Imidazoles-derivatives

Synthesis and properties of amides of 2-[(4-methylphenyl)(2-thienylsulfonyl)amino]acetic acid was written by Tyuneva, I. V.;Filimonov, S. I.;Balakin, K. V.;Skorenko, A. V.;Kravchenko, D. V.;Dorogov, M. V.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2004.Recommanded Product: 24134-26-7 This article mentions the following:

A series of [(4-methylphenyl)(2-thienylsulfonyl)amino]acetamides I (R¹ = H, R² = cyclopentyl, 2-ClC₆H₄CH₂, PhCHMe, 4-ClC₆H₄CH₂CH₂, etc.; R¹R²N = 4-benzyl-1-piperidinyl, 2,3-dihydro-1-indolyl, etc.) was synthesized by reaction of 2-thiophenesulfonyl chloride with Me (4-methylphenylamino)acetate followed by the ether group hydrolysis and amination with various primary and secondary amines. Some important physico-chem. properties of I, such as partition coefficient, solubility, amount of non-terminal rotating bonds and the total number of hydrogen bond donors and acceptors, were calculated In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Recommanded Product: 24134-26-7).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 24134-26-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sustainable Production of o-Xylene from Biomass-Derived Pinacol and Acrolein was written by Hu, Yancheng;Li, Ning;Li, Guangyi;Wang, Aiqin;Cong, Yu;Wang, Xiaodong;Zhang, Tao. And the article was included in ChemSusChem in 2017.COA of Formula: C7H13ClN2 This article mentions the following:

O-Xylene (OX) is a large-volume commodity chem. that is conventionally produced from fossil fuels. In this study, an efficient and sustainable two-step route is used to produce OX from biomass-derived pinacol and acrolein. In the first step, the phosphotungstic acid (HPW)-catalyzed pinacol dehydration in 1-ethyl-3-methylimidazolium chloride ([emim]Cl) selectively affords 2,3-dimethylbutadiene. The high selectivity of this reaction can be ascribed to the H-bonding interaction between Cl^– and the hydroxy group of pinacol. The stabilization of the carbocation intermediate by the surrounding anion Cl^– may be another reason for the high selectivity. Notably, the good reusability of the HPW/[emim]Cl system can reduce the waste output and production cost. In the second step, OX is selectively produced by a Diels-Alder reaction of 2,3-dimethylbutadiene and acrolein, followed by a Pd/C-catalyzed decarbonylation/aromatization cascade in a one-pot fashion. The sustainable two-step process efficiently produces renewable OX in 79 % overall yield. Analogously, biomass-derived crotonaldehyde and pinacol can also serve as the feedstocks for the production of 1,2,4-trimethylbenzene. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8COA of Formula: C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.COA of Formula: C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and Radiosynthesis of Prospective 2-Nitroimidazole Hypoxia PET Tracers via Thiazolidine Ligation with 5-Fluorodeoxyribose (FDR) was written by Musolino, M.;Dall’Angelo, S.;Zanda, M.. And the article was included in SynOpen in 2017.Electric Literature of C5H5N3O4 This article mentions the following:

The first prospective fluorinated PET tracers for imaging hypoxia obtained via thiazolidine-ligation are reported. Three 1,2-thiol-amine linkers were combined with four different 2-nitroimidazole spacers via amide or urea bond formation. The resulting compounds, e.g., I were submitted to thiazolidine-ring-forming ligation reaction with the fluorinated carbohydrate L-5-fluoro-5-deoxy-ribose (FDR), affording the desired candidate PET tracers, e.g., II in variable yields. The same ligation reactions performed on L-ribose – a byproduct of [18F]FDR radiosynthesis – under conditions mimicking a radiochem. production and showed that the fluorinated adducts can be efficiently purified and isolated by HPLC. Finally, one of the prospective hypoxia tracers was successfully produced in radiolabeled form in 29.2% radiochem. yield from [18F]FDR. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Electric Literature of C5H5N3O4).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Electric Literature of C5H5N3O4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New bi-functional zinc catalysts based on robust and easy-to-handle N-chelating ligands for the synthesis of cyclic carbonates from epoxides and CO₂ under mild conditions was written by Luo, Rongchang;Zhou, Xiantai;Zhang, Wuying;Liang, Zhongxiu;Jiang, Jun;Ji, Hongbing. And the article was included in Green Chemistry in 2014.Reference of 21252-69-7 This article mentions the following:

Novel zinc complexes were prepared by covalent linkage of various imidazolium-based ionic liquid moieties with the 2,2′-bipyridine ligand on the two sides of the 4,4′-position. The zinc(II) complexes containing the rigid N-chelating ligand proved to be stable, highly efficient and easy-to-handle catalysts towards the synthesis of cyclic carbonate from epoxide and CO₂ without the use of any co-catalyst or organic solvent. The catalysts can be easily recovered and reused without significant loss of activity and selectivity by control of the solvent. The kinetic study uncovered that the reaction was 1st-order with respect to the epoxide. Also, a plausible reaction mechanism was proposed, in which the zinc center could promote ring-opening of the epoxide for the synergetic effect with the anion X^– in ILs. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cornstalk liquefaction in methanol/water mixed solvents was written by Zhu, Wei-Wei;Zong, Zhi-Min;Yan, Hong-Lei;Zhao, Yun-Peng;Lu, Yao;Wei, Xian-Yong;Zhang, Dongke. And the article was included in Fuel Processing Technology in 2014.Computed Properties of C4H5N3O2 This article mentions the following:

Cornstalk liquefaction (CSL) in methanol, water or methanol/water mixed solvents was studied at 250-320 °C. Each reaction mixture was separated into extract 1 (E₁, including the solute in filtrate and methanol-extractable portion), extract 2 (E₂, methanol-inextractable but isometric carbon disulfide/acetone-extractable portion) and residue (isometric carbon disulfide/acetone-inextractable portion) by filtration and sequential extraction with methanol and isometric carbon disulfide/acetone mixed solvent. The cornstalk, E₁, E₂ and the residues were analyzed using a Fourier transformation IR spectrometer and each E₁ was analyzed using a gas chromatog./mass spectrometer. The microstructures of the cornstalk and its derived residues were observed with a scanning electron microscope. The results show that methanol and water exhibited a synergic effect on the CSL. The isometric methanol and water mixed solvent was found to be most effective for CSL at 300 °C for 30 min. Under such conditions, the total yield of gases, E₁ and E₂ and the yield of E₁ reached 88.1% and 52.4%, resp. The yields decreased as the temperature or time was further increased, suggesting that some of the extractable species were repolymd. at higher temperatures or for prolonged time. E₁ consisted of hydrocarbons, alkanols, tetrahydrofuranylmethanols, arenols, methoxyalkanes, methoxyarenes, ketones, carboxylic acids, esters, chloromethylbenzenes, nitrogen-containing species and several other species. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Computed Properties of C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Computed Properties of C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Deubiquitinase-targeting chimeras for targeted protein stabilization was written by Henning, Nathaniel J.;Boike, Lydia;Spradlin, Jessica N.;Ward, Carl C.;Liu, Gang;Zhang, Erika;Belcher, Bridget P.;Brittain, Scott M.;Hesse, Matthew J.;Dovala, Dustin;McGregor, Lynn M.;Valdez Misiolek, Rachel;Plasschaert, Lindsey W.;Rowlands, David J.;Wang, Feng;Frank, Andreas O.;Fuller, Daniel;Estes, Abigail R.;Randal, Katelyn L.;Panidapu, Anoohya;McKenna, Jeffrey M.;Tallarico, John A.;Schirle, Markus;Nomura, Daniel K.. And the article was included in Nature Chemical Biology in 2022.Category: imidazoles-derivatives This article mentions the following:

Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we present deubiquitinase-targeting chimeras (DUBTACs), heterobifunctional small mols. consisting of a deubiquitinase recruiter linked to a protein-targeting ligand, to stabilize the levels of specific proteins degraded in a ubiquitin-dependent manner. Using chemoproteomic approaches, we discovered the covalent ligand EN523 that targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1. We showed that a DUBTAC consisting of our EN523 OTUB1 recruiter linked to lumacaftor, a drug used to treat cystic fibrosis that binds ΔF508-cystic fibrosis transmembrane conductance regulator (CFTR), robustly stabilized ΔF508-CFTR protein levels, leading to improved chloride channel conductance in human cystic fibrosis bronchial epithelial cells. We also demonstrated stabilization of the tumor suppressor kinase WEE1 in hepatoma cells. Our study showcases covalent chemoproteomic approaches to develop new induced proximity-based therapeutic modalities and introduces the DUBTAC platform for TPS. [graphic not available: see fulltext] In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Category: imidazoles-derivatives).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Potential inhibitors for SARS-CoV-2 Mpro from marine compounds was written by Tam, Nguyen Minh;Pham, Minh Quan;Nguyen, Huy Truong;Hong, Nam Dao;Hien, Nguyen Khoa;Quang, Duong Tuan;Thu Phung, Huong Thi;Ngo, Son Tung. And the article was included in RSC Advances in 2021.Product Details of 145040-37-5 This article mentions the following:

Preventing the biol. activity of SARS-CoV-2 main protease using natural compounds is of great interest. In this context, using a combination of AutoDock Vina and fast pulling of ligand simulations, eleven marine fungi compounds were identified that probably play as highly potent inhibitors for preventing viral replication. In particular, four compounds including M15 (3-O-(6-O-α-L-arabinopyranosyl)-β-D-glucopyranosyl-1,4-dimethoxyxanthone), M8 (wailupemycins H), M11 (cottoquinazolines B), and M9 (wailupemycins I) adopted the predicted ligand-binding free energy of -9.87, -9.82, -9.62, and -9.35 kcal mol^-1, resp., whereas the other adopted predicted ligand-binding free energies in the range from -8.54 to -8.94 kcal mol^-1. The results were obtained using a combination of Vina and FPL simulations. Notably, although, AutoDock4 adopted higher accurate results in comparison with Vina, Vina is proven to be a more suitable technique for rapidly screening ligand-binding affinity with a large database of compounds since it requires much smaller computing resources. Furthermore, FPL is better than Vina to classify inhibitors upon ROC-AUC anal. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Product Details of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Product Details of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A method for the design of distillation systems aided by ionic liquids was written by Ramirez-Corona, Nelly;Ek, Natanael;Jimenez-Gutierrez, Arturo. And the article was included in Chemical Engineering and Processing in 2015.Electric Literature of C4H7ClN2 This article mentions the following:

Ionic liquids (ILs) have recently been considered for several applications in chem. processes. Particularly, as they promote an evident salting-out effect over vapor-liquid equilibrium properties and integrate the advantages of a liquid entrainer with the benefits of a solid salt, the use of ILs for the ethanol-water separation has gained wider interest. In this work, a design method for distillation systems aided by ILs is presented. The method is based on tray-by-tray calculations from the outside to the inside of the column, and the feed stage is determined by using a min. distance concept. The method is illustrated with an ethanol dehydration design. An anal. on the effect of ILs on the column composition profiles is also carried out. The method is shown to provide an effective tool for the conceptual design of these types of systems. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Electric Literature of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Case studies of enhanced pharmacodynamic activity of poorly oral bioavailable drugs via solid lipid nanoparticles was written by Raju, D.. And the article was included in Journal of Drug Delivery and Therapeutics in 2021.SDS of cas: 145040-37-5 This article mentions the following:

Solid lipid nanoparticles (SLNs) considered as an alternative vehicle for the enhanced oral absorption of drugs, and also to enhance therapeutic effectiveness after oral administration. Pharmacodynamic activity of drug is mainly describes the pharmacol. and therapeutic activity of drug to the biol. system. Lipid nanoparticles especially SLNs made of physiol. inert lipid mols. and helps the lymphatic transport. Numerous literatures is available on the effect of SLNs and other colloidal carrier systems on the pharmacokinetic activity of poorly bioavailable drugs, to improve their oral absorption and also resp. mechanisms for the improved oral bioavailability. However, very few literatures is reported on the pharmacodynamic activity and the effect of dose on the pharmacodynamic activity. Therefore, the current review is mainly dealing with the effect of SLNs on the pharmacodynamic activity discussed. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5SDS of cas: 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of ribosyl-ribosyl-adenosine-5′,5”,5”'(triphosphate)-the naturally occurring branched fragment of poly(ADP ribose) was written by Liu, Qiang;Kistemaker, Hans. A. V.;Overkleeft, Herman S.;van der Marel, Gijsbert A.;Filippov, Dmitri V.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Electric Literature of C4H7ClN2 This article mentions the following:

Poly-ADP ribose (PAR) is a branched biopolymer that occurs as a result of post-translational modification of proteins. In 1981 Miwa et al. determined the structure of enzymically prepared branched PAR. We present the first synthesis of the same branched PAR fragment and have shown by NMR that the structure proposed by Miwa is correct. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Electric Literature of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem