Imidazoles-derivatives

Thiel, W. published the artcileDithiocarboxylic acids, dithiocarboxylic esters, or thiocarboxylic amides by reaction of methylene-active chloromethyl compounds with sulfur, SDS of cas: 4760-35-4, the publication is Journal fuer Praktische Chemie (Leipzig) (1989), 331(2), 243-62, database is CAplus.

With a mixture of S and amine in DMF at room temperature halomethyl compounds can be oxidized to give thiocarboxylic acids and their derivatives The reaction was studied in detail especially with chloroacetic derivatives or chloromethyl heterocycles formally derived from chloroacetic acid. The resulting thiooxalic acid derivatives represent activated acids and very useful C₂-synthons, especially for the synthesis of heterocycles. Oxidation in the presence of Et₃N leads to dithiocarboxylates which can be alkylated to dithioesters in high yields. As a rule, with different primary and secondary amines instead of tertiary amines these dithiocarboxylates or dithiocarboxylic esters can be transformed already at low temperatures to thioamides.

Journal fuer Praktische Chemie (Leipzig) published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C16H12O, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sulaimon, Aliyu Adebayo published the artcilePredicting naphthenate precipitation and evaluating the effect of ionic liquids on its deposition, Related Products of imidazoles-derivatives, the publication is Journal of Petroleum Science & Engineering (2022), 109865, database is CAplus.

Naphthenic acids that are naturally carboxylic compounds contained in heavy crude oil are the main source of corrosion and blockage in a crude oil pipeline. The blockage is due to the formation of naphthenate deposits through a reaction of naphthenic acid with metal ions present in the crude oil. In the present study, model oil is used to evaluate the effect of water cut in the range of 10%-90%, brine pH in the range of 6-10, Ca²⁺ concentration in the range of 0.5%-2.5% and temperature in the range of 30 °C-60 °C towards naphthenate deposition with the aid of response surface methodol. NMR (NMR) and Fourier Transform IR (FTIR) were used to evaluate the structure of the naphthenic acids used. Results show that Ca²⁺ concentration contributes mostly to the naphthenate deposition, followed by brine pH, water cut and temperature Two math. models were developed to predict the final pH of the oil-brine system and the mass of precipitates with average relative errors (AREs) of 0.0328 and 0.0325 resp. The effects of two ionic liquids (ILs), 1-ethyl-3-methylimidazolium chloride (EMIM-Cl) and 1-butyl-3-methylimidazolium chloride (BMIM-Cl), on naphthenates precipitation, were also evaluated. Anal. showed that both ILs can reduce the amount of naphthenate deposited, with the BMIM-Cl showing better performance than the EMIM-Cl.

Journal of Petroleum Science & Engineering published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C13H26N2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kaliszan, Roman published the artcileSuppression of deleterious effects of free silanols in liquid chromatography by imidazolium tetrafluoroborate ionic liquids, Formula: C17H20ClN3, the publication is Journal of Chromatography A (2004), 1030(1-2), 263-271, database is CAplus and MEDLINE.

Silica-based stationary phases are commonly used in liquid chromatog., but their surface acidity causes known problems, especially when separating basic compounds Deleterious effects of free silanols are not fully removed by standard prevention procedures consisting in adding alkylamines or other amino quenchers to the eluents. Ionic liquids of the imidazolium tetrafluoroborate class, added to mobile phases at concentrations of 0.5-1.5% (volume/volume), blocked silanols and provided excellent thin-layer chromatog. separations of strongly basic drugs which were otherwise not eluted, even with neat acetonitrile as the mobile phase. The silanol suppressing potency of imidazolium tetrafluoroborates was demonstrated to markedly exceed that of the standard mobile phase additives, like triethylamine, dimethyloctylamine and ammonia. The proposed new mobile phase additives also provide reliable lipophilicity parameters of base drug analytes as determined by gradient mode of HPLC. By applying the readily available and environmentally friendly imidazolium tetrafluoroborate ionic liquids, simple and efficient means of improvement of liquid chromatog. anal. of organic bases were elaborated.

Journal of Chromatography A published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Formula: C17H20ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Agatonovic-Kustrin, S. published the artcileCompatibility studies between mannitol and omeprazole sodium isomers, Recommanded Product: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is Journal of Pharmaceutical and Biomedical Analysis (2008), 48(2), 356-360, database is CAplus and MEDLINE.

Omeprazole, commonly used in the treatment of various gastrointestinal disorders degrades rapidly in acidic pHs and results in inter-individual variability due to different rates of metabolism amongst patients. Since S-omeprazole shows more predictable bioavailability and excipients were known to interact with active pharmaceutical ingredients to produce altered bioavailability, it was decided to investigate the compatibility of omeprazole sodium isomers with mannitol, the major excipient in omeprazole formulations using differential scanning calorimetry (DSC) for bulk drug, attenuated total reflectance (ATR) IR spectroscopy in a powder mixture and localized thermal anal. (LTA) from a drug disk. DSC results clearly indicate an interaction between mannitol and R-omeprazole sodium due to decreased melting temperatures and broadening peaks. The DSC of S-omeprazole sodium does not show melting temperature although the drug was crystalline Because of the accelerated temperature conditions during DSC experiments applied in this work, ATR-IR was undertaken to determine whether these results occurred at room temperature for the solid dosage form. The ATR-IR results show a difference between R- and S-omeprazole sodium with mannitol by the appearance of both the amino (N-H) and imino (=N-H) stretching frequencies for R-omeprazole and only the N-H for the S-omeprazole sodium. It may thus be concluded that different ratios for the tautomeric forms for S- and R-omeprazole sodium result in changes in the degree of crystallinity and are responsible for the interaction with mannitol, common excipient in formulation. These interactions may be directly related to the difference in terms of bioavailability.

Journal of Pharmaceutical and Biomedical Analysis published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Recommanded Product: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Nusz, Greg J. published the artcileLabel-Free Plasmonic Detection of Biomolecular Binding by a Single Gold Nanorod, Application In Synthesis of 359860-27-8, the publication is Analytical Chemistry (Washington, DC, United States) (2008), 80(4), 984-989, database is CAplus and MEDLINE.

The authors report the use of individual gold nanorods as plasmonic transducers to detect the binding of streptavidin to individual biotin-conjugated nanorods in real time on a surface. Label-free detection at the single-nanorod level was performed by tracking the wavelength shift of the nanorod-localized surface plasmon resonant scattering spectrum using a dark-field microspectroscopy system. The lowest streptavidin concentration that was exptl. measured was 1 nM, which is a factor of 1000-fold lower than the previously reported detection limit for streptavidin binding by biotinylated single plasmonic nanostructures. The authors believe that the current optical setup is able to reliably measure wavelength shifts as small as 0.3 nm. Binding of streptavidin at 1 nM concentration induces a mean resonant wavelength shift of 0.59 nm suggesting that the authors are currently operating at close to the limit of detection of the system.

Analytical Chemistry (Washington, DC, United States) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Application In Synthesis of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Shiye published the artcileIonic liquid-modulated aerobic oxidation of isoeugenol and β-caryophyllene via nanoscale Cu-MOFs under mild conditions, Safety of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Molecular Catalysis (2022), 112416, database is CAplus.

Novel synergistic systems based on Cu-1,3,5-benzenetricarboxylate and ionic liquid are developed for the convenient conversion of renewable olefins, isoeugenol and β-caryophyllene, under very mild conditions (i.e. 313 K and 1 atm O₂). Using acidic ionic liquid [C₄mim][HSO₄] (5.0 mol%) as co-catalyst, Cu₃(BTC)₂-Lauric acid (LA) afforded high selectivity (95.8%) and excellent yield (86.3%) for vanillin Me ketone during the aerobic oxidation of isoeugenol. In comparison, 91.1% selectivity for vanillin together with 28.9% conversion of isoeugenol was obtained over Cu₃(BTC)₂-LA in the presence of amino acid ionic liquid, [C₄mim][Ala]. Addnl., 91.3% selectivity and 86.5% yield for β-caryophyllene epoxide were provided by Cu₃(BTC)₂-LA with the aid of neutral [C₄mim]Cl (5.0 mol%), indicating the importance of different types of ILs in tuning the microenvironments of designed Cu₃(BTC)₂-LA nanosystems. Simultaneously, Cu₃(BTC)₂-LA/IL showed superior stability during above-mentioned transformations, as verified by TEM, FT-IR and XRD analyses. Insights into the synergistic free radical routes were supported by fluorescence and DRUV-Vis characterizations.

Molecular Catalysis published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Safety of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Abd-Elbary, A. published the artcileInteraction of carbopol 934 with certain antihistaminic drugs, HPLC of Formula: 2508-72-7, the publication is Pharmazie (1981), 36(5), 356-8, database is CAplus.

Increases in Carbopol 934 [9007-16-3] concentration and pH of the buffer solutions resulted in an increased interaction of antazoline-HCl (I-HCl) [2508-72-7] and cyproheptadine-HCl (II-HCl) [969-33-5] with Carbopol 934 while increases in I-HCl or II-HCl concentrations or the presence of NaCl resulted in a decreased interaction. IR spectrum anal. showed that I-HCl reaction was chem., while II-HCl reaction with Carbopol 934 was probably phys. in nature.

Pharmazie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, HPLC of Formula: 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Muscat Galea, Charlene published the artcileInvestigation of the effect of mobile phase composition on selectivity using a solvent-triangle based approach in achiral SFC, Application In Synthesis of 2508-72-7, the publication is Journal of Pharmaceutical and Biomedical Analysis (2017), 247-257, database is CAplus and MEDLINE.

Defining a method development methodol. for achiral drug impurity profiling in SFC requires a number of steps. Initially, diverse stationary phases are characterized and a small number of orthogonal or dissimilar phases are selected for further method development. In this paper, we focus on a next step which is the investigation of the modifier composition on chromatog. selectivity. A solvent-triangle based approach is used in which blends of organic solvents, mainly ethanol (EtOH), propanol (PrOH), acetonitrile (ACN) and THF mixed with methanol (MeOH) are tested as modifiers on six dissimilar stationary phases. The tested modifier blends were composed to have equal eluotropic strengths as calculated on bare silica. The modifier leads to minor changes in terms of elution order, retention and mixture resolution However, varying only the modifier composition on a given stationary phase does not lead to the creation of dissimilar systems. Therefore the modifier composition is an optimization parameter, with the stationary phase being the factor determining most the selectivity of a given mixture in achiral SFC.

Journal of Pharmaceutical and Biomedical Analysis published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Application In Synthesis of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Galea, Charlene published the artcileMethod development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases, Related Products of imidazoles-derivatives, the publication is Journal of Pharmaceutical and Biomedical Analysis (2015), 333-343, database is CAplus and MEDLINE.

Supercritical fluid chromatog. (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both anal. and on a preparative scale. The use of SFC as a technique for drug impurity profiling is examined here. To define starting conditions in method development for drug impurity profiling, a set of dissimilar stationary phases is screened in parallel. The possibility to select a set of dissimilar columns using the retention factors (k-values) for a set of 64 drugs measured on 27 columns in SFC was examined Experiments were carried out at a back-pressure of 150 bar and 25 °C with a mobile phase consisting of CO₂ and methanol with 0.1% isopropylamine (5-40% over 10 min) at a flow rate of 3 mL/min. These k-values were then used to calculate correlation coefficients on the one hand and to perform a principal component anal. on the other. The Kennard and Stone algorithm, besides dendrograms and correlation-coefficient color maps were used to select a set of 6 dissimilar stationary phases. The stationary phase characterization results from this study were compared to those from previous studies found in the literature. Retention mechanisms for compounds possessing different properties were also evaluated. The dissimilarity of the selected subset of 6 stationary phases was validated using mixtures of compounds with similar properties and structures, as one can expect in a drug impurity profile.

Journal of Pharmaceutical and Biomedical Analysis published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Podder, Nirmalya published the artcileAerobic oxidation of 2-aminophenol catalysed by a series of mononuclear copper(II) complexes: phenoxazinone synthase-like activity and mechanistic study, Synthetic Route of 4760-35-4, the publication is New Journal of Chemistry, database is CAplus.

Three mononuclear copper(II) complexes of types [Cu(L¹)(Cl)₂]·MeOH (1·MeOH), [Cu(L²)(Cl)₂]·H₂O (2·H₂O) and [Cu(L³)(Cl)₂] (3) have been synthesized from three reduced Schiff base tridentate N₃ ligands, namely N-(pyridin-2-ylmethyl)quinolin-8-amine ([H₂]L¹), N-(1-methylbenzimidazol-2-ylmethyl)quinolin-8-amine ([H₂]L²), and N-(1-methylimidazol-2-ylmethyl)quinolin-8-amine ([H₂]L³), resp., having variable donor moieties. During metalation all three reduced Schiff base ligands undergo oxidative dehydrogenation in situ under aerobic conditions to yield the corresponding Schiff base ligated mononuclear copper(II) complexes. All complexes have been characterized using various spectroscopic techniques such as IR, HRMS-ESI, UV-vis, and EPR. Structural characterization of each complex by single crystal x-ray diffraction reveals that the coordination environment around the copper ion is distorted square pyramidal. The three complexes effectively catalyze the aerial oxidation of 2-aminophenol (H₂AP) to 2-amino-phenoxazine-3-one (APX), thus mimicking the catalytic function of the enzyme phenoxazinone synthase. Kinetic studies have been done to arrive at the following catalytic efficiency order: 3 â‰?2·H₂O > 1·MeOH. The observed trend can be explained by considering the structure-function relation of the catalytic activity. Intramol. charge distribution (valence tautomerism) within a complex-substrate adduct leads to the generation of a “Cu^I-(substrate radical)” tautomer. This phenomenon has been established by EPR spectroscopy, particularly using 2-anilino-4,6-di-tert-butylphenol (H₂AP^Ph,t-Bu, a structural analog of H₂AP) as a substrate. Such a “Cu^I-(substrate radical)” species is believed to promote dioxygen activation. The effects of temperature and pH on the reaction rates have been studied. Activation parameters (E_a, ΔH^{â€?/sup>, and ΔSâ€?/sup>) have been evaluated from temperature-dependent kinetic measurements. A plausible reaction pathway has been proposed on the basis of stoichiometry determination, spectroscopic data and kinetic anal.}

New Journal of Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Synthetic Route of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem