal (Russian Edition) in 1982.Product Details of 83741-35-9 This article mentions the following:

Ground- and excited-state electron d. distributions were calculated for imidazole, benzimidazole, their protonated and anionic forms, and 1-phenylimidazole by the PMO LCAO SCF method. The results of the calculations corresponded to exptl. reactivity data. The lowest singlet-singlet transition energies were also calculated for benzimidazoles, and these agreed with exptl. spectra. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-benzoimidazole (cas: 83741-35-9Product Details of 83741-35-9).

4-Bromo-1H-benzoimidazole (cas: 83741-35-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Product Details of 83741-35-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors was written by Wang, Xie;Lin, Zongtao;Bustin, Katelyn A.;McKnight, Nate R.;Parsons, William H.;Matthews, Megan L.. And the article was included in Journal of the American Chemical Society in 2022.Safety of (1H-Imidazol-2-yl)methanamine dihydrochloride This article mentions the following:

Electrophilic cofactors are widely distributed in nature and play important roles in many physiol. and disease processes, yet they have remained blind spots in traditional activity-based protein profiling (ABPP) approaches that target nucleophiles. More recently, reverse-polarity (RP)-ABPP using hydrazine probes identified an electrophilic N-terminal glyoxylyl (Glox) group for the first time in secernin-3 (SCRN3). The biol. function(s) of both the protein and Glox as a cofactor has not yet been pharmacol. validated because of the lack of selective inhibitors that could disrupt and therefore identify its activity. Here, we present the first platform for analyzing the reactivity and selectivity of an expanded nucleophilic probe library toward main-chain carbonyl cofactors such as Glox and pyruvoyl (Pyvl) groups. We first applied the library proteome-wide to profile and confirm engagement with various electrophilic protein targets, including secernin-2 (SCRN2), shown here also to possess a Glox group. A broadly reactive indole ethylhydrazine probe was used for a competitive in vitro RP-ABPP assay to screen for selective inhibitors against such cofactors from a set of com. available nucleophilic fragments. Using Glox-containing SCRN proteins as a case study, naphthyl hydrazine was identified as a potent and selective SCRN3 inhibitor, showing complete inhibition in cell lysates with no significant cross-reactivity detected for other enzymes. Moving forward, this platform provides the fundamental basis for the development of selective Glox inhibitors and represents a starting point to advance small mols. that modulate electrophile-dependent function. In the experiment, the researchers used many compounds, for example, (1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7Safety of (1H-Imidazol-2-yl)methanamine dihydrochloride).

(1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Safety of (1H-Imidazol-2-yl)methanamine dihydrochloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem