Imidazoles-derivatives

Ionic Liquid Modified Electrochemical Capacitor with Long-Term Performance was written by Znaniecki, Szymon;Szwabinska, Katarzyna;Wojciechowski, Jaroslaw;Skrzypczak, Andrzej;Lota, Grzegorz. And the article was included in ChemElectroChem in 2021.Reference of 21252-69-7 This article mentions the following:

Ionic liquids are used, for example, as corrosion inhibitors for metals, steel, and metal alloys. The method of preventing corrosion through the whole group of these kinds of compounds, called inhibitors, is to use them as additives to aggressive environments, including aqueous electrolytes. In this article, we present the inhibitive effect of imidazolium ionic liquids with 2,5-dihydroxybenzenesulfonate anion on the corrosion of 316L stainless steel in neutral medium. In addition, we demonstrate that when the ionic liquid is used as an additive to the electrolyte solution (1 M Na₂SO₄) of a sym. carbon/carbon electrochem. capacitor with 316L stainless-steel current collectors, the capacitor lifetime is significantly extended. The ionic-liquid additive inhibits corrosion of the current collector surface and, in effect, prevents activated carbon porous space from being blocked by corrosion products. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Organic energy devices from ionic liquids and conducting polymers was written by Brooke, Robert;Fabretto, Manrico;Krasowska, Marta;Talemi, Pejman;Pering, Samuel;Murphy, Peter J.;Evans, Drew. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2016.Product Details of 404001-48-5 This article mentions the following:

The use of smart technologies in the daily lives, from smart phones to auto-dimming windows to touch sensors, has become pervasive. With growing desire for these devices to be conformable and flexible, traditional materials are being replaced to create a class of products known as active organic electronic devices (OEDs). These new devices owe their ability to switch elec. and/or optical function to the intimate interaction between an inherently conducting polymer and electrolyte, typically an ionic liquid Herein, the authors provide the 1st observations that specific ionic liquids can reduce or oxidize conducting polymers upon intimate contact in the absence of any elec. stimuli. The ability to reduce or oxidize the inherently conducting polymer depends on the cation and anion pair within the ionic liquid Extending the utility of this phenomenon is made by fabricating OEDs such as prototype fuel cells, supercapacitors and smart windows. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Product Details of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Product Details of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

An elegant method for the preparation of 3-cyanomethyl derivatives of imidazo[1,2-a]pyridines was written by Chinnapillai, Rajendiran;Nallamaddi, Ravikumar Reddy;Daliparthi, Eswaraprasad Rao;Poguri, Eswaraiah. And the article was included in Pharma Chemica in 2012.Quality Control of N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine This article mentions the following:

A series of 3-(cyanomethyl)imidazo[1,2-a]pyridines were synthesized by using ClCO₂Et as alkylating agent for the generation of quaternary ammonium salts from 3-[(dimethylamino)methyl]imidazo[1,2-a]pyridines and subsequent cyanation. This novel process is elegant and simple with excellent yields. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5Quality Control of N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine).

N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Phenotypic and transcriptomic response of auxotrophic Mycobacterium avium subsp. paratuberculosis leuD mutant under environmental stress was written by Chen, Jenn-Wei;Scaria, Joy;Chang, Yung-Fu. And the article was included in PLoS One in 2012.Product Details of 26832-08-6 This article mentions the following:

Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of severe gastroenteritis in cattle. To gain a better understanding of MAP virulence, we investigated the role of leuD gene in MAP metabolism and stress response. For this, we have constructed an auxotrophic strain of MAP by deleting the leuD gene using allelic exchange. The wildtype and mutant strains were then compared for metabolic phenotypic changes using Biolog phenotype microarrays. The responses of both strains to physiol. relevant stress conditions were assessed using DNA microarrays. Transcriptomic data was then analyzed in the context of cellular metabolic pathways and gene networks. Our results showed that deletion of leuD gene has a global effect on both MAP phenotypic and transcriptome response. At the metabolic level, the mutant strain lost the ability to utilize most of the carbon, nitrogen, sulfur, phosphorus and nutrient supplements as energy source. At the transcriptome level, more than 100 genes were differentially expressed in each of the stress condition tested. Systems level network anal. revealed that the differentially expressed genes were distributed throughout the gene network, thus explaining the global impact of leuD deletion in metabolic phenotype. Further, we find that leuD deletion impacted metabolic pathways associated with fatty acids. We verified this by exptl. estimating the total fatty acid content of both mutant and wildtype. The mutant strain had 30% less fatty acid content when compared to wildtype, thus supporting the results from transcriptional and computational analyses. Our results therefore reveal the intricate connection between the metabolism and virulence in MAP. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Product Details of 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Product Details of 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole analogues of resveratrol: synthesis and cancer cell growth evaluation was written by Bellina, Fabio;Guazzelli, Nicola;Lessi, Marco;Manzini, Chiara. And the article was included in Tetrahedron in 2015.SDS of cas: 25676-75-9 This article mentions the following:

Novel trans-restricted analogs of resveratrol in which the C-C double bond of the natural derivative was replaced by diaryl substituted imidazole analogs were designed. The syntheses of 1,4-, 2,4-, and 2,5-diarylimidazoles, in which the two aryl moieties are linked to the heteroaromatic core in a 1,3 fashion to preserve the trans stereochem., were successfully carried out by regioselective sequential transition metal-catalyzed arylations of simple, com. available imidazole precursors. The anticancer activity of selected analogs was evaluated in vitro against the NCI-60 human tumor cell lines panel. From this screening, the authors were able to select a synthetic candidate that resulted more active than its natural lead. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9SDS of cas: 25676-75-9).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 25676-75-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis, characterizations and anticorrosion applications of three new gemini ionic liquids. was written by Nessim, M. I.;Zaky, M. T.;Deyab, M. A.. And the article was included in Journal of Molecular Liquids in 2018.Related Products of 21252-69-7 This article mentions the following:

Three gemini ionic liquids namely, 3,3′-(1,4-phenylenebis(methylene))bis(1-alkyl-1H-imidazol-3-ium)bromide IL1, IL2, and IL3, were prepared and characterized via the conventional tools of anal., elemental anal., IR, and ¹H NMR spectroscopy. The thermal stability of these compounds was studied, using thermogravimetric anal. (TGA) technique. The gemini ionic liquids were tested as corrosion inhibitors for stainless steel (304 SS) in 0.5 M H2SO4 solution using electrochem. techniques. The Results showed that gemini ionic liquids were effective with optimal corrosion inhibition values of 90.7%, 97.3% and 82.6% for IL1, IL2 and IL3, resp. The data confirmed also gemini ionic liquids are mixed type inhibitors. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Related Products of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Related Products of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Molecular Control of the Catalytic Properties of Rhodium Nanoparticles in Supported Ionic Liquid Phase (SILP) Systems was written by Bordet, Alexis;Moos, Gilles;Welsh, Calum;Licence, Peter;Luska, Kylie L.;Leitner, Walter. And the article was included in ACS Catalysis in 2020.HPLC of Formula: 21252-69-7 This article mentions the following:

Rhodium nanoparticles (NPs) immobilized on imidazolium-based supported ionic liquid phases (Rh@SILP) act as effective catalysts for the hydrogenation of biomass-derived furfuralacetone. The structure of ionic liquid-type (IL) mol. modifiers was systematically varied regarding spacer, side chain, and anion to assess the influence on the NP synthesis and their catalytic properties. Well-dispersed Rh NPs with diameters in the range of 0.6-2.0 nm were formed on all SILP materials, whereby the actual size was dependent significantly on the IL structure. The resulting variations in catalytic activity for hydrogenation of the C=O moiety in furfuralacetone allowed control of the product selectivity to obtain either the saturated alc. or the ketone in high yield. Experiments conducted under batch and continuous flow conditions demonstrated that Rh NPs immobilized on SILPs with suitable IL structures are more active and much more stable than Rh@SiO₂ catalyst synthesized on unmodified silica. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7HPLC of Formula: 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. HPLC of Formula: 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In vitro studies on the antioxidant and protective effect of 2-substituted-8-hydroxyquinoline derivatives against H₂O₂-induced oxidative stress in BMSCs was written by Wang, Ting-Ting;Zeng, Gong-Chang;Li, Xi-Can;Zeng, He-Ping. And the article was included in Chemical Biology & Drug Design in 2010.Synthetic Route of C9H8N2O This article mentions the following:

Novel 2-vinyl-8-hydroxyquinoline derivatives as potential antioxidants and regulators of H₂O₂-induced oxidative stress in rat bone marrow mesenchymal stem cells (MSCs) are first reported. The antiradical properties and the reducing power of these compounds were assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and auto-oxidation of pyrogallol method, resp. The activity against lipid peroxidation was determined using ammonium thiocyanate method. The results revealed that introduction of electron-donating groups at 2nd position decreased the antioxidant activities of 8-hydroxyquinoline derivatives In addition, compound 4, the structure of which is similar to melatonin, exhibited superior antioxidant activities in scavenging DPPH free radical,.O₂ free radical, and anti-LPO activities. Except for compounds 7, 12, and 15, the other compounds exhibited a stimulatory effect on MSCs growth. Using hydrogen peroxide (H₂O₂), we also investigated the protective efficacy of 2-vinyl-8-hydroxyquinoline derivatives against oxidative stress-induced cell death of MSCs. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Synthetic Route of C9H8N2O).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Synthetic Route of C9H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Organocatalytic upgrading of the key biorefining building block by a catalytic ionic liquid and N-heterocyclic carbenes was written by Liu, Dajiang;Zhang, Yuetao;Chen, Eugene Y.-X.. And the article was included in Green Chemistry in 2012.Application of 92507-97-6 This article mentions the following:

The present study of rapid degradation of the key biorefining building block 5-hydroxymethylfurfural (HMF) in an ionic liquid (IL), 1-ethyl-3-methylimidazolium acetate ([EMIM]OAc), has led to highly selective and efficient upgrading of HMF to 5,5′-di(hydroxymethyl)furoin (DHMF), a promising C₁₂ kerosene/jet fuel intermediate. This HMF upgrading reaction is carried out under industrially favorable conditions (i.e., ambient atm. and 60-80 °C), catalyzed by N-heterocyclic carbenes (NHCs), and complete within 1 h; this process selectively produces DHMF with yields up to 98% (by HPLC or NMR) or 87% (unoptimized, isolated yield). Mechanistic studies have yielded four lines of evidence that support the proposed carbene catalytic cycle for this upgrading transformation catalyzed by the acetate IL and NHCs. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Application of 92507-97-6).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 92507-97-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design and evaluation of Candesartan cilexetil solid dispersion incorporated in hard gelatin capsule was written by Shree, A. J. Divya;Ravichandra, V. D.. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2022.Computed Properties of C33H34N6O6 This article mentions the following:

Candesartan cilexetil is widely used for the treatment of hypertension. Candesartan cilexetil is a pro-drug administered orally, rapidly converted to its active metabolite candesartan during absorption in the gastrointestinal tract. Candesartan cilexetil is a BCS II drug that is practically insoluble in the water of 0.00771 mg/mL & it has a low dissolution rate, hence; to improve dissolution rate & bioavailability, solid dispersion of Candesartan cilexetil were prepared by kneading method, solvent evaporation method & Microwave method in 1:0.5, 1:1 & 1:1.5 ratios of Candesartan cilexetil and hydroxy Pr beta-cyclodextrin/PVP K 30. Further, the SDs were filled into empty hard gelatin capsules with excipients like starch (8%), lactose, talc & Aerosil by manual capsule filling method. The formulated solid dispersions were evaluated for drug content and in-vitro dissolution studies. Accelerated stability studies was conducted for the optimized SD formulations, the optimized drug & carrier SD were confirmed & characterized by FT-IR. The drug content of the prepared Candesartan cilexetil SD formulations was found to be range from 94.35 ± 0.95% to 98.44 ± 0.56%. XRD studies showed that the drug exists in an amorphous state as there was no drug peak in the formulation. The solid dispersion of Candesartan cilexetil prepared by kneading method with HPβCD (1:1.5) showed a maximum drug release of 94.05 ± 0.11% compared to other solid dispersion formulations. It is concluded that the dissolution rate of Candesartan cilexetil can be improved by the solid dispersion method. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Computed Properties of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Computed Properties of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem