Imidazoles-derivatives

Verma, Raman K. published the artcileDesign and Synthesis of Benzimidazole-Linked meta-Substituted Benzylidenes/Benzyls as Biologically Significant New Chemical Entities, Computed Properties of 4760-35-4, the publication is Synthetic Communications (2013), 43(14), 1882-1895, database is CAplus.

Meta-Linked thiazolidinedione (TZD)- and di-Et malonate (DEM)-based benzylidenes and Me acetoacetate (MAA)-based benzyl moieties linked to the 2-position of N-Me benzimidazole were synthesized. TZD- and DEM-based compounds were synthesized by condensation of 2,4-thiazolidinedone and DEM resp. with the corresponding 3-substituted benzaldehyde, whereas MAA-based compounds were obtained by halogen displacement with the corresponding 3-substituted phenol. These new chem. entities were designed to provide a balanced agonism at the peroxisome proliferator activated receptor alpha/gamma in the management of type 2 diabetes: a move from glitazones to selective PPAR modulators.

Synthetic Communications published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C4H3Cl2N3, Computed Properties of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Fedyuk, D. V. published the artcileFluorine-containing derivatives of imidazole and benzimidazole exhibiting hypotensive properties, Safety of (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, the publication is Ukrainskii Khimicheskii Zhurnal (Russian Edition) (1999), 65(11-12), 81-86, database is CAplus.

Fluorine-containing analogs of the hypotensive preparation Losartan, e.g., I (R = Bu, SCF₂CF₃, SCF₂CF₂CF₃; R¹ = H, CF₃CF₂O, CF₃S, CF₃CF₂S, CF₃CF₂CF₂SO₂) and II, were prepared

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Safety of (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Pawlaczyk, Jan published the artcileMineral contamination of drugs. I. Application of spectrography and atomic absorption spectrometry to the analysis of metal ion traces, SDS of cas: 2508-72-7, the publication is Acta Poloniae Pharmaceutica (1979), 36(1), 59-62, database is CAplus and MEDLINE.

Ca, Ag, Cu, Al, Bi, Ni, Fe, Mg, Pb, and Zn ions were the most abundant contaminants in phenylbutazone [50-33-9], Na aminosalicylate [133-10-8], carbromal [77-65-6], methylphenobarbital [115-38-8], chlorpromazine-HCl [69-09-0], Et aminobenzoate [94-09-7], nitrofurantoin [67-20-9], glutethimide [77-21-4], antazoline-HCl [2508-72-7], barbital [57-44-3], phenytoin [630-93-3], and bromisoval [496-67-3] preparations In some cases, the levels of the contaminants were determined by at. absorption spectrometry upon mineralization or extraction with HCl.

Acta Poloniae Pharmaceutica published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, SDS of cas: 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Goswami, Shyamaprosad published the artcileA FRET-based rhodamine-benzimidazole conjugate as a Cu²⁺-selective colorimetric and ratiometric fluorescence probe that functions as a cytoplasm marker, Safety of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is RSC Advances (2014), 4(12), 6300-6305, database is CAplus.

On the basis of fluorescence resonance energy transfer (FRET) from benzimidazole to a rhodamine moiety, a rhodamine-benzimidazole conjugate (RBC) ratiometric fluorescent probe has been designed and synthesized. The RBC selectively binds to Cu²⁺, showing visually observable changes in absorption and emission behavior, and demonstrates an effective intracellular Cu²⁺ imaging ability, allowing it to function as a cytoplasm marker.

RSC Advances published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Safety of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Basappa, B. H. Doreswamy published the artcileReduction of aldehydes and oximes to their corresponding alcohols and amines by catalytic hydrogenation method, HPLC of Formula: 79047-41-9, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2005), 44B(1), 148-151, database is CAplus.

The reduction of aldehydes such as 2-butyl-5-chloro-3H-imidazole-5-carboxaldehyde and veratraldehyde, which are pharmaceutical key intermediates, were reduced to alcs. by a catalytic hydrogenation method in the presence of Mg and also oximes are reduced to primary amines successively by the Mg/ammonium formate system, is a large scale feasible and cheaper method. The crystal structure of the product, 2-butyl-5-chloro-3H-imidazole-4-ylmethanol, is reported.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, HPLC of Formula: 79047-41-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ariki, Zachary T. published the artcilePreparation of Quaternary Centers via Nickel-Catalyzed Suzuki-Miyaura Cross-Coupling of Tertiary Sulfones, Category: imidazoles-derivatives, the publication is Journal of the American Chemical Society (2018), 140(1), 78-81, database is CAplus and MEDLINE.

We describe the development of a nickel-catalyzed Suzuki-Miyaura cross-coupling of tertiary benzylic and allylic sulfones with arylboroxines. A variety of tertiary sulfones, which can easily be prepared via a deprotonation-alkylation route, were reacted to afford sym. and unsym. quaternary products in good yields. We highlight the use of either BrettPhos or Doyle’s phosphines as effective ligands for these challenging desulfonative coupling reactions. The utility of this methodol. was demonstrated in the concise synthesis of a vitamin D receptor modulator analog.

Journal of the American Chemical Society published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kosmulski, Marek published the artcileZeta potential in dispersions of titania nanoparticles in moderately polar solvents stabilized with anionic surfactants, Application of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Journal of Molecular Liquids (2022), 118972, database is CAplus.

Electrophoretic mobility of titania nanoparticles in ethane-1,2-diol and in propane-1,2-diol in the presence of SDS and sodium octadecylsulfate was measured. Several dispersions were acidified with HCl or alkalized with NaOH. Addition of acid resulted in pos. and addition of base resulted in neg. zeta potential. Anionic surfactants have moderate effect on the zeta potential. They enhanced neg. zeta potential, but their effect became significant at surfactant concentrations as high as 1 g/L. Sodium octadecylsulfate was more efficient than SDS in shifting the zeta potential to more neg. values.

Journal of Molecular Liquids published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Application of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ding, Haoshu published the artcilePyrolytic characteristics of Fushun oil shale and its by-products, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Journal of Thermal Analysis and Calorimetry (2022), 147(8), 5255-5267, database is CAplus.

FTIR, TG-DTG, TG-FTIR, and Py-GC-MS were employed to investigate the similarities and differences in the pyrolytic characteristics of Fushun oil shale and its byproducts, i.e., semi-coke and residual. The semi-coke was obtained by slowly pyrolyzing the oil shale to 450°C. The residual was a solid residue prepared by completely extracting the semi-coke with a 1-butyl-3-methylimidazolium chloride and N-Me pyrrolidon mixture The pyrolysis of three samples is related to the cleavages of weak bonds (200-400°C), decomposition of major organic structures (400-600°C), and the cleavages of 3-4 kinds of chem. bonds. Gaussian fitting methods was used to fit the DTG curves to evaluate the contributions of various covalent bonds to the pyrolysis. The flash pyrolysis products and typical gaseous products were identified, showing the most outstanding performances of the aliphatic compounds The differences in the pyrolytic characteristics of three samples are mainly attributed to the diverse forms of thermal bitumen. The attendance of thermal bitumen in the semi-coke, especially its light components generated from oil shale pyrolysis, prompts the more active mass loss behaviors at relatively low temperatures, while the absence of thermal bitumen results in a fairly low mass loss of the residual.

Journal of Thermal Analysis and Calorimetry published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wei, Yi-Ming published the artcileIron-catalyzed stereospecific arylation of enol tosylates using Grignard reagents, Related Products of imidazoles-derivatives, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(7), 1101-1104, database is CAplus and MEDLINE.

The stereospecific Fe-catalyzed arylation of enol tosylates with Grignard reagents was reported for the synthesis of Z- and E- tri/tetrasubstituted acrylates (Ar)(R)C=C(CO₂R¹)(R²) [R = Me, i-Pr, Ph, etc.; R¹ = Me, Et; R² = H, Me, Ph; Ar = Ph, 2-CNC₆H₄, 2-thienyl, etc.]. Various tri- or tetrasubstituted Z or E-enol tosylates of β-keto esters were arylated using common and Knochel-type Grignard reagents with complete stereofidelity. The precursors for Z/E-zimelidine, tamoxifen and other bioactive compounds were facilely prepared without precious and toxic transition metals.

Chemical Communications (Cambridge, United Kingdom) published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C39H35N5O8, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Han, Bo published the artcileChromium- and Cobalt-Catalyzed, Regiocontrolled Hydrogenation of Polycyclic Aromatic Hydrocarbons: A Combined Experimental and Theoretical Study, Computed Properties of 258278-25-0, the publication is Journal of the American Chemical Society (2019), 141(22), 9018-9026, database is CAplus and MEDLINE.

Polycyclic aromatic hydrocarbons are difficult substrates for hydrogenation because of the thermodn. stability caused by aromaticity. We report here the first chromium- and cobalt-catalyzed, regiocontrolled hydrogenation of polycyclic aromatic hydrocarbons at ambient temperature These reactions were promoted by low-cost chromium or cobalt salts combined with diimino/carbene ligand and methylmagnesium bromide and are characterized by high regioselectivity and expanded substrate scope that includes tetracene, tetraphene, pentacene, and perylene, which have rarely been reduced. The approach provides a cost-effective catalytic protocol for hydrogenation, is scalable, and can be utilized in the synthesis of tetrabromo- and carboxyl-substituted motifs through functionalization of the hydrogenation product. The systematic theor. mechanistic modelings suggest that low-valent Cr and Co monohydride species, most likely from zerovalent transition metals, are capable of mediating these hydrogenations of fused PAHs.

Journal of the American Chemical Society published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Computed Properties of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem