Imidazoles-derivatives

Nguyen, Thanh Binh published the artcileSulfur-Catalyzed Oxidative Coupling of Dibenzyl Disulfides with Amines: Access to Thioamides and Aza Heterocycles, COA of Formula: C19H14N2, the publication is Advanced Synthesis & Catalysis (2019), 361(8), 1787-1791, database is CAplus.

In the presence of catalytic amounts of elemental sulfur, dibenzyl disulfide/DMSO was found to be an excellent thiobenzoylating agent of amines to provide a wide range of thioamides. The reaction becomes autocatalytic when anilines substituted by an o-cyclizable group were used as nucleophile, leading to the corresponding 2-aryl aza heterocycles.

Advanced Synthesis & Catalysis published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, COA of Formula: C19H14N2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kerche, Eduardo Fischer published the artcileThe influence of ionic liquid concentration on microcrystalline cellulose modification, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Carbohydrate Polymer Technologies and Applications (2022), 100211, database is CAplus.

Ethanolic ionic liquid (IL) solutions, containing different 1-n-butyl-3-methylimidazolium chloride (C₄MImCl) concentrations were used to modify the surface of com. microcrystalline cellulose (MCC). The chosen ratios were: 4, 8, 16, and 32 weight% of IL, in relation to the MCC mass. These treatments with IL did not affect the MCC morphol. FTIR anal. showed the characteristic bands of C₄MImCl when the IL concentration was higher than 4 weight%. XRD diffractograms show that the crystals may have been disrupted for IL concentrations above 4 weight%. ¹H NMR confirmed the formation of strong hydrogen bonds between C₄MImCl and MCC, especially for MCC treated with 4 weight% of IL. The functionalization using IL, regardless of the content, showed two DTG peaks, without altering the MCC Arrhenius’ parameters and degradation mechanisms. 4 Weight% of C₄MImCl proved to be suitable for the MCC surface modification, improving thermal stability without detrimental effects on MCC morphol.

Carbohydrate Polymer Technologies and Applications published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Stairs, Shaun published the artcileMetabolic Glycan Imaging by Isonitrile-Tetrazine Click Chemistry, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is ChemBioChem (2013), 14(9), 1063-1067, database is CAplus and MEDLINE.

This paper presents a proof-of-principle study in which isonitrile-bearing sugars are incorporated into cell surfaces and labeled by a bioorthogonal isonitrile-tetrazine click reaction. Isonitrile-tetrazine chem. is orthogonal to the popular azide-alkyne chem., simultaneous differential multi-sugar imaging is a real possibility with the chem.

ChemBioChem published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C17H26BNO3, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Saab, Marina published the artcileStraightforward access to chalcogenoureas derived from N-heterocyclic carbenes and their coordination chemistry, Formula: C27H39ClN2, the publication is Dalton Transactions, database is CAplus and MEDLINE.

Chalcogen-based urea compounds supported by a wide range of N-heterocyclic carbenes were synthesized and fully characterized. Coordination of selenoureas is further explored with Group 11 transition metals to form new copper, gold and silver complexes. Single crystal x-ray analyses unambiguously establish the solid-state coordination of these complexes and show that the geometry of a complex is highly influenced by a combination of electronic properties – mainly π-accepting ability – and steric hindrance of the ligands, as well as the nature of the metal, affording a variety of coordination behaviors. The authors study these phenomena using several exptl. methods.

Dalton Transactions published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Formula: C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Popov, I. I. published the artcileStudy of unsaturated azole derivatives. VII. Novel syntheses of 2-vinylbenzimidazoles, Synthetic Route of 7467-35-8, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1978), 1104-7, database is CAplus.

Vinylbenzimidazole I (R = H, R¹ = H, Me; R = Me, MeO, NO₂, R¹ = Me) were obtained in 50-90% yields in 3 steps from II (R = H, NO₂) by cyclocondensation with ClCH₂CO₂H or from III (R = H, Me, MeO, R¹ = Me, R² = CH₂OH) by chlorination with SOCl₂ to give III (R = CH₂Cl) which were treated with Ph₃P to give 62-94% triphenylphosphonium chloride which were condensed with CH₂O via a Wittig reaction.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Synthetic Route of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Popov, I. I. published the artcileStudy of unsaturated azole derivatives. VII. Novel syntheses of 2-vinylbenzimidazoles, Name: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1978), 1104-7, database is CAplus.

Vinylbenzimidazole I (R = H, R¹ = H, Me; R = Me, MeO, NO₂, R¹ = Me) were obtained in 50-90% yields in 3 steps from II (R = H, NO₂) by cyclocondensation with ClCH₂CO₂H or from III (R = H, Me, MeO, R¹ = Me, R² = CH₂OH) by chlorination with SOCl₂ to give III (R = CH₂Cl) which were treated with Ph₃P to give 62-94% triphenylphosphonium chloride which were condensed with CH₂O via a Wittig reaction.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Name: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sekhar Pattanaik, Sudhansu published the artcileInvestigation of the inter-ionic interactions of an imidazolium-based ionic liquid with the aqueous solutions of tripotassium citrate and trisodium citrate through volumetric, acoustic and FTIR routes, Computed Properties of 79917-90-1, the publication is Journal of Molecular Liquids (2022), 118644, database is CAplus.

Volumetric, acoustic and spectroscopic characteristics of an imidazolium-based ionic liquid, 1-Butyl-3-methylimidazolium chloride ([bmim][Cl]) in water and aqueous solutions of tri-potassium citrate, K₃Cit, and tri-sodium citrate, Na₃Cit were studied at five different temperatures T = (298.15 K, 303.15 K, 308.15 K, 313.15Kand 318.15 K) and atm. pressure (0.1Mpa). The apparent molar volume,VΦ, and apparent molar compressibility, KΦ, S were computed from the exptl. data of densities and ultrasonic speeds. The derived properties such as standard partial molar volume, V⁰Φ , partial molar compressibilities, K⁰Φ,S, limiting apparent molar expansivity, E⁰Φ, and their corresponding transfer volumes, Δ_trV⁰Φ, transfer compressibilities, ΔtrK⁰Φ,S, of [bmim][Cl] from water to aqueous potassium/sodium citrate solutions were also determined The transfer properties have been used to discuss the solute-solvent interactions that exist in the solutions The pos. value of Hepler’s constant indicates that the IL has structure-making ability in the studied solutions In addition, FTIR spectroscopy was executed on the systems. Based on these data, the predominant mol. interactions occurring between [bmim][Cl] and water and in between [bmim][Cl] and K₃Cit/Na₃Cit were found to be hydrogen bonds.

Journal of Molecular Liquids published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C10H16Br3N, Computed Properties of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jinnouchi, Hikari published the artcileDivergent synthesis of (+)-tanikolide and its analogues employing stereoselective rhodium(II)-catalyzed reaction, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Tetrahedron (2018), 74(10), 1059-1070, database is CAplus.

In this study, we described the divergent synthesis of (+)-tanikolide (I) and its analogs, such as (4S)- and (4R)-hydroxytanikolides, and nortanikolide, employing a stereoselective dirhodium(II)-catalyzed reaction to construct the quaternary chiral center of tanokolides. The key steps involve (a) a dirhodium(II)-catalyzed oxonium ylide formation-[2,3]-sigmatropic rearrangement, (b) an N-heterocyclic carbene-catalyzed ring-expansion lactonization of tetrahydrofurfural, or (c) an oxidative cleavage of tetrahydrofuran-5-methanol to γ-lactone using a 2-iodobenzamide catalyst. This route would provide high flexibility for analog synthesis because the long side chain can be introduced at a later stage in the synthesis.

Tetrahedron published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Maddiboyina, Balaji published the artcilePreparation and evaluation of esomeprazole enteric coated tablets, Safety of Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is International Journal of Pharmacy and Pharmaceutical Research (2020), 18(1), 16-30, database is CAplus.

Esomeprazole sodium is a proton pump inhibitor used to treat peptic ulcer, duodenal ulcer, gastro oesophageal reflux disease by inhibiting the enzyme H⁺/K⁺ATPase. The objective of the revision is to formulate and evaluate the Delayed Release tablets and parallel with that of innovator product. The principal intension is to delay the release of drug which is incapacitated by the stomach contents. Methacrylicacid copolymer (EudragitL30D55) was used as an enteric coating material in the formulation. Eight formulations of enteric coated tablets of Esomeprazole was advanced by preparing core tablets using mannitol as diluent, Crospovidone as super disintegrant, povidone (PVP K-30) as binder in diverse extents and variable the compositions of sub coating and enteric coating using sicovit yellow, titanium dioxide and eudragit.The core tablets were prepared by dry granulation method. Formulation F7 was institute to be acid resistant and invitro drug release was also insightful and akin to the innovator product. Stability study is conceded out for 2 mo at 25°C; 60% RH: and 40°C; 75%RH, bestowing to ICH guidelines. The tablets were tested for acid release through the stability period and inveterate that results were institute within the limits. H⁺/K⁺ATPase, inhibition by the Esomeprazole effect the gastric acid formation progression and is dose-dependent and delivers for exceedingly operative inhibition of both basal acid secretion and stimulated acid secretion, irresp. of the stimulus.

International Journal of Pharmacy and Pharmaceutical Research published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Safety of Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Tanaka, Katsunori published the artcileDevelopment of bis-unsaturated ester aldehydes as amino-glue probes: sequential double azaelectrocyclization as a promising strategy for bioconjugation, Product Details of C18H34N4O5S, the publication is Organic & Biomolecular Chemistry (2013), 11(42), 7326-7333, database is CAplus and MEDLINE.

The unsaturated ester aldehyde, (E)-3-alkoxycarbonyl-5-phenyl-2,4-dienal, was efficiently dimerized by applying the strain-promoted double-Click reaction with sym-dibenzo-1,5-cyclooctadiene-3,7-diyne. The resulting dimerized probe was sequentially reacted first with one peptide mol. and then with a protein or the amino groups on the surface of a live cell through double azaelectrocyclization to achieve highly efficient bioconjugation.

Organic & Biomolecular Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C7H8N2, Product Details of C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem