Imidazoles-derivatives

Solvatochromism of Heteroaromatic Compounds: XIV. 5-Amino-1-methyl-4-nitropyrazole and Its Analogs was written by Vokin, A. I.;Shulunova, A. M.;Krivoruchka, I. G.;Krylova, O. V.;Lopyrev, V. A.;Turchaninov, V. K.. And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) in 2002.Application In Synthesis of 1-Methyl-4-nitroimidazole This article mentions the following:

The solvatochromism of H complexes of 5-amino-1-methyl-4-nitropyrazole and 2-nitroaniline derivatives in aprotic protophilic media was described on a quant. level with the aid of Kamlet-Taft empirical parameters. Specific solvation affects only one of the two long-wave bands, that corresponding to an electronic transition involving orbital electron d. transfer from the H-bound N atom. When such transfer does not occur, which is typical of the second transition, specific solvatochromic effect is either weak or absent. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Application In Synthesis of 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application In Synthesis of 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Asymmetric Umpolung (3+2) Cycloadditions of Iminoesters with α,β-Unsaturated-2-acyl Imidazoles for the Synthesis of Substituted Pyrrolidines was written by Gill, Mamta;Das, Arko;Singh, Vinod K.. And the article was included in Organic Letters in 2022.Computed Properties of C6H8N2O This article mentions the following:

An enantioselective (3+2) cycloaddition reaction of iminoesters occurring with opposite regioselectivity was reported. This reaction provided chiral polysubstituted pyrrolidines with high enantioselectivities (up to 97%), diastereoselectivities (>20:1), and yields (up to 99%). Interestingly, changing the alpha-substituents of the iminoesters from an aryl to an aliphatic (benzyl) group or hydrogen resulted in the formation of normal (3+2) cycloaddition products, also in excellent enantioselectivities. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Computed Properties of C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Computed Properties of C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enhancing the solar energy conversion and harvesting characteristics of multiwalled carbon nanotubes-modified 1-hexyl-3-methyl-imidazolium cation ionic liquids was written by Boldoo, Tsogtbilegt;Lee, Minjung;Cho, Honghyun. And the article was included in International Journal of Energy Research in 2022.COA of Formula: C18H31F6N3O4S2 This article mentions the following:

The concept of solar energy absorption or photothermal energy conversion of nanofluids as a working fluid is a promising idea utilized in various applications. However, the lack of diversity of the base agents restricts the usage of solar thermal conversion systems in extreme conditions such as extreme cold or hot environments. The ionic liquids were used as a base agent to broaden the applicable conditions of the solar thermal conversion system considering the remarkable favorable characteristics of ionic liquids In this study, key factors of solar energy conversion characteristics and performance of the various 1-hexyl-3-methylimidazolium cation-based ionic liquids and MWCNT nanoparticle-enhanced ionic liquids (NEILs) were exptl. investigated. This study dives deep into the optical properties of the ionic liquids compared to the previous studies in the open literature. In the manufacturing process, MWCNT nanoparticles are dispersed in various ionic liquids at 20 kHz and coated with the Gum-Arabic. It was found that 1-hexyl-3-methylimidazolium cation-based pure room temperature ionic liquids were almost transparent in the visible light spectrum with nearly 0% absorbance; however, adding a small amount of addnl. MWCNT nanoparticles sharply increased the absorbance rate up to nearly 100% (Fâˆ?). Besides, the transmittance of the MWCNT NEILs decreased with the increasing concentration Under the simulated solar light, the final temperature of the samples increased with the increasing concentration of MWCNT NEIL. Moreover, the maximum photothermal energy conversion efficiency (η_PEC) of each MWCNT NEILs was 38.0%, 40.9%, 40.2%, and 39.8% in the case of [HMIM][Tf₂N], [HMIM][TfO], [HMIM][Pf₆], and [C₁₂MIM][Tf₂N], resp., at a concentration and operating time of 1 wt% and 7200 s. In addition, SER value sharply increased with the increasing nanoparticle concentration, and it almost doubled compared to the base agents. Furthermore, the nanoparticle concentration affects the solar energy absorption capability of ionic liquids more than anions in their chem. structure. This study can deliver the necessary data to design a direct absorption solar thermal collector using ionic liquids, which are new green designer working fluids. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5COA of Formula: C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.COA of Formula: C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Highly Efficient SO₂ Absorption and Its Subsequent Utilization by Weak Base/Polyethylene Glycol Binary System was written by Yang, Zhen-Zhen;He, Liang-Nian;Zhao, Ya-Nan;Yu, Bing. And the article was included in Environmental Science & Technology in 2013.Formula: C11H20N2 This article mentions the following:

A binary system consisting of polyethylene glycol (PEG, proton donor)/PEG-functionalized base with suitable basicity was developed for efficient gas desulfurization (GDS) and is regarded as an alternative approach to circumvent the energy penalty problem in the GDS process. High capacity for SO₂ capture (â‰?.88 mol SO₂/mol base) was achieved, even under low SO₂ partial pressure. SO₂ desorption operates smoothly under mild conditions (N₂, 25°); no significant drop in SO₂ absorption was observed after 5 successive absorption/desorption cycles. SO₂ absorbed by PEG₁₅₀MeIm/PEG₁₅₀, considered the activated form of SO₂, can be directly transformed into value-added chems. under mild conditions, eliminating the energy penalty for SO₂ desorption and simultaneously recycling the absorbents. Thus, this SO₂ capture and utilization process offers an alternative way for GDS and potentially enables SO₂ conversion from flue gas to useful chems. as a value-added process. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Polymer inclusion membranes (PIMs) doped with alkylimidazole and their application in the separation of non-ferrous metal ions was written by Radzyminska-Lenarcik, Elzbieta;Ulewicz, Malgorzata. And the article was included in Polymers (Basel, Switzerland) in 2019.Related Products of 21252-69-7 This article mentions the following:

The study involved the transport of zinc(II), cadmium(II), and nickel(II) ions from acidic aqueous solutions using polymer inclusion membranes (PIMs). PIMs consisted of cellulose triacetate (CTA) as a support; o-nitrophenyl pentyl ether (o-NPPE) as a plasticizer; and 1-octylimidazole (1), 1-octyl-2-methylimidazole (2), 1-octyl-4-methylimidazole (3), or 1-octyl-2,4-dimethylimidazole (4) as ion carriers. The membranes were characterized by means of at. force microscopy (AFM) and SEM (SEM). The results show that Zn(II) and Cd(II) are effectively transported across PIMs, while Ni(II) transport is not effective. The rate of transport of metal ions across PIMs is determined by the diffusion rate of the M(II)-carrier complex across the membrane. The best result achieved for Zn(II) removal after 24 h was 95.5% for the ternary Zn(II)-Cd(II)-Ni(II) solution for PIM doped (4). For this membrane, the separation coefficients for Zn(II)/Cd(II), Zn(II)/Ni(II), and Cd(II)/Ni(II) were 2.8, 104.5, and 23.5, resp. Addnl., the influence of basicity and structure of carrier mols. on transport kinetics was discussed. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Related Products of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formulation and Bioavailability of Novel Mucoadhesive Buccal Films for Candesartan Cilexetil in Rats was written by Mady, Omar Y.;Abulmeaty, Mahmoud M. A.;Donia, Ahmed A.;Al-Khureif, Abdulaziz A.;Al-Shoubki, Adam A.;Abudawood, Manal;Abdel Moety, Doaa A.. And the article was included in Membranes (Basel, Switzerland) in 2021.Reference of 145040-37-5 This article mentions the following:

Candesartan cilexetil (CC) is an antihypertensive drug. It has low solubility and faces hepatic first-pass metabolism after oral ingestion. We formulated bioadhesive buccal films and studied the resp. drug pharmacokinetics. Different bioadhesive films were prepared (40, 80, 120, 160, 200, and 240 mg CC per film) by using the solvent casting method. The drug concentrations used affect the drug entrapment mechanism, which was reflected in the film physicochem. properties like thickness, weight, drug content, bioadhesion, and drug release. Low drug concentration (F2, 40 mg per film) led to minute drug crystal dispersion while increasing the drug concentration (F7, 240 mg per film) showed drug crystal encapsulation, which affects the drug release. The drug pharmacokinetic from the prepared films was studied compared to the oral form by serial blood sampling via an inserted catheter in the carotid of rats. High-Performance Liquid Chromatog. assay was used to measure the plasma concentration of CC in different forms. Compared to other films, the F2 showed the highest maximal concentration (C_max) and the lowest elimination half-life (_1/2). Bioadhesion buccal film of CC has better bioavailability, especially at low concentrations The ease, robustness, and ruggedness of the preparation suggests the same procedure for drugs like CC. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Reference of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Reference of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Alkyl Methyl Imidazolium-Based Ionic Liquids at the Au(111) Surface: Anions and Alkyl Chain Cations Induced Interfacial Effects was written by Kamalakannan, Shanmugasundaram;Prakash, Muthuramalingam;Al-Mogren, Muneerah Mogren;Chambaud, Gilberte;Hochlaf, Majdi. And the article was included in Journal of Physical Chemistry C in 2019.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

The structure, stability, and adsorption mechanism on the Au(111) surface of hydrophilic/hydrophobic ionic liquids (ILs) with various lengths of the alkyl chain group in the cation were studied using 1st-principles approaches including electrostatic potential (ESP), electron d. anal., and dispersion-corrected d. functional theory (DFT-D3) methods. A suitable selection of ILs is considered. Indeed, the authors treat ILs [C_nMIm]⁺[X]^–, where X = Cl^–, PF₆^–, and TFSA^–, MIm = methylimidazolium and where the authors varied the alkyl chain (C_n) length for n = 0, 2, 4, 6, 8, and 10. The adsorption energies (E_ads‘s) of fluorinated ILs are lower (by âˆ?0%) than those of nonfluorinated ILs. Computations show that the nature of the anion within the ILs and the alkyl chain length play a very important role to alter the interfacial interactions between ILs and Au surface. Indeed, the alkyl groups of the cation affect the cation-anion interaction strength within ILs because of specific modes of adsorption of alkyl chains on the Au(111) surface. Also, structural-induced adsorption effects are observed during the variation of alkyl chain and anions. These are due to the modification of the local properties of the Au surface upon IL adsorption, where the authors identify, in some specific cases, an enhancement of the charge transfers between the ILs and the Au(111) surface through van der Waals and dispersive interactions. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors was written by Hao, Chenzhou;Zhao, Fan;Song, Hongyan;Guo, Jing;Li, Xiaodong;Jiang, Xiaolin;Huan, Ran;Song, Shuai;Zhang, Qiaoling;Wang, Ruifeng;Wang, Kai;Pang, Yu;Liu, Tongchao;Lu, Tianqi;Huang, Wanxu;Wang, Jian;Lin, Bin;He, Zhonggui;Li, Haitao;Li, Feng;Zhao, Dongmei;Cheng, Maosheng. And the article was included in Journal of Medicinal Chemistry in 2018.HPLC of Formula: 3034-41-1 This article mentions the following:

Herein, we report the discovery and characterization of a novel class of PAK4 inhibitors with a quinazoline scaffold. Based on the shape and chem. composition of the ATP-binding pocket of PAKs, we chose a 2,4-diaminoquinazoline series of inhibitors as a starting point. Guided by X-ray crystallog. and a structure-based drug design (SBDD) approach, a series of novel 4-aminoquinazoline-2-carboxamide PAK4 inhibitors were designed and synthesized. The inhibitors’ selectivity, therapeutic potency, and pharmaceutical properties were optimized. One of the best compounds, 31 (CZh226), showed remarkable PAK4 selectivity (346-fold vs PAK1) and favorable kinase selectivity profile. Moreover, this compound potently inhibited the migration and invasion of A549 tumor cells by regulating the PAK4-directed downstream signaling pathways in vitro. Taken together, these data support the further development of 31 as a lead compound for PAK4-targeted anticancer drug discovery and as a valuable research probe for the further biol. investigation of group II PAKs. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1HPLC of Formula: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.HPLC of Formula: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic Liquids Can Significantly Improve Textile Dyeing: An Innovative Application Assuring Economic and Environmental Benefits was written by Bianchini, Roberto;Cevasco, Giorgio;Chiappe, Cinzia;Pomelli, Christian Silvio;Rodriguez Douton, Maria Jesus. And the article was included in ACS Sustainable Chemistry & Engineering in 2015.Safety of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

Owing to economic reasons, the textile dyeing industry generally employs traditional and absolutely no-eco-friendly processes: very large quantities of water are indeed required together with a large number of added chems. which represent dramatic environmental issues. In order to improve the sustainability of the process, we have investigated the dyeing of wool, polyester, and cotton with disperse Red 13 using ionic liquids as the sole additive. The results obtained in isothermal dyeing at 95 °C show an outstanding effect of the ionic liquid 1-(2-hydroxyethyl)-3-methylimidazolium chloride. This ionic liquid assures efficient dyeing of polyester and wool in open vessels, in the absence of whichever auxiliary agent with total dyebath exhaustion, thus allowing in principle the recycling of the dye bath. The environmental benefits arising from the substitution of a number of usually employed auxiliary agents with only an ionic liquid are highlighted together with the economic ones. This article reports for the first time, to the best of our knowledge, dyeing processes for several kinds of fibers (cotton, wool, and polyester) employing exclusively three components: pure disperse dye, water, and an appropriate ionic liquid In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Safety of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Safety of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Regio- and Enantioselective Allylic Amination of Aliphatic MBH Adducts with N-Heteroaromatics was written by Wang, Haixia;Yu, Lulu;Xie, Mingsheng;Wu, Jiang;Qu, Guirong;Ding, Kuiling;Guo, Haiming. And the article was included in Chemistry – A European Journal in 2018.Quality Control of 7-Methyl-1H-benzo[d]imidazole This article mentions the following:

Palladium-catalyzed regio- and enantioselective allylic amination of aliphatic Morita-Baylis-Hillman (MBH) adducts with N-heteroaromatic nucleophiles (e.g., benzimidazole, 4,5-diphenylimidazole, benzotriazole, and purines) was achieved by using a spiroketal-based diphosphine (SKP) ligand, and afforded a range of chiral, branched N-allyl products with high selectivity. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Quality Control of 7-Methyl-1H-benzo[d]imidazole).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of 7-Methyl-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem