Imidazoles-derivatives

β-Carotene: A green, inexpensive, and convenient solvatochromic probe for the determination of solvent polarizability was written by Loffredo, Carina;Pires, Paulo Augusto R.;Imran, Muhammad;El Seoud, Omar A.. And the article was included in Dyes and Pigments in 2013.Application of 21252-69-7 This article mentions the following:

Solvent polarizability has been previously determined by using the solvatochromic probe 3,20-di-tert-butyl-2,2,21,21-tetramethyl-3,5,7,9,11,13,15,17,19-docosanonaene whose synthesis involves 15 steps. We show here that the natural dye β-carotene, 1,1′-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis[2,6,6-trimethylcyclohexene], can be conveniently employed for the accurate determination of the same solvent property. This conclusion is based on both theor. calculations and exptl. data. The former includes free energies of solvation, and the wavenumber of the longest wavelength (i.e., the solvatochromic) transition. Both quantities for β-carotene correlate linearly with the corresponding values of the docosanonaene, with slopes and correlation coefficients of practically unity. The plot of exptl. calculated solvent polarizability of β-carotene vs. that of the docosanonaene was found to be linear for 68 solvents. Previously unknown solvent polarizability values are reported for eight ROCH₂CH₂OH (R = C₁ to C₁₀) and four 1-allyl-3-R-imidazolium chloride ionic liquids (R = C₆ to C₁₀). The dependence of solvent polarizability on the number of carbon atoms in the hydrocarbon chains of several classes of solvents is calculated, it shows the importance of van der Waals interactions in ionic liquids In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Application of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Representation of phase behavior of ionic liquids and their mixtures using various forms of cubic-two-state equation of state was written by Haghtalab, Ali;Shojaeian, Abolfazl. And the article was included in Fluid Phase Equilibria in 2017.Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

In this work, in addition of Soave-Redlich-Kwong (SRK) equation of state, two other alternative cubic models such as Peng- Robinson (PR) and Cubic Square Well (CSW) EoSs are combined with the Two-State Association Model (TSAM) and the new forms of the Cubic-Two-State equation of state (CTS EoS) as PR-TS and CSW-TS are presented. In the beginning, the present models are used to correlate the saturated vapor pressure and liquid d. of pure water, alcs. and phenol. The models are also employed to predict vapor molar volume and second virial coefficients of pure compounds to explore the predictability of the different type of the CTS models. Also, the liquid d. of different pure ionic liquids (ILs) at various temperatures from 298.15 K up to 500 K and pressure from 0.1 MPa up to 59.59 MPa is correlated and the parameters of the CTS models are obtained. Following successful application of the models for the pure components, using one temperature independent binary interaction parameter, the SRK-TS and PR-TS models are applied to predict the vapor-liquid equilibrium of the several binary mixtures consists of IL with non-association and association components at various temperatures from 298.15 K up to 363.15 K and pressure from 0.09 kPa up to 216 kPa. The results of the SRK-TS and PR-TS models for pure and binary systems containing ILs are in very good agreement with experiments and also are compared with various equations of states that show better results. In overall for the systems that are presented in this work, the PR-TS model shows slightly better results with respect to the SRK-TS model specially in prediction, and PR-TS and SRK-TS models present superiority with respect to the CSW-TS EoS. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dissolution of Maize Starch in Aqueous Ionic Liquids: The Role of Alkyl Chain Length of Cation and Water:Ionic Liquid Ratio was written by Ren, Fei;Wang, Jinwei;Yu, Jinglin;Xiang, Fengjuan;Wang, Shuo;Wang, Shujun;Copeland, Les. And the article was included in ACS Sustainable Chemistry & Engineering in 2019.Recommanded Product: 79917-89-8 This article mentions the following:

The dissolution behavior of maize starch in water:ionic liquid (IL) mixtures at ambient temperature (22-23 °C) was studied. The ionic liquids used were 1-butyl-3-methylimidazolium chloride ([C₄ mim][Cl]), 1-propyl-3-methylimidazolium chloride ([C₃ mim][Cl]), and 1-ethyl-3-methylimidazolium chloride ([C₂ mim][Cl]). Structural analyses indicated that long- and short-range mol. order in the starch decreased with decreasing water:IL ratio. At water:IL ratios of 10:1 and 5:1, the extent of disruption of starch structure followed the order [C₄ mim][Cl] > [C₃ mim][Cl] > [C₂ mim][Cl]. At lower water:IL ratio (2:1), the complete disruption of starch granule morphol. and ordered structures in water:[C₃ mim][Cl] and water:[C₂ mim][Cl] mixtures indicated these mixtures were more effective in dissolving starch than water:[C₄ mim]Cl mixture Results from rheol., FTIR, and ¹H NMR analyses of water:IL mixtures showed that as water:IL ratio decreased, the viscosity of solutions increased, the interaction between IL and water decreased, and the interaction between the cation and the anion increased. Stronger interaction between the IL and water and higher viscosity of water:IL mixtures were noted for cations with longer alkyl chains. Our results clearly showed that both the alkyl chain length of cations and water:IL ratio played key roles in the dissolution of starch, predominantly by affecting the interaction between ILs and water and viscosity of water:IL mixtures In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Recommanded Product: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design, formulation, and characterization of stearic acid-based solid lipid nanoparticles of candesartan cilexetil to augment its oral bioavailability was written by Mahajan, Anu;Kaur, Satvinder. And the article was included in Asian Journal of Pharmaceutical and Clinical Research in 2018.Reference of 145040-37-5 This article mentions the following:

Objective: Poor aqueous solubility and suboptimal oral bioavailability hamper the therapeutic efficacy of candesartan cilexetil (CDC). This study is designed to prepare solid lipid nanoparticle (SLN) of CDC and to enhance the oral absorption of CDC compared with free drug suspension. The development and characterization of CDC-loaded SLN, using stearic acid as main encapsulating lipid, stabilized with poloxamer188 using “modified emulsification-ultrasonication technique.” Results: CDC-SLN with a total drug content of 88.33 ± 1.23% and entrapment efficiency of 78.28 ± 1.91%, with an average particle size of 197.9 nm and zeta potential value -21.3 mV, was prepared Differential scanning calorimetry and powder X-ray diffraction (PXRD) results confirmed the mol. encapsulation of the drug in amorphous state. CDC-SLN released 60.43% of drug in comparison to 17.11% released by CDC suspension in 24 h (p<0.05). The results of pharmacoKinetic studies in rat showed that AUC0-t of CDC-SLN was significantly enhanced over 3-folds than that of free drug suspension (p<0.05). Conclusion: SLN of CDC could be successful in improving the oral bioavailability of poorly soluble CDC. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Reference of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A facile and convenient synthesis of new substituted heteroarylchalcones and flavones by microwave irradiated Suzuki-Miyaura cross coupling reaction in aqueous medium was written by Joshi, Vidya;Hatim, Jaywant Govind. And the article was included in Indian Journal of Heterocyclic Chemistry in 2012.COA of Formula: C4H5BrN2 This article mentions the following:

Chalcones I (R = heteroaryl) and corresponding flavones II (same R) having various heteroaryl substituents have been synthesized. The starting compound 5-formyl-2-methoxyphenylboronic acid (III) was prepared by a series of reactions; bromination of 4-methoxybenzaldehyde with catalyst anhydrous AlCl₃ in DCE (1,2-dichloroethane) gave 3-bromo-4-methoxybenzaldehyde. The aldehydic in 3-bromo-4-methoxybenzaldehyde was protected by acetalization with 1,3-propanediol and Et orthoformate with phase transfer catalyst tetrabutylammonium tribromide producing the corresponding 2-(3-bromo-4-methoxyphenyl)-1,3-dioxane, which on treatment with tri-Me borate [(MeO)₃B] in presence of n-butyllithium at 70° gave III. Suzuki-Miyaura coupling of III with different heteroaryl bromides in presence of [(C₆H₅)₃P]₄Pd(0) catalyst, aqueousNa₂CO₃ (2N) as base, and aqueous DMF as solvent and microwave irradiation for 1 to 2.5 min. in a Panasonic microwave set at 1000 W and 80% microwave power yielded 3-heteroaryl-4-methoxybenzaldehydes. Claisen-Schmidt condensation of the latter with 2-hydroxyacetophenone in presence of ethanolic KOH produced 3-heteroaryl-2′-hydroxy-4-methoxychalcones (I, R = heteroaryl). Cyclizing I with a mixture of I₂ and DMSO gave 3′-heteroaryl-4′-methoxyflavones (II, same R). In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9COA of Formula: C4H5BrN2).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C4H5BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

FTIR metabolomic fingerprint reveals different modes of action exerted by active pharmaceutical ingredient based ionic liquids (API-ILs) on Salmonella typhimurium was written by Mester, P.;Jehle, A. K.;Leeb, C.;Kalb, R.;Grunert, T.;Rossmanith, P.. And the article was included in RSC Advances in 2016.Name: 1-ethyl-2,3-dimethylimidazolium chloride This article mentions the following:

Since their incorporation into various chem. and biochem. processes, ionic liquids (ILs) have now been found useful for biomedical applications, including active pharmaceutical ingredients (APIs) such as antimicrobial agents or antibiotics. Recently, synergistic API-ILs with great potential have been reported, which show either increased antimicrobial activity or the ability to overcome bacterial resistance. In this study a total of 19 API-ILs, based on the antibiotic nalidixic acid, combined with different cation species, were investigated for synergistic effects against the important foodborne pathogen Salmonella. Furthermore, 19 resp. ILs with chloride as the anion were used to control the effects of the different cation species. The antimicrobial activities of all 38 ILs against six different Salmonella species, as well as two nalidixic acid-resistant S. typhimurium strains, were determined via the microbroth dilution assay. The response pattern of the main cellular constituents, namely proteins, carbohydrates, and lipids of the bacterial cells to the most promising API-ILs was further investigated by Fourier transform IR (FTIR) spectroscopy. While a number of active API-ILs based on nalidixic acid could be synthesized, no evidence for synergistic effects, such as increased antimicrobial activity or the ability to overcome resistance was found with either microbiol. or spectroscopic methods. However, it could be demonstrated for the first time that while the different IL species ([TC₈MA]⁺ and [TMC₁₆A]⁺) showed similar antimicrobial activity, the FTIR spectral patterns indicated changes in bacterial membrane fluidity suggesting different modes of action. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Name: 1-ethyl-2,3-dimethylimidazolium chloride).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Name: 1-ethyl-2,3-dimethylimidazolium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Interaction of Imidazolium-Based Room-Temperature Ionic Liquids with DOPC Phospholipid Monolayers: Electrochemical Study was written by Galluzzi, Massimiliano;Zhang, Shengwen;Mohamadi, Shahrzad;Vakurov, Alexander;Podesta, Alessandro;Nelson, Andrew. And the article was included in Langmuir in 2013.Related Products of 404001-48-5 This article mentions the following:

To test the biocompatible character of room-temperature ionic liquids (ILs), the interaction of various ILs with biol. membrane (biomembrane) models was studied. Dioleoyl phosphatidylcholine (DOPC) adsorbed on a Hg electrode forms an impermeable defect-free monolayer which is a well established biomembrane model, prone to be studied by electrochem. techniques. The authors have monitored the modifications of the Hg supported monolayer caused by ILs using rapid cyclic voltammetry (RCV), a.c. voltammetry (ACV), and electrochem. impedance spectroscopy (EIS). Imidazolium-based ILs were studied whose interaction highlighted the role of anion and lateral side chain of cation during the interaction with DOPC monolayers. The hydrophobic and lipophilic character of the IL cations is a primary factor responsible for this interaction. Hg-supported monolayers provide an accurate anal. of the behavior of ILs at the interface of a biomembrane leading to a comprehensive understanding of the interaction mechanisms involved. At the same time, these experiments show that the Hg-phospholipid model is an effective toxicity sensing technique as shown by the correlation between literature in vivo toxicity data and the data. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Related Products of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Combining Organocatalysis with Central-to-Axial Chirality Conversion: Atroposelective Hantzsch-Type Synthesis of 4-Arylpyridines was written by Quinonero, Ophelie;Jean, Marion;Vanthuyne, Nicolas;Roussel, Christian;Bonne, Damien;Constantieux, Thierry;Bressy, Cyril;Bugaut, Xavier;Rodriguez, Jean. And the article was included in Angewandte Chemie, International Edition in 2016.Related Products of 85692-37-1 This article mentions the following:

Suitably substituted enantioenriched 4-aryl-1,4-dihydro-pyridines prepared by an organocatalytic enantioselective Michael addition were oxidized with MnO₂ into axially chiral 4-arylpyridines with central-to-axial chirality conversion. Moderate to complete percentages (cp) were observed, and a model for the conversion of chirality is discussed. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Related Products of 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Related Products of 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Stability of Titania Nanomaterials Dispersed in Aqueous Solutions of Ionic Liquids of Different Alkyl Chain Lengths was written by Rouster, Paul;Pavlovic, Marko;Cao, Tianchi;Katana, Bojana;Szilagyi, Istvan. And the article was included in Journal of Physical Chemistry C in 2019.SDS of cas: 35487-17-3 This article mentions the following:

Charging and aggregation of titania nanosheets (TNS) and spherical titania nanoparticles (TNP) were studied in aqueous solutions of ionic liquids The pH and the length of the alkyl chain of the IL cations [1-methylimidazolium (MIM⁺), 1-ethyl-3-methylimidazolium (EMIM⁺), and 1-butyl-3-methylimidazolium (BMIM⁺)] were systematically varied in the experiments No detectable interaction was observed between the IL cations and the pos. charged TNS or TNP surfaces at low pH, where the imidazolium derivatives are the co-ions. For the neg. charged titania nano-objects, significant adsorption of MIM⁺ and EMIM⁺ took place, leading to charge neutralization and overcharging at appropriate concentrations The BMIM⁺ behaved like a simple salt constituent causing charge screening. For both TNS and TNP, the MIM⁺ < EMIM⁺ < BMIM⁺ counterion order was obtained in the critical coagulation concentrations, indicating that MIM⁺ was the most effective in destabilization of the dispersions. The major interparticle forces were of electrostatic origin; however, viscous stabilization was also observed at high IL concentrations The same aggregation mechanism and charging behavior were found for the titania nano-objects irresp. of their shape. The results shed light on the hydrophilic nature of the surface of the TNS and TNP of neg. charge, in contrast to earlier findings with hydrophobic colloidal particles, where the increasing alkyl chain length gave rise to higher destabilization power. The charging properties were governed by specific adsorption of the IL constituents, while the major interparticle forces were qual. well-predicted by the Derjaguin, Landau, Verwey, and Overbeek theory. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3SDS of cas: 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.SDS of cas: 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Highly efficient gel electrolytes by end group modified PEG-based ABA triblock copolymers for quasi-solid-state dye-sensitized solar cells was written by Masud;Kim, Kyeong Min;Kim, Hwan Kyu. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2021.Recommanded Product: 1-Methylbenzimidazole This article mentions the following:

To get highly efficient quasi-solid-state dye-sensitized solar cells (QSS-DSSCs) with long-term stability using polymer gel electrolytes (PGEs), well-defined ABA triblock copolymers ([Poly(Me methacrylate)]₂-block-poly(ethylene glycol)) with different end functionality and components of I^–/I^–₃ liquid electrolytes (LEs) are studied and optimized for the fabrication of PGE-based QSS-DSSCs. Triblock copolymers are synthesized in a one-step reaction using bifunctional PEG-macro chain transfer agent (MCTA) by reversible addition-fragmentation chain transfer (RAFT) polymerization Due to the high reactivity and toxicity of sulfur-containing trithiocarbonate end groups, ABA triblock copolymers prepared from RAFT polymerization are further modified to sulfur-free 2-methylpropionitrile and 4-cyanopentanoic acid end functional triblock copolymers by radical-induced exchange reactions. Dodecyl trithiocarbonate end functional PEG-MCTA and triblock copolymers absorb UV-light in the region of 260-380 nm, whereas sulfur-free carboxylic acid and 2-methylpropionitrile end functional polymers do not absorb in that UV-light region. Among three different end functional polymers, the carboxylic acid end functional triblock copolymer has the highest thermal stability. Based on electrochem. parameters, photovoltaic performance, and long-term stability, 1,2-dimethyl-3-propylimidazolium iodide (DMPII) ionic liquid and 4-tert-butylpyridine (TBP) additive containing acetonitrile-based I^–/I^–₃ LEs are effective for PGEs. The highest power conversion efficiency (PCE) for QSS-DSSCs achieved under simulated 1-sun illumination is up to 10.34%, which is comparable with the highest PCE of 10.39% for LE-DSSCs. Considering the high reactivity, thermal stability, UV-absorption, and the toxicity of the trithiocarbonate end group, the SGT-643-C triblock copolymer with carboxylic acid end group can be a promising candidate as a sulfur-free polymeric matrix for gel electrolytes of QSS-DSSCs. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem