Imidazoles-derivatives

Extraction of butan-1-ol from aqueous solution using ionic liquids: An effect of cation revealed by experiments and thermodynamic models was written by Domanska, Urszula;Wlazlo, Michal;Paduszynski, Kamil. And the article was included in Separation and Purification Technology in 2018.Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

Production of bio-butanol from biomass by fermentation in an aqueous phase needs new solutions and entrainers for the separation of product. Ionic liquids (ILs) are attractive significant attention as novel, low pressure solvents alternative to conventional organic solvents for biphasic solvent extraction Ternary liquid-liquid equilibrium data are presented for mixtures of {ionic liquid (1) + butan-1-ol (2) + water (3)} at T = 298.15 K and ambient pressure to analyze the performance of the IL in the extraction of butan-1-ol from aqueous phase. The bis{(trifluoromethyl)sulfonyl}amide-based ILs have been studied: octyltriethylammonium bis{(trifluoromethyl)sulfonyl}amide, [N_8,2,2,2][NTf₂], methyltrioctylammonium bis{(trifluoromethyl)sulfonyl}amide, [N_8,8,8,1][NTf₂], 1-dodecyl-3-methylimidazolium bis{(trifluoromethyl)sulfonyl}amide, [DoMIM][NTf₂] and 1-hexyloxymethyl-3-methylimidazolium bis{(trifluoromethyl)sulfonyl}amide, [C₆H₁₃OCH₂MIM][NTf₂]. The results are discussed in terms of the selectivity and the solute distribution ratio of separation for the related systems. The IL with three octyl alkyl chains, [N_8,8,8,1][NTf₂] at the ammonium-based cation shows higher selectivity and the same distribution ratio in comparison to the other ILs in this process. Addnl., the viscosity of [N_8,2,2,2][NTf₂], and d. and viscosity of the best IL, [N_8,8,8,1][NTf₂] were measured for the collection of physico-chem. properties of the ILs used in this work. The non-random two liquid NRTL model was used successfully to correlate the exptl. tie-lines. The prediction of ternary compositions was shown with good precision using COSMO RS for the ILs used in this work and for data from literature. The data and calculations presented here indicate the possible use of the model COSMO RS for the prediction of ternary LLE and of the use of [N_8,8,8,1][NTf₂], as a good solvent for the separation of butan-1-ol from water using solvent extraction In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of tin nanocrystals in room temperature ionic liquids was written by Le Vot, Steven;Dambournet, Damien;Groult, Henri;Ngo, Anh-tu;Petit, Christophe;Rizzi, Cecile;Salzemann, Caroline;Sirieix-Plenet, Juliette;Borkiewicz, Olaf J.;Raymundo-Pinero, Encarnacion;Gaillon, Laurent. And the article was included in Dalton Transactions in 2014.Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

The aim of this work was to study the synthesis of tin nanoparticles (NPs) or tin/carbon composites, in room temperature ionic liquids (RTILs), that could be used as structured anode materials for Li-ion batteries. An innovative route for the synthesis of Sn nanoparticles in such media is successfully developed. Compositions, structures, sizes and morphologies of NPs were characterized by high-energy x-ray diffraction (HEXRD), XPS and high-resolution TEM (HRTEM). (i) metallic tetragonal β-Sn was obtained and (ii) the particle size could be tailored by tuning the nature of the RTILs, leading to nano-sized spherical particles with a diameter ranging from 3 to 10 nm depending on synthesis conditions. To study carbon composite materials for Li-ion batteries, Sn nanoparticles were successfully deposited on the surface of multi-wall carbon nanotubes (MWCNT). Also, electrochem. properties were studied in relation to a structural study of the nanocomposites. The poor electrochem. performances as a neg. electrode in Li-ion batteries is due to a significant amount of RTIL trapped within the pores of the nanotubes as revealed by XPS studies. This dramatically affected the gravimetric capacity of the composites and limited the diffusion of lithium. The findings of this work however offer valuable insights into the exciting possibilities for synthesis of novel nano-sized particles and/or alloys (e.g. Sn-Cu, Sn-Co, Sn-Ni, etc.) and the importance of carbon morphol. in metal pulverization during the alloying/dealloying process as well as prevention of ionic liquid trapping. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lubrication Properties of the Ionic Liquid Dodecyl-3 Methylimidazolium bis(trifluoromethylsulfonyl)imide was written by Battez, A. Hernandez;Ramos, D.;Blanco, D.;Gonzalez, R.;Fernandez-Gonzalez, A.;Viesca, J. L.. And the article was included in Tribology Letters in 2018.Product Details of 404001-48-5 This article mentions the following:

The ionic liquid (IL) dodecyl-3 methylimidazolium bis(trifluoromethylsulfonyl)imide was tested as neat lubricant and as additive (at 1 and 4 wt%) in a polar oil (diester). Tribol. tests were performed using a reciprocating configuration for 90 min at 30 and 70 N, 10 Hz, 4 mm stroke length, and at room temperature and 100°C. Wear volume and surface-IL interaction were determined by confocal microscopy, SEM, and XPS. The main findings were: Neat ionic liquid showed the best tribol. behavior; the IL-containing mixtures had similar behavior than the base oil at the lower load; meanwhile, the mixture with 4 wt% of IL outperformed the antiwear behavior of the neat base oil at the higher load; surface-IL chem. interaction was found mainly at 100°C. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Product Details of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Product Details of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Properties and catalytic activity of magnetic and acidic ionic liquids: Experimental and molecular simulation was written by Zhou, Cunshan;Yu, Xiaojie;Ma, Haile;Huang, Xingyi;Zhang, Henan;Jin, Jian. And the article was included in Carbohydrate Polymers in 2014.Safety of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

The exploitation of dual functional magnetic and acidic ionic liquids (MAILs) for hydrolysis of cellulose to platform chems. can solve some practical challenges through easy separation of products and efficient catalyst recyclability. In this work, seven C_nmim/FeCl₄ MAILs were synthesized and investigated with combined exptl. and mol. dynamics. The MAILs contained FeCl^–₄ anions and exhibited a typical hard magnetic materials behavior with rather strong magnetic susceptibilities. These MAILs were stable up to 250-310 °C, the decomposition was started up at 250/310-480-810 °C in two steps with the formation of the undecomposed residue. The Gibbs energy for the reaction of glucose/xylose conversion to 5-hydroxymethylfurfural by metal chlorides in the C_nmimCl ionic liquid was studied using the d. functional theory calculations and the results that C₃mim/WCl₃ may be the most hopeful catalyst. The MAILs have the potential to open up promising new catalytic systems because of their easy product separation and efficient catalyst recyclability. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Safety of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Safety of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dynamic wetting of imidazolium-based ionic liquids on gold and glass was written by Delcheva, I.;Beattie, D. A.;Ralston, J.;Krasowska, M.. And the article was included in Physical Chemistry Chemical Physics in 2018.Synthetic Route of C18H31F6N3O4S2 This article mentions the following:

The present study explores the dynamic wetting of three ionic liquids (with a different length of hydrocarbon chain in the cation) on gold and glass substrates, both of which are relevant for nano- and micromech. machine applications, under well-controlled environmental conditions. The form of data capture (Wilhelmy plate) allows for a direct anal. using anal. expressions for the two dominant approaches for dynamic wetting: the hydrodynamic and mol. kinetic models. All ionic liquids yield data that are described best by the mol. kinetic model. Substrate-ionic liquid and water-ionic liquid interactions contribute to the mechanisms involved in the wetting process. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Synthetic Route of C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Synthetic Route of C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of 2-alkyl-substituted benzimidazoles by thermal decomposition of 2-azidobenzenamines in the presence of an aldehyde was written by Wallace, Jeffery M.;Soderberg, Bjorn C. G.;Hubbard, Jeremiah W.. And the article was included in Synthetic Communications in 2006.SDS of cas: 4887-83-6 This article mentions the following:

2-Substituted benzimidazoles, e.g., I, were prepared by reaction of 2-azidoaminobenzenes, e.g., II, with with aldehydes under thermal conditions. The reaction probably proceeds via a sequential imine formation, azide decomposition forming a nitrene, and electrocyclization. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6SDS of cas: 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. SDS of cas: 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nsc-mediated solid-phase synthesis of polyamides containing pyrrole amino acid was written by Choi, Jin Seok;Lee, Hwa-Sun;Lee, Younjoo;Jeong, Nakcheol;Kim, Hack-Joo;Kim, Young-Deug;Han, Hogyu. And the article was included in Tetrahedron Letters in 2002.Quality Control of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate This article mentions the following:

The synthesis of the Nsc-protected amino acid, Nsc-Py-OH (I) [Nsc = 2-(4-nitrophenylsulfonyl)ethoxycarbonyl] and its oligomerization on solid-phase are described. The suitability of the Nsc methodol. for preparation of polyamides containing heteroaromatic amino acids was demonstrated. In the experiment, the researchers used many compounds, for example, Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9Quality Control of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate).

Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Quality Control of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Characterization of substituted nitroimidazoles on paper and thin-layer chromatography by colorimetric reactions was written by Stambaugh, J. E.;Manthei, Roland W.. And the article was included in Journal of Chromatography in 1967.Application In Synthesis of 1-Methyl-4-nitroimidazole This article mentions the following:

The characterization of substituted nitroimidazoles (I) by colorimetric reaction after paper and thin-layer chromatog. is studied. The colorimetric reactions depend upon reduction of I to the corresponding aminoimidazoles, followed by coupling with either diazotized sulfanilic acid (II), p-(dimethylamino)benzaldehyde (III), or ninhydrin (IV). The paper chromatograms can be developed in BuOH saturated with H2O, 70:30 PrOH-NH3, or in 120:30:50 BuOH-HOAc-H2O. The developed chromatograms are sprayed with 1.5% TiCl2 in 10% HOAc, to reduce the NO2 group, before spraying with a chromogenic reagent. Avicel thin-layer plates can be developed in BuOH saturated with H2O, 160:8:32 iso-PrOH-NH3-H2O, or 154:20:26 BuOH-HCO2H-H2O. The plates are then sprayed similarly to the paper chromatograms. The Rf values and colors obtained with I (Ehrlich’s reagent), III (Pauly’s reagent), and IV are tabulated for imidazole, 4(5)-nitroimidazole, and 12 I. A comparison of the reaction rate and sequence of color development of known I with the chromogenic reagents permit a tentative identification of substituents on a nitroimidazole ring, especially the 2-Me group. Mechanisms are proposed for the reaction of the reduced I with the 3 chromogenic reagents. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Application In Synthesis of 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application In Synthesis of 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Toward Lead-Oriented Synthesis: One-Pot Version of Castagnoli Condensation with Nonactivated Alicyclic Anhydrides was written by Ryabukhin, Sergey V.;Panov, Dmitriy M.;Granat, Dmitry S.;Ostapchuk, Eugeniy N.;Kryvoruchko, Dmitriy V.;Grygorenko, Oleksandr O.. And the article was included in ACS Combinatorial Science in 2014.Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

One-pot variation of Castagnoli condensation, i.e., reaction of cyclic anhydrides, amines, and aldehydes, has been developed as a combinatorial approach to 1,2-disubstituted 5-oxopyrrolidine- and 6-oxopiperidine-3-carboxylic acids (e.g., I and II), as well as their benzo-analogs. Utility of the method to multigram preparation of building blocks and synthetic intermediates was also demonstrated. The final products are obtained in high yields and diastereoselectivity. The method fits well in the concept of lead-oriented synthesis; in particular, it can be used for the design of lead-like compound libraries, even if the strictest cut-offs are applied to the physicochem. properties of their members. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reactions of nitroheteroarenes with carbanions: bridging aromatic, heteroaromatic, and vinylic electrophilicity was written by Seeliger, Florian;Blazej, Sylwia;Bernhardt, Sebastian;Makosza, Mieczyslaw;Mayr, Herbert. And the article was included in Chemistry – A European Journal in 2008.Formula: C4H5N3O2 This article mentions the following:

The relative rate constants for the vicarious nucleophilic substitution (VNS) of the anion of chloromethyl Ph sulfone (1^–) with a variety of nitroheteroarenes, for example, nitropyridines, nitropyrroles, nitroimidazoles, 2-nitrothiophene, and 4-nitropyrazole, were determined by competition experiments Nitropyridines are approx. four orders of magnitude more reactive than nitrobenzene. Among the five-membered heterocycles 2-nitrothiophene is the most active followed by nitroimidazoles and 4-nitropyrazole. Nitropyrroles are the least electrophilic nitroheteroarenes with reactivities comparable to nitrobenzene. Quantum chem. calculated Me anion affinities (B3LYP/6-311G(d,p)//B3LYP/6-31G(d)) of the nitroarenes correlated only moderately with the partial relative rate constants The correlation of these activities with the LUMO energies of nitroarenes is even worse. By measuring the second-order rate constants of the addition of 1^– to nitroarenes and to di-Et arylidenemalonates it was possible to link the electrophilic reactivities of nitroheteroarenes with the comprehensive electrophilicity scale based on the linear-free-energy-relation log k(20° C) = s(N + E). In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Formula: C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Formula: C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem