Imidazoles-derivatives

Printable biflourene based ultra-violet (UV) organic light-emitting electrochemical cells (OLECs) with improved device performance was written by Arumugam, Sasikumar;Li, Yi;Pearce, James E.;Court, Katie L.;Piana, Giacomo;Jackman, Edward H.;Ward, Oliver J.;Charlton, Martin D. B.;Tudor, John;Harrowven, David C.;Beeby, Steve P.. And the article was included in Organic Electronics in 2022.Electric Literature of C11H20N2 This article mentions the following:

A series of printable UV emitting ionic bifluorene derivatives have been prepared incorporating pendent alkylimidazolium groups. Herein, we detail the synthesis of compounds and the methods used in device fabrication. We show how ink formulation is improved by increasing the solubility of the active bifluorene through extension of the alkyl chain length and switching the counter ion from PF^–₆ to CF₃SO^–₃. We also show how organic light emitting electrochem. cells (OLECs) can be fabricated by spray coating to achieve an active layer with a thickness of 鈭?50-200 nm, leading to working devices with a turn on voltage of around 6.5 V. This gives electroluminescent (EL) that peaks between 385 nm and 390 nm with a maximum EL emission intensity of 1.29 渭W/cm². Thus, EL emission within the UV range has been demonstrated successfully with the synthesized mols. via spray coating onto glass slides. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Electric Literature of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

DFT study on the effect of exocyclic substituents on the proton affinity of 1-methylimidazole was written by Liu, Haining;Bara, Jason E.;Turner, C. Heath. And the article was included in Chemical Physics in 2013.SDS of cas: 3034-41-1 This article mentions the following:

A deeper understanding of the acid/base properties of imidazole derivatives will aid the development of solvents, polymer membranes and other materials that can be used for CO₂ capture and acid gas removal. The authors employ d. functional theory calculations to study the effect of various electron-donating and electron-withdrawing groups on the proton affinity of 1-methylimidazole. Electron-donating groups are able to increase the proton affinity relative to 1-methylimidazole, i.e., making the mol. more basic. But electron-withdrawing groups cause a decrease of the proton affinity. When multiple substituents are present, their effects on the proton affinity are additive. This finding offers a quick approach for predicting and targeting the proton affinities of this series of mols., and the authors show the strong correlation between the calculated proton affinities and exptl. pK_a values. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1SDS of cas: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).SDS of cas: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

From industrial black liquor to pure phenolic compounds: A combination of catalytic conversion with ionic liquids extraction was written by Garron, Anthony;Arquilliere, Philippe P.;Maksoud, Walid Al;Larabi, Cherif;Walter, Jean-Jacques;Santini, Catherine C.. And the article was included in Applied Catalysis, A: General in 2015.HPLC of Formula: 404001-48-5 This article mentions the following:

The conversion, in a sustainable way, of paper industry wastes such as black liquor into value-added mols. is still challenging. Herein, a direct catalytic conversion of black liquor into an aqueous solution has been achieved at moderate temperature and pressure (<250 掳C, 2 MPa). For this purpose, a multimetallic catalyst (Pd_0.5/Ni₁Cu₁-Mg₃₀AlO_x) has been synthesized and fully characterized. In presence of this material, a carbon-based conversion of 12 weight% has been obtained. The final liquid is composed of value-added phenolic compounds (i.e., guaiacol, creosol…) and the reaction can be afforded up to five cycles without deactivation. The green chem. concept consists of extracting these compounds without the use of volatile solvent and in safe operating conditions. For these reasons, the use of hydrophobic ionic liquids for the liquid-liquid extraction of these phenols has been investigated. The influences of the side chains of sym. and asym. imidazolium-NTf₂ as well as operational conditions (stirring rate and temperature) have been studied. As a result, [C₁C₆Im][NTf₂] has been found to be efficient in one-step total extraction phenolic components contained in the solution issued from the catalytic conversion of black liquor. This study showed that the catalytic hydropyrolysis of black liquor could be considered as an alternative source of phenolic compounds to conventional fossil resources. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5HPLC of Formula: 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. HPLC of Formula: 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A highly effective sulfamic acid/methanol catalytic system for the synthesis of benzimidazole derivatives at room temperature was written by Zhang, Zhan-Hui;Li, Tong-Shuang;Li, Jian-Jiong. And the article was included in Monatshefte fuer Chemie in 2007.Safety of 7-Methyl-1H-benzo[d]imidazole This article mentions the following:

Sulfamic acid/methanol was an efficient catalytic system for the synthesis of benzimidazole compounds through the condensation of o-phenylenediamines with orthoesters in high yields at room temperature In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Safety of 7-Methyl-1H-benzo[d]imidazole).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Safety of 7-Methyl-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tetracoordinate borates as catalysts for reductive formylation of amines with carbon dioxide was written by Jiang, Xiaolin;Huang, Zijun;Makha, Mohamed;Du, Chen-Xia;Zhao, Dongmei;Wang, Fang;Li, Yuehui. And the article was included in Green Chemistry in 2020.COA of Formula: C8H8N2 This article mentions the following:

We report sodium trihydroxyaryl borates as the first robust tetracoordinate organoboron catalysts for reductive functionalization of CO2. These catalysts, easily synthesized from condensing boronic acids with metal hydroxides, activate main group element-hydrogen (E-H) bonds efficiently. In contrast to BX3 type boranes, boronic acids and metal-BAr4 salts, under transition metal-free conditions, sodium trihydroxyaryl borates exhibit high reactivity of reductive N-formylation toward a variety of amines (106 examples), including those with functional groups such as ester, olefin, hydroxyl, cyano, nitro, halogen, MeS-, ether groups, etc. The over-performance to catalyze formylation of challenging pyridyl amines affords a promising alternative method to the use of traditional formylation reagents. Mechanistic investigation supports electrostatic interactions as the key for Si/B-H activation, enabling alkali metal borates as versatile catalysts for hydroborylation, hydrosilylation, and reductive formylation/methylation of CO2. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3COA of Formula: C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.COA of Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid was written by Kortagere, Sandhya;Madani, Navid;Mankowski, Marie K.;Schon, Arne;Zentner, Isaac;Swaminathan, Gokul;Princiotto, Amy;Anthony, Kevin;Oza, Apara;Sierra, Luz-Jeannette;Passic, Shendra R.;Wang, Xiaozhao;Jones, David M.;Stavale, Eric;Krebs, Fred C.;Martin-Garcia, Julio;Freire, Ernesto;Ptak, Roger G.;Sodroski, Joseph;Cocklin, Simon;Smith, Amos B. III. And the article was included in Journal of Virology in 2012.HPLC of Formula: 5496-35-5 This article mentions the following:

The HIV-1 capsid (CA) protein plays essential roles in both early and late stages of virl replication and has emerged as a novel drug target. We report hybrid structure-based virtual screening to identify small mols. with the potential to interact with the N-terminal domain (NTD) of HIV-1 CA and disrupt early, preintegration steps of the HIV-1 replication cycle. The small mol. 4,4′-[dibenzo[b,d]furan-2,8-diylbis(5-phenyl-1H-imidazole-4,2-diyl)]dibenzoic acid (CK026), which had anti-HIV-1 activity in single- and multiple-round infections but failed to inhibit viral replication in peripheral blood mononuclear cells (PBMCs), was identified. Three analogs of CK026 with reduced size and better drug-like properties were synthesized and assessed. Compound I-XW-053 (4-(4,5-diphenyl-1H-imidazol-2-yl)benzoic acid) retained all of the antiviral activity of the parental compound and inhibited the replication of a diverse panel of primary HIV-1 isolates in PBMCs, while displaying no appreciable cytotoxicity. This antiviral activity was specific to HIV-1, as I-XW-053 displayed no effect on the replication of SIV or against a panel of nonretroviruses. Direct interaction of I-XW-053 was quantified with wild-type and mutant CA protein using surface plasmon resonance and isothermal titration calorimetry. Mutation of Ile37 and Arg173, which are required for interaction with compound I-XW-053, crippled the virus at an early, preintegration step. Using quant. PCR, we demonstrated that treatment with I-XW-053 inhibited HIV-1 reverse transcription in multiple cell types, indirectly pointing to dysfunction in the uncoating process. In summary, we have identified a CA-specific compound that targets and inhibits a novel region in the NTD-NTD interface, affects uncoating, and possesses broad-spectrum anti-HIV-1 activity. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5HPLC of Formula: 5496-35-5).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 5496-35-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Computationally guided high-throughput design of self-assembling drug nanoparticles was written by Reker, Daniel;Rybakova, Yulia;Kirtane, Ameya R.;Cao, Ruonan;Yang, Jee Won;Navamajiti, Natsuda;Gardner, Apolonia;Zhang, Rosanna M.;Esfandiary, Tina;L’Heureux, Johanna;von Erlach, Thomas;Smekalova, Elena M.;Leboeuf, Dominique;Hess, Kaitlyn;Lopes, Aaron;Rogner, Jaimie;Collins, Joy;Tamang, Siddartha M.;Ishida, Keiko;Chamberlain, Paul;Yun, DongSoo;Lytton-Jean, Abigail;Soule, Christian K.;Cheah, Jaime H.;Hayward, Alison M.;Langer, Robert;Traverso, Giovanni. And the article was included in Nature Nanotechnology in 2021.Related Products of 145040-37-5 This article mentions the following:

Nanoformulations of therapeutic drugs are transforming our ability to effectively deliver and treat a myriad of conditions. Often, however, they are complex to produce and exhibit low drug loading, except for nanoparticles formed via co-assembly of drugs and small mol. dyes, which display drug-loading capacities of up to 95%. There is currently no understanding of which of the millions of small-mol. combinations can result in the formation of these nanoparticles. Here we report the integration of machine learning with high-throughput experimentation to enable the rapid and large-scale identification of such nanoformulations. We identified 100 self-assembling drug nanoparticles from 2.1 million pairings, each including one of 788 candidate drugs and one of 2,686 approved excipients. We further characterized two nanoparticles, sorafenib-glycyrrhizin and terbinafine-taurocholic acid both ex vivo and in vivo. We anticipate that our platform can accelerate the development of safer and more efficacious nanoformulations with high drug-loading capacities for a wide range of therapeutics. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Related Products of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Related Products of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dialkylimidazolium dimethyl phosphates as solvents and catalysts for the Knoevenagel condensation reaction was written by Zicmanis, Andris;Anteina, Liene. And the article was included in Tetrahedron Letters in 2014.Reference of 21252-69-7 This article mentions the following:

The reaction between benzaldehyde and Et cyanoacetate is investigated in 1,3-dialkylimidazolium salts as solvents. The impact of both ions in these ionic liquids on the yield of the condensation reaction product is examined Potentiometric titrations are employed for quant. anal. of the best ionic liquids, revealing these to be 1,3-dialkylimidazolium di-Me phosphates. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Stability-indicating liquid chromatographic methods with photodiode array detection and light scattering detection for simultaneous determination of candesartan and hydrochlorothiazide was written by de Diego, Marta;Godoy, Ricardo;Mennickent, Sigrid;Vergara, Carola;Miranda, Daniel;Navarro, Pia. And the article was included in Journal of Chromatographic Science in 2018.Electric Literature of C33H34N6O6 This article mentions the following:

Development, validation and comparison of two stability-indicating LC methods, one with photodiode array detector (DAD) and the other with evaporative light scattering detector (ELSD), were performed for simultaneous determination of candesartan cilexetil (CANC) and hydrochlorothiazide (HCTZ), in pharmaceutical samples. A RP-18 column (125mm 脳 4 mm, 5 渭m) was used for separation of CANC, HCTZ and its major degradation products, using acetonitrile and phosphate buffer (pH 6.0) for DAD method and acetonitrile and water with acetic acid and triethylamine (pH 4.1) for ELSD method, as mobile phase in a gradient mode. The response with ELSD was fitted to a power function and the DAD response by a linear model over a range of 32-160 渭g/mL for CANC and 25-125 渭g/mL for HCTZ. The precision and accuracy of the methods were similar, with RSD below 3.0% and recovery between 98.1% and 103.9%. The drugs were subjected to stress conditions of hydrolysis, oxidation, photolysis, humidity and temperature The degradation products were satisfactory separated from the main peaks and from each other. Both drugs mainly degrade by hydrolysis, showing the formation of one degradation product for HCTZ and two for CANC; its identification was conducted by LC/MS/MS. The methods were successfully applied to the anal. of CANC and HCTZ in combined com. tablets. The performance of DAD and ELSD methods are comparable, therefore both methods are suitable for stability study and determination of CANC and HCTZ in pharmaceutical samples. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ru@PsIL-Catalyzed Synthesis of N-Formamides and Benzimidazole by using Carbon Dioxide and Dimethylamine Borane was written by Saptal, Vitthal B.;Sasaki, Takehiko;Bhanage, Bhalchandra M.. And the article was included in ChemCatChem in 2018.Reference of 4887-83-6 This article mentions the following:

The synthesis and characterization of ruthenium nanoparticles (Ru NPs) supported on polymeric ionic liquids (PILs) was reported. This catalyst showed high catalytic activity towards the N-formylation of amines and synthesis of benzimidazoles from 1,2-diamines and carbon dioxide (CO₂) by reductive dehydrogenation of dimethylamine borane. This methodol. showed excellent functional group tolerance with broad substrate scope towards the synthesis of N-formamides and benzimidazoles. Interestingly, this protocol also provided the tandem reduction of 2-nitroamines and CO₂ to synthesize benzimidazoles. It was proposed that the ionic liquid phase of the polymer played pivotal roles such as assisting the stabilization of nanoparticles electrostatically, providing an ionic environment, and controlling the easy access of the substrates/reagents to the active sites. The developed methodol. utilized CO₂ as a C₁ source and water/ethanol as a green solvent system. Addnl., the catalyst was found to be recyclable in nature and showed five consecutive recycling runs without significant loss in its activity. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Reference of 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem