Mohammad, Ali et al. published their research in Tenside, Surfactants, Detergents in 2015 | CAS: 35487-17-3

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride

Ionic liquid in thin-layer chromatography of anionic surfactants: selective separation of sodium deoxycholate and identification in commercial products was written by Mohammad, Ali;Mobin, Rizwana. And the article was included in Tenside, Surfactants, Detergents in 2015.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

The coupling of a silica static flat phase impregnated with an ionic liquid (1-methylimidazolium chloride) as stationary phase with 2-methyltetrahydrofuran an alternative green solvent of THF as mobile phase has been very successful for a selective separation of sodium deoxycholate from other commonly used anionic surfactants. The proposed thin-layer chromatog. system is capable to anal. discriminate among the anionic surfactants in relation to their migration behavior on an ionic liquid loaded silica layer. The surface structure and chem. composition of silica gel G modified by impregnation were examined with the aid of SEM (SEM) and energy dispersive X-ray spectrophotometry (EDX) resp. Effects of concentration level of 1-Me imidazolium chloride as impregnant and its substitution by other ionic liquids (1,2,3-trimethylimidazolium Me sulfate, 1-ethyl-3-methylimidazolium tetrafluoroborate) were also studied to decide the optimum exptl. conditions for better separation possibilities. Chromatog. parameters such as ΔRF, the separation factor (α) and the resolution (RS) for the separation and limit of detection were calculated The developed method has been usefully applied for the identification of sodium deoxycholate and sodium lauryl sulfate in formulated and com. available products (Colgate toothpaste and Head & Shoulder Shampoo). In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yang, Jian et al. published their research in Organic Chemistry Frontiers in 2022 | CAS: 85692-37-1

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C6H8N2O

Construction of chiral chroman skeletons via catalytic asymmetric [4+2] cyclization of ortho-hydroxyphenyl-substituted para-quinone methides catalyzed by a chiral-at-metal rhodium complex was written by Yang, Jian;Ming, Siliang;Yao, Gang;Yu, Haifeng;Du, Yu;Gong, Jun. And the article was included in Organic Chemistry Frontiers in 2022.Formula: C6H8N2O This article mentions the following:

An efficient asym. [4+2] cyclization of α,β-unsaturated 2-acyl imidazoles I (R1 = Me, iso-Pr, phenyl; R2 = Ph, 2-naphthyl, 1-methyl-1H-indol-3-yl, etc.) with ortho-hydroxyphenyl-substituted para-quinone methide derivatives II (R3 = H, 3-fluoro, 4-Me, 5-methoxy, etc.) catalyzed by a chiral-at-metal rhodium complex III has been developed. Enantioenriched chroman derivatives bearing three contiguous tertiary stereocenters IV (R4 = H, 6-methoxy, 7-Me, 8-fluoro, etc.) were obtained in generally high yields (up to 97%) and good stereoselectivities (up to >20:1 dr, >99% ee). This reaction represents the first catalytic asym. [4+2] cyclization of ortho-hydroxyphenyl-substituted p-QMs using chiral Lewis acids as catalysts, which will enrich the field of the catalytic asym. reactions of p-QM derivatives More importantly, it also provides a useful method for constructing chiral chroman skeletons. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yang, Ji et al. published their research in Fenxi Ceshi Xuebao in 2011 | CAS: 26832-08-6

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C4H5N3O

Investigation of glucose/asparagine model system nonaqueous phase maillard reaction by thermogravimetry-solid phase microextraction/gas chromatography-mass spectrometry was written by Yang, Ji;Yang, Liu;Lu, Lan;Wu, Yiqin;Cao, Qiue. And the article was included in Fenxi Ceshi Xuebao in 2011.Electric Literature of C4H5N3O This article mentions the following:

A new combination system of thermogravimetry-solid phase microextraction/gas chromatog.-mass spectrometry (TG-SPME/GC-MS) was applied for anal. of the thermal properties of the glucose/asparagine model system nonaqueous phase Maillard reaction. 46 Main pyrolysis evolved products were identified and the dynamic changes of relative content of these products were monitored. The heating rate and air flow were set at 10°C/min and 400 mL/min, resp. The evolved components were extracted with solid phase microextraction in the temperature range of 50-400°C. A continuous sampling method was adopted at different temperature section according to the results of TG/DTA. There were 5 temperature zones in whole reaction process. Addnl., the extract was separated and analyzed by GC-MS. The results showed that the whole thermo decomposition procedure of glucose/ asparagine could be divided into four stages. A lot of volatile flavor compounds were produced in these stages. The reaction was an endothermic process. The thermolysis activation energy of glucose and asparagine, resp., was higher than that of their mixed counter parts. There were 43 chromatog. peaks to be detected. Category and quantity of Maillard reaction product changed the following rise of temperature In the low-temperature section, long-chain alkane, ketone and furfural were found. In the high-temperature section, pyridine, pyrrole, imidazole and other heterocyclic compounds which contained N atom were detected. Adding vitamin C and ferulic acid is an effective method to reduce acrylamide in glucose/asparagine model system nonaqueous phase Maillard reaction, and vitamin C on inhibition of acrylamide formation is more efficient than ferulic acid. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Electric Literature of C4H5N3O).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C4H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hirohata, R.’s team published research in Proceedings of the International Congress of Biochemistry in | CAS: 45533-87-7

Proceedings of the International Congress of Biochemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Name: (2-Methyl-1H-imidazol-4-yl)methanol.

Hirohata, R. published the artcileSynthesis of ophidine, Name: (2-Methyl-1H-imidazol-4-yl)methanol, the publication is Proceedings of the International Congress of Biochemistry (1955), 20, database is CAplus.

Ophidine is an anserine-like compound from cobra muscle. Kendo (C.A. 45, 3438c) reported that it is β-alanyl-2-methylhistidine. To confirm this structure, 2-methyl-4(5)-hydroxymethylimidazole (I), m. 114°, was synthesized from NH4OH, fructose, and AcH. I was converted to the chloromethyl compound (II), m. 125°. AcNHCH(CO2Et)2 was condensed with II, yielding Et α-acetamido-α-carbethoxy-2-methyl-4(5)-imidazolepropionate (III), m. 122°. III was hydrolyzed and decarboxylated to 2-methylhistidine (IV), m. 231°, which was acetylated and resolved by means of acylase 1. The resulting L-IV with phthaloyl-β-alanyl chloride in the presence of NEt3 at -10° yielded phthaloyl-β-alanyl-2-methylhistidine (V), m. 240°. By treating V with N2H4.H2O solution 2 days, the phthaloyl group was detached, and β-alanyl-2-methylhistidine, m. 249°, was obtained. It gave no depression in m.p. when mixed with natural ophidine. Few exptl. details are given.

Proceedings of the International Congress of Biochemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Name: (2-Methyl-1H-imidazol-4-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Issa, I. M.’s team published research in Pharmazie in 33 | CAS: 2508-72-7

Pharmazie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Computed Properties of 2508-72-7.

Issa, I. M. published the artcilePolarographic estimation of antazoline hydrochloride, Computed Properties of 2508-72-7, the publication is Pharmazie (1978), 33(8), 513-15, database is CAplus and MEDLINE.

Antazoline-HCl (I-HCl) [2508-72-7] was estimated polarog. at a dropping Hg electrode in KCl-HCl supporting electrolyte (pH 3.2). Two waves were produced with E1/2 values of -1.35 V and -1.65 V. As revealed from the study of the effect of Hg column height, pH of the medium, and concentration of the depolarizer, the polarog. reduction of the antazolinium cation was preceded by a catalytic H-wave. The diffusion-controlled nature of the electrode process allowed I determination at â‰?.0 × 10-4 M. The procedure is simple, accurate, and sensitive and could be used in the presence of tablet additives.

Pharmazie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Computed Properties of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Baca, Kalin R.’s team published research in ACS Sustainable Chemistry & Engineering in 10 | CAS: 79917-90-1

ACS Sustainable Chemistry & Engineering published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Synthetic Route of 79917-90-1.

Baca, Kalin R. published the artcilePhase Equilibria and Diffusivities of HFC-32 and HFC-125 in Ionic Liquids for the Separation of R-410A, Synthetic Route of 79917-90-1, the publication is ACS Sustainable Chemistry & Engineering (2022), 10(2), 816-830, database is CAplus.

Current legislation calling for the phase out of hydrofluorocarbon (HFC) refrigerants is driving a global market shift that has prompted industry and research institutions to investigate new refrigerant mixtures and sustainable separation techniques for recycling refrigerants. The recent American Innovation and Manufacturing (AIM) Act of 2020 requires an 85% phase down of HFC production over the next 15 years. To achieve this goal, azeotropic refrigerant mixtures, such as R-410A composed of 50 wt % HFC-32 (difluoromethane, CH2F2) and 50 wt % HFC-125 (pentafluoroethane, CHF2CF3), will have to be separated to recycle the lower global warming HFC-32 component. The present work investigates the solubility of HFC-32 and HFC-125 in six ionic liquids (ILs) with halogen anions for the purpose of developing the thermophys. property data required for designing extractive distillation recycling processes and understanding the choice of cation and anion type. A gravimetric microbalance was used to collect isothermal vapor-liquid equilibrium data for each of the ILs at 298.15 K and pressures from 0.05 to 1.0 MPa. The Peng-Robinson equation of state was used to model the solubility of the HFCs in the ILs. The solubility of HFC-32 in the ILs showed small differences, while the solubility of HFC-125 had significant variations with respect to the anion type and the cation alkyl chain length. Fick’s law was applied to calculate diffusion coefficients for each HFC/IL system. HFC-32 has a greater diffusivity than HFC-125 based on the smaller mol. size. The 1-n-hexyl-3-methylimidazolium chloride and the trihexyl(tetradecyl)phosphonium chloride ILs have the highest HFC-125/HFC-32 selectivity at 298.15 K. Based on both the mass uptake and selectivity ratio, these two ILs are potential entrainers for the separation of R-410A using extractive distillation

ACS Sustainable Chemistry & Engineering published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Synthetic Route of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Dazhi’s team published research in Organic Letters in 21 | CAS: 258278-25-0

Organic Letters published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Quality Control of 258278-25-0.

Li, Dazhi published the artcileSynthesis of Imidazolidinone, Imidazolone, and Benzimidazolone Derivatives through Oxidation Using Copper and Air, Quality Control of 258278-25-0, the publication is Organic Letters (2019), 21(10), 3572-3575, database is CAplus and MEDLINE.

A new synthetic method of urea derivatives using copper and air was developed. These mild conditions provided moderate to very good yields for 15 examples (53-93%), while low yields were obtained with sterically hindered substrates (3 examples). The reaction was found to go through an in situ generated copper-N-heterocyclic carbene, which was then oxidized into cyclic urea derivatives possessing alkyl, benzyl, aryl, hydroxy, Boc-protected, and tertiary amine groups.

Organic Letters published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Quality Control of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Dazhi’s team published research in Journal of Organometallic Chemistry in 906 | CAS: 258278-25-0

Journal of Organometallic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Product Details of C27H39ClN2.

Li, Dazhi published the artcileMechanism studies of oxidation and hydrolysis of Cu(I)-NHC and Ag-NHC in solution under air, Product Details of C27H39ClN2, the publication is Journal of Organometallic Chemistry (2020), 121025, database is CAplus.

The decomposition of copper(I)-NHC and silver-NHC complexes in solution under air was studied. The Cu(I)-NHCs were oxidized into urea derivatives and hydrolyzed into imidazoliums or benzimidazoliums. The decomposition of Ag-NHC with a saturated backbone led to ring-opening product, while the Ag-NHC with an unsaturated backbone led to imidazolium and Ag-bisNHC complex. The effects of steric property, hydrophilicity, and binding energy of NHC to O2 and H2O on the decomposition of Cu(I)-NHC were studied using theor. calculations Steric hindrance played an important role on the stability of Cu(I)-NHC. Pathways for the decomposition of Cu(I)-NHC and Ag-NHC were proposed.

Journal of Organometallic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Product Details of C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Handy, Scott T.’s team published research in Journal of Organic Chemistry in 70 | CAS: 45533-87-7

Journal of Organic Chemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Synthetic Route of 45533-87-7.

Handy, Scott T. published the artcileThe 2-Position of Imidazolium Ionic Liquids: Substitution and Exchange, Synthetic Route of 45533-87-7, the publication is Journal of Organic Chemistry (2005), 70(5), 1915-1918, database is CAplus and MEDLINE.

The 2-position of imidazolium cations is known to be relatively acidic, leading to the useful Arduengo-type carbenes. At the same time, the acidity of this site can lead to undesired side reactions when using imidazolium-based ionic liquids as solvents. In this note, we describe the surprisingly facile deuterium exchange at this position and also the synthesis and exchange under modestly basic conditions (triethylamine) of a series of 2-methyl-substituted compounds

Journal of Organic Chemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Synthetic Route of 45533-87-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Handy, Scott T.’s team published research in Proceedings – Electrochemical Society in 2004-24 | CAS: 45533-87-7

Proceedings – Electrochemical Society published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Related Products of imidazoles-derivatives.

Handy, Scott T. published the artcileImidazolium ionic liquids: C2 substitution and acidity, Related Products of imidazoles-derivatives, the publication is Proceedings – Electrochemical Society (2006), 548-555, database is CAplus.

Although imidazolium room temperature ionic liquids (RTILs) have found considerable application, they are not the “inert” solvents that they are frequently considered to be. In particular, the 2 position is prone to deprotonation to form a stabilized carbene. Although this can be beneficial, it can also result in unwanted side reactions under basic conditions. We have studied the acidity of this position in substituted and unsubstituted imidazolium RTILs and discovered that even simple Me substitution does not avoid reasonably facile deprotonation at this site.

Proceedings – Electrochemical Society published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem