Imidazoles-derivatives

Preparation of AgCl with enhanced photocatalytic activity using ionic liquid as chlorine source was written by Li, Zhao;Huang, Jiao;Zhong, Junbo;Li, Jianzhang. And the article was included in Applied Physics A: Materials Science & Processing in 2020.Recommanded Product: 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Abstract: In this study, Ag/AgCl photocatalysts were prepared by using chloride ionic liquid (IL) as a chlorine source. The structure, composition, morphol., light response ability and surface properties of IL-AgCl were characterized by X-ray diffraction, scanning electron microscope, XPS, Raman spectroscopy, UV-Vis diffuse reflection spectra, sp. surface area and surface photovoltage spectrum. The photocatalytic activity of the samples was investigated by measuring the residual concentration of rhodamine B used as a simulated pollutant. The exptl. results show that the ionic liquid can promote the stability of AgCl, furthermore, all the IL-AgCl photocatalysts have a higher separation rate of photogenerated charge pairs than the reference AgCl. The surface properties and photocatalytic activity of AgCl prepared tightly relate to the type of IL used, among all the AgCl prepared, AgCl prepared by 1-carboxyethyl-3-methyl-imidazolium chloride has the best catalytic activity. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Recommanded Product: 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic liquid-mediated transcutaneous protein delivery with solid-in-oil nanodispersions was written by Araki, Shota;Wakabayashi, Rie;Moniruzzaman, Muhammad;Kamiya, Noriho;Goto, Masahiro. And the article was included in MedChemComm in 2015.Computed Properties of C18H31F6N3O4S2 This article mentions the following:

As a potentially safe and non-invasive vaccination method, transcutaneous immunization represents an attractive alternative to conventional vaccine delivery by injection. However, the development of transcutaneous immunization has remained a challenge for a large number of hydrophilic macromols. including protein and peptide antigens. We report a novel ionic liquid (IL)-mediated transcutaneous vaccine formulation consisting of a solid-in-oil (S/O) nanodispersion of antigen coated with pharmaceutically accepted surfactants dispersed in IL-containing oil. The introduction of the IL [C₁₂mim][Tf₂N] (1-dodecyl-3-Me imidazolium bis(trifluoromethyl sulfonyl) amide) as a penetration enhancer in the formulation significantly enhanced the skin permeability of ovalbumin (OVA), a model antigen. It was also found that the IL-mediated S/O nanodispersion obtained high levels of OVA-specific serum IgG compared with both S/O nanodispersions without IL and PBS control. These findings clearly indicate that ILs – which are potentially attractive “green” and “designer” solvents – could serve as potential skin penetration enhancers in transcutaneous vaccination for hydrophilic macromols. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Computed Properties of C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Computed Properties of C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cooperative Catalytic Activation of Si-H Bonds: CO₂-Based Synthesis of Formamides from Amines and Hydrosilanes under Mild Conditions was written by Luo, Rongchang;Lin, Xiaowei;Chen, Yaju;Zhang, Wuying;Zhou, Xiantai;Ji, Hongbing. And the article was included in ChemSusChem in 2017.Quality Control of 1-Octyl-1H-imidazole This article mentions the following:

A simple cooperative catalytic system was successfully developed for the solvent-free N-formylation of amines such as morpholine, 2,3-dihydro-1H-indole, 2,6-dimethylpiperazine, etc. with CO₂ and hydrosilanes under ambient conditions and composed of a Zn(salen) catalyst and quaternary ammonium salt. These com. available binary components activated the Si-H bonds effectively, owing to the intermol. synergistic effect between Lewis base and transition metal center (LB-TM), and subsequently facilitated the insertion of CO₂ to form the active silyl formats, thereby leading to excellent catalytic performance at a low catalyst loading. Furthermore, the bifunctional Zn(salen) complexes, with two imidazolium-based ionic-liquid (IL) units at the 3,3′-position of salen ligand, acted as intramolecularly cooperative catalysts, and the solvent-regulated separation resulted in facile catalyst recycling and reuse. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Quality Control of 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Quality Control of 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Proteolytic enzymes. Models for electrophilic assistance by NH in acylation was written by Williams, A.;Salvadori, G.. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1972.Category: imidazoles-derivatives This article mentions the following:

The effect of increasing dioxane content of the medium was used to examine the possibility of intramol. electrophilic assistance by NH in alk. hydrolysis of the Me esters of 2-acetamidobenzoic, 2-pyrrolecarboxylic (I), and benzimidazole-4(7)-carboxylic (II) acids. Significant rate constant enhancement was observed for positional isomers where participation was possible; enhancements increased rapidly with increasing dioxane concentration, thus agreeing with a built-in solvation by NH of the incipient alkoxide ion (derived from the carbonyl O) of the transition state. I and II had maximum in their rate enhancements as the dioxane content increased. The NH to alkoxide bond distance in I and II is larger than normally found for direct H-bonding and the maximum may arise from a H2O bridge acting as a relay between electrophilic NH and incipient alkoxide ion in the transition state. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Category: imidazoles-derivatives).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Highly Stable Polymeric Ionic Liquid Modified Electrode to Immobilize Ferricyanide for Electroanalysis of Sulfide was written by Chang, Jen-Lin;Wei, Guor-Tzo;Chen, Tsu-Yin;Zen, Jyh-Myng. And the article was included in Electroanalysis in 2013.Product Details of 915358-85-9 This article mentions the following:

We report the preparation and application of a highly stable polymeric ionic liquid-modified electrode to immobilize ferricyanide for sulfide anal. Good long-term stability of the modified electrode verifies its potential in sensor applications. The electrocatalytic sulfide oxidation signal at �.0 V vs. Ag/AgCl in pH 7 PBS at the modified electrode was used for sulfide detection by hydrodynamic chronoamperometry and a detection limit of 12.9nM (S/N =3) was obtained. Practical utility of the system is applied to the determination of sulfides in hot spring water and groundwater. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Product Details of 915358-85-9).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Product Details of 915358-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cu-Catalyzed Regioselective C-H Alkylation of Benzimidazoles with Aromatic Alkenes was written by He, Yu-Ting;Mao, Yang-Jie;Hao, Hong-Yan;Xu, Zhen-Yuan;Lou, Shao-Jie;Xu, Dan-Qian. And the article was included in Organic Letters in 2020.Computed Properties of C8H8N2 This article mentions the following:

Herein we report a novel Cu-catalyzed regioselective C2-H alkylation of benzimidazoles such as N-methylbenzimidazole with aromatic alkenes. The reaction features exclusive regioselectivity and broad substrate scope in the intermol. alkylation of benzimidazoles with terminal and internal aromatic alkenes, constituting a modular access toward benzimidazole-containing 1,1-di(hetero)aryl alkanes such as I. The intramol. C2-H alkylation of benzimidazoles with aromatic alkenes such as N-cinnamylbenzimidazole has been achieved in an endo-selective manner to yield fused benzimidazoles such as cyclopentapyrrolobenzimidazole II. The enantioselective C2 alkylation of benzimidazoles has also been realized with moderate to good stereocontrol; for example, using (S,S)-Ph-BPE, (+)-I and (+)-II were prepared in 85:15 er and 68:32 er, resp. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Computed Properties of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Computed Properties of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dominance of hydrophobic attraction in attachment of microbubbles and Graphene oxide (GO) was written by Yahya, M. S.;Lau, E. V.. And the article was included in Chemical Engineering Science in 2022.Name: 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

This paper presents the synthesis of GO-coated microbubbles which would be useful for environmental remediation and enhanced heat transfer applications. The mechanism of microbubble-GO attachment including electrostatic interactions, hydrophobic attraction, contact angle and Gibb’s free energy were determined Preliminary experiments indicated that water alone is not favorable, which thus necessitated the use of a bridging surfactant. The optimum attachment between microbubbles and GO occurred at the GO’s isoelec. point (IEP) in the ionic liquid as surfactant (IL), in which the IL concentration allowed GO to achieve maximum hydrophobicity. Therefore, it is inferred that hydrophobic attraction is the dominant force for microbubble-GO attachment with minor contributions from electrostatic interactions. Further studies showed that the longest carbon chain length IL, i.e. 1-Dodecyl-3-methylimidazolium chloride ([C₁₂mim]Cl) produced the most conducive environment for microbubble-GO attachment at its IEP concentration of 350 ppm. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Name: 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Name: 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Transition-metal-free, direct C-H radical trifluoromethylation of nitroimidazoles with Togni’s reagent was written by Wang, Hezhen;Wei, Chunyong;Zou, Haiyan;Linghu, Chengcheng;Wang, Zhiyuan;Wang, Jing;Chen, Yongzheng;Zhang, Lei. And the article was included in Tetrahedron Letters in 2022.HPLC of Formula: 169770-25-6 This article mentions the following:

In present study, a green, mild and practical method which allows for the transition-metal-free, direct C-H radical trifluoromethylation of nitroimidazoles with Togni’s regent II as the CF₃ radical precursor was described. Diverse nitroimidazoles and their drug mols. were smoothly transformed into trifluoromethylated compounds in moderate to good yields under mild conditions. This new method provided an alternative approach for the prepare of trifluoromethylated compounds, as well as late-stage modification of bioactive nitroimidazoles. In the experiment, the researchers used many compounds, for example, Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6HPLC of Formula: 169770-25-6).

Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 169770-25-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Identification of Prazosin as a Potential Flagellum Attachment Zone 1(FAZ1) Inhibitor for the Treatment of Human African Trypanosomiasis was written by Orahoske, Cody M.;Afrin, Marjia;Li, Yaxin;Hanna, Jovana;Marbury, Myah;Li, Bibo;Su, Bin. And the article was included in ACS Infectious Diseases in 2022.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

Human African trypanosomiasis (HAT) remains a health threat to sub-Saharan Africa. The current treatments suffer from drug resistance and life-threatening side effects, making drug discovery for HAT still important. A high-throughput screening of the library of pharmaceutically active compounds identified prazosin, an α-adrenoceptor antagonist, that showed selective activity toward Trypanosoma brucei brucei. Furthermore, a series of prazosin analogs were examined, and overall, the new analogs had improved activity and selectivity. To elucidate the binding partner, a biotin-conjugated probe was synthesized, and a protein pulldown assay combined with a proteomic anal. identified the flagellum attachment zone 1 (FAZ1) filament as an interacting partner. Addnl., prazosin treatment resulted in dysfunction of the flagellum of trypanosome cells, which is indicative of a FAZ1 irregularity. We also examined the drug distribution by utilizing immunofluorescence with a designed fluorescent analog that showed partial colocalization with FAZ1. With the activity of the prazosin analogs, a structure-activity relationship (SAR) was summarized for future lead optimization. Our findings provide a new group of FAZ1 inhibitors as novel antitrypanosomal agents. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Carbohydrates-tailored phase tunable systems composed of ionic liquids and water. [Erratum to document cited in CA153:297068] was written by Chen, Yuhuan;Wang, Yige;Cheng, Qingyan;Liu, Xiaoli;Zhang, Suojiang. And the article was included in Journal of Chemical Thermodynamics in 2010.Reference of 79917-89-8 This article mentions the following:

On page 1056, the first Author’s name should read: Yuhuan Chen. The correct version of the Author line has been corrected On page , in Figure 5, D of phenol in {[C3mim]BF4 + glucose + H2O} system is 2.51, not 13.04. The correct version of Figure 5 is given. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Reference of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Reference of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem