Imidazoles-derivatives

Aqueous-phase, palladium-catalyzed Suzuki reactions under mild conditions was written by Cai, Yueqin;Song, Gonghua;Wu, Zhongyuan;Zhang, Jiawei. And the article was included in Green and Sustainable Chemistry in 2013.Electric Literature of C11H20N2 This article mentions the following:

A series of biaryls I [R¹ = H, 4-Me, 2-MeO, etc.; R² = H, 4-Me, 4-MeO, etc.] were prepared by Suzuki coupling of aryl halides and aryl boronic acids using ionic liquid-supported diols as phosphine-free ligands under mild conditions in aqueous solvent. It was found that 2,2-bis((1-hexylimidazolium)-methyl) propane-1,3-diol hexafluorophosphate in combination with palladium (II) salts gave the most significant and reusable catalyst. Notably, the reactions of hydrophilic aryl bromides gave high yields in neat water. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Electric Literature of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Oxidative degradation of chitosan by H₂O₂ in acidic ionic liquid aqueous solutions was written by Wu, Changchun;Zang, Hongjun;Li, Daqing;Zhang, Mingchuan;Yu, Jianchun;Cheng, Bowen. And the article was included in Gaofenzi Cailiao Kexue Yu Gongcheng in 2014.Name: 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

In this paper, ionic liquid 1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate ([MIMBS]HSO₄) with better dissolution performance was selected. The oxidative degradation of high mol. weight chitosan was conducted with H₂O₂ in the above-mentioned ionic liquid aqueous solution, and the reaction system was homogeneous. In order to optimize the reaction conditions, the influence of dosage of ionic liquid, n (H₂O₂): n (chitosan), reaction temperature and reaction time on the degradation were studied. The mol. weight of chitosan was determined by viscosity method. The structures of original and degraded chitosan were characterized by FT-IR and XRD. The results indicate that the crystal structures of chitosan are destroyed, and the crystallinity decreases. The oxidative degradation reactions proceed more completely with increasing ionic liquid concentration At the meantime, the increased dosage of H₂O₂, enhanced reaction temperature and prolonged reaction time also promote this degradation reaction. The optimum conditions are determined as follows: the aqueous solution of 8% [MIMBS]HSO₄, n (H₂O₂): n (chitosan) = 5:1, reaction temperature equal to 80°C and reaction time equal to 3 h. Under the above reaction conditions, the yield of the regenerated chitosan is 74%, and the viscosity-average mol. weight is 21.2 × 10³. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Name: 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The Zuellig Pharma Korea Consortium Database: an on-site drug wholesales database for pharmacoepidemiological studies using real-world data was written by Jeong, Han Eol;Oh, In-Sun;Li, Junqing;Vilfeu, Erwan;Ryuu, Sang A.;Shin, Ju-Young. And the article was included in International Journal of Clinical Pharmacology and Therapeutics in 2019.Category: imidazoles-derivatives This article mentions the following:

Objective: To assess the value and representativeness of the Zuellig Pharma Korea Consortium (ZPK-C) database, which contains drug wholesales data collected in a weekly interval, for its prospective use as a data source for pharmacoepidemiol. studies. Materials and methods: Wholesales and nationwide claims data of antidiabetic and antihypertensive products were compared in 17 administrative regions using the defined daily dose per 100,000 inhabitants per day (DID) and its proportion for standardized evaluation. Results: We found regional concordance in 12 and 13 regions (out of 17) for antidiabetic and antihypertensive products, resp., of which concordance was higher in rural than metropolitan regions. Conclusion: The ZPK-C showed potential as a valuable data source for pharmacoepidemiol. research. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Category: imidazoles-derivatives).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Solubility of argon, krypton and xenon in ionic liquids was written by Song, Tangqiumei;Lubben, Michael J.;Brennecke, Joan F.. And the article was included in Fluid Phase Equilibria in 2020.SDS of cas: 404001-48-5 This article mentions the following:

This work presents the results of argon, krypton and xenon solubility measurements in a series of imidazolium-based ionic liquids (ILs) with the bis(trifluoromethylsulfonyl)imide ([TFSI]^–), 2-cyanopyrrolide ([2CNPyr]^–) and hexafluorophosphate ([PF₆]^–) anions, as well as ILs with the trihexyltetradecylphosphonium ([P₆₆₆₁₄]⁺) cation paired with 2-cyanopyrrolide ([2CNPyr]^–) and 1,2,4-triazolide ([4-triaz]^–) anions. The solubility of Ar was measured at 295 K and pressures up to 9 MPa, Kr was also measured at 295 K and pressures up to 5 MPa, and Xe was measured at temperatures from 295 K to 333 K and pressures up to 0.3 MPa. Noble gases are simple nonpolar, spherical atoms with varying sizes and polarizabilities. While their separation, especially from air, is relevant because they have uses in providing inert atmospheres and in fluorescent lights, the main purpose of this study is to gain fundamental understanding of the influence of size and polarizability on gas solubility in ILs. As a result, the temperature effects on the dissolution of argon and xenon were investigated in order to determine enthalpies of dissolution The solubilities of noble gases correlate strongly with the IL molar volume, indicating the importance of entropic interactions, because free volume generally correlates with molar volume. While van der Waals interactions are the dominant forces between smaller noble gas (like Ar) and the IL, Xe has sufficiently high polarizability that both van der Waals and induced dipole-dipole interactions contribute to its dissolution In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5SDS of cas: 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).SDS of cas: 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Anodic Oxidation of Dithiane Carboxylic Acids: A Rapid and Mild Way to Access Functionalized Orthoesters was written by Garcia, Anthony D.;Leech, Matthew C.;Petti, Alessia;Denis, Camille;Goodall, Iain C. A.;Dobbs, Adrian P.;Lam, Kevin. And the article was included in Organic Letters in 2020.HPLC of Formula: 13060-24-7 This article mentions the following:

A new electrochem. methodol. has been developed for the preparation of a wide variety of functionalized orthoesters under mild and green conditions from easily accessible dithiane derivatives The new methodol. also offers an unprecedented way to access tri(fluorinated) orthoesters, a class of compound that has never been studied before. This provides the community with a rapid and general method to prepare libraries of functionalized orthoesters from simple and readily available starting materials. In the experiment, the researchers used many compounds, for example, 2-Octylbenzimidazole (cas: 13060-24-7HPLC of Formula: 13060-24-7).

2-Octylbenzimidazole (cas: 13060-24-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 13060-24-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sequence-specific protection of plasmid DNA from restriction endonuclease hydrolysis by pyrrole-imidazole-cyclopropapyrroloindole conjugates was written by Fujimoto, Kazuhisa;Iida, Hirokazu;Kawakami, Masako;Bando, Toshikazu;Tao, Zhi-Fu;Sugiyama, Hiroshi. And the article was included in Nucleic Acids Research in 2002.Category: imidazoles-derivatives This article mentions the following:

The pyrrole-imidazole (Py-Im) triamide-cyclopropa pyrroloindole (CPI) conjugates ImPyImLDu86 (7) and ImImPyLDu86 (14) were synthesized and their alkylating activities and inhibitory effects on DNA hydrolysis by restriction endonucleases were examined Sequencing gel anal. demonstrated that conjugates 7 and 14 specifically alkylated DNA at 5′-CGCGCG-3′ and 5′-PyGGCCPu-3′, resp. Agarose gel electrophoresis indicated that incubation of a supercoiled plasmid, pSPORT I (4109 bp), with conjugate 7 effectively inhibited its hydrolysis by BssHII (5′-GCGCGC-3′), whereas conjugate 14 had no effect on this hydrolysis. These results suggest that conjugate 7 sequence-specifically inhibits the hydrolysis of DNA by BssHII. Sequence-specific alkylation by the Py-Im triamide-CPI conjugates was further confirmed by inhibition of the Eco52I (5′-CGGCCG-3′) hydrolysis of conjugate 14-treated pQBI PGK (5387 bp). In clear contrast, hydrolysis of pQB1 PGK by DraI (3′-TTTAAA-3′) was not inhibited by 5 μM conjugate 14. That ImImPy did not inhibit the hydrolysis of pQB1 PGK indicates that covalent bond formation is necessary for inhibition. A similar experiment, using linear pQBI PGK, achieved the same extent of protection of the DNA with approx. half the concentration of conjugate 14 as was required to protect supercoiled DNA from hydrolysis. In the experiment, the researchers used many compounds, for example, Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9Category: imidazoles-derivatives).

Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chemiluminescence intensities of substituted lophines was written by Philbrook, George E.;Maxwell, Michael A.. And the article was included in Tetrahedron Letters in 1964.Reference of 5496-35-5 This article mentions the following:

The intensities of the chemiluminescence and the ir and uv absorption spectra were investigated for lophine, 4-dimethylamino-, 4-acetamino, 4-methoxy, 3,4-dimethoxy, 3,4-diethoxy, 4-methyl, 4-isopropyl-, 4-chloro-, 4-fluoro-, 4-bromo-, 3-nitro, 4-nitro-, 4-phenoxy-, and 4-carboxylophine (substituents in the 2 position on the ring) in 70% Me2SO in 30% N NaOH. The curves, log I/I0 = f(σ) (Hammett) were plotted; I depended linearly on the lophine concentration and could be increased by H2O2. Spontaneous evaporation and spontaneous absorption were not found. All the chemiluminescence processes investigated were explained by the fact that, at times, the same mol. fragment was formed. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Reference of 5496-35-5).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 5496-35-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chemistry of fairy ring. Clarification of the identity of the fairy and application to agriculture was written by Choi, Jae-Hoon;Kawagishi, Hirokazu. And the article was included in Kagaku to Seibutsu in 2011.Application In Synthesis of 1H-Imidazole-4-carboxamide This article mentions the following:

A review on the “fairy ring” (fungus-stimulated plant growth) on lawns; enhancement of grass growth by Lepista sordida; identification of 2-azahypoxanthine (AHX) and imidazole-4-carboxamide (ICA) as a pos. and neg. growth regulator for grasses in the culture medium of L. sordida; stimulation of plant growth by AHX; increased expression of GST, BBI, and OsTIP2;1 genes in rice by AHX treatment; and increase of the yields of rice by AHX and ICA. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Application In Synthesis of 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application In Synthesis of 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Advancing the Therapeutic Efficacy of Bioactive Molecules by Delivery Vehicle Platforms was written by Tsiailanis, Antonis D.;Tzakos, Andreas G.;Mavromoustakos, Thomas. And the article was included in Current Medicinal Chemistry in 2021.Recommanded Product: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

Drugs have to overcome numerous barriers to reach their desired therapeutic targets. In several cases, drugs, especially the highly lipophilic mols., suffer from low solubility and bioavailability and therefore their desired targeting is hampered. In addition, undesired metabolic products might be produced or off-targets could be recognized. Along these lines, nanopharmacol. has provided new technol. platforms, to overcome these boundaries. Specifically, numerous vehicle platforms such as cyclodextrins and calixarenes have been widely utilized to host lipophilic drugs such as antagonists of the angiotensin II AT1 receptor (AT₁R), as well as quercetin and silibinin. The encapsulation of these drugs in supramols. or other systems refines their solubility and metabolic stability, increases their selectivity and therefore decreases their ED and improves their therapeutic index. In this mini review we report on the formulations of silibinin and AT₁R antagonist candesartan in a 2-HP-β-cyclodextrin host mol., which displayed enhanced cytotoxicity and increased silibinin′s and candesartan′s stability, resp. Moreover, we describe the encapsulation of quercetin in gold nanoparticles bearing a calixarene supramol. host. Also, the encapsulation of temozolomide in a calixarene nanocapsule has been described. Finally, we report on the activity enhancement that has been achieved upon using these formulations as well as the anal. and computational methods we used to characterize these formulations and explore the mol. interactions between the host and quest mols. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Recommanded Product: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Organosolv and ionosolv processes for autohydrolyzed poplar fractionation: Lignin recovery and characterization was written by Ovejero-Perez, Antonio;Rigual, Victoria;Dominguez, Juan Carlos;Alonso, M. Virginia;Oliet, Mercedes;Rodriguez, Francisco. And the article was included in International Journal of Biological Macromolecules in 2022.Synthetic Route of C4H7ClN2 This article mentions the following:

Biomass fractionation plays a major role in the search for competitive biorefineries, where the isolation and recovery of the three woody fractions is key. In this sense, we have used autohydrolyzed hemicellulose-free poplar as feedstock to compare two fractionation processes, organosolv and ionosolv, oriented to lignin recovery. The recovered lignins were then characterize by different techniques (NMR, GPC, TGA). Both treatments were tested at different temperatures to analyze temperature influence on lignin recovery and properties. The highest lignin recovery was obtained with the ionosolv process at 135°C, reaching a solid yield of ∼70%. Lignin characterization showed differences between both treatments. Lignins enriched in C-O linkages and G units were recovered with the organosolv process, where increasing temperature led to highly depolymerized lignins. However, lignins with higher C-C linkages and S units contents were obtained with the ionosolv process, producing more thermically stable lignins. In addition, increasing temperature caused lignin repolymn. when employing ionic liquids as solvents. Therefore, this work outlines the most important differences between ionosolv and organosolv processes for biomass fractionation, focusing on lignin recovery and its properties, which is the first step in order to valorize all biomass fractions. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Synthetic Route of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Synthetic Route of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem