Imidazoles-derivatives

Nicastri, Michael C. published the artcileSynthesis of Sterically Hindered Primary Amines by Concurrent Tandem Photoredox Catalysis, Application of 2-(2-Methyl-1H-imidazol-1-yl)pyridine-4-carbonitrile, the publication is Journal of the American Chemical Society (2020), 142(2), 987-998, database is CAplus and MEDLINE.

Primary amines are an important structural motif in active pharmaceutical ingredients (APIs) and intermediates thereof, as well as members of ligand libraries for either biol. or catalytic applications. Many chem. methodologies exist for amine synthesis, but the direct synthesis of primary amines with a fully substituted α carbon center is an underdeveloped area. We report a method which utilizes photoredox catalysis to couple readily available O-benzoyl oximes with cyanoarenes to synthesize primary amines with fully substituted α-carbons. We also demonstrate that this method enables the synthesis of amines with α-trifluoromethyl functionality. Based on exptl. and computational results, we propose a mechanism where the photocatalyst engages in concurrent tandem catalysis by reacting with the oxime as a triplet sensitizer in the first catalytic cycle and a reductant toward the cyanoarene in the second catalytic cycle to achieve the synthesis of hindered primary amines via heterocoupling of radicals from readily available oximes.

Journal of the American Chemical Society published new progress about 1016841-67-0. 1016841-67-0 belongs to imidazoles-derivatives, auxiliary class Imidazoles, name is 2-(2-Methyl-1H-imidazol-1-yl)pyridine-4-carbonitrile, and the molecular formula is C10H8N4, Application of 2-(2-Methyl-1H-imidazol-1-yl)pyridine-4-carbonitrile.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Villemejeanne, Benoit published the artcileHalide based ionic liquid mixture for a sustainable electrochemical recovery of precious metals, Name: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Journal of Environmental Chemical Engineering (2022), 10(1), 107063, database is CAplus.

Precious metal refining from ore or electronic devices includes hydrometallurgical processes with major concern about toxicity or wastewater production As an alternative, one-step electroleaching-electrochem. deposition process (EL-ECD) using ionic liquid mixtures was evaluated for palladium and gold recovery. A halide based ionic liquid combined with a diluting ionic liquid was chosen among ten electrolytes after cyclic voltammetry and potentiostatic experiments These low viscous electrolytes allow complexing Au and Pd, leading to metal leaching at low anodic potential. Moreover, the complexes formed could be simultaneously deposited at the cathode. Metal behavior is similar for all halide anions tested (chloride, bromide and iodide). Results show that chloride based mixtures are the more suitable electrolyte providing the highest leaching faradic yield. This process appears more sustainable than conventional processes (chlorination, cyanide leaching) thanks to the electrolyte stability limiting solvent losses but also workers exposition.

Journal of Environmental Chemical Engineering published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C9H21NO3, Name: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hyun, Jinho published the artcileFabrication of “smart” protein nanostructures using molecular recognition and dip-pen nanolithography, Application of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is PMSE Preprints (2003), 261-262, database is CAplus.

Dip-pen nanolithog. in combination with the high-affinity streptavidin-biotin and streptavidin-iminobiotin protein ligand system provide a simple bottom-up approach to creating smart nanoscale biomol. structures in a step-wise fashion by patterning a self-assembled monolayer of a CO₂H-terminated alkanethiol on a gold substrate, followed by covalent immobilization of a high-affinity, small mol. ligand (biotin) on the nanopatterned self-assembled monolayer and mol. recognition of its protein binding partner, streptavidin from solution The resulting nanopattern provides a universal platform for mol. recognition-mediated protein immobilization. Both irreversible immobilization of a biotin-tagged protein and stimulus-triggered, reversible immobilization of N-hydroxysuccinimidoiminobiotin are presented.

PMSE Preprints published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Application of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Sang Hyun published the artcileThe Hildebrand solubility parameters, cohesive energy densities and internal energies of 1-alkyl-3-methylimidazolium-based room temperature ionic liquids, Formula: C16H23F6N3O2, the publication is Chemical Communications (Cambridge, United Kingdom) (2005), 3469-3471, database is CAplus and MEDLINE.

The Hildebrand solubility parameters, cohesive energy densities and internal energies of 1-alkyl-3-methylimidazolium-based room temperature ionic liquids were determined by the intrinsic viscosity method and their dependencies on the length of the alkyl group analyzed.

Chemical Communications (Cambridge, United Kingdom) published new progress about 862731-66-6. 862731-66-6 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid, name is 1-octyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imide, and the molecular formula is C16H23F6N3O2, Formula: C16H23F6N3O2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sarker, Aniruddha published the artcileResidue Monitoring and Risk Assessment of Cyazofamid and Its Metabolite in Korean Cabbage Under Greenhouse Conditions, Product Details of C11H8ClN3, the publication is Bulletin of Environmental Contamination and Toxicology (2020), 105(4), 595-601, database is CAplus and MEDLINE.

The residual characteristics and risk assessment with respect to cyazofamid and its metabolite 4-chloro-5-p-tolylimidazole-2-carbonitrile were monitored in case of Korean cabbage at different preharvest intervals during a greenhouse trial. The 0.02 kg a.i/ha of cyazofamid was sprayed twice on seven-day intervals (i.e., on day 0, 7, 14, and 21 before harvest). The liquid chromatog.-tandem mass spectrometry anal. was used to monitor the residual amount of fungicide. The matrix-matched calibration curves with respect to the cyazofamid in Korean cabbage exhibited good linearity (R2 �0.999) and acceptable recoveries of 84.1%-114.9%. The biol. half-life of cyazofamid in Korean cabbage was 3.18 days. During the treatment, the preharvest residue of cyazofamid in Korean cabbage 14 days before harvest (0.80 mg/kg) was lower than that specified by the MFDS-MRL (Ministry of Food and Drug Safety-Maximum Residue Limit, 2.0 mg/kg) and should be recommended as the safe preharvest-interval application limit. The hazard quotient showed low toxicity (70.58%) during the risk assessment study of cyazofamid.

Bulletin of Environmental Contamination and Toxicology published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C11H8ClN3, Product Details of C11H8ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Im, Jaewan published the artcileStructural characteristics and thermal properties of regenerated cellulose, hemicellulose and lignin after being dissolved in ionic liquids, SDS of cas: 79917-90-1, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2022), 365-375, database is CAplus.

This study investigated the use of ionic liquids such as 1-butyl-3-methylimidazolium chloride, 4-butyl-4-Me morpholinium chloride, 1-butyl-1-methylpiperidinium chloride, and 1,3-dimethylimidazolium methylphosphite to dissolve cellulose, hemicellulose, and lignin biomass, as alternatives to highly toxic organic solvents. The biomass treated with the ionic liquids is characterized by SEM, X-ray diffraction, thermogravimetric anal., and Fourier-transform IR spectroscopy. The X-ray diffraction results revealed that most of the biomass treated with ionic liquids had low crystallinity after treatment with the ionic liquids Thermogravimetric anal. confirmed that the pyrolysis temperature of the biomass treated with the ionic liquid decreased. However, it was found that the pyrolysis temperature of the biomass was increased again after the ionic liquid was washed with an antisolvent. This result was interpreted using Fourier-transform IR spectroscopy to show that the O-H hydrogen bonding of cellulose was restored. The exptl. results from this study can help provide a better understanding of the biomass regeneration mechanism of ionic liquids and increase the applicability of biomass in various fields.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, SDS of cas: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Park, Sangjin published the artcileDual Functional, Polymeric Self-Assembled Monolayers as a Facile Platform for Construction of Patterns of Biomolecules, Formula: C18H34N4O5S, the publication is Langmuir (2007), 23(22), 10902-10905, database is CAplus and MEDLINE.

The authors report a facile approach to the construction of patterns of biomols. based on polymeric self-assembled monolayers (pSAMs) that possess dual functions: “bio-reactive (post-functionalizable)” and “bio-inert (anti-biofouling)” properties. To prepare pSAMs on Si/SiO₂ wafers were new random copolymers synthesized by radical polymerization of poly(ethylene glycol) Me ether methacrylate (PEGMA), 3-(trimethoxysilyl)propyl methacrylate (TMSMA), and N-acryloxysuccinimide (NAS), and referred to as poly(TMSMA-r-PEGMA-r-NAS). Poly(TMSMA-r-PEGMA-r-NAS) was designed to play triple roles: “surface-reactive”, “bio-reactive”, and “bio-inert” ones. The pSAMs of poly(TMSMA-r-PEGMA-r-NAS) were formed on Si/SiO₂ wafers with 1 h incubation of the substrates in the polymer solution, which showed approx. a 1 nm-thick film as measured by ellipsometry. After the formation of the pSAMs, the feasibility of the pSAMs as a dual functional surface (bio-inert and bio-reactive properties) was examined The ability of the pSAMs to block nonspecific adsorption of proteins was evaluated against bovine serum albumin as a model protein. High-resolution N(1s) XPS anal. on the protein adsorption revealed that significant reduction up to âˆ?7% was observed compared to the unmodified Si/SiO₂ wafer. In addition, micropatterns of streptavidin with high signal-to-noise ratios were achieved using microcontact printing (μCP) of NH₂-bearing biotin onto the pSAMs of poly(TMSMA-r-PEGMA-r-NAS) on glass slides, which suggests that other biomols. could also be efficiently immobilized onto the pSAMs with high specificity while minimizing nonspecific adsorption. The surface d. of both bio-reactive and anti-biofouling functionality could be tailored by simply changing initial feed ratios of each monomer in the polymer synthesis:different molar ratios of the bio-reactive group (NAS: 33%, 20%, and 10%, resp.) were employed. When micropatterns of streptavidin were constructed, the pSAMs with 33% NAS moiety showed the highest immobilization of the protein. Taken together, the present dual functional, random copolymers may have warrant applications in the field of biosensors and biochips.

Langmuir published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Zee-Won published the artcileSingle cell array of biotinylated cells using surface functionalization and microcontact printing, Category: imidazoles-derivatives, the publication is Chemistry Letters (2005), 34(5), 648-649, database is CAplus.

This paper describes a versatile method for generating single cell arrays on a glass substrate, which could be applicable to any arbitrary cell types, by a combination of surface functionalization, biotinylation of cells, and microcontact printing (μCP).

Chemistry Letters published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Bong Soo published the artcileSurface-Initiated, Atom Transfer Radical Polymerization of Oligo(ethylene glycol) Methyl Ether Methacrylate and Subsequent Click Chemistry for Bioconjugation, Quality Control of 359860-27-8, the publication is Biomacromolecules (2007), 8(2), 744-749, database is CAplus and MEDLINE.

Click chem. was applied to polymeric nanobrushes presenting azide groups at the terminal. Specifically, the non-biofouling oligoethylene glycol Me ether methacrylate film was functionalized to achieve maximized biospecific interactions between surface-attached ligands and target mols. with PEG as an inert background.

Biomacromolecules published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Quality Control of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem