Imidazoles-derivatives

Inhibition of hydrogen sulfide corrosion of steel by benzimidazole derivatives was written by Starchak, V. G.;Kosukhina, L. D.. And the article was included in Zashchita Metallov in 1989.Recommanded Product: 13060-24-7 This article mentions the following:

The influence was studied of benzimidazole and 2-alkylbenzimidazoles on the corrosion inhibition of steel 45 in acidic H₂S media by using a weight-loss method. The electrochem. method was used to study the corrosion of Armco Fe, and the polarization resistance of steel St. 3 was measured. Derivatives of benzimidazole, exhibiting synergism in H₂S media, significantly increase the corrosion resistance of steel. The mechanism of inhibition is basically related to blocking and ψ¹-effects. In the experiment, the researchers used many compounds, for example, 2-Octylbenzimidazole (cas: 13060-24-7Recommanded Product: 13060-24-7).

2-Octylbenzimidazole (cas: 13060-24-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: 13060-24-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The ultrasound-assisted synthesis of some novel fused-ring heterocyclic systems bearing structurally diverse benzazoles via a copper-catalyzed cross-coupling reaction was written by Karimi, Nafiseh;Mahboubi-Rabbani, Mohammad;Dastjerdi, Hossein Fasihi;Nematpour, Manijeh;Rezaee, Elham;Tabatabai, Sayyed Abbas. And the article was included in Monatshefte fuer Chemie in 2022.Application In Synthesis of 1-Methylbenzimidazole This article mentions the following:

A novel ultrasonic-assisted process involving CuI-catalyzed intra-mol. C-H activation of benzazoles were developed. This methodol. offered affordable starting materials, mild reaction conditions, easy handling of the catalyst, a simple work-up process and short reaction times. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application In Synthesis of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application In Synthesis of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale was written by McCoy, Michael A.;Spicer, Dominique;Wells, Neil;Hoogewijs, Kurt;Fiedler, Marc;Baud, Matthias G. J.. And the article was included in Journal of Medicinal Chemistry in 2022.Synthetic Route of C9H9N3 This article mentions the following:

The canonical Wingless-related integration site signaling pathway plays a critical role in human physiol., and its dysregulation can lead to an array of diseases. β-Catenin is a multifunctional protein within this pathway and an attractive yet challenging therapeutic target, most notably in oncol. This has stimulated the search for potent small-mol. inhibitors binding directly to the β-catenin surface to inhibit its protein-protein interactions and downstream signaling. Here, we provide an account of the claimed (and some putative) small-mol. ligands of β-catenin from the literature. Through in silico anal., we show that most of these mols. contain promiscuous chem. substructures notorious for interfering with screening assays. Finally, and in line with this anal., we demonstrate using orthogonal biophys. techniques that none of the examined small mols. bind at the surface of β-catenin. While shedding doubts on their reported mode of action, this study also reaffirms β-catenin as a prominent target in drug discovery. In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Synthetic Route of C9H9N3).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Synthetic Route of C9H9N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Asymmetric Michael Addition of 2-Acetyl Azaarenes to β-CF₃-β-(3-indolyl)nitroalkenes Catalyzed by a Cobalt(II)/(imidazoline-oxazoline) Complex was written by Wang, Cong;Li, Nan;Zhu, Wen-Jing;Gong, Jun-Fang;Song, Mao-Ping. And the article was included in Journal of Organic Chemistry in 2019.Computed Properties of C6H8N2O This article mentions the following:

The first enantioselective Michael addition of 2-acetyl azaarenes to β-CF₃-β-(3-indolyl)nitroalkenes has been successfully achieved in the presence of a Co(II)/(imidazoline-oxazoline) complex as the catalyst. The reaction affords a series of CF₃– and 3-indole-containing adducts featuring a trifluoromethylated all-carbon quaternary stereocenter in good to excellent yields (up to 99%) and enantioselectivities (up to 96% ee). Furthermore, the functional groups in the adducts including C=O, NO₂, and the azaarene provide a large variety of useful transformations, leading to the formation of valuable intermediates such as optically active secondary alc., pyrroline, ester, and pyrrolidinone which all contain a 3-substituted indole and a trifluoromethylated all-carbon quaternary stereocenter. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Computed Properties of C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Computed Properties of C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic liquid copolymerized polyurethane membranes for pervaporation separation of benzene/cyclohexane mixtures was written by Xi, Tao;Lu, Yingying;Ai, Xinyu;Tang, Lin;Yao, Lulu;Hao, Wentao;Cui, Peng. And the article was included in Polymer in 2019.Application of 915358-85-9 This article mentions the following:

Benzene and cyclohexane are both important raw materials in polymer chem. industry. However, they are hard to be separated via the traditional distilling methods. In this work, ionic liquid copolymerized waterborne polyurethane (IL-co-PU) membranes were proposed for the pervaporation separation of benzene/cyclohexane mixtures The results, including swelling rate, diffusion coefficients, partial flux, permeance and selectivity, showed that the IL-co-PU membranes could preferentially absorb and transfer benzene mols. rather than cyclohexane. The ILs might have functioned as facilitated transporter in the membranes. The permeation flux and separation factor of the IL-co-PU membranes increased simultaneously with the increase of IL contents. That is, these membranes had no trade-off between permeability and selectivity, which most of the polymer membranes suffered. With consideration of the good performance and easy handling property of the IL-co-PU membranes, they are of great potential in pervaporation separation of benzene/cyclohexane mixtures In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Application of 915358-85-9).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application of 915358-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Catalytic Conjugate Additions of Carbonyl Anions under Neutral Aqueous Conditions was written by Myers, Michael C.;Bharadwaj, Ashwin R.;Milgram, Benjamin C.;Scheidt, Karl A.. And the article was included in Journal of the American Chemical Society in 2005.Electric Literature of C6H8N2O This article mentions the following:

The conjugate addition of carbonyl anions catalyzed by thiazolium salts that is fully operative under neutral aqueous conditions has been accomplished. The combination of α-keto carboxylates and thiazolium-derived zwitterions produces reactive carbonyl anions in a buffered protic environment that readily undergo conjugate additions to substituted α,β-unsaturated 2-acyl imidazoles. The scope of the reaction has been examined and found to accommodate various α-keto carboxylates and β-aryl substituted unsaturated 2-acyl imidazoles. The optimal precatalyst for this process is the com. available thiazolium salt, 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride, a simple analog of thiamin diphosphate. In this process, no benzoin products from carbonyl anion dimerization are observed The corresponding 1,4-dicarbonyl compounds can be efficiently converted into esters and amides by way of activation of the N-methylimidazole ring via alkylation. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Electric Literature of C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Production of alkylated gasoline using ionic liquids and immobilized ionic liquids was written by Kumar, Prashant;Vermeiren, Walter;Dath, Jean-Pierre;Hoelderich, Wolfgang F.. And the article was included in Applied Catalysis, A: General in 2006.Computed Properties of C7H13ClN2 This article mentions the following:

Ionic liquids (ILs) and silica-immobilized ionic liquids were used as acid catalysts for the liquid phase alkylation of raffinate II (the C₄-cut of the steam cracker offgases after removal of butadienes, isobutene, and C₃-hydrocarbons) and isobutane. The influences of reactant concentration (molar ratio of i-C₄/C₄-alkenes), time, temperature and acid strength of the ionic liquids were studied. Using a step-up design under batch conditions with a very dilute mixture of isobutane and alkene, the conversion for a variety of ionic liquids followed a pattern based on acid strength of the catalyst. Imidazolium-based ILs were superior to phosphonium-based ILs. Novel Lewis-Acid Catalysts II (NLAC II, immobilization by grafting on siliceous MCM 41 or on silica FK 700) were better than other solid acid catalysts tested, such as SAC 13, zeolite H-Beta (Si/Al = 14:1) and NLAC I (impregnation of ILs on silica FK 700). Possible leaching of the ionic liquid from the catalyst surface was followed by ICP measurements of the catalyst after reaction and of the reaction mixture In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Computed Properties of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Computed Properties of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New amphiphilic imidazolium/benzimidazolium calix[4]arene derivatives: synthesis, aggregation behavior and decoration of DPPC vesicles for Suzuki coupling in aqueous media was written by Burilov, Vladimir;Garipova, Ramilya;Sultanova, Elsa;Mironova, Diana;Grigoryev, Ilya;Solovieva, Svetlana;Antipin, Igor. And the article was included in Nanomaterials in 2020.Safety of 1-Methylbenzimidazole This article mentions the following:

In this study, new types of amphiphilic calix[4]arene derivatives bearing N-alkyl/aryl imidazolium/benzimidazolium fragments, e.g., 11,23-bis[(3-methyl-1H-imidazolium-1-yl)methyl]-25,27-dihydroxy-26,28-dibutoxycalix[4]arene dichloride were designed and synthesized by two step transformation: Regioselective Blanc chloromethylation of distal-di-O-Bu calix[4]arene and subsequent interaction with N-Substituted imidazole/benzimidazole. Critical aggregation concentration (CAC) values were estimated using pyrene fluorescent probe. Obtained macrocycles were found to form submicron particles with electrokinetic potential +44-+57 mV in aqueous solution For the first time it was found that amphiphilic calixarene causes the fast transformation of 1,2-dipalmitoyl-sn-glycero-3- phosphocholine (DPPC) multilamellar vesicles into unilamellar ones and leads to the ordering of the lipid in membranes at the molar calixarene/DPPC ratio more than 0.07. In situ complexes of calixarene aggregates with Pd(OAc)₂ were found to be active in Suzuki-Miyaura coupling of 1-bromo-4- nitrobenzene with phenylboronic acid in water. It was shown that bulky N-substituents of heterocycle decrease the catalytic activity of the aggregates. These result can be assigned to the inhibition effect of Pd(II) complex in situ formation by bulky substituents located on the aggregate surface. Embedding of the most active palladium N-heterocyclic carbene (NHC) complex with methylimidazolium headgroups into DPPC vesicles enhances its catalytic activity in Suzuki-Miyaura coupling. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Safety of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Safety of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Biorefinery potential of sustainable municipal wastewater treatment using fast-growing willow was written by Sas, E.;Hennequin, L. M.;Fremont, A.;Jerbi, A.;Legault, N.;Lamontagne, J.;Fagoaga, N.;Sarrazin, M.;Hallett, J. P.;Fennell, P. S.;Barnabe, S.;Labrecque, M.;Brereton, N. J. B.;Pitre, F. E.. And the article was included in Science of the Total Environment in 2021.Quality Control of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

The use of willow plantations can be a sustainable approach for treating primary municipal wastewater, potentially reducing both the environmental and economic burdens associated with conventional treatment. However, the impact of wastewater irrigation upon the willow biorefinery potential has not yet been established. To investigate this effect, three-year-old field grown willows were harvested from plots kept as either controls or irrigated with primary municipal wastewater effluent at 29.5 million L ha^-1 yr^-1. Biomass compositional anal., ionic liquid pretreatment and enzymic saccharification were assessed and differential abundance of persistent extractable phytochems. was evaluated using untargeted metabolite profiling. Glucan significantly increased by 8% in wastewater treated trees, arabinose and galactose were significantly decreased by 8 and 29%, resp., while xylose, mannose and lignin content were unaltered. Ionic liquid pretreatment and enzymic saccharification efficiencies did not vary significantly, releasing >95% of the cell wall glucose and recovering 35% of the lignin. From a total of 213 phytochem. features, 83 were significantly depleted and 14 were significantly enriched due to wastewater irrigation, including flavonoids and lignan derivatives Considered alongside increased biomass yield from wastewater irrigation (+200%), lignocellulosic bioenergy yields increased to 8.87 t glucose ha^-1 yr^-1 and 1.89 t ha-1 yr-1ha^-1 yr^-1 recovered lignin, while net extractives yields increased to 1.48 t ha^-1 yr^-1, including phytochems. of interest. The maintenance of glucose accessibility after low-cost ionic liquid pretreatment is promising evidence that sustainable lignocellulose bioenergy production can complement wastewater treatment. Untargeted metabolite assessment revealed some of the phytochem. toolkit employed by wastewater irrigated willows, including accumulation of flooding and salinity tolerance associated flavonoids glabraoside A and glabrene. The extractable phytochems. underpin a novel high biomass phenotype in willow and, alongside lignocellulosic yields, could help enhance the economic feasibility of this clean wastewater treatment biotechnol. through integration with sustainable biorefinery. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Quality Control of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Quality Control of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Long Chain Alkylated Ionic Liquids as Pour Point Depressant and Rheology Improver for Crude Oil was written by Hazrati, N.;Abdouss, M.;Miran-Beigi, A. A.;Pasban, A. A.. And the article was included in Petroleum Chemistry in 2021.Electric Literature of C18H31F6N3O4S2 This article mentions the following:

Abstract: Cold flow properties of Iranian crude oil have been investigated by two different imidazolium ionic liquids including 1-dodecyl-3-methylimidazolium reduce the pour point up to bis(trifluoromethanesulfonyl) imide ([C₁₂min][NTf₂]) and 1-tetradecyl-3-methylimidazolium bis(trifluoromethanesulfonyl) imide ([C₁₄min][NTf₂]). ([C₁₄min][NTf₂]) showed high ability to 12°C optimal performance by addition of 2000 ppm. Wax crystallization behavior of untreated and treated crude oil was monitored using differential scanning calorimetry (DSC) and the polarized optical microscopy (POM). Results from DSC and POM revealed that the presence of both ILs changes the process of crystallization and extends wax precipitation time. Furthermore, rheol. behavior of the crude oil was improved and viscosity was decreased by 73% at 23.5°C and 87% at 15°C by addition of [C₁₄mim][NTf₂]. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Electric Literature of C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem