Imidazoles-derivatives

Isojima, Yasushi published the artcileCkIε/δ-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock, Category: imidazoles-derivatives, the publication is Proceedings of the National Academy of Sciences of the United States of America (2009), 106(37), 15744-15749, S15744/1-S15744/74, database is CAplus and MEDLINE.

A striking feature of the circadian clock is its flexible yet robust response to various environmental conditions. To analyze the biochem. processes underlying this flexible-yet-robust characteristic, we examined the effects of 1260 pharmacol. active compounds in mouse and human clock cell lines. Compounds that markedly (>10 s.d.) lengthened the period in both cell lines, also lengthened it in-central clock tissues and peripheral clock cells. Most compounds inhibited casein kinase Iε (CKIε) or CKIδ phosphorylation of the PER2 protein. Manipulation of CKIε/δ-dependent phosphorylation by these compounds lengthened the period of the mammalian clock from circadian (24 h) to circabidian (48 h), revealing its high sensitivity to chem. perturbation. The degradation rate of PER2, which is regulated by CKIε/δ-dependent phosphorylation, was temperature-insensitive in living clock cells, yet sensitive to chem. perturbations. This temperature-insensitivity was preserved in the CKIε/δ-dependent phosphorylation of a synthetic peptide in vitro. Thus, CKIε/δ-dependent phosphorylation is likely a temperature-insensitive period-determining process in the mammalian circadian clock.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Furukawa, Yoshiyasu published the artcileNonpeptide angiotensin II receptor antagonists. Synthetic studies on imidazoleacetic acid derivatives, Quality Control of 79047-41-9, the publication is Takeda Kenkyushoho (1991), 56-74, database is CAplus.

An improved synthetic route using 4-hydroxymethyl-2-phenylimidazole was developed for the synthesis of diuretic and angiotensin II-inhibitory CV-2198 (I, R = R¹ = H) (II). This route achieved a facile synthesis of 2-alkyl-1-benzyl-4-chloroimidazole-5-acetic acids. Study of structure-activity relationships on the 10 compounds indicated that Bu, pentyl, and hexyl groups were favorable as the 2-alkyl groups and substitution by a Cl or NO₂ group at the o-position of the benzyl moiety increased the activity. Thus, I (R = Bu, R¹ = Cl) (CV-2947) and I (R = Bu, R¹ = NO₂) (CV-2961) had angiotensin II-inhibitory activity 100-fold stronger than that of II.

Takeda Kenkyushoho published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Quality Control of 79047-41-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zinser, Caroline M. published the artcileA simple synthetic entryway into palladium cross-coupling catalysis, SDS of cas: 258278-25-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(57), 7990-7993, database is CAplus and MEDLINE.

Allylpalladium cationic complexes with imidazolylidene NHC ligands were prepared by a simple protocol, comprising synthesis of a family of allylpalladates containing with an imidazolium counterion with subsequent deprotonation with an external base. These “ate” complexes can be easily converted into well-defined palladium-N-heterocyclic carbene (NHC) complexes. The synthetic protocols leading to the “ate” and to the Pd-NHC neutral complexes have been exemplified with various NHC ligands. The palladates prove efficient pre-catalysts enabling Suzuki-Miyaura and Mizoroki-Heck reactions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C19H36BNO2Si, SDS of cas: 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Islam, Mohammad Shahidul published the artcileMizoroki-Heck Cross-Coupling of Acrylate Derivatives with Aryl Halides Catalyzed by Palladate Pre-Catalysts, Safety of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is European Journal of Inorganic Chemistry (2019), 2019(43), 4695-4699, database is CAplus.

The Mizoroki-Heck (MH) reaction involving aryl halides with various acrylates and acrylamide was studied using air and moisture-stable imidazolium-based palladate pre-catalysts for the synthesis of internal alkenes RHC=CH(R¹)(C(O)R²) [R = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, etc.; R¹ = H, Me, 4-MeOC₆H₄CH₂, etc.; R² = OMe, On-Bu, NH₂, etc.]. These pre-catalysts were converted into Pd-NHC species (NHC = N-heterocyclic carbene) under catalytic conditions and were capable of facilitating the Mizoroki-Heck reaction of aryl halides with various acrylates. The effects of solvent, catalyst loading, temperature and bases on the reaction outcome were investigated. Various coupling partners were tolerated under the optimal reaction conditions catalyzed by palladate [SIPr·H][Pd(η³-2-Me-allyl)Cl₂]. The efficiency of the optimized synthetic methodol. was tested on various aryl halides and substituted acrylates as well as acrylamides. The MH reaction yielded the coupled products in good to excellent isolated yields (up to 98%).

European Journal of Inorganic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Safety of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Gaber, Abd El-Aal M. published the artcileThermal fragmentation and rearrangement of 3-phenyl-4-aryl-5-phenylimino-1,2,4-oxadiazoline derivatives, Category: imidazoles-derivatives, the publication is Afinidad (2009), 66(541), 252-257, database is CAplus.

Thermal fragmentation of 3-phenyl-4-aryl-5-phenylimino-1,2,4-oxadiazolines I and II (Ar = Ph, p-tolyl) in a sealed tube under nitrogen gives rise to benzonitrile, arylamines, anilides, phenols, arylureas, and benzimidazole derivatives In the presence of naphthalene as solvent, I gave a- and P-naphthols beside the previous products. Also, heating of I under reflux in boiling anhydrous tetraline leads to the formation of 1-hydroxytetraline, α-tetralone and 1,1′-bi-tetralyl as the major products. The isolated products have been interpreted in terms of a free radical mechanism involving the homolysis of N-O and/or C-N bond.

Afinidad published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sieron, Leslaw published the artcileTrityl losartan, Synthetic Route of 79047-41-9, the publication is Acta Crystallographica, Section C: Crystal Structure Communications (2004), C60(11), o821-o823, database is CAplus and MEDLINE.

The title compound (systematic name: {2-butyl-4-chloro-1-[2′-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-yl}methanol), C₄₁H₃₇ClN₆O, crystallizes in the centrosym. space group P1̅ with two independent mols. in the asym. unit. Crystallog. data are given. These mols. differ significantly only in the relative orientations of the rings in the biphenylyltetrazole moieties. One of the mols. shows disorder for three C atoms in the Bu group. H bonds link the mols. in an infinite chain along the a axis.

Acta Crystallographica, Section C: Crystal Structure Communications published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C14H26O2, Synthetic Route of 79047-41-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kitamura, Mitsuru published the artcileDirect Azidation of Phenols, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is European Journal of Organic Chemistry (2019), 2019(33), 5824-5827, database is CAplus.

Direct azidation of phenols was developed. By treating chloroimidazolinium chloride I and sodium azide with phenol in the presence of a secondary amine in methoxyethanol, ortho-azidation of phenol was achieved.

European Journal of Organic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Bachhav, Rishikesh S. published the artcileAssay Test procedure as a CPP at Bulk-Solution stage – Esomeprazole Sodium Injection 40MG, Category: imidazoles-derivatives, the publication is World Journal of Pharmaceutical Research (2020), 9(5), 1565-1580, database is CAplus.

A review. To develop & validate the anal. Assay Test procedure as a Critical Processing Parameters at the Bulk-Solution stage during manufacturing of Esomeprazole Sodium Injection 40mg. As per current available literature and the references, Esomeprazole active substance is available in market in five forms, i.e. Esomeprazole as Plan active [Tablet]; Esomeprazole Magnesium Trihydrate [Tablet, Capsule Delayed Release]; Esomeprazole Potassium [Tablet & Capsule]; Esomeprazole Strontium [Capsule Delayed Release] and Esomeprazole Sodium [Injectable]. Assay test for Active & other dosage forms [Tablet, Capsule] were available. Available Test procedure are based on either Potentiometory Titration or HPLC basis. Esomeprazole Sodium Injection 40mg Dosage form is not in any pharmacopeia. As per available reference & literature assay test method for intermediate testing & finished product is based on HPLC. Intermediate testing [In-Process Testing] require as Critical Process Parameters [CPP] to ensure the quality i.e. appropriate bulk-solution purity, before to proceed for filling of Bulk-solution in unit dosage form [Vials]. To test the bulk solution purity approx. 5-6 h required. Which leads to hold the Bulk solution, further it impact & may risk bio-burdon of bulk solution Also it impact & reduce the productivity of line by 5-6 h. HPLC testing required special skilled manpower & cost. Considering all above concerns of current available test methods; this article project is selected to develop & validate the anal. Assay Test procedure as a Critical Processing Parameters at the Bulk-Solution stage during manufacturing of Esomeprazole Sodium Injection 40mg.

World Journal of Pharmaceutical Research published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Chakrabarty, Manas published the artcileA Keggin heteropoly acid as an efficient catalyst for an expeditious, one-pot synthesis of 1-methyl-2-(hetero)arylbenzimidazoles, Application In Synthesis of 2622-67-5, the publication is Tetrahedron Letters (2007), 48(30), 5239-5242, database is CAplus.

The Keggin heteropoly acid, silicotungstic acid, H₄SiW₁₂O₄₀, was demonstrated to be highly efficient for an expeditious, one-pot synthesis of arylbenzimidazoles, e.g., I, from N-methyl-1,2-benzenediamine and arylaldehydes in Et acetate at room temperature The catalyst worked equally well for N-phenyl-1,2-benzenediamine.

Tetrahedron Letters published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Application In Synthesis of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sarkar, Sujoy published the artcileIonic liquid-assisted synthesis of tri-functional ruthenium oxide nanoplatelets for electrochemical energy applications, SDS of cas: 79917-90-1, the publication is Journal of Materials Science (2022), 57(15), 7680-7693, database is CAplus.

Nanostructured crystalline metal oxides are in great demand in industrial processes due to their unique physicochem. properties and ionic liquids (ILs) are promising solvent for synthesizing such materials. Herein, we report an IL-assisted, facile, and environmental benign approach to synthesize rutile phase of ruthenium oxide (RuO₂) nanoplatelets (NPLs) structure with a size distribution of a few tens of nm. The key to this synthesis methodol. is the use of imidazolium-based ILs as solvents and binder in the ionothermal process. The obtained RuO₂ phase is thoroughly characterized by spectroscopic and microscopic techniques. Further, the material is used as electrocatalyst toward electrochem. energy storage and conversion in an alk. solution The platelet morphol. of RuO₂ exhibits excellent supercapacitor performance and its capacitance value is âˆ?200 F g^-1 in 1 M KOH solution Besides, the as-synthesized RuO₂ NPLs shows superior water oxidation and chlorine evolution processes at a minimal overpotential, i.e., 1.47 V in 1 M KOH and 1.5 V in 3 M KCl (pH 3) electrolyte, resp., exhibiting its tri-functional electrochem. behavior toward production of renewable energies. The present study demonstrates that single-step production of the NPL morphol. of RuO₂ has potential implications in the field of electrolysis and supercapacitors.

Journal of Materials Science published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, SDS of cas: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem