Imidazoles-derivatives

Mizuhara, Tsukasa published the artcileDesign and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182, SDS of cas: 359860-27-8, the publication is Bioorganic & Medicinal Chemistry (2013), 21(7), 2079-2087, database is CAplus and MEDLINE.

To investigate the mechanism of action of the potent antiviral compound PD 404182, three novel photoaffinity probes equipped with a biotin or alkyne indicator were designed and synthesized based on previous structure-activity relationship studies. These probes retained the potent anti-HIV activity of the original pyrimidobenzothiazine derivatives In photoaffinity labeling studies using HIV-1-infected H9 cells (H9IIIB), eight potential proteins were observed to bind PD 404182.

Bioorganic & Medicinal Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, SDS of cas: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Eom, Young Woo published the artcileCytotoxicity of substituted benzimidazolyl curcumin mimics against multi-drug resistance cancer cell, Quality Control of 7467-35-8, the publication is Bulletin of the Korean Chemical Society (2013), 34(4), 1272-1274, database is CAplus.

Recently, we discovered that introduction of benzimidazole groups to the feruloyl scaffold through aldol condensation greatly improved the cytotoxicity of synthetic curcumin mimics against various cancer cells. Because the benzimidazole mols. exhibit a variety of biol. properties such as anticancer, antiviral, and anti-hypertensive activity, we can expect their novel cytotoxic properties come from benzimidazolyl groups attached to the feruloyl structure. Our goal was to evaluate the cytotoxicity of novel curcumin mimics with structurally diverse benzimidazol moieties against multidrug resistance (MDR) cancer cells. A novel curcumin mimics library has been synthesized with the purpose of discovering novel anticancer drug candidates that inhibit a proliferation both MDR cancer cells and non-MDR cancer cells at the same time. We confirmed that our novel curcumin mimics inhibit the growth of MDR cancer cells more strongly than our previous inhouse curcumin mimic libraries and curcumin; among the tested derivatives, 13b, 14b, and 14h are the strongest candidates inhibiting multidrug resistance cancer cells.

Bulletin of the Korean Chemical Society published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Quality Control of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Huang, Zhen published the artcileGlobal Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10-2474, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is ACS Chemical Biology (2019), 14(2), 192-197, database is CAplus and MEDLINE.

Clin. investigation of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 resulted in serious adverse neurol. events. Structurally unrelated FAAH inhibitors tested in humans have not presented safety concerns, suggesting that BIA 10-2474 has off-target activities. A recent activity-based protein profiling (ABPP) study revealed that BIA 10-2474 and one of its major metabolites inhibit multiple members of the serine hydrolase class to which FAAH belongs. Here, we extend these studies by performing a proteome-wide anal. of covalent targets of BIA 10-2474 metabolites. Using alkynylated probes for click chem.-ABPP in human cells, we show that des-methylated metabolites of BIA 10-2474 covalently modify the conserved catalytic cysteine in aldehyde dehydrogenases, including ALDH2, which has been implicated in protecting the brain from oxidative stress-related damage. These findings indicate that BIA 10-2474 and its metabolites have the potential to inhibit multiple mechanistically distinct enzyme classes involved in nervous system function.

ACS Chemical Biology published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wysokowski, Marcin published the artcileIonic liquid-assisted synthesis of chitin-ethylene glycol hydrogels as electrolyte membranes for sustainable electrochemical capacitors, Related Products of imidazoles-derivatives, the publication is Scientific Reports (2022), 12(1), 8861, database is CAplus and MEDLINE.

A novel chitin-ethylene glycol hybrid gel was prepared as a hydrogel electrolyte for elec. double-layer capacitors (EDLCs) using 1-butyl-3-methylimidazolium acetate [Bmim][Ac] as a chitin solvent. Examination of the morphol. and topog. of the chitin-EG membrane showed a homogeneous and smooth surface, while the thickness of the membrane obtained was 27μm. The electrochem. performance of the chitin-EG hydrogel electrolyte was investigated by cyclic voltammetry and galvanostatic charge/discharge measurements. The specific capacitance value of the EDLC with chitin-EG hydrogel electrolyte was found to be 109 F g^-1 in a potential range from 0 to 0.8 V. The tested hydrogel material was electrochem. stable and did not decompose even after 10,000 GCD cycles. Addnl., the EDLC test cell with chitin-EG hydrogel as electrolyte exhibited superior capacitance retention after 10,000 charge/discharge cycles compared with a com. glass fiber membrane.

Scientific Reports published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C6H4ClNO2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kassem, A. A. published the artcileFormulation and stabilization of antazoline hydrochloride nasal drops, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Bulletin of the Faculty of Pharmacy (Cairo University) (1978), 15(2), 161-76, database is CAplus.

The influence of storage and various stabilizers on the degradation of antazoline-HCl (I) [2508-72-7] nasal drops was investigated. The degradation reaction of I was 1st order with half life of 162.8 days. Addition of stabilizers increased the stability of the drug. A mixture of 20% propylene glycol [57-55-6] with 0.1% w/v Na metabisulfite was relatively better than other stabilizers tested and the half life of the drug is protracted to 1995 days.

Bulletin of the Faculty of Pharmacy (Cairo University) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kassem, A. A. published the artcilePhysicochemical stability and bioavailability of antazoline hydrochloride suppositories, Quality Control of 2508-72-7, the publication is Bulletin of the Faculty of Pharmacy (Cairo University) (1977), 14(2), 239-49, database is CAplus.

Antazoline-HCl (I) [2508-72-7] suppositories formulated in 1:1 Witepsol H15 [18348884-L]-Witepsol E75 [18348884-L] base remained stable for 1 yr, while compositions in carbowax [25322-68-3] and cocoa butter preparations showed discoloration, crystallization, and other deterioration indications during storage. Bioavailability of I was good from Witepsol and cocoa butter formulations. I was rapidly absorbed from the rectum as indicated by protection of guinea pigs against injected histamine.

Bulletin of the Faculty of Pharmacy (Cairo University) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Quality Control of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zaouak, Amira published the artcileDegradation mechanism of losartan in aqueous solutions under the effect of gamma radiation, Product Details of C8H13ClN2O, the publication is Radiation Physics and Chemistry (2021), 109435, database is CAplus.

In this paper, the impact of gamma radiation on one of emerging pharmaceutical pollutant was investigated. Deriving from sartan class, losartan, one of the most consumed antihypertensive drug was irradiated at doses of 0.5-4 kGy in aqueous solutions The removal of COD (COD) and total organic carbon (TOC) during the irradiation process reflects that the mineralization efficiency increases with increasing radiation dose. During the mineralization process some aromatic intermediates such as 4-[2-(1H-1,2,3,4-tetrazol-5-yl) phenyl] phenol, 2-butyl-4-chloro-5-(hydroxymethyl) imidazole-1-ol, 2,4prime-dihydroxybiphenyl, tetrazole, 1,2,4 benzentriol, 1,4-hydroxyquinone and quinone were identified by LC/MS. These results show that degradation process starts with cleavage of the starting mol. by hydroxyl radicals, which are generated by the radiolysis of water. Based on these observations, a mechanistic schema of losartan was proposed. At the end, losartan kinetic study was performed indicating a pseudo first order degradation process.

Radiation Physics and Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C14H10O4, Product Details of C8H13ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Fukuda, Jun-ichi published the artcileCobalt-Catalyzed Reduction of Aryl Sulfones to Arenes by Means of Alkylmagnesium Reagents, HPLC of Formula: 258278-25-0, the publication is Asian Journal of Organic Chemistry (2018), 7(10), 2049-2052, database is CAplus.

A cobalt-catalyzed reduction of aryl sulfones to the corresponding arenes was developed. With a cobalt-IPr catalyst and a primary alkylmagnesium reagent as the hydride source, a range of aryl sulfones and some other organosulfur compounds were reduced.

Asian Journal of Organic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, HPLC of Formula: 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Constanti, A. published the artcileAntagonism by some antihistamines of the amino acid-evoked responses recorded from the lobster muscle fiber and the frog spinal cord, Quality Control of 2508-72-7, the publication is British Journal of Pharmacology (1976), 58(4), 583-92, database is CAplus and MEDLINE.

On lobster muscle in vitro, histamine [51-45-6] H1 receptor blockers, e.g. antazoline-HCl (I-HCl) [2508-72-7] (40μM-1mM) reversibly antagonized responses to both-applied glutamate [56-86-0] (0.1mM), aspartate [56-84-8] (1 or 2 mM), or quisqualic acid [52809-07-1] (1-6μM), but not GABA [56-12-2] (40μM). Histamine (â‰?mM) had no effect on this preparation The H1 antagonists produced a small increase in muscle hyperpolarization; procaine [59-46-1] (1mM) decreased membrane conductance but did not affect responses to GABA or glutamate. The H2 antagonist burimamide (II) [34970-69-9] blocked glutamate and GABA-evoked responses on the lobster muscle without affecting resting potential or conductance. In the frog spinal cord, bath-applied histamine produced ventral root depolarizations and dorsal root hyperpolarizations which were reduced by tetrodotoxin but not by I or II; II reversibly antagonized responses to both glutamate and GABA on tetrodotoxin-treated cords whereas I was ineffective. Antihistamines may act as nonspecific amino acid antagonists by interacting at the level of the receptor-coupled ionophores.

British Journal of Pharmacology published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Quality Control of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Mitra, Mainak published the artcileNonheme Fe(IV) Oxo Complexes of Two New Pentadentate Ligands and Their Hydrogen-Atom and Oxygen-Atom Transfer Reactions, Synthetic Route of 4760-35-4, the publication is Inorganic Chemistry (2015), 54(15), 7152-7164, database is CAplus and MEDLINE.

Two new pentadentate {N5} donor ligands based on the N4Py (N4Py = N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine) framework were synthesized, viz. [N-(1-methyl-2-benzimidazolyl)methyl-N-(2-pyridyl)methyl-N-(bis-2-pyridyl Me)amine] (L¹) and [N-bis(1-methyl-2-benzimidazolyl)methyl-N-(bis-2-pyridylmethyl)amine] (L²), where one or two pyridyl arms of N4Py were replaced by corresponding (N-methyl)benzimidazolyl-containing arms. [Fe^II(MeCN)(L)]²⁺ (L = L¹Â 1; L²Â 2) were synthesized, and reaction of these ferrous complexes with iodosylbenzene gave the ferryl complexes [Fe^IV(O)(L)]²⁺ (L = L¹Â 3; L²Â 4), which were characterized by UV-visible spectroscopy, high resolution mass spectrometry, and Mossbauer spectroscopy. Complexes 3 and 4 are relatively stable with half-lives at room temperature of 40 h (L = L¹) and 2.5 h (L = L²). The redox potentials of 1 and 2, as well as the visible spectra of 3 and 4, indicate that the ligand field weakens as ligand pyridyl substituents are progressively substituted by (N-methyl)benzimidazolyl moieties. The reactivities of 3 and 4 in H-atom transfer (HAT) and O-atom transfer (OAT) reactions show that both complexes exhibit enhanced reactivities when compared to the analogous N4Py complex ([Fe^IV(O)(N4Py)]²⁺), and that the normalized HAT rates increase by âˆ? order of magnitude for each replacement of a pyridyl moiety; i.e., [Fe^IV(O)(L²)]²⁺ exhibits the highest rates. The 2nd-order HAT rate constants can be directly related to the substrate C-H bond dissociation energies. Computational modeling of the HAT reactions indicates that the reaction proceeds via a high spin transition state.

Inorganic Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Synthetic Route of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem