Imidazoles-derivatives

Lahann, Joerg published the artcileMicroengineered surfaces for biomedical applications based on a polymer active ester, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) (2001), 42(2), 113-114, database is CAplus.

A generic method for generating patterns of proteins and/or cells based on reactive coating and spatially directed self-assembly was developed. [2.2]Paracyclophane-4-carboxylic acid pentafluorophenol (I) ester was synthesized via three step synthesis. A reactive coating process was done by chem. vapor deposition polymerization of I to produce a reactive film of poly[p-xylylene carboxylic acid pentafluorophenol ester-co-para-xylylene] on the substrate. Surface patterns of biotin-conjugated human antibody against α₅-integrin were designed by the following procedure: (1) reactive coating process, (2) surface patterning using microcontact printing, and (3) generating cell patterns by layer-by-layer self-assembly on the patterned substrates. The method was demonstrated in patterns of endothelial cells.

Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lehnherr, Dan published the artcileElectrochemical Synthesis of Hindered Primary and Secondary Amines via Proton-Coupled Electron Transfer, Application of 2-(2-Methyl-1H-imidazol-1-yl)pyridine-4-carbonitrile, the publication is Journal of the American Chemical Society (2020), 142(1), 468-478, database is CAplus and MEDLINE.

Accessing hindered amines, particularly primary amines α to a fully substituted carbon center, is synthetically challenging. We report an electrochem. method to access such hindered amines starting from benchtop-stable iminium salts and cyanoheteroarenes. A wide variety of substituted heterocycles (pyridine, pyrimidine, pyrazine, purine, azaindole) can be utilized in the cross-coupling reaction, including those substituted with a halide, trifluoromethyl, ester, amide, or ether group, a heterocycle, or an unprotected alc. or alkyne. Mechanistic insight based on DFT data, as well as cyclic voltammetry and NMR spectroscopy, suggests that a proton-coupled electron-transfer mechanism is operational as part of a hetero-biradical cross-coupling of α-amino radicals and radicals derived from cyanoheteroarenes. Safety: cyanide may be released as a byproduct leading to release of toxic HCN.

Journal of the American Chemical Society published new progress about 1016841-67-0. 1016841-67-0 belongs to imidazoles-derivatives, auxiliary class Imidazoles, name is 2-(2-Methyl-1H-imidazol-1-yl)pyridine-4-carbonitrile, and the molecular formula is C10H8N4, Application of 2-(2-Methyl-1H-imidazol-1-yl)pyridine-4-carbonitrile.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Wei-Jie published the artcileHofmann-MOF derived nanoball assembled by FeNi alloy confined in carbon nanotubes as a magnetic catalyst for activating peroxydisulfate to degrade an ionic liquid, Computed Properties of 79917-90-1, the publication is Separation and Purification Technology (2022), 120945, database is CAplus.

As ionic liquids (ILs) are increasingly consumed, release of ILs into water environment has posed risks to aquatic ecol. due to their toxicities. Since 1-Butyl-3-methylimidazolium chloride (BMIMCl) represents the most typical IL, development of useful techniques to eliminate BMIM from water is urgent and critical While SO^•-₄-based oxidation processes are useful for degrading BMIM, very few studies have been conducted using peroxydisulfate (PDS), and almost no studies exist for developing heterogeneous activation of PDS to degrade BMIM. Thus, the aim of this study is to develop a useful heterogeneous catalyst for the first time to activate PDS for degrading BMIM in water. Herein, a special catalyst is developed from a unique Hofmann-type MOF ([Fe]pyrazine[Ni(CN)₄]) through carbonization to afford a nanoball assembled from carbon nanotubes (CNTs) with confinement of FeNi alloy nanoparticles. Such a FeNi@CNT (i.e., FeNiC) nanoball exhibits many advantageous features, including embedment of effective metals (Fe and Ni), strong magnetism, protection of FeNi by CNT, synergy of FeNi and CNT, and unique interwoven assembled structures, making FeNiC a promising heterogeneous catalyst for activating PDS to degrade BMIM. FeNiC is proven to exhibit a much higher catalytic activity (RSE = 0.0388) than Fe₃O₄ for PDS activation (RSE = 0.0155). FeNiC/PDS also shows a lower activation energy (i.e., 40.4 kJ/mol) for BMIM degradation then other reported values, revealing promising advantages of FeNiC. The activation mechanism as well as degradation pathway of BMIM degradation by FeNiC/PDS is also investigated here through theor. DFT calculations and exptl. evidences to provide valuable insights into degradation behaviors of BMIM using Hofmann MOF-derived catalysts.

Separation and Purification Technology published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Computed Properties of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Oh, Sangmi published the artcileIdentification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities, Quality Control of 13682-33-2, the publication is ACS Medicinal Chemistry Letters (2021), 12(4), 563-571, database is CAplus and MEDLINE.

This study evaluated the potential use of senescence-inducing small mols. in the treatment of melanoma. We screened com. available small-mol. libraries with high-throughput screening and high-content screening image-based technol. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogs were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within.

ACS Medicinal Chemistry Letters published new progress about 13682-33-2. 13682-33-2 belongs to imidazoles-derivatives, auxiliary class Imidazole,Amine,Benzene, name is 4-(1H-Imidazol-2-yl)aniline, and the molecular formula is C9H9N3, Quality Control of 13682-33-2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jiang, Li-Ping published the artcileThe dominance of sulfate over two organic ligands in the solvothermal assembly of an undecanuclear cobaltous cluster: crystallography and mass spectrometry, Recommanded Product: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Dalton Transactions (2020), 49(48), 17683-17688, database is CAplus and MEDLINE.

An unexpected dominance of the coordination affinity of the sulfate anion over those of two organic chelating ligands, (1-methyl-1H-benzo[d]imidazol-2-yl)methanol (Hmbm) and pyridin-2-ylmethanamine (pma), was observed during the study of the solvothermal assembly of [Co₁₁(mbm)₆(pma)₂(SO₄)₈(H₂O)₆(CH₃OH)₆]·5CH₃OH (1), from CoSO₄·7H₂O at 100°C in methanol. ESI-MS of solutions at different periods of the assembly reveal a hierarchical sequence, [Co₁] → [Co₂] → [Co₃] → [Co₄] → [Co₅] → [Co₉], where the lower nuclearity species are richer in Co²⁺ and SO₄^2- before the inclusion of more mbm ligands at the last step. Its crystal structure consists of an almost sym. wheel of nine cobalt atoms, [Co₉(mbm)₆(SO₄)₈(H₂O)₆] in edge-sharing octahedral coordination arranged in triangles with two peripheral dangling [Co(pma)(CH₃OH)₃]. The sulfate ions exhibit three different coordination modes, two in μ₆-, two in μ₃– and four as μ₂-bridging. Its thermal, optical and magnetic properties are also reported.

Dalton Transactions published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Recommanded Product: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Verma, Raman K. published the artcileHeterocyclyl linked anilines and benzaldehydes as precursors for biologically significant new chemical entities, Related Products of imidazoles-derivatives, the publication is Journal of Chemical Sciences (Bangalore, India) (2012), 124(5), 1063-1069, database is CAplus.

Syntheses of benzaldehydes and anilines, linked at the para position with an alkoxy ether linkage to 3 crucial heterocycles, namely benzimidazole, indole, and acridone, were reported. Representative procedures for the preparation of 1,3-diester, 2,4-thiazolidinedione, and α-bromopropanoic acid ester derivatives in case of benzimidazole, and a 1,3-diester and 2,4-thiazolidinedione derivative in case of indole-based precursors were optimized, and the said compounds were successfully synthesized.

Journal of Chemical Sciences (Bangalore, India) published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H4F6O, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Verma, Raman K. published the artcileHeterocyclyl linked anilines and benzaldehydes as precursors for biologically significant new chemical entities, Computed Properties of 4760-35-4, the publication is Journal of Chemical Sciences (Bangalore, India) (2012), 124(5), 1063-1069, database is CAplus.

Syntheses of benzaldehydes and anilines, linked at the para position with an alkoxy ether linkage to 3 crucial heterocycles, namely benzimidazole, indole, and acridone, were reported. Representative procedures for the preparation of 1,3-diester, 2,4-thiazolidinedione, and α-bromopropanoic acid ester derivatives in case of benzimidazole, and a 1,3-diester and 2,4-thiazolidinedione derivative in case of indole-based precursors were optimized, and the said compounds were successfully synthesized.

Journal of Chemical Sciences (Bangalore, India) published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C25H47NO8, Computed Properties of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Chopra, Radhika published the artcileDevelopment of a supramolecular ensemble of an AIEE active hexaphenylbenzene derivative and Ag@Cu₂O core-shell NPs: an efficient photocatalytic system for C-H activation, Formula: C19H14N2, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(66), 10179-10182, database is CAplus and MEDLINE.

A supramol. ensemble having Ag@Cu₂O core-shell nanoparticles stabilized by aggregates of a hexaphenylbenzene derivative has been developed which exhibits excellent photocatalytic efficiency in reactions involving preparation of imidazole and benzimidazole derivatives via C-H activation.

Chemical Communications (Cambridge, United Kingdom) published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Formula: C19H14N2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Qian, Weirui published the artcileReceipt of several pesticide petitions filed for residues of pesticide chemicals in or on various commodities, Category: imidazoles-derivatives, the publication is Federal Register (2011), 76(236), 76674-76677, database is CAplus.

The Environmental Protection Agency’s receipt of several initial filings of pesticide petitions requesting the establishment or modification of regulations for residues of pesticide chems. in or on various commodities is announced.

Federal Register published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C5H5NO3S, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Xinyu published the artcileCyazofamid; pesticide tolerances, Recommanded Product: 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, the publication is Federal Register (2008), 73(79), 21834-21839, database is CAplus.

A tolerance of 0.09 ppm is established for combined residues of cyazofamid and its metabolite CCIM in or on carrot, roots. Interregional Research Project Number 4 (IR-4) requested this tolerance under the Federal Food, Drug, and Cosmetic Act (FFDCA).

Federal Register published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C8H5F3N4, Recommanded Product: 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem