Imidazoles-derivatives

Synthesis, surface activity and aggregation behavior of Gemini imidazolium surfactants 1,3-bis(3-alkylimidazolium-1-yl) propane bromide was written by Ren, Chengcheng;Wang, Fang;Zhang, Zhiqing;Nie, Huihui;Li, Nan;Cui, Mei. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2015.Reference of 21252-69-7 This article mentions the following:

A novel class of Gemini imidazolium surfactants 1,3-bis(3-alkylimidazolium-1-yl) propane bromide [C_n-3-C_ni.m.]Br₂ (n = 8, 10, 12) were synthesized and characterized by FT-IR, ¹H NMR and elemental anal. The surface activity and aggregation behavior of [C_n-3-C_ni.m.]Br₂ (n = 8, 10, 12) were investigated by surface tension, conductivity and steady fluorescence methods. A series of surface active parameters, including cmc, Γ_max, pC₂₀, cmc/C₂₀, A_min, γ_cmc and Π_cmc were obtained from surface tension measurement. It was indicated that Gemini imidazolium surfactants with the longer alkyl chain showed the higher surface activity. The thermodn. parameters of micellization process, namely, standard Gibbs free energy (ΔG^ο_m), enthalpy (ΔH^ο_m) and entropy (ΔS^ο_m) were derived from conductivity measurement at different temperatures The micropolarity and the mean aggregation number (N_agg) of micelles were evaluated from steady fluorescence spectra. The results revealed that the micropolarity and N_agg of micelles decreased with the increase of hydrocarbon chain length. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Selective reductions of 1-(carbonyl)substituted 2-nitroimidazoles with alkali metal borohydrides and with borane-tetrahydrofuran was written by Threadgill, Michael D.;Webb, Paul. And the article was included in Synthetic Communications in 1990.Application In Synthesis of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid This article mentions the following:

NaBH₄, LiBH₄, and BH₃.THF reduce carbonyl groups (esters, amide) in 1-substituted 2-nitroimidazoles I ( R = CO₂Me, CONH₂) in high yield without reduction of the nitroheterocycle to give I ( R = CH₂OH, CH₂NH₂) resp. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Application In Synthesis of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Novel drug discovery platform for spinocerebellar ataxia, using fluorescence technology targeting β-III-spectrin was written by Rebbeck, Robyn T.;Andrick, Anna K.;Denha, Sarah A.;Svensson, Bengt;Guhathakurta, Piyali;Thomas, David D.;Hays, Thomas S.;Avery, Adam W.. And the article was included in Journal of Biological Chemistry in 2021.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

Numerous diseases are linked to mutations in the actin-binding domains (ABDs) of conserved cytoskeletal proteins, including β-III-spectrin, α-actinin, filamin, and dystrophin. A β-III-spectrin ABD mutation (L253P) linked to spinocerebellar ataxia type 5 (SCA5) causes a dramatic increase in actin binding. Reducing actin binding of L253P is thus a potential therapeutic approach for SCA5 pathogenesis. Here, we validate a high-throughput screening (HTS) assay to discover potential disrupters of the interaction between the mutant β-III-spectrin ABD and actin in live cells. This assay monitors FRET between fluorescent proteins fused to the mutant ABD and the actin-binding peptide Lifeact, in HEK293-6E cells. Using a specific and high-affinity actin-binding tool compound, swinholide A, we demonstrate HTS compatibility with an excellent Zâ€?factor of 0.67 ± 0.03. Screening a library of 1280 pharmacol. active compounds in 1536-well plates to determine assay robustness, we demonstrate high reproducibility across plates and across days. We identified nine Hits that reduced FRET between Lifeact and ABD. Four of those Hits were found to reduce Lifeact cosedimentation with actin, thus establishing the potential of our assay for detection of actin-binding modulators. Concurrent to our primary FRET assay, we also developed a high-throughput compatible counter screen to remove undesirable FRET Hits. Using the FRET Hits, we show that our counter screen is sensitive to undesirable compounds that cause cell toxicity or ABD aggregation. Overall, our FRET-based HTS platform sets the stage to screen large compound libraries for modulators of β-III-spectrin, or disease-linked spectrin-related proteins, for therapeutic development. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Syntheses, protonation constants and antimicrobial activity of 2-substituted N-alkylimidazole derivatives was written by Kleyi, Phumelele;Walmsley, Ryan S.;Gundhla, Isaac Z.;Walmsley, Tara A.;Jauka, Tembisa I.;Dames, Joanna;Walker, Roderick B.;Torto, Nelson;Tshentu, Zenixole R.. And the article was included in South African Journal of Chemistry in 2012.Computed Properties of C11H20N2 This article mentions the following:

A series of N-alkylimidazole-2-carboxylic acid, N-alkylimidazole-2-carboxaldehyde and N-alkylimidazole-2-methanol derivatives [alkyl = benzyl, Me, Et, Pr, Bu, heptyl, octyl and decyl] have been synthesized and the protonation constants determined The antimicrobial properties of the compounds were tested against Gram-neg. (Escherichi coli), Gram-pos. (Staphylococcus aureus & Bacillus subtilis subsp. spizizenii) bacterial strains and yeast (C. albicans). Both the disk diffusion and broth microdilution methods for testing the antimicrobial activity showed that N-alkylation of imidazole with longer alkyl chains and the substitution with low pK_a group at 2-position resulted in enhanced antimicrobial activity. Particularly, the N-alkylimidazole-2-carboxylic acids exhibited the best antimicrobial activity due to the low pK_a of the carboxylic acid moiety. Generally, all the N-alkylimidazole derivatives were most active against the Gram-pos. bacteria [S. aureus (MIC = 5-160 μg mL^-1) and B. subtilis subsp. spizizenii (5-20 μg mL^-1)], with the latter more susceptible. All the compounds showed poor antimicrobial activity against both Gram-neg. (E. coli, MIC = 0.15 to >2500 μg mL^-1) bacteria and all the compounds were inactive against the yeast (Candida albicans). In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Computed Properties of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Computed Properties of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic Liquid Mixtures-An Analysis of Their Mutual Miscibility was written by Omar, Salama;Lemus, Jesus;Ruiz, Elia;Ferro, Victor R.;Ortega, Juan;Palomar, Jose. And the article was included in Journal of Physical Chemistry B in 2014.Name: 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

The use of ionic liquid mixtures (IL-IL mixtures) is being investigated for fine solvent properties tuning of the IL-based systems. The scarce available studies, however, evidence a wide variety of mixing behaviors (from almost ideal to strongly nonideal), depending on both the structure of the IL components and the property considered. In fact, the adequate selection of the cations and anions involved in IL-IL mixtures may ensure the absence or presence of two immiscible liquid phases. In this work, a systematic computational study of the mixing behavior of IL-IL systems is developed by means of COSMO-RS methodol. Liquid-liquid equilibrium (LLE) and excess enthalpy (H^E) data of more than 200 binary IL-IL mixtures (including imidazolium-, pyridinium-, pyrrolidinium-, ammonium-, and phosphonium-based ILs) are calculated at different temperatures, comparing to literature data when available. The role of the interactions between unlike cations and anions on the mutual miscibility/immiscibility of IL-IL mixtures was analyzed. On the basis of proposed guidelines, a new class of immiscible IL-IL mixtures was reported, which only is formed by imidazolium-based compounds In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Name: 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of ionic liquids coated nanocrystalline zeolite materials and their application in the simultaneous determination of adenine, cytosine, guanine, and thymine was written by Kaur, Balwinder;Srivastava, Rajendra. And the article was included in Electrochimica Acta in 2014.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

Ionic liquids coated nanocrystalline zeolite based inorganic-organic hybrid materials were synthesized. Nanocrystalline ZSM-5 zeolite was prepared under hydrothermal condition in the presence of propyltriethoxysilane as an additive in the synthesis composition of conventional ZSM-5. Ionic liquids (methylimidazolium chloride and 1-butyl-3-methylimidazolium chloride) were coated on the surface of nanocrystalline ZSM-5 by the post synthesis method. For comparative study, ionic liquids coated conventional ZSM-5 based inorganic-organic hybrid materials were also prepared Ionic liquids coated nanocrystalline ZSM-5/ZSM-5 modified electrodes were constructed for the simultaneous determination of all four DNA bases such as adenine, cytosine, guanine, and thymine. Difference in the electro-catalytic activity of the modified electrode is explained with the help of textural properties, conductivity, and d. functional theory. The anal. performance of the proposed method was demonstrated in the simultaneous determination of all four DNA bases in calf thymus DNA sample. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The effects of structural changes on the anti-microbial and anti-proliferative activities of diimidazolium salts was written by Cancemi, Patrizia;Buttacavoli, Miriam;D’Anna, Francesca;Feo, Salvatore;Fontana, Rosa Maria;Noto, Renato;Sutera, Alberto;Vitale, Paola;Gallo, Giuseppe. And the article was included in New Journal of Chemistry in 2017.Formula: C11H20N2 This article mentions the following:

An array of diimidazolium salts has been synthesized and used to investigate their anti-microbial and anti-proliferative activities. In particular, salts based on the 3,3′-di-n-alkyl-1,1′-(1,n-phenylenedimethylene)diimidazolium cation and differing in the alkyl chain length on the imidazolium ion, the isomeric substitution on the aromatic spacer and in the anion nature were used. The anti-proliferative activity was evaluated against cervical (HeLa), colon adenocarcinoma (HT-29) and breast (SKBR3) cancer cell lines. In the latter case, also a morphol. assessment after treatment with salts was performed. All salts were tested for their hemolytic activity against human erythrocytes. On the other hand, the anti-microbial activity was investigated using both Gram-neg. (Escherichia coli) and Gram-pos. (Kokuria rhizophila, Staphylococcus aureus and Bacillus subtilis) strains. On the whole, the data collected demonstrate that biol. activity is the result of the combined action of both cation and anion structures. In general, the cation hydrophobicity plays the most significant role with structural features of the anion becoming more relevant in the presence of a shorter alkyl chain on the cationic head. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In situ generation of hydrophobic magnetic ionic liquids in stir bar dispersive liquid-liquid microextraction coupled with headspace gas chromatography was written by Trujillo-Rodriguez, Maria J.;Anderson, Jared L.. And the article was included in Talanta in 2019.Reference of 21252-69-7 This article mentions the following:

For the first time, an in situ stir bar dispersive liquid-liquid microextraction approach has been developed and coupled with headspace gas chromatog.-mass spectrometry for the determination of a group of organic pollutants. The method exploits a new generation of magnetic ionic liquids (MILs) that contain paramagnetic cations based on Ni²⁺ or Co²⁺ metal centers coordinated with either N-butylimidazole or N-octylimidazole ligands and chloride anions. The reactants are added to an aqueous solution containing a high field neodymium rod magnet, followed by the addition of the bis[(trifluoromethyl)sulfonyl]imide anion that promotes a metathesis reaction for the in situ generation of a hydrophobic MIL. Concurrently, a high stirring rate is maintained to exceed the magnetic field of the rod magnet and disperse the generated MIL in the sample solution When stirring is stopped, the MIL coats the rod magnet due to its paramagnetic nature, facilitating the MIL transfer and subsequent desorption and anal. Under optimum conditions, the method required a 2.5-18% (w/v) aqueous solution of sodium chloride, 10 mL of sample, 20 or 30 mg of MIL, the addition of a small volume of dispersive solvent, and stirring for 5-7.5 min, depending on the MIL. The method provided limits of detection (LODs) down to 10μg L^-1, adequate reproducibility (with relative standard deviation values lower than 10% for a spiked level of 80μg L^-1), and relative recoveries between 72.5% and 102%. Furthermore, the method was successfully applied in the anal. of tap and mineral water. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic PMMA/nanosilica interfaces from grafting ionic liquids under supercritical CO₂ conditions was written by Fedosse Zornio, Clarice;Livi, Sebastien;Jestin, Jacques;Duchet, Jannick;Gerard, Jean-Francois. And the article was included in European Polymer Journal in 2018.Product Details of 21252-69-7 This article mentions the following:

Supercritical carbon dioxide (scCO₂) was considered as an environmental friendly medium for grafting the surface of silica nanoparticles with a series of reactive imidazolium-based ionic liquids (IL), denoted as IL-silanes. The effects of the reaction conditions on the resulting IL-grafted layers on the silica surface were characterized from thermogravimetric (TGA) and transmission electronic microscopy (TEM) analyses. The IL-grafted nanoparticles were introduced into poly(Me methacrylate) (PMMA) via melt mixing in order to design nanocomposites and to demonstrate the ability of IL-grafted nanoparticles to be dispersed into a polymer medium. The role of the IL-grafted surfaces on the morphol. of PMMA-based nanocomposites was evidenced by TEM and small angle neutron scattering (SANS). It was demonstrated that longer the alkyl chain length of the IL-silane, better the state of dispersion of nanoparticles within PMMA. In addition, better thermal stabilities and mech. performances, as well as new surface properties were observed for the designed PMMA-based nanocomposites. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Product Details of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Product Details of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

All-Solid-State Polymer Electrolyte with Efficiency and Stability Superior to Its Smectic Precursor for Photoelectrochemical Devices was written by Zhou, Jiwen;Wang, Caihong;Zhang, Xiaoqian;Luo, Jie;Ji, Junyi;Wu, Yong;Tan, Shuai. And the article was included in Industrial & Engineering Chemistry Research in 2021.Category: imidazoles-derivatives This article mentions the following:

All-solid-state electrolytes have attracted wide interest for versatile energy devices owing to their stability improvement toward sustainable applications; however, the low conductivity and interfacial contact remain to be addressed. Herein, a facile method was proposed for preparing superior all-solid-state electrolytes from ionic liquid crystals. A vinylimidazolium thiolate/disulfide redox-based lamellar nanostructured electrolyte showing a smectic mesophase was prepared as a precursor, and flexible polyethylene oxide (PEO) was introduced to gel the smectic domains of the precursor to form a microphase segregation nanostructure. The PEO chains assembled at domain interfaces could significantly improve the charge transport through the smectic domain boundaries in the electrolyte. The dynamic liquid crystal gel was first assembled in a dye-sensitized solar cell (DSSC) to provide good interfacial contact, and then, in situ polymerization was performed to fabricate an all-solid-state electrolyte. The microphase segregation nanostructure was well maintained within the polymerized electrolytes for efficient charge transport. Thus, the all-solid-state electrolytes exhibited ion conductivity, thermal stability, and DSSC efficiency much superior to its smectic precursor despite the loss of fluidity. The work here sheds new light on developing desirable all-solid-state electrolytes from ionic liquid crystals for energy devices. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Category: imidazoles-derivatives).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem